[C] (SucD) COG0074 Succinyl-CoA synthetase, alpha subunit 9 genomes BUD0163 9 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG1542 rrnAC0474 HVO_2464 Hbo2363 Hmu1147 Hut1132 hla1061 NP4354A HQ2857A

Pairwise sequence scores
Consensus score	2156	Hut1132	HQ2857A	hla1061	VNG1542	HVO_2464	Hbo2363	NP4354A	rrnAC0474	Hmu1147
1850	Hut1132	2138	1661	1752	1789	1729	1770	1792	1763	1805
1848	HQ2857A	1661	2157	1799	1742	1816	1797	1739	1701	1715
1982	hla1061	1752	1799	2160	1889	1929	1946	1835	1821	1823
1959	VNG1542	1789	1742	1889	2138	1841	1893	1851	1803	1794
1988	HVO_2464	1729	1816	1929	1841	2161	2006	1851	1814	1794
1985	Hbo2363	1770	1797	1946	1893	2006	2154	1845	1829	1834
1929	NP4354A	1792	1739	1835	1851	1851	1845	2157	1869	1841
1921	rrnAC0474	1763	1701	1821	1803	1814	1829	1869	2176	1962
1926	Hmu1147	1805	1715	1823	1794	1794	1834	1841	1962	2162

290 symbols
consensus       MSILVDDDTRVVVQGITGGEGKFHTEQMIEYGTNVVAGAVPGKGGQEVAGVPVYDTVDRA
#oth            ..11..21...1.........2..141.31........11..1..1114.1..11..45.
Hut1132         ::::::E::::I:::::::::E::A:::::::::::::::::::::::H:::::::::::
HQ2857A         :::F:::E:::::::::::::::::SE::T::::::::::::R::D:IN:::::N:::A:
hla1061         :::F::::::::::::::::::::AG::::::::::::::::::::::E:::::::::E:
VNG1542         ::::::::::::::::::::::::A::::::::::::::::::::::::::::::::NQ:
HVO_2464        :::F:::::::::::::::::::::R::V:::::::::TS::::::D:D:I::::::EE:
Hbo2363         :::::::::::::::::::::N:::Q::V:::::::::::::::::::D:I::::::NQ:
NP4354A         ::::::N::::::::::::::::::G::L:::::::::::::R:::::E::::::::HK:
rrnAC0474       ::V:::E:::::::::::::::::::::L:::::::::::::R::::::::::F:::QG:
Hmu1147         ::V:::E:::::::::::::::::::::M:::::::::::::R:::::::::::::::::

consensus       VREEDANASVVFVPPAFAADAIFEALDAD-LDLVVAITEGIPTQDMAKVYKRLSETDTRL
#oth            13211.111.11...1..2..3..1..2212111......1.2..122.3321411..2.
Hut1132         A:::::D::::::::::::::L::::::P:::V::::::::::::VSE::AE:ED:::H:
HQ2857A         ::T:::::A::::::R::S::::::::::::E::::::::::::::T::HQ::::V::::
hla1061         :EA:N:D:::I:::::::::::::S::T:::::A:::::::::::::::N:::::V::::
VNG1542         :VA:N:D::::L:::::::::V:::::TP:::::::::::::S::::::::::::V::::
HVO_2464        :D::::::::::::::::G::::::::T::::::::::::V::::::::N::::::::::
Hbo2363         :E::::D:::::::::::G::V:::::T:::::::::::::::::::::N:::::V::H:
NP4354A         A:::::::A::::::::::::L:::::SP:V:::::::::::Q:::::::RK:R::::N:
rrnAC0474       A::A::::A:::::::::G::C::::::KGI::::::::::::::::R::RK:Q::::H:
Hmu1147         A:::N::TA:::::::::G::L::::::P:V:::::::::::::::SR:KRKQD::::H:

consensus       IGPNCPGIITPGEAKLGILPGNIFEEGNVGLVSRSGTLTYQVVDNLTERGIGQTTAIGIG
#oth            2......2....22..........24.2.............1.11..4.12..1..1...
Hut1132         V::::::V:::::S::::::::::S::S:::::::::::::I::S:::::::::::V:::
HQ2857A         ::::::::::::QT:::::::::::P:S:::::::::::::::S:::D:D::::::::::
hla1061         ::::::::::::::::::::::::SD::::::::::::::::::::::::L::S::::::
VNG1542         L::::::::::::::::::::::::A::::::::::::::::::S::A::V:::::::::
HVO_2464        :::::::::::::::::::::::::::::::::::::::::::S::::::::::::::::
Hbo2363         V::::::L:::::::::::::::::S:::::::::::::::::S:::D::::::::::::
NP4354A         :::::::L::::::::::::::::A:::::::::::::::::::S::Q::::::::V:::
rrnAC0474       V::::::V::::V:::::::::::SS:::::::::::::::::::::N:::::S::::::
Hmu1147         V::::::V::::V:::::::::::SS:D:::::::::::::::::::N:D:::S::::::

consensus       GDPIIGTSFIDALELFEADPDTEAVVMCGEIGGEDEEQAARYIGEHMDTPVAGFIAGRTA
#oth            ....1..2.111.13..2.22.3..............2..31.313.....1........
Hut1132         ::::V::G::::::::::::E::::::::::::::::A::E::A:E:::::V::::::::
HQ2857A         ::::V::::::T:DA::S::H:::::::::::::::::::AF:T:Q::::::::::::::
hla1061         :::::::::::::DA::::D::D::::::::::::::::::F::::::::::::::::::
VNG1542         :::::::D::::::::::::E::::::::::::::::A::A::D::::::::::::::::
HVO_2464        :::::::::V::::A::N::::H:::::::::::::::::K::A:N::::::::::::::
Hbo2363         :::::::::V:::::::::K::D:::::::::::::::::K::A:N::::::::::::::
NP4354A         :::::::D:V::::M::N:::::::::::::::::::E::EF::AN::::::::::::::
rrnAC0474       :::::::D::G:::Q:::::::H::::::::::::::E:::F::::::::::::::::::
Hmu1147         ::::::::::::::::::::::K:::::::::::::::::::::::::::::::::::::

consensus       PPGKRMGHAGAIVSGSGTGTAESKISALNDAGVPVGDTPEEVADHIEDFL
#oth            ...............1.....2...4..2312.1..2..31.1141.221
Hut1132         :::::::::::::::G:::::Q:::D::EA:::E::E::SD:::LV::IA
HQ2857A         :::::::::::::::::::::::::N::T::D::::N::D:::EY::S::
hla1061         :::::::::::::::::::::Q:::D:::::::::::::::::::V::::
VNG1542         :::::::::::::::::::::D::::::::::::::::::::::D::EL:
HVO_2464        :::::::::::::::::::::::::::::::S:::::::N::::::::::
Hbo2363         :::::::::::::::::::::::::::::::::::::::N::::::::::
NP4354A         :::::::::::::::::::::::::N:::N::::::::::::::N::S::
rrnAC0474       :::::::::::::::::::::Q:::T::E:N::::::::::::::V::L:
Hmu1147         :::::::::::::::::::::::::E::ESN:::::::::::V::V::I: