[S] (-) COG1430 Uncharacterized conserved protein 9 genomes BUD0072 11 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG0121 rrnAC2315 HVO_0504 Hbo1036 Hmu0240 Hut2538 hla0760 hla1873 NP0004A HQ1140A HQ1203A

Pairwise sequence scores
Consensus score	1241	NP0004A	hla1873	HQ1203A	VNG0121	HQ1140A	hla0760	Hut2538	HVO_0504	Hbo1036	Hmu0240	rrnAC2315
665	NP0004A	1420	578	510	388	425	477	462	502	506	541	521
655	hla1873	578	1513	675	387	435	395	409	429	426	443	364
530	HQ1203A	510	675	1385	387	374	334	376	433	426	371	361
585	VNG0121	388	387	387	1249	467	334	480	454	437	445	451
664	HQ1140A	425	435	374	467	1231	464	458	571	582	488	520
638	hla0760	477	395	334	334	464	1180	487	558	481	483	480
673	Hut2538	462	409	376	480	458	487	1285	558	568	514	543
874	HVO_0504	502	429	433	454	571	558	558	1226	733	604	597
761	Hbo1036	506	426	426	437	582	481	568	733	1153	547	606
754	Hmu0240	541	443	371	445	488	483	514	604	547	2481	698
742	rrnAC2315	521	364	361	451	520	480	543	597	606	698	1459

369 symbols
consensus       ------MDRRRRVVLLVIGVLVAGAVVAG----GLTNPAL--------------------
#oth            122222566454676553226343454571113267626544323233433332222222
NP0004A         ::::::::T::V:GYA:AA:AL:A:A:LLAFST::IA:F:GDG:YDPDAYDPDD::::::
hla1873         :MQPVPPPM:::G::AA:::ASI:-GL:::::C:GSA:TEDDG:GEDGEGGRNDTGTDDL
HQ1203A         MQSNMPLPSS::QC:QY:A:G:T::GF:::::CVGDS::QSETTTEDSD:::::::::::
VNG0121         ::::::----M:WTV::VAAF:V::GCG:::::---P:MAAQD:::::::::::::::::
HQ1140A         ::::MNRTLFL:A:IVA:::::V:VI:I-::::-TVI:GI::::::::::::::::::::
hla0760         ::::::VN::LLAIASAL:AIALLL:A:I::::-AA::::::::::::::::::::::::
Hut2538         ::::::V:YS:L:DV::VVL:ALAT:LSL:::T:P:S:LA::::::::::::::::::::
HVO_0504        :::::::TS:A:TA:::VA:V::V:S::Y::::-:::::V::::::::::::::::::::
Hbo1036         ::::::---------VF:VAS::AV:::F::::---::TV::::::::::::::::::::
Hmu0240         :::::::E:STA::GGT::L::V::L:VW:::S:VWLQFV::::::::::::::::::::
rrnAC2315       :::::::Q:PAV:::GLV:L:::A:::LQ:::T::WVEV:GTGEYEEGTVTVREGSDAVT

consensus       ----PPGG-ASYERTTVTVVD-ETGDELGTVDARIADTREKRYT----------------
#oth            212274535552363225352565156224.6211.216631231111111111111111
NP0004A         ::::SY::DTD::H:::::::G:::A:::A:::A::::FN:::L::::::::::::::::
hla1873         PTDW:S:TY:D:DAA::::RS:PED:D::A:R:A:::::::::L::::::::::::::::
HQ1203A         ::::ITQVH:E::T:D:RIES:AE::R::::T:A::::G:L::L::::::::::::::::
VNG0121         ::::::STPE:GDAPM:::::AD::V:H:S:AVAV:A::GE:::::::::::::::::::
HQ1140A         ::::G:T::-E:DSE::KIT:NK::NQ:ER:SV:::::PQ::::::::::::::::::::
hla0760         ::::LIA::--:DT:::EA::G::::S:A::ET:V::GFA:Q:V::::::::::::::::
Hut2538         :::::ILSPL:::EP:ISIS:::N:T::A:::V:V:::DRE::I::::::::::::::::
HVO_0504        ::::V::STDG:::::L::::D:::ET:A::N::V::::A::F:::::::::::::::::
Hbo1036         ::::L::::DQ:N::::SLIS:-D:ERVAE:NV:V:::Y:::::::::::::::::::::
Hmu0240         ::::D::S:--::::::::::::G:T:::A::::::::WQQ:LVGLSRTDSLAVDEGMLF
rrnAC2315       TTATQ:STD::TPG:::A:REKNA:EP::::EV:::Q:FDQ::V::::::::::::::::

consensus       ------------------------------------------------------------
#oth            111111111111111111111111111111111111111111111111111111111111
NP0004A         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
hla1873         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
HQ1203A         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
VNG0121         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
HQ1140A         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
hla0760         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hut2538         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
HVO_0504        ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hbo1036         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hmu0240         VHDRQDQHGYVMRRMSFPLDIVFVAENGTITRIHHAPTPADGASESDLREYSGEGKYVLE
rrnAC2315       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

consensus       ------------------------------------------------------------
#oth            111111111111111111111111111111111111111111111111111111111111
NP0004A         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
hla1873         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
HQ1203A         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
VNG0121         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
HQ1140A         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
hla0760         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hut2538         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
HVO_0504        ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hbo1036         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hmu0240         VNRGWTNATGVSVGDRLLISGETSDDAVSDEAAGDQQATASTPECPAGPTGTPSPDNATV
rrnAC2315       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

consensus       --------------------------GLSDTESLAENEGMLFVHDES-GEYAYVMRDMSF
#oth            11111111111111111111111111...5223.3522..2.12425117351...4.2.
NP0004A         :::::::::::::::::::::::::::::A:DG:P:DR::F::::SP:DD:T::::::::
hla1873         ::::::::::::::::::::::::::::::AT::P::A:::::FS:PRDSLRF:::E:D:
HQ1203A         ::::::::::::::::::::::::::::::::N:P::R::::IY:S:::NRTF:::E:D:
VNG0121         :::::::::::::::::::::::::::::TR:::SAD:::::::ERA::SR:::::S:A:
HQ1140A         :::::::::::::::::::::::::::::N::::::D:::::I::SE:DR:G::::::::
hla0760         :::::::::::::::::::::::::::::E:DE::DD:::::::::T::KH:::::G:::
Hut2538         :::::::::::::::::::::::::::::R::::SDG:::::::A::::T:P::::N:A:
HVO_0504        ::::::::::::::::::::::::::::::::::::::::W::::S:::T::::::::D:
Hbo1036         :::::::::::::::::::::::::::::A::::GT:::::::::SE::::S::::::A:
Hmu0240         TALDDDCAPLGTVSVAIADNSSERIT:::::::::VD::::::FP:I:::H:F:::E:::
rrnAC2315       :::::::::::::::::::::::::::::N::::GP::::::::::A::Q:T::::N:::

consensus       PIDIVFIDANGTITRIHHAPL-PEGTEDGPLTRYPGTGKYVLEVPYGWTNRTGIEVGDRL
#oth            11..112243121.4112.54223345346654.6.6.21...3243124332254..52
NP0004A         G::::YA::D::::AV:E::A::GPN:::DDHE:::Y:Q:::::NK::MADR:AG:::K:
hla1873         G:::IYA::E:::::::N::E::GPN:::SEQ::::S:Q:::::::K::D:N::::::T:
HQ1203A         G:::IYA:SE:V::S::::DA::GPD:::NNQQ:S:Q:Q::::INKD::TARD::A::V:
VNG0121         ::::IYVG:DRN::S::::TVPDG---:::::::E:H::W::::SLN::AAHNVS::::V
HQ1140A         ::::I::::T::::::Y::KV::TD:TTDE:N::S:R:R:::::S:NY:E:HN:TI::EI
hla0760         GL::::VAP:::V:E::E:A-::D---SR:Y:::A:::R::::A:R::SE:N:VGP::::
Hut2538         ::::::::T:::::T::::E:PADP--SD:QQQ:W:E:Q::::::F::::E::::T::HV
HVO_0504        :L::::VAE::::::::::E:D::::SESD::::R::::::::L:::Y::E:::DA:::V
Hbo1036         :L:::::::D::::A::::E:P::::P::G:KH:T::::::::::::Y::E::V::::TV
Hmu0240         :L:::YVA::::V:::::::V::::EYE---R::::E:::::::NR::::E::VS:::::
rrnAC2315       :L::I:::::::::T::::::P::::SESG::G:A:R:::::::NR:::::::VA::::V

consensus       RIEA-----
#oth            543784421
NP0004A         :F:L:::::
hla1873         AFDL:::::
HQ1203A         VS::IA:::
VNG0121         ::P:AGE::
HQ1140A         Q:NRQ::::
hla0760         VF:VD::::
Hut2538         S:PESVRP:
HVO_0504        EV:-:::::
Hbo1036         :::NY::::
Hmu0240         :LPNVTAAS
rrnAC2315       ELPPEAT::