[QR] (SmtA) COG0500 SAM-dependent methyltransferases 9 genomes BUD0181 9 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG0294 rrnAC1812 HVO_0773 Hbo0757 Hmu0657 Hut0559 hla2743 NP1178A HQ1168A

Pairwise sequence scores
Consensus score	1790	NP1178A	hla2743	HQ1168A	VNG0294	HVO_0773	Hbo0757	Hut0559	rrnAC1812	Hmu0657
1394	NP1178A	1824	1170	1172	964	1178	1194	1271	883	1255
1294	hla2743	1170	2391	1106	870	1247	1178	1147	824	1237
1343	HQ1168A	1172	1106	2008	848	1236	1307	1205	891	1244
1055	VNG0294	964	870	848	1354	926	941	889	988	941
1484	HVO_0773	1178	1247	1236	926	1895	1460	1255	944	1342
1533	Hbo0757	1194	1178	1307	941	1460	1820	1324	981	1335
1414	Hut0559	1271	1147	1205	889	1255	1324	1796	997	1381
1105	rrnAC1812	883	824	891	988	944	981	997	1356	1126
1496	Hmu0657	1255	1237	1244	941	1342	1335	1381	1126	1806

317 symbols
consensus       -----------------------------------------------------VKGQEWY
#oth            111111111111111111111111111111111111111111111111111112112211
NP1178A         :::::::::::::::::::::::::::::::::::::::::::::::::::::M::::::
hla2743         VIGSTRRPPRRSNCRPIPRSNRCPVPGRHPRRLRANADRIQYGFVGRVCSTDN::::D::
HQ1168A         :::::::::::::::::::::::::::::::::::::::::::::::::::::M::K:::
VNG0294         :::::::::::::::::::::::::::::::::::::::::::::::::::::-------
HVO_0773        ::::::::::::::::::::::::::::::::::::::::::::::::::::::::K:::
Hbo0757         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::K:::
Hut0559         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
rrnAC1812       :::::::::::::::::::::::::::::::::::::::::::::::::::::-------
Hmu0657         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

consensus       QADDVAEEYDSKRFSRGGRLIDRREKEAVLDALGPVE-DKRVLEIACGTGRFTVMLAERG
#oth            131221221232111311321131113111423312312442112111111113...22.
NP1178A         :E::I::A::D::::G:::Y:::::::::::::A::D:G::I::V:::::::::::::::
hla2743         :::E:::::EDV:::G::E:::Q:::::::S::::I:EGH::::V::::::::T:::DQ:
HQ1168A         ::::::QA:E::::::::Q:::::::R::::S:N::T:GADI:::::::::::A::::::
VNG0294         -------------------------------------:----------------::::::
HVO_0773        :::E::Q::::::::K::::::::::::::A:::::::::NI:::::::::::::::QE:
Hbo0757         ::::::Q:::::::::::::::H:::Q:::::V:::::::D:::::::::::::::::::
Hut0559         :::EI::A:EE::::G::::::::::Q:::N:I::::::S::::::::::::::::::::
rrnAC1812       -------------------------------------:----------------::::::
Hmu0657         :T::::::::::::::::Q:::::::::::::I:::D:::S:::V::::::::A:::D::

consensus       ADIVGLDISRAMLQQGREKARAAGVADTLEFLRGDAARLPFPDDHFDAVFAMRFFHLADT
#oth            .211.2...42.151..3..352.152221121...2......1...2.2.......123
NP1178A         :::::M:::E:::E:::A:::::::EE::S::Q:::G::::::N::::::::::::::PD
hla2743         :H:::I::::E::E:::Q::AE::LS::V::V::::S::::::::::T:V:::::::M:D
HQ1168A         :N:::I:::D:::A:::R:::NN::N::::L::::::::::::N::::::::::::::E:
VNG0294         :::T:::::GP:::E::Q::AQ::::::I::M::::G::::::N:::S:::::::::::S
HVO_0773        :NV:::::::::MV:::::::R:::::RI::::::::::::::::::::::::::::::A
Hbo0757         ::::::::::::M::::::::R:::::HV:::::::::::::::::::::::::::::::
Hut0559         ::V::::::S:::K:::::::S:::QSH:::M::::G::::::::::::I::::::::::
rrnAC1812       :N:T:::::GP:::::::::Q:T::D:RV::M:::::::::::::::T::::::::::::
Hmu0657         :::::::::GP::S::::::KS:::D:H:::M:::::::::::::::T:V::::::::::

consensus       PAKFLAEMARVSKDQVFFDTFNRFSTRSIYNWLLPMGSRLYSRREVDRLLSGAGLELADA
#oth            .25113.12..12421.....134.2.33.1.1.....1..13322441132.2.41312
NP1178A         :EG:IK::R::T:::I:::::K:Y:A::::::A:::::::::T::AKE:VV::D::::::
hla2743         ::P::::LC:::A:::::::::SR:L:TL:T:::::::::::E:Q:AAM::E:D:T:SGE
HQ1168A         :GT::T::::::N:I:::::::HR:::I::::::::::H::::SQ:KK:::D:E:AMV:D
VNG0294         ::TY:R:::::::Q::::::::::::::L::::::::::::GS:::RA:V:::::T::::
HVO_0773        :::::::::::::G::::::::DG:L:VA:::::::::::::E:D:R:::GD:::D::G:
Hbo0757         ::::::::::::::V:::::::DT:A:VV::::::::::::GEE:::G:::D:::K:T::
Hut0559         ::SY::::R::::EV:::::::::::::::::A::::::::::W::N:::GE:D:::V::
rrnAC1812       ::A:::::R::::E::::::::::::::::::A::::::::::W:I::::D::::::T::
Hmu0657         ::S:::::R::::H:::::::::::L::L:::A::::::::::W::::::D:::::::GE

consensus       THDFVLPYGFYRKIPNDLARPFRSLDTSVGDTPLGDRLASVSYWNARV------------
#oth            5..124.1.1..22.352.641.64.542.5235.2511.....4343443333233233
NP1178A         A:::IV::::::AV:RW::::::MA::TI:R:TA::::::::::D::IPE::::::::::
hla2743         E:::::::::::EL:GPV:K:::A::EL::N:IP::YV::::::::::PAGKNGSGGSVD
HQ1168A         ::::L::::::::::::::HG::DV:K:L:ESEF::A:::::::T:T:DTDSATTDTAET
VNG0294         D:::IA::::::EV:DWI:::::NA:VTL::::::EP:::::::DV:L::::::::::::
HVO_0773        K::::I:F:::::V::GI:QA:::::LA:::S::::D:::::::::::ESADESSRAATR
Hbo0757         :::::::::L::::::GI:GEL:GF::::::::::E::::::::S:S:LTDD::::::::
Hut0559         :::::F:::L::A::DS::SA::TV:Q:::RV:G:G::S:::::HCQG::::::::::::
rrnAC1812       N::WL:::::::::::E::AS::::::AL:G::::EK::::::::TH:::::::::::::
Hmu0657         A::::::::::::::::::SG:::I:EV::AS:V::KV::::::DT::::::::::::::

consensus       -----------------
#oth            33333222111111111
NP1178A         :::::::::::::::::
hla2743         SENNAGAE:::::::::
HQ1168A         NLETSQHTPDGTVAADD
VNG0294         :::::::::::::::::
HVO_0773        ASDAE::::::::::::
Hbo0757         :::::::::::::::::
Hut0559         :::::::::::::::::
rrnAC1812       :::::::::::::::::
Hmu0657         :::::::::::::::::