[E] (TrpD) COG0547 Anthranilate phosphoribosyltransferase 9 genomes BUD0098 10 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG1912 rrnAC3306 HVO_2226 Hbo1933 Hmu2280 Hut2466 hla0432 NP0532A NP3062A HQ3122A

Pairwise sequence scores
Consensus score	2680	VNG1912	NP0532A	NP3062A	Hut2466	HQ3122A	hla0432	HVO_2226	Hbo1933	rrnAC3306	Hmu2280
2023	VNG1912	2680	1819	1854	1826	1772	1856	1893	1826	1929	1886
2124	NP0532A	1819	2702	1905	1886	1863	1949	1953	1896	1851	1852
2150	NP3062A	1854	1905	2678	1877	1867	1964	1977	1855	1992	1892
2125	Hut2466	1826	1886	1877	2661	1915	1984	1978	1919	1866	1878
2097	HQ3122A	1772	1863	1867	1915	2734	1878	2078	2123	1861	1806
2302	hla0432	1856	1949	1964	1984	1878	2814	2136	2064	2112	1961
2325	HVO_2226	1893	1953	1977	1978	2078	2136	2752	2277	2063	1953
2180	Hbo1933	1826	1896	1855	1919	2123	2064	2277	2732	1938	1895
2226	rrnAC3306	1929	1851	1992	1866	1861	2112	2063	1938	2719	2163
2143	Hmu2280	1886	1852	1892	1878	1806	1961	1953	1895	2163	2720

375 symbols
consensus       ----MAQATSEFGEWPLKRLMTEVVGSGHKSAEDMTREQATEAFRRILAGEPDETTLGAF
#oth            112133555521.1......1.1.111.4...2.12.2..21.22..1231..3......
VNG1912         ::::---MAD:Y::::::::N::::A::P:::G::D::::R:::Q:::DLK::Q::::::
NP0532A         :::::LTEKQ:::D::::::::::::T:I::::::S:::::D:::::V::::::::::::
NP3062A         ::::::ATSETY::::::::::::::::::::D:::::::SD::::::D:::::::::::
Hut2466         ::::----M:DY::::::::::::::::T::::::::::::::ME:::DD:::P::::::
HQ3122A         MAKASEAVE:::::::::::::::::::V::::::S:::::D:I:::::N:::Q::::::
hla0432         :::::::::Q:::D::::::::D:C:::::::D:L::A::::::E::::D:::P::::::
HVO_2226        ::::::VVE:::::::::::::::::T:T:::::::::::S::M:::::::::H::::::
Hbo1933         ::MAQ:PESP::::::::::::::::T:V::::::::::::::MQ::::::::H::::::
rrnAC3306       :::::::::R:Y::::::::::::::::::::D::S:T::R:::Q:::GD:::H::::::
Hmu2280         :::::::::::Y::::::::::::::::::::::::::::R:::Q:::D:::::::::::

consensus       WLANRWKRNTPEELAAYVDVMAEE-VETAEPDADPVDCGANYDGKGRSAILGVAAGVVAA
#oth            .......2.221..2.13.11615122413.32............341.2..111.3...
VNG1912         :::::::K:N::::G::::::Y::SRH::A:::::::::::::::A:::V::::::I:::
NP0532A         ::::::::::::::::FL:::L:S:::R:::K:::::::::::::AET::::::::A:::
NP3062A         :::::::::::::::::::::D:G:I:S:A:EC::::::::::::::::L::::S:L:::
Hut2466         :::::::H::G::::::::A::DR::::GV::V::::::::::::E:T::::::::::::
HQ3122A         :::::::H:VAQ::S::A::V::D::I::V::::::::::::::::DT::::A:::I:::
hla0432         ::::::::::A:::G::::::C:R:::Y::::::::::::::::::::::::::::::::
HVO_2226        :::::::H:NA::::::A:::::H:::Y::::::::::::::::::TT::::::::::::
Hbo1933         :::::::H:NA::::::T:::C:H:::Y::::::::::::::::::KT::::A:::I:::
rrnAC3306       ::::::::::::::G::::::S::S::::T:E:::::::::::::::::::::G::::::
Hmu2280         ::::::::::::::::F::::R::S::V:A:S:::::::::::::HT:::::::::::::

consensus       AAGTPVVVHSGDRVPTQKQDAYKHVLDELGVRTELDPEESADMVDETGFGFYYQPAFNPA
#oth            1....1.1.1..11.1..42...1...1..23.215.43..321122...1.1..3.1.5
VNG1912         :::::I::::::H::S::EV:::::::A:::::::T::A::R::::H::::::::::::T
NP0532A         G::::::::G:::I:S::SP:::D:::::::T:::::::::A::::::::::F:::::::
NP3062A         :::::::::::::::::::::::::::::::::::A:A:::S:T:TV::::::::N:A:E
Hut2466         ::::::::::::::::::N::::::::::::::V:R:AK::A::E:::::::::::::::
HQ3122A         G:::::::::::::::::::::::::::::IQ::IE:V:::A:::::::::::::::A:H
hla0432         :::::::::::::::::::::::::::::::H:::T:SD:::::::::::::::::::::
HVO_2226        :::::::::::::::::::::::::::::::::::::::::::::D:::::::::R::::
Hbo1933         G::::::A::::::::::::::::::::::I::::S::::::Q::::::::::::::::V
rrnAC3306       ::::::::::::::::::::::::::::::::::IE:S::::::::V:::Y::::E:::G
Hmu2280         ::::::::::::::::::L:::::::::::AT:D:S:G::::L::DV::::::::::::G

consensus       IDDLFDRRDQMGVRTFVNTIETLANPADASVHLGSFYHLAFAKKMVDTFEASETHDLDRV
#oth            132141...4.....12..1..11...3.2.........31.11214.3542155743.1
VNG1912         V:A:W::::K:::::::::V:::::::::A::::::::::::E:::E:VRE::HAGFE::
NP0532A         ::::Y::::E:::::::::::::::::G:::::::::::T::E:VI::IR:A:RSRF::A
NP3062A         VAG:E::::::::::::::::::::::::::::::::::PY::RLIN::D:A::ATV:::
Hut2466         V:::::::::::::::I::V:::::::G:::::::::::S::::V:E:::R::A:Y::::
HQ3122A         :NGIN::::K::::::F:::::IM:::K:D:::::::::::::::::::KKM::QHPH::
hla0432         :::::::::::::::::::::::::::G::::::::::::::::V::::VE::F::::::
HVO_2226        :HA:WE:::N::::::::::::I::::N::::::::::::::::::N::::::H::::::
Hbo1933         :H::WE::::::::::::::::I::::K:D::::::::::::::V:::::Q::QLSPR::
rrnAC3306       ::A::E:::N:::::::::V:::::::N::::::::::::::::::R:LAQ:::SSVE:A
Hmu2280         V::::E:::M:::::Y:::V:::::::::::::::::::::::R::K:LKK:RRNPAE:A

consensus       LMFQGMEGYDDIRPGYTKVAEWT----DGDD----------FADFEIETAEYGMDFETED
#oth            22...1.....1...3.31111443243335421111111135122.1.331...2141.
VNG1912         :::::L:::::V:::S:T::::D::::A:S:::::::::::L:::T:::P::::::::::
NP0532A         IL::::::::::::::::::::ADDGALD:V::::::::::MN:Y::::::L:::::YD:
NP3062A         V::::::::::V:::S::::V:N::::E:K:::::::::::ID::D:::PN::::::G::
Hut2466         I:::::::::::::::::F::::::::EAEG::::::::::L:SD::::GA:::::::D:
HQ3122A         :::::::::::::::::::G:::::::::E-:::::::::::I:Y::::P:::::::Y::
hla0432         :::::::::::V::::::::::DAAGG:::EAGDAGSEGAS:D:::::::K::::L:E::
HVO_2226        ::::::::::::::::::::::::TGD::ETT::::::::::D::D:::::::::::YD:
Hbo1933         V::::::::::::::::::G:S:::::::E-:::::::::::T:::::::::::::::::
rrnAC3306       :F:::::::::V:::E:I::::PVTGEES::ED::::::::I:::::R:G:::::I:S::
Hmu2280         :F:::::::::::::A:V::::PSDDAEA:ENG::::::::IL:Y::R:S:::::IQG::

consensus       LAV--DDVAGDSAAITEAVLAGERTDQFADAVALNAALRIYAREDADTIDAGLEAAREAI
#oth            .5.221.1.41..41.23122.2.21813..121.1.2.1..131123223.123.2331
VNG1912         :H:::E:::A:::T::KD::S:::::::H:::LV:::::L:::T:V::L:E:I:::ERV:
NP0532A         :::::::I:A::::::::::T:::::::R:::L::G:F::::GG:::SFE:::D::ER:L
NP3062A         :::::::::A:::::::S::::::::E::::::V::::::::GG:::D:::::D:::::L
Hut2466         :S:::E:::::::RL:RE::T:D:::LWH::::::::V::::GGNV::L::::D:::T::
HQ3122A         :E:NP::::::::KL:REIIS:N:::Y:V::::::::F:::::D::E::ET:::M:H:S:
hla0432         :::::::::VE::E::::::T:::DGP::::::V:::::::::::::S:ED::D:::AV:
HVO_2226        :G:DE::::::::E::::::::::E:R:::::::::::::::::::E:::E:::M:::T:
Hbo1933         :E:DP::::D:::E:::S:IT:D:D:H::::IE::::F::::::::E:LEE:::M:::S:
rrnAC3306       :Q:::::::EE:::::::::::::E:G::::::::::::::::::::S:QD:::Q:::::
Hmu2280         :E:::E:::::::T:::E:V::D:E:A:::::E::::::::::::VSGL:D:IAE::A::

consensus       DDGSAAAVLEDLRSF
#oth            32.3.223.44.151
VNG1912         S::T:E:L:A:::A:
NP0532A         :::::::::T::Q::
NP3062A         ES:A::ER:ST:Q::
Hut2466         :N::::::::N::G:
HQ3122A         ES::::::::::QA:
hla0432         :::::HD:::A::D:
HVO_2226        AS:D:E:::::::D:
Hbo1933         ES:A:E:::::::E:
rrnAC3306       A::::::T:DE::T:
Hmu2280         S:::::::::::::Y