[R] (GloB) COG0491 Zn-dependent hydrolases, including glyoxylases 9 genomes BUD0170 9 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG2073 rrnAC2810 HVO_1918 Hbo1790 Hmu3122 Hut2021 hla0541 NP1688A HQ3137A

Pairwise sequence scores
Consensus score	2362	hla0541	NP1688A	HQ3137A	HVO_1918	Hbo1790	VNG2073	Hut2021	rrnAC2810	Hmu3122
1449	hla0541	2392	1228	1130	1296	1302	1100	1106	1052	1100
1490	NP1688A	1228	2289	1149	1179	1250	1151	1250	1217	1244
1535	HQ3137A	1130	1149	2370	1304	1498	1248	1174	1126	1111
1667	HVO_1918	1296	1179	1304	2373	1610	1186	1171	1268	1143
1829	Hbo1790	1302	1250	1498	1610	2373	1305	1356	1266	1223
1627	VNG2073	1100	1151	1248	1186	1305	2353	1380	1283	1318
1626	Hut2021	1106	1250	1174	1171	1356	1380	2331	1323	1420
1575	rrnAC2810	1052	1217	1126	1268	1266	1283	1323	2570	1403
1574	Hmu3122	1100	1244	1111	1143	1223	1318	1420	1403	2369

336 symbols
consensus       ---------------------------MAIGDV--RAVGGCDDLYYVDTGMYETEEYGSV
#oth            111111111111111111111111111.41.1323542646613322.2..13144..3.
hla0541         ::::::::::::::::::::::::::::HA:EF::ES:R:IA:::VH::::FG:D:::A:
NP1688A         ::::::::::::::::::::::::::::G:::::::S:ESVV:C::::::::G:DG::A:
HQ3137A         ::::::::::::::::::::::::::::D:::I::AT:DTA::I::M:::::::PG::::
HVO_1918        :::::::::::::::::::::::::::::::::::EP:PDST::::::S::::V:K::T:
Hbo1790         :::::::::::::::::::::::::::::::::::T::P:T::V:::::::::::M::::
VNG2073         ::::::::::::::::::::::::::::SA:::::FD:S::PGISF::::::D:A:::::
Hut2021         ::::::::::::::::::::::::::::G::::RQV:T:S:S::WF::::::AVSQ::::
rrnAC2810       MALPFLLPDCHDSHSITVLPPPVTRTC:G::::HEVT::D:I:VH:::V:::GVA:::P:
Hmu3122         ::::::::::::::::::::::::::::::::A:V::RAVH::CW:::::::DV::::::

consensus       YIIDAERPALVDTGIGTNHERILDALDEVGIAPEDLEYILPTHVHLDHAGGAGFLAEACP
#oth            .23.212..311..212331322331234124343234233..2.........4.22321
hla0541         :VY:T:K::VI:::T:V:R:ALFKT:::I::GR:E:AW:::::A:::::::::H:V:RY:
NP1688A         ::Y:T::::::::::::HYD:::::::A:::GRSE::::I:::A:::::::::::V:ETA
HQ3137A         :::::DQ::I::::::::Y:::I:::GR:D:DTNS:AHLFV::A:::::::::::LAD::
HVO_1918        :LV::::::::::::AADR:AVFGM:::::V--D::A::::::::::::::::Y:::RY:
Hbo1790         :::::::::F::::::::::HL::::::LD::R::V::L::::I:::::::::Y::D:::
VNG2073         :V:::D:::V::::T:::Y:::::::E:H::Q:A::QAV:L::::::::::::L::::::
Hut2021         ::L::::::I:E:::::H:D::::::E:::L:::AI:V:AV:::::::::::::::::::
rrnAC2810       ::::::::::::::T:AR::T::S:MES:::::::::V:AA::::::::::::Y:::D::
Hmu3122         :LV:GD::::::::L:::V::V::L:EAA:V:::A:DV:AL::::::::::::P:V::::

consensus       NATVYTHEIGARHLVDPERLWEGTKAAVGDQWQFYVEPTPVPEDRIEELTDGDTIDLGDR
#oth            2.31521.51231131.34.21..14..21.142.32.7.2212.244121.2421..11
hla0541         ::E:RLP:K:V:::I:::A:VA:::S::Q::::Y:DD:A:::::::SG:AE::R::::::
NP1688A         -:D:::P:AA:QF:I::SG::::::R:::E:I:::T::R::::S:L:P:A::A:L:::::
HQ3137A         ::::H:::RA:P::S::TQ:I:::R::::E:::Y::::N:A:AS::NA::::::VH::::
HVO_1918        D:::M:::L::P:::::S::I:::::::E:::R::D::L:IE:::V:G:::::E::::::
Hbo1790         ::::M:::::VS::I:::K:IA::::::::::E:::::K::::::::P::::NE::::::
VNG2073         ::D::V::L::::V::::::V::::Q:::::::Y:::::::::::VV:::::::V:::S:
Hut2021         ::SIVV:::::P::AA:::::A:::Q:::::ITH::::E::::A::R:IE:::R:::::H
rrnAC2810       :::::V::S:K::::::::::::::H:::::IE::GK:I::A:::::T:::::V:::::H
Hmu3122         ::::FV::S::::::::A:::A:::Q:::::IDY:T::::I::S:::T:::::A:::::H

consensus       TLTAHHAPGHAPHQVVFHDPADDAVFTADAAGIYVPERDRVRQTSPPPQFDLEQALDDVR
#oth            4.4343....12.143242466141.21..1.11414523333.1..42.3.24223.23
hla0541         E:VV:E:::::::HAFY:E:DA:V::::::::::::AV:T::P:T:::::::D:C:T:LS
NP1688A         E:VL:D:::::F::GIL:E:D:AV::A::::::::::L:T::E::::AD::::GVVE:AE
HQ3137A         S:::VA:::::L::MM:Y:TTE:TL::G::::::I:MQ::IQ:::::S::N::TC:::::
HVO_1918        :::V:::::::::::M:::DG::VL:VG::L::WE:RSRTL::::::S::H:QK::::::
Hbo1790         ::SVF:::::::::TM:L:SK::LL::G::::::::::GQ:::::::S:::::AC:::::
VNG2073         ::::::::::T::::::E:HSC:::::::::::W:RAQ::::E::::TD:::::CI:::E
Hut2021         A:R:::::::::::::YE:::N:::::G::::L:::::G::EP:::::D:::::::R::E
rrnAC2810       S:ETL::::::::::::Y:::I:G::::::::::N:ST:EMHV:T::VN:T:D::::::A
Hmu3122         R:R:R::::::::::::DA:EL::::::::::::T:ST:E:HV:::::N:::DG:::::A

consensus       MIEDIDPETLCFGHFGP--AYTDDLLEEYKRTLVEWVEAVRQKREELGDDEAVIEHFVET
#oth            3144211242212.1.2143545443531443252..2213421332521211121.335
hla0541         A::E::::Y:::::::::RE:EPS:IG:A::AY::::::::E:::A:::::::V:::E::
NP1688A         L:A:L::::I:Y::::::::PAA:RI:T:IAVITD:::S:EAA::R:E:::::::::::Q
HQ3137A         A:DSMA::::::::::::RV:D:E::SS:::A::::::::::::G:ANS::D::QY:SDN
HVO_1918        T::::::::V::::::::KP:DT::A:K:::V:::::::I::::A:::V:::::D::::H
Hbo1790         T::E:A::RI::::::S:CE:SEE:M:S::::::::::::::::::::::D::::::A:H
VNG2073         ::RRL:::::LYA::::GP:D::AV:K::EHV:RD::A::KREVI:RHSEA:A:D::AA:
Hut2021         T:QA::::::LYS:::::::MATGQ:A::A:::SD::Q::AAA:A::E::D::::::AGE
rrnAC2810       ::Q:L::DI:M:::::A::VE:G:K::T:TEI:P:::AE:ER:::::D::::::DY:::R
Hmu3122         :LA:L:RTW::YA:Y:::::R::AR:D::AT::ET:::::ETA:ADRS:::::V::::::

consensus       TQMDDVWGERKARAEAALNVRGVLTYLDR-RAE---
#oth            356635.23411131431.2..1.51.151533332
hla0541         SRDVEF:NPER:::D:S::S::I::::N:IEG:SEA
NP1688A         STI:E::::T:G:::V:M::::::Q:::S:E--:::
HQ3137A         AELI::::AE::::::R:::::::A:::W:Q:AQTD
HVO_1918        ::::EE:::::::D:ER::T::::G:::Y:IGDDE:
Hbo1790         :::T:L::::::SE:EK:::::::G:::W:Q::QE:
VNG2073         :TVE:::::H:::::TKM::::::R::NT:::-:::
Hut2021         :AAS:I::PD:G:G:T:M::::::::::::T:-:::
rrnAC2810       ADT:T-:::::G:::MR:::::::VA::N::D::::
Hmu3122         VETPA::SDH:::::V:M::::::::::::HG:DA: