9 genomes BUD0059 12 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG2335 rrnAC1190 rrnAC3097 HVO_0071 Hbo1429 Hmu1865 Hmu2626 Hut1594 hla0377 NP0952A HQ1907A HQ3466A

Pairwise sequence scores
Consensus score	824	HQ1907A	rrnAC1190	Hmu1865	VNG2335	NP0952A	Hut1594	hla0377	Hbo1429	HVO_0071	rrnAC3097	HQ3466A	Hmu2626
457	HQ1907A	846	551	562	270	286	375	376	331	367	369	307	381
482	rrnAC1190	551	793	584	298	325	390	375	361	422	417	357	395
475	Hmu1865	562	584	815	286	302	388	405	343	417	415	337	398
451	VNG2335	270	298	286	2074	386	350	379	423	392	431	407	364
483	NP0952A	286	325	302	386	787	365	437	495	477	470	451	419
551	Hut1594	375	390	388	350	365	832	427	420	483	478	451	550
604	hla0377	376	375	405	379	437	427	850	506	538	552	503	500
609	Hbo1429	331	361	343	423	495	420	506	816	611	579	592	577
689	HVO_0071	367	422	417	392	477	483	538	611	986	642	586	574
683	rrnAC3097	369	417	415	431	470	478	552	579	642	804	617	592
603	HQ3466A	307	357	337	407	451	451	503	592	586	617	867	602
654	Hmu2626	381	395	398	364	419	550	500	577	574	592	602	811

263 symbols
consensus       ------------------------------------------------------------
#oth            111111111111111111111111111111111111111111111111111111111111
HQ1907A         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
rrnAC1190       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hmu1865         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
VNG2335         MLYCSGGPGWHGDYDGNRARSGVQPRGSQPASTGAPGVRVILRSGQRRSGCTRATGRQDA
NP0952A         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hut1594         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
hla0377         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hbo1429         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
HVO_0071        ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
rrnAC3097       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
HQ3466A         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hmu2626         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

consensus       ------------------------------------------------------------
#oth            111111111111111111111111111111111111111111111111111111111111
HQ1907A         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
rrnAC1190       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hmu1865         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
VNG2335         SIGLEPPTWGLAPSRAWRTRLRPTASHKPIPTIQNGPTGGRTRAVVRTDDGWTRRPPSTP
NP0952A         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hut1594         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
hla0377         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hbo1429         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
HVO_0071        ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
rrnAC3097       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
HQ3466A         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hmu2626         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

consensus       ----------------------------MTEFDPEKFED-KYAHYFPELQRAYKNAFEQM
#oth            111122222222222222222222222234521114.231..221.42113..2311371
HQ1907A         ::::::::::::::::::::::::::::::K::::::DN:::E:::E:IEQ::SD:YQ:L
rrnAC1190       :::::::::::::::::::::::::::::::::A:::DE:::V:::E::ET::S::YQEL
Hmu1865         ::::::::::::::::::::::::::::V:A:::::::R:::E:::E::ET::S::YQ:L
VNG2335         KAGSHPPAGVLCAGGSDGHLQAGVQTTS:SDLT::E::EQ::VD:::K:ET:::R::DD:
NP0952A         ::::::::::::::::::::::::::::---M:A:T:DEQ::VDL::Q::Q::::V:NRL
Hut1594         ::::::::::::::::::::::::::::::::::DR:T::::E:::T:::Q::RR:::A:
hla0377         :::::::::::::::::::::::::::MAD::::::::::::::::N::::::::::N::
Hbo1429         :::::::::::::::::::::::::::::AD:::::::::::V::::Q:::::::::NT:
HVO_0071        ::::LLYKIHNSDELTVRFFAGSAKAPS:::::::::::::::N::::::::::::::T:
rrnAC3097       ::::::::::::::::::::::::::::::T::::::::::::N::::::K:::::::R:
HQ3466A         :::::::::::::::::::::::::::::A:::::Q:::::::N::A:::::::::::S:
Hmu2626         ::::::::::::::::::::::::::::::A:::::::::::E:::T:::K:::Q:::V:

consensus       NDRYDSELIHAIDQQILNESEPFYEGDGE-FSVELPDDPTERLTA-VPVDDEKLDAVLDE
#oth            2344.1522121.131.2....3.142342.514..213721254136212362541143
HQ1907A         HGGC:::ILR:::RKV:S::::L:::N:K::H:R::::ID::AQP:L:G:E:SFN:::::
rrnAC1190       HGQ::::VLRG::R:::S::::V:::N:T:::IR::::TAA:AQS:L:G:EATF:T::SA
Hmu1865         HGQV::AVLRT::R:V:S::::V:D:::T::R:T::::AK:TARP:L:G:EDTF::::E:
VNG2335         :GT::RK:V::::::V:S:::::::A:SG:::::::A::LD::AG::Q::ADHARD:I::
NP0952A         :EE:::T::::::::V::::::::DD:A:G:Y:::::::YD:::G::A:EE:TFES::ET
Hut1594         SE:H::D:::G:::R::A:::::::::::::RID::::ASD::PD:--::ADR:ET::G:
hla0377         ::::::::::G:::TV:::::::::-:::::R::::EN:R::IRGA::::::LFKEA:N:
Hbo1429         :EE:::T:::::::::::::::M::-::D::HIQ::EN:S::::G::V:E:::::::::R
HVO_0071        ::EF::S:::GV::::::::::::D-::D::::Q:::::A:::::::EI::DE::::::R
rrnAC3097       ::T:::::V:::::::::::::::D-::::::::::EN:::::S:::I::::::::::S:
HQ3466A         :N::::::::::::::::::::::DTETDS:EIQ::EN::D:::::IV:::Q::QT::ET
Hmu2626         ::::::::::::::::::::::V::::::::GID::E:::::::::IV::::::ET::ER

consensus       YTDEIESELRRVFGFEE------
#oth            23321372134413446442212
HQ1907A         F:TR::H::HNL:V::FEE::::
rrnAC1190       F::A::R::::L:E::-::::::
Hmu1865         F::R::D::::L:E:D:::::::
VNG2335         H::R:CVH::DQ::IGGQADEKA
NP0952A         :IG:L:A::E:T::E--::::::
Hut1594         ::G:L:TQ::S::D:::AW::::
hla0377         :V:R:::::Y:TL:VDRPE::::
Hbo1429         :L::LVA:H::I::LNG::::::
HVO_0071        :V::::::::::::V:A::::::
rrnAC3097       :V::::R::::::DIDD::::::
HQ3466A         :V::LQQQH:::::LDDESEPKV
Hmu2626         :VE:L::QH:TI:::::::::::