[R] (-) COG2108 Uncharacterized conserved protein related to pyruvate formate-lyase activating enzyme 9 genomes BUD0157 9 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG2155 rrnAC2733 HVO_0300 Hbo1180 Hmu2928 Hut1947 hla0228 NP5164A HQ3257A

Pairwise sequence scores
Consensus score	2611	Hut1947	NP5164A	rrnAC2733	Hmu2928	VNG2155	hla0228	HQ3257A	HVO_0300	Hbo1180
2263	Hut1947	2707	2169	2226	2130	2117	2169	2112	2187	2108
2344	NP5164A	2169	2591	2333	2259	2242	2180	2197	2241	2146
2361	rrnAC2733	2226	2333	2689	2359	2247	2241	2166	2234	2184
2346	Hmu2928	2130	2259	2359	2695	2279	2218	2160	2221	2186
2353	VNG2155	2117	2242	2247	2279	2633	2257	2194	2279	2194
2393	hla0228	2169	2180	2241	2218	2257	2588	2246	2303	2215
2355	HQ3257A	2112	2197	2166	2160	2194	2246	2599	2307	2204
2425	HVO_0300	2187	2241	2234	2221	2279	2303	2307	2605	2259
2307	Hbo1180	2108	2146	2184	2186	2194	2215	2204	2259	2521

352 symbols
consensus       ----MISKGCEQCAKGGKMVLFVYGYCDQRDCFYCPLGENRKNVTDVYANERPVESDEDV
#oth            111111121111113.....2.......................211.....21.224.2
Hut1947         :::::::E::::::::::::I:::::::::::::::::::::::::::::::K::D:Q:L
NP5164A         :::::::E::::::V::::::::::::::::::::::::::::::Q:::::::::TES:I
rrnAC2733       :::::::E:::::::::::::::::::::::::::::::::::::QM::::::I:D:A::
Hmu2928         ::::::::::::::E:::::M:::::::::::::::::::::::DQ::::::::::::::
VNG2155         MRHQ::::::::::E:::::::::::::::::::::::::::::QQ:::::::::D:::I
hla0228         ::::::::::::::::::::::::::::::::::::::::::::::::::::K:::N:::
HQ3257A         ::::::::::::::::::::::::::::::::::::::::::::::::::::L::::S:I
HVO_0300        ::::::::::::::M:::::::::::::::::::::::::::::::::::::K::::A::
Hbo1180         ::::----------M:::::::::::::::::::::::::::::::::::::L::::D::

consensus       IEEAKRMDALGTSITGGEPQEALDRTCRYLSLLKDEFGEDHHTHLYTGITGGRENMRRLS
#oth            .2..11.1...1.1.......1121.12.12.......1...1......1..1....1.1
Hut1947         :::::::::::S:L:::::::VM::::::I::::::::::::I::::::::::::::::A
NP5164A         :::::::::::S:::::::::V:E:::N:I::::::::::::::::::::::E::::::A
rrnAC2733       :::::::S:::::::::::::V:::::H::E::::::::::::::::::P::::::::::
Hmu2928         :A:::L:::::::::::::::::::::H::E:::::::::::::::::::::::::::::
VNG2155         :S:::L:::::::::::::::V::::::::R:::::::::::::::::::::::::::::
hla0228         :A:::::S::::::::::::::MAK:::::E:::::::::::::::::::::::::::::
HQ3257A         :A::H::::::::::::::::::AK:T:::::::::::S::::::::::::::::::A:A
HVO_0300        :::::::::::S::::::::::::K::::I::::::::::::I::::::::::::::::A
Hbo1180         :S::::::::::::::::::::::K::H::::::::::::::::::::::::::::::::

consensus       EAGLDEIRFHPPLEQWGDLHGTEWEDILYIAREEGLTPAFEIPGIRAEPEFLEFLDEGAA
#oth            1...........112..11.1....1..11..11.1..........1.3..12.11....
Hut1947         :::::::::::::DM:::::::::::::::::::::::::::::::P:D::IT:VE::::
NP5164A         :::::::::::::::::::::::::::::T::DA:I::::::::::::::::::::::::
rrnAC2733       ::::::::::::::::::::::::::::::::::::::::::::::::E:::::::::::
Hmu2928         :::::::::::::::::::::::::E::::::::::::::::::::::E:::D:::::::
VNG2155         ::::::::::::Y:L:::M::::::E::::::::::::::::::::::D:::::::::::
hla0228         ::::::::::::::M:::M:::::::::H:::::::::::::::::::::::::::::::
HQ3257A         S:::::::::::Y::::N::D:::::::::::::::::::::::::::::::::::::::
HVO_0300        ::::::::::::::L:::M:::::::::::::::::::::::::::::::::D:::::::
Hbo1180         ::::::::::::Y:L:::M::::::E::::::::::::::::::::::Q:::D:::::::

consensus       EFCNINEFEMSDGNYRRMQEEGFELQEGHMSAVEGSKD-AILDEMGDHEKVYFCTSVFKD
#oth            1.1.1......1..11...22.111211.....1..11121124.13.12..........
Hut1947         ::V:V::::::Q:::::::QK::D:K:D::::::::H::-V::S:AK:P:::::::::::
NP5164A         ::::::::::::::::::::A::::R:D::::::::H::-::ET:::::R::::::::::
rrnAC2733       D::::::::::::::::::::::::K:D::::::::H::-::EK::::::::::::::::
Hmu2928         D:::::::::::::F::::A::::RK::::::::::HE:-::ET::::::::::::::::
VNG2155         D::::::::::::::E::::A:Y::::::::::D::::::::S::A:::Q::::::::::
hla0228         ::::::::::::::::::::::::::::::::::::::DS:VS::AS:::::::::::::
HQ3257A         ::::V::::::::::::::QK:Y:::D::::::::::E:::::T::N::Q::::::::::
HVO_0300        ::::::::::::::::::::K:Y:::D::::::D:::E:::::::::::R::::::::::
Hbo1180         ::::V:::::::::::::::::::::D::::::D:::::::::A:A:::R::::::::::

consensus       AAQHRNRLKRMARNIRRPFDEVTDDGTLVYGKTWVDADRLDELGVPEEFYTVKSDHVEVA
#oth            .....1.1....2121.1..12.....1....1325251243....211.32..2...2.
Hut1947         ::::::::::::K:V::::::T::::::::::A:::::::::::::A:Y:VE::E:::::
NP5164A         :::::S::::::::V::E:::I:::::I:::::::TET:::::::::SY:::::::::L:
rrnAC2733       :::::S::::::::::::::D:::::::::::A:TSEA::ET::::::Y:::::E:::L:
Hmu2928         :::::S:M:::::::G:E:::::::::::::::::GE:::Q:::::::::A:::E:::L:
VNG2155         :::::S::::::::V::E:::I:::::::::::T:G:G:IR:::::::Y:::::::::::
hla0228         ::::::::::::K::::E::::::::::::::AFA::::FEA::::::::::::::::::
HQ3257A         ::::::::::::QTV::::::I:::::I:::::::APK:F:S::::D:::::::::::I:
HVO_0300        ::::::::::::::L::::::::::::::::::YTP:E:FI:::::D:::SI::N:::::
Hbo1180         ::::::::::::K::::::::::::::::::::::TE:D:QA::::::::::::::::::

consensus       WWLLEEMIEDGDVDDGEIVEQYPTYDGTVVERTPLA----------------
#oth            .......121..233......1..21.1......123133313321332111
Hut1947         ::::::::AE::IAE:::::::::V::::::::::PDGSIEGTESAQSVRAE
NP5164A         :::::::VDE::IE::::::::::::::::::::::::::::::::::::::
rrnAC2733       :::::::V:E:::EK::::::::::::::::::::SNGADAGRATADD::::
Hmu2928         :::::::V:::::EK::::::H:::::::::::::SSGQPGGGQSAAGD:::
VNG2155         ::::::::D:::I::::::::::::::Q::::::::::::::::::::::::
hla0228         :::::::V::::L:R:::::::::T:::::::::V:::::::::::::::::
HQ3257A         ::::::::::::::::::::::::V:::::::::::::::::::::::::::
HVO_0300        ::::::::::::::::::::::::::::::::::::::::::::::::::::
Hbo1180         :::::::::E:::PE:::::::::VN::::::::::::::::::::::::::