[H] (ThiF) COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 9 genomes BUD0110 10 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG0084 rrnAC2090 HVO_0558 Hbo0973 Hmu0376 Hut0837 hla0124 hla1980 NP0052A HQ1425A

Pairwise sequence scores
Consensus score	2072	Hut0837	rrnAC2090	Hmu0376	VNG0084	HQ1425A	hla1980	NP0052A	hla0124	HVO_0558	Hbo0973
1304	Hut0837	2015	1192	1203	1216	1099	1162	1196	1121	1073	1195
1656	rrnAC2090	1192	2082	1685	1432	1357	1456	1495	1357	1337	1457
1640	Hmu0376	1203	1685	2096	1381	1338	1438	1458	1352	1336	1455
1613	VNG0084	1216	1432	1381	2103	1331	1575	1517	1345	1332	1402
1571	HQ1425A	1099	1357	1338	1331	2271	1309	1381	1451	1453	1555
1607	hla1980	1162	1456	1438	1575	1309	2206	1566	1356	1293	1368
1721	NP0052A	1196	1495	1458	1517	1381	1566	2079	1526	1509	1575
1617	hla0124	1121	1357	1352	1345	1451	1356	1526	2083	1603	1613
1619	HVO_0558	1073	1337	1336	1332	1453	1293	1509	1603	2070	1675
1725	Hbo0973	1195	1457	1455	1402	1555	1368	1575	1613	1675	2078

312 symbols
consensus       --------------------------MSLSLDATQLDRYSRHIIMDDVGPEGQAALLDAS
#oth            111111111111111111111111124523.233.....1.111.111.14..23.1335
Hut0837         :::::::::::::::::::::::::MS:PN:EQG:::::A:Q:V::::::A::::::EG:
rrnAC2090       :::::::::::::::::::::::::::RPD::PE:::::::::::N::::::::T:::TD
Hmu0376         ::::::::::::::::::::::::::-MVD::PE::::::::V:::::::S:::::::::
VNG0084         :::::::::::::::::::::::::MSG:E:::::::::::::::::::AT:::::RE:A
HQ1425A         MSPPPAPRPNDGSESTSNSDESTRVPGG::::S:::::::::::::EL::::::Q::N:D
hla1980         :::::::::::::::::::::::::MSD:D::P::::::::::::::::::::K:::::E
NP0052A         :::::::::::::::::::::::::MTD:::S:D:::::::::::::::::::KR::::N
hla0124         :::::::::::::::::::::::::::::::::D::::::::V:::E::::::KR:::GR
HVO_0558        :::::::::::::::::::::::::::T::::::::::::::::::E::::::GR::SSR
Hbo0973         ::::::::::::::::::::::::::::::::::::::::::::::E:::P::KR:::::

consensus       VLVVGAGGLGSPVIQYLAAAGVGTLGIVDDDVVERSNLQRQVIHGDDDVGRPKVDSAAAF
#oth            1122.1....1.21.....1.1.31121.1.3..1......12.422...44.11..231
Hut0837         :::::V::::::::::::::::::::L:::::::::::::::V::T:::::A:::::E::
rrnAC2090       :::I::::::A::L:::::::I:R::::::::::::::::::::K::::::S::::::E:
Hmu0376         :::::::::::::L:::::::I:R::::::::::::::::::L:T::::::::::::SE:
VNG0084         ::::::::::::::::::::::::I::A:::A::L::::::T:::T::::EQ::::::::
HQ1425A         ::I:::::::::::::::::::::I::::::I::::::::::::R:E:::DS::::::R:
hla1980         :::L::::::A:I:::::::::::I::A:::E::L::::::::::N:::::K::::::D:
NP0052A         ::CI::::::::I::::::::::::::A::::::::::::::::::::::Q:::E:::::
hla0124         A:::::::::A:::::::::::::I::::G::::::::::::::::A:::E:::E:::RY
HVO_0558        :V::::::::A:A::::::V:::E:VV:::::::::::::::V:C:::::T::AE:::::
Hbo0973         :::::::::::::::::::::::H::::::::::::::::::V:R:::::T:::E:::::

consensus       VAGLNPDVTVETHETRLDADNVEELIAGYDVVVDASDNFATRYLVNDACTLAGIPFSHGA
#oth            1551...12.45224.3334327322331.4.1.22.11411122..2133423.32..1
Hut0837         ::Q:::::::RCY:::F:E:E:P--LGE::::I::T:SIEAL:QL::::VT:EL:LV:::
rrnAC2090       :T::::::::DR::L::ARE:ATD:V:D::I:::::::::::F::::::::S:T::::::
Hmu0376         ::DR::::::DAY::::TR::A::V::D::L::::::::G:::::::::::::T:V::::
VNG0084         :DT:::::D:QR:DQ:VT::T:TD:::A:::::::::::R::::I::::::::V::::::
HQ1425A         ITD::::I::V::R::I:KQSIS:V:P:::M::::::::P::::L::F:Q:QK::IA:::
hla1980         ::Q::::ID:RK::M:VT:::I::::S:::F:::GT:::::::::::::::::V:::::S
NP0052A         :EA::::::::P::::VT:::IDG:L:E::::::G::::::::::::::::::V::A:::
hla0124         :DR::::ID:::Y:::::EG::RD:L::::L:::CA:::R:::V::::ARIE:L:VV:::
HVO_0558        :R::::::S::PV:A:V:KS::H:VV::S::::::::::P::::L::V:RFE:::LV:::
Hbo0973         :H::::::::::Y::::EKE::-GVL:D:::::::::::P:::::::F:RINE::VA:::

consensus       IYKFEGQVTTF--GPDGPCYRCLFPEAPEPGTVPDCATAGVLGVLPGTVGCIQATEAVKL
#oth            133....3.11325322........1..12.21.1.211..1.11.111.13....22.3
Hut0837         VSA::::::S:::DGGA:::::::::::PA::I:::E::::I:AV:SVI:S::::::I:H
rrnAC2090       :FQ::::::::::SG:S:::::::::::PE::::::::::::::::::I::M::::V:::
Hmu0376         ::R::::::::::SGE:::::::::S::PE:A::::::::::::::::I::F::::V::W
VNG0084         :FQ::::::::TG:D:::::::::::::PA::::::::::::::::::I:S:::::T::H
HQ1425A         :::::::L::L::I::::::::::::::::::I::::AT::::A:::::::L:::::M:V
hla1980         :F:::::::::AG:E:S:::::::::::PA:M::N:S::::::::::::::L::::T::H
NP0052A         :LR::::I:::EAT:E::::::::::::::::::::::::::::::::::::::::::::
hla0124         :::::::A::L::V::::::::::::::::::::::::T::::::::::::::::::I::
HVO_0558        :::::::A::L::V::::::::::::::::::::::::T::::::::::::::::::M::
Hbo0973         ::::::::::L::T::::::::::::::::::::::::T:::::::::::::::::::::

consensus       ILDEGETLDGRLLFYDAADMSFEEVPYAPRPDCPVCGDDP-IDSVADVEYTGSCAVSED-
#oth            4226.33.3.22231..421212413445332.12..23123522443314541425533
Hut0837         L::I:T::T::::R:::RS:::T:I:FES:E::QT::ES::AGGP:AT:R:RGSTLE--:
rrnAC2090       AM:Y::::E:::VA::::E:::::::I::K::::::::::A:A::::AS:E:R:SLA:::
Hmu0376         F:::::S::::::V:::SE::VD:::I::N:::::::S::ALS::TEA::D:R:SL::SV
VNG0084         ::GV:DS::::::::::::::::T:AL:Q::E::I:::S:VV:::QE:A::E::::TG:A
HQ1425A         ::NA:NP:T:K:I::::LEAT::QIS:Q:D:T::::::T:::Q:IES:::::::E:::-:
hla1980         :IG:::::::SM::F::L::E:DK:EIPK:D:::::::::A:E::H::::SA:::IDIGD
NP0052A         V:GH:::::::M::::::::::::I:VEK:::::::::GG:VE::H::D:EST::I---:
hla0124         L::T:::::::V:::::M::T::S:::RRN:::::::::G::ETIEGID:S:G:R:DA::
HVO_0558        L:::::A::::::::::M::T::T:::RTN:::::::EGG:V::IE:ID:VE:::I:L::
Hbo0973         V::::DP:V::::::::M::T::T:::RRNS::::::::::::::::::::DA::::L::

consensus       ------------
#oth            321111111111
Hut0837         ::::::::::::
rrnAC2090       ::::::::::::
Hmu0376         SD::::::::::
VNG0084         TTE:::::::::
HQ1425A         ::::::::::::
hla1980         DDESEPEIEASD
NP0052A         ::::::::::::
hla0124         ::::::::::::
HVO_0558        ::::::::::::
Hbo0973         ::::::::::::