9 genomes BUD0196 9 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG1236 rrnAC0513 HVO_1313 Hbo0229 Hmu1508 Hut0961 hla1456 NP3360A HQ3351A

Pairwise sequence scores
Consensus score	3575	VNG1236	NP3360A	HQ3351A	hla1456	HVO_1313	Hbo0229	Hut0961	rrnAC0513	Hmu1508
2285	VNG1236	3539	1756	1863	1806	1894	1861	1860	1885	1787
2489	NP3360A	1756	3638	1867	1954	2080	2142	1941	1910	1961
2386	HQ3351A	1863	1867	4182	2020	2136	2246	1821	1763	1700
2617	hla1456	1806	1954	2020	4215	2410	2334	1797	1981	2049
2811	HVO_1313	1894	2080	2136	2410	3584	2647	1915	2050	2088
2730	Hbo0229	1861	2142	2246	2334	2647	3689	1820	1949	2038
2291	Hut0961	1860	1941	1821	1797	1915	1820	3623	2065	2091
2454	rrnAC0513	1885	1910	1763	1981	2050	1949	2065	3766	2266
2482	Hmu1508	1787	1961	1700	2049	2088	2038	2091	2266	3593

629 symbols
consensus       ------------------------------------------------------------
#oth            111111111111111111111111111111111111111111111111111111111111
VNG1236         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP3360A         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
HQ3351A         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
hla1456         VPTTWPRRPARSPIPTRRRSRPSTSAPAATARDGSDTSDATATDDATTATDDTTTATDDA
HVO_1313        ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hbo0229         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hut0961         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
rrnAC0513       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hmu1508         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

consensus       ------NMIDRDAVRDNAKYLRNVRPIDPEEIAEYVEGQPHPAVVRQTLREEAFDLGLVE
#oth            1111122342132113313...3...2..31141.1214..11..2211.13.31.115.
VNG1236         ::::::MPV::G::::A:::::G:::L::AALR:::P::::E:::::V:::Q:A:::II:
NP3360A         ::::::-:T:TE::L:T:R:::E:::::::::Y:::D::::::::::::::H::E:::K:
HQ3351A         ::::::-::::E:::T:::::::::::::N::Y::I:D::::::::E:::Q:::E:::R:
hla1456         ATETRT:::::E:::N::N::::::::::::::::I::S:::::::E:::::::::R:R:
HVO_1313        ::::::-:::::::::::::::::::V::D:::D:I::A::::::K:::::::H::::F:
Hbo0229         ::::::-::::::::S::::::::::::::::C::I::T:::::::E:::::::::::::
Hut0961         :::::M:PDQ:::IL:SVR::::::::::D::R:::PD::::G::T::I::S:VE:::S:
rrnAC0513       :::::M:QDT:QQI::::Q:::::::L::::LH::::::::::::K:V:::::::::I::
Hmu1508         :::::M:DET::SI:S::::::Q:::::::::C:::D:R:::::::RV::::::::::::

consensus       REDGTFVPAPEEPVPPPFWGVEAFPERYARALEDLLVERYGANWHRGESGDRLRERIRRL
#oth            12..1.113432244445441441.3715343223.2433.33.24312.15..241133
VNG1236         :A:::::VP:::::G:::N::S:L::::E:VV:AE:TAA::PD::::DT::S:::T:::F
NP3360A         ::::A:::VEDGT:H:D:T:::R:::Q:::Q::S:::D::::G:PDSDA::::::H:DQ:
HQ3351A         :A:::::::STD:I:D:M:QPDML:R::NEVIA:H::::F:PE:Y::D::AM::ST::::
hla1456         ::::A:E:VS:::::A:G:APT:L::N:SF:::::::REF::::::E::::K:::AV:::
HVO_1313        :::::::::NAD:A:VRN:SPA:::DD:SF::::::IG:::::::V::::::::::V:Q:
Hbo0229         :D::::::VED::::YRD:SPTE:::A::F:F::::I::::V::::D::::::::V::::
Hut0961         :A:::::::::G:LDASVDR::T::DG:T:IV::Q::GEF::G:PT::::AT::S:::AV
rrnAC0513       QD:::::::::GRLSVD:D:::R::DS:EQQVI:::T:WG:LE::S:D:::E::::::DI
Hmu1508         ::::::E:IGD::PS:A:E::D:L:AEHV:R::::::::E:VG:PD::::::::D:::AI

consensus       KEDYLRGNDVEYDEETALGYAIYHLPDYYAAIQYVLDDLAEDGLLPRRLRVLDVGAGVGG
#oth            .32.23334.2..342..1.12..122...242.1132.33422.3452.1..2...1..
VNG1236         :D::Y:R:P::::R:V:::::V:::AG::::V::::AG::R::::GHD:::::L::::::
NP3360A         :V::FADA::T:::::::A::L:::::::::::::::::GSA:::G:::::::::::T::
HQ3351A         :R::YQQ:P::::QTV::::::::FS::::::G::::::L:Q:C:SQT::I:::::::::
hla1456         :D:::Y::::A::RVA::::::::::A:::T:G::::::T:N:::D:T::::::::::::
HVO_1313        ::::Y:::S:::::DA:::::::::::::::VG:::S::::RS::::KP::::::::T::
Hbo0229         ::::YYQ:E:A::::A::::G::::::::::VG::::G:::R:::::V:::::::::T::
Hut0961         ::S::Q:E::A::RL:::A:::::::::::VG::A:GP:LA:DR::AQ:::::I::::::
rrnAC0513       ::R::Q:QA:::::L::::::V::::::::VAK:::A:::A:::::SQ::::::::::::
Hmu1508         ::R:::QQP::::DL:::A:::::::::::VT:::IA::LS::::D::I:::::::::::

consensus       PALGLHDYLPDDA-LVDYHAVEPSAAADVLEAMLAETRRNFRTTIHRETAESFDP-----
#oth            .1211312121441211.11.....21.1135214213322421212231.3.5121111
VNG1236         ::V::F:F:::E::::E:::::::::::::D:L::::P::VH:::::::::::Q::::::
NP3360A         :M::I:E:::EET:::::D::::::::::F:Q:AS::::G:EP:LY:::::::S::::::
HQ3351A         ::A:I:::::ESS:::E::G:::::GV:L:TDI:::::::::::::H:S:::::::::::
hla1456         ::::::::::::::V:::::::::::::::DR::D::G::::P:::E::::::FGI::::
HVO_1313        ::::::::::::S:V::::::::::S::::DR::G:::::::::V::::::A:A::::::
Hbo0229         ::::::::::ENS:::E::::::::S::::::::S:::S::K::V::::::A::::::::
Hut0961         :::::L:LVC:AGGI:::::::::::::::SEL:D::A::AH::V:::R::D:E::::::
rrnAC0513       ::VA:R:L:::::::L:::::::::::::::HL:EDSGQ:V:WE:::AL::E:::SSPLV
Hmu1508         :::::L:L:GEEC:::::::::::::::::::::ET:PPSVQ:::::T:V:::E::::::

consensus       ----------------DGE---FDLVVFANVLSELDDPAAVLERYLDALADDGSVVALAP
#oth            11111111112433241333321.213231..2..23133132413342131.243132.
VNG1236         ::::::::::::::::A:::::Y:::LACS:::::::A:S::RK:A::M:A::TAL::::
NP3360A         ::::::::::::::::::D:::Y::I:::::::::SQ::::F:::::H:::::T:::VS:
HQ3351A         ::::::::::TCIGSA:N:RP:::VIL:G:::::::E:YI:AR:::S:V:T:::FIG:::
hla1456         :::::::::DGGAKSG:NDPDE::::::G:::::::::V::V:AA:GR:::::::::F::
HVO_1313        ::::::::::::::::::::::Y:I:L::S:::::::::::V:K::::::A::A:::I::
Hbo0229         :::::::::::ASVLP:::::G::::C:::::::::::TS:A:::::YV:::::F:GI::
Hut0961         ::::::::::::::::::T::::::I::S:::D::ES::T:::H:G:::EP:::IL::S:
rrnAC0513       GDDSGSGAGDGDSGSD:STDEGY::II:G::::::::A::T:Y::VE::::::TLL::::
Hmu1508         :::::::::::::::::DQ::::::::C::::N:::E::S:V:GA::W::PA::LA:IE:

consensus       ADRNTAIGLREVERAV------------------------------ADDGDATVYAPTLR
#oth            .132.123..31..2111111111111111111111111111111345343312.2.13.
VNG1236         ::KH:STH::A:::::::::::::::::::::::::::::::::::-E:DPF:::G::P:
NP3360A         :EER::TR::DI::E::::::::::::::::::::::::::::::LDRRP::::::::I:
HQ3351A         ::KH:S:H::AI::MLTGDPLTEPILEDEGQILSERAGDLTPAATPD:EI:::I::::::
hla1456         ::::::M::::::::::::::::::::::::::::::::::::::ATPETGVET:S::::
HVO_1313        :::::S::::::::E::::::::::::::::::::::::::::::APA:::V:::S:A::
Hbo0229         ::L::SM::::::::L:::::::::::::::::::::::::::::APA:::V::::::::
Hut0961         ::KR::T:::TI::::::::::::::::::::::::::::::::::--EDTY:I::::V:
rrnAC0513       :::::::Q::T:::E:::::::::::::::::::::::::::::::::G:P::::G::V:
Hmu1508         :::::::::::I::::::::::::::::::::::::::::::::::::::P::::G::V:

consensus       LWPGESPSDRGWSFDRRPDIDVPPFQRRLDD-----------AAGD-D-------DGEFV
#oth            ..3263.3242.1.12442243.43.31.123332222222234526244111113.212
VNG1236         :::DRR:T:S:::::E::AVE::AV:S::A:::::::::::::SQ::-:::::::P:::R
NP3360A         :::D::::::::T:T:QA::EP:A::T:::AAAADDAAADGI:::G:-:::::::::TYT
HQ3351A         ::S:KT:::::::::::SRVTA::T:QQ:::APRVVNKSETT:::QM:RDSETAG::R:R
hla1456         :::DAT:::G:::::VAD:L:I::::::::ET:::::::::::ERGSTDE:::::P::::
HVO_1313        ::D:YA:::::::::V:::L:::G::::::EG::::::::::R:::E::::::::E:T::
Hbo0229         ::::HA:::H::::::GE::VA:S::::::EAGE:::::::::TE:R:PG:::::::T:T
Hut0961         :::::T:AGEC:::::K::LAA::::Q::::::::::::::::CD:T:HD:::::::::R
rrnAC0513       :::HQ::NSES:::::K:::E::TM:Q:::::::::::::::P::G:-:::::::T::::
Hmu1508         ::AH:::TGES::::V::::::::::::::E:::::::::::G:SGP:HQ:::::P::::

consensus       NTDVQFAYSILRTDGRRRIDVRANPDRVAKMADAERHVTDRIDLLAVKLSHDLSE-----
#oth            221.1111421.3.14224324324535241222162..1.213323...31.2453111
VNG1236         H:::R:S::L::R:D:::HA:ELSG::LLALG::DDR::::A:::VA:::RN:AGA::::
NP3360A         K:T::Y::LL:::::::A:EYTPD::T::::::MDA::::::::A:L:::P:::S:::::
HQ3351A         :ET:::S:T:I:R::TA:AP:S:::R:H:A:ETM:T:::N::::I::::::::TTSPTEN
hla1456         :V::::::A:::P::K::V::Q::DG:C:R:::S:E:::::VNY::::::::::D:::::
HVO_1313        :V:::YS::V:::::E::L:::G::A:F::::EM:::::N::::::::::::::::::::
Hbo0229         :ET:::SSVV::H::E::V::T:SGE:Y::::EM:::::N:::::::::::::T:HD:::
Hut0961         :::::Y::::::R:DATA:EY:PDES::TT::::DSY::::V:VVGI:::P:::SGP:::
rrnAC0513       :::::::::V:::::K:VH::TPDRGIH:P:::::NY::::VNF:G:::::::A:RE:::
Hmu1508         :V:::Y::::::::::TA::A:G:RSQ:::::E:DSY:::::N::G::::G::T::::::

consensus       -----------------DANPLFKIGDGSQAVDHYAVLTRESSLNEDLRAADYGDLLSFE
#oth            1111111111111111124.211221...1321111.313523.14425513..22152.
VNG1236         :::::::::::::::::::::V:RVS::::TT:C::::V:PT:::GGIE:::::::V:I:
NP3360A         ::::::::::::::::::G:::Y::S:::E:::::::::::::::RE:P::P::S::R::
HQ3351A         SNQYRRGHGSSNLQTSY:T::V::::::::TT:::::V:VKDT:T:P:LT:E::AI:A::
hla1456         :::::::::::::::::GD:A:YRV:::::T::::L:C:::TV::D:::T::::SVVFV:
HVO_1313        :::::::::::::::::GN:QV:::::::E:::::::R::DTV::A:VAD:::::V:V::
Hbo0229         :::::::::::::::::G::::::VS:::ES:E::::::KRD::::W:AR:::::V:V::
Hut0961         :::::::::::::::::::::::LV::::E:I::F:::::::T::RG:VESQ::::::::
rrnAC0513       :::::::::::::::::G::::YLL:::::Q:::F::::EA:I::::::K::::::::::
Hmu1508         :::::::::::::::::AG:::YL:S::::ST::F::::EA:I::::::D:::::::L::

consensus       NALVLWNDDEGAYNLVVDDETVVDRVA--
#oth            12.3......2...1...3.111.43331
VNG1236         D:::::::::D:::::::E:::::A:-::
NP3360A         :V::::::::D::::::::::::::L:::
HQ3351A         :V:C::::::D:::::::::S:I:II:::
hla1456         :G::::::::::::V:::::::::L::P:
HVO_1313        :V:S::::::E::::::::::L:::::::
Hbo0229         :V:A::::::::::::::G::::::::::
Hut0961         :::A::::::::::::::A:::::S:PVP
rrnAC0513       ::::::::::E:::V:::G:::I::AR::
Hmu1508         ::::::::::::::V:::G:::::::PA: