[E] (HisC) COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase 9 genomes BUD0192 9 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG1033 rrnAC0529 HVO_1295 Hbo0247 Hmu1487 Hut1058 hla1907 NP2140A HQ3364A

Pairwise sequence scores
Consensus score	2729	HQ3364A	HVO_1295	Hbo0247	VNG1033	Hut1058	hla1907	NP2140A	rrnAC0529	Hmu1487
1997	HQ3364A	2878	1961	1940	1565	1620	1774	1793	1730	1799
2107	HVO_1295	1961	2762	2090	1727	1658	1875	1771	1835	1891
2168	Hbo0247	1940	2090	2743	1714	1733	1836	1783	1913	1874
2031	VNG1033	1565	1727	1714	3030	1807	1766	1814	1850	1821
2036	Hut1058	1620	1658	1733	1807	2703	1694	1839	1895	1855
2113	hla1907	1774	1875	1836	1766	1694	2753	1793	1879	1837
2119	NP2140A	1793	1771	1783	1814	1839	1793	2689	1926	1926
2245	rrnAC0529	1730	1835	1913	1850	1895	1879	1926	2745	2161
2251	Hmu1487	1799	1891	1874	1821	1855	1837	1926	2161	2733

414 symbols
consensus       -----------------------------MQPRDLSAHEPYRAGRGIEEVARELGLDPDD
#oth            11111111111111111111111111111.22....3.54.21...31.1..1123..22
HQ3364A         :::::::::::::::::::::::::::::::::::::::::VP:::TK::::::EV:::S
HVO_1295        ::::::::::::::::::::::::::::::::::::::A::VP:::T::::::::M::E:
Hbo0247         :::::::::::::::::::::::::::::::::::::::A:VP:::A::::::::M::EE
VNG1033         MRTTHLNPMIPERRPREGILKDGPAVTPS:EL::::D:VE:::::::::::::::R::SE
Hut1058         ::::::::::::::::::::::::::::::DT::::S:TI:::::::::T:::::V::EE
hla1907         ::::::::::::::::::::::::::::::::::::D:S::VP:::V:::::DR::::::
NP2140A         ::::::::::::::::::::::::::::::::::::H:VA:E::::::::::::::::::
rrnAC0529       ::::::::::::::::::::::::::::::E:::::::TV::::::::::::::::::::
Hmu1487         ::::::::::::::::::::::::::::::::::::::GV::::::::::::::D:::::

consensus       LVKLSSNENPHGPSPKAVEAIREAAERVHSYPKASHADLTDALADRWDVTPEQVWLSNGG
#oth            22..1....23....2.23.1343.45324...2211..3331114121442.1.122.1
HQ3364A         :I:::::::::::::A::D::ADT::T:NT:::S::T:::ARI::Y:GLS:::I:::P:A
HVO_1295        :T::::::::::::::::A::ED::PT:SV:::TA:T:::ER:::K:GLA:::::V:P:A
Hbo0247         :T:::::::::::::D::::VEA::SEI:V:::T::::::::::E:::L:S::::V:A::
VNG1033         F::::::::::::::::TI::::::TG::R::::V:::::G::::::::GDD:::VA:::
Hut1058         :I:::::::AL::::::::::::H::AL:::::::::::GE:::E::G:::::I::A:::
hla1907         :I:::::::::::::A::D::::H:D:::Q:::S::T:::AK::EK:::ST::::V:P:A
NP2140A         ::::::::::F::::::A:::::H:D::N:::::AAT::RGEIG:LLS:DAA::::G:::
rrnAC0529       M:::A::::MF::::D::::::GS:::M:::::::::::V:E:::M::::::::::::::
Hmu1487         ::::A::::MY::::A:::::QSS::QM:::::::::::V:R:::::GLA::::::G:::

consensus       DGALDYLARAMLDPGDAVLVPDPGFAYYAMSARYHHGEVAEYPLSK-ADDFEQTADTVLD
#oth            ..22.212..412.1163.314.1.2.13..1.1...5253.52321211.313124114
HQ3364A         :::I:::S::F:T:::TM:IS::::S::P::::::::SIRT::V:::EQ::Q:R:SDI:T
HVO_1295        ::SI:::T::V:E:D:RI:E:A:::S::S::::::::DAVQ:EV:::D::::::::L:::
Hbo0247         :::::N:S::F:E:D:R::T:K:::S::::::::::::::::S::::::::A::PE:I::
VNG1033         ::::::::::T:::::S::::S:::T::G::::F:::N::::DVAEG::G::M:::A:V:
Hut1058         :::M:C:::::I:::Q:A:::::D:T:HS::V:::::::HT:::VE:::G:K:SP:RI::
hla1907         ::SI:::S::A:E:::E::::E:::::::::::::::::S::A::P:D:G:A:D:E:::S
NP2140A         ::::::::::::::D:G:::::::::::G::::::::Q:NS::IE::D:::::SP:AI:E
rrnAC0529       :::::C:::::::::QD::::S:::::::::::::::::N::T::::::::A:::::::K
Hmu1487         ::V:::F:::::E::::::::A::::::P::::F:::TIR::T::::::::::::E:::E

consensus       AYDGERIVYLTSPHNPTGSELPLDEVVAIAERTDEETLVVVDEAYGEFAEEPSAIALVD-
#oth            3.11..32.1.1....1.234444224221141214..211....1.12272.126.331
HQ3364A         Q::D::LL:V:T::::S:::::IP:IT:L::GV:DQ::I:I::::::YSNN::::K:IQ:
HVO_1295        ::::::M::::T:::::::V::RE:L:EL::SVE:H::L::::::::::::::::D:LS:
Hbo0247         :::::::::::T::::::::MAREDI:TLL:SVEDH:::::::::::YS::::::G:L::
VNG1033         ::::::V::::T::::::ARFT:::I::V:D::::D:::L::::::::T:T:::VT:F:G
Hut1058         ::::::MI:::::::::::TVS:A::EE::::::DG:::::::::N:::DR:::VE::E:
hla1907         ::G:::::::::::::S::VM:::::R:::DA:A::::::::::::::::VD:::P::::
NP2140A         S:::::::::::::::::::VS:SD:E:V::G:::::::::::::::::DS:::V:::E:
rrnAC0529       D:::::::::::::::::A:FTT:A:RT:::E:::Q::::::::::::T:K::KRP:LS:
Hmu1487         ::::::::::::::::::T:IGN:D:AE::D::::::::L::::::::TDAT::R:::::

consensus       -------ERDDVAVLRTFSKAYGLAGLRLGYAVVPEAWADAYARVNTPFAASEIACRAGL
#oth            111111131.12.32.....11....2.1..241.33.11..1.11...1.123..1.11
HQ3364A         ::::::::Y:NI::::::::::::::::I:::A:::S:::::::I::::::NKT::Q:A:
HVO_1295        ::::::::Y:N::A::::::::::::::I:::C::::::::::::::::::::V::::A:
Hbo0247         ::::::::Y:NL::I::::::F::::::I:::A:::::::::::::::::::KV::::A:
VNG1033         QPAGGHAP:::I::::::::::::::I::::::::DS::::::::Q::::::V:::Q::V
Hut1058         :::::::A::::::V:::::V:::::::::::IT:AE:::::E:I::::S::::::::::
hla1907         ::::::::::::::::::::::::::::I::S::::::GE:::::::::::N:L::::A:
NP2140A         ::::::::::::::::::::::::::V::::::::GE:::::::::::::::::::::::
rrnAC0529       :::::::D:::::L::::::::::::I:::::::::D:::::::I::::S:::L::::::
Hmu1487         :::::::::::::I::::::::::::V::::GF:::E:::::::I::::::::L::::::

consensus       AALDDDEHVEKSVETARWAREYYREELDAPTWESGGNFVLAEVGDAEAVAEAAQRRGVIV
#oth            ..12123.124221213.2.112432.313.2213...1.22...14211211132.111
HQ3364A         ::IE:QS:::H:I::::::::H:::::::R::P:::::::C::::GN::::::KQE:::I
HVO_1295        :::::E::::::::S:::S:D:L::H::::::::E:::::V:::::T::T:::::E::::
Hbo0247         :::GNE::I:::::::::::::::D::N:N::P:::::::V:::::T:::::TK:::I::
VNG1033         ::::::D:::ATTDSVA:G:D:IHD::A:R:Y::H::::::N::::GR:::::K:E::L:
Hut1058         :::E:::::DAITDLVE:G::::Y:H:::K:Y:T::::::V:::::SR::Q:TKE:::::
hla1907         :::::E:::AE:::::::::::IAD::::::V::A::::::::::::R:::E::E::::I
NP2140A         :::E::A::::T::::::::::I:ST:ECR:Y::A:::::CA:::GGE::::::KE::::
rrnAC0529       ::::::::::R::D::A:::::LSA:::::::D:A:::I:::::::S:I:D:::E::::I
Hmu1487         :::::::::::T::::Q::::::H:H::::::::::::::::::::::::D::::D::::

consensus       RDCTSFGLPECIRISCGTREETKRAVEVLNEVLADV------------------
#oth            ..12.....311.112..123.22..3321433432433222111111111121
HQ3364A         ::T::::::::V::::::::Q:::::DIISA:IE::ETATTTTESGVETEVGRP
HVO_1295        :::G:::::::::V::::ETQ:::::D:::RIVSE:PTA:::::::::::::::
Hbo0247         ::TS:::::A:::V::::::::::::::::::I:::EAT:::::::::::::KP
VNG1033         ::::::::::HV::TI:::S::E:::A:::::CDT-::::::::::::::::::
Hut1058         :::S::::::H::V::::::::R::::TI::::---::::::::::::::::::
hla1907         :::::::::NHV:::T::::G:RE::AR:::T:::LGLGVRA::::::::::::
NP2140A         ::T::::::S::::T:::::::::::::V:DL:---::::::::::::::::::
rrnAC0529       :::S::::::::::T:::::D:E:::S:::::IEE:KA::::::::::::::::
Hmu1487         :::G:::::::V::T:::::D::T::::V:G::D--::::::::::::::::::