[J] (KsgA) COG0030 Dimethyladenosine transferase (rRNA methylation) 9 genomes BUD0209 9 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG1165 rrnAC0257 HVO_2746 Hbo2479 Hmu1190 Hut1311 hla1155 NP3678A HQ2878A

Pairwise sequence scores
Consensus score	2124	hla1155	HQ2878A	VNG1165	Hut1311	rrnAC0257	Hmu1190	NP3678A	HVO_2746	Hbo2479
1644	hla1155	2285	1440	1423	1397	1367	1402	1391	1496	1529
1592	HQ2878A	1440	2215	1352	1485	1377	1374	1335	1351	1416
1582	VNG1165	1423	1352	2136	1410	1394	1461	1316	1437	1447
1704	Hut1311	1397	1485	1410	2210	1585	1577	1483	1429	1460
1674	rrnAC0257	1367	1377	1394	1585	2147	1775	1430	1428	1421
1708	Hmu1190	1402	1374	1461	1577	1775	2212	1420	1483	1471
1623	NP3678A	1391	1335	1316	1483	1430	1420	2059	1415	1494
1688	HVO_2746	1496	1351	1437	1429	1428	1483	1415	2158	1711
1757	Hbo2479	1529	1416	1447	1460	1421	1471	1494	1711	2183

316 symbols
consensus       MTDD------A-------TG--ARDPDALIRRAGARGDPDQDQHFLVDDRVLDRIPTYLP
#oth            12665455555111111152226....1.42...5121133.....1....1..1.3.13
hla1155         :::LSTGAGA::::::::Y:::D::::::A::::E:AN::R:::::::::::::::G:::
HQ2878A         :::ATSGSDPDSTTPVDL::EDF::::::R::::VS:::NF:::::I::::::::::::L
VNG1165         ::A-::::::-:::::::--::P:::::::::::-:PN::F:::::I:::::::::::AD
Hut1311         :AGEDAADGPN:::::::V:::G::::::LA:::::::::::::::::::::::::::AT
rrnAC0257       ::TT::::::E:::::::::::T::::::V::::K:A:TR::::::::::::::::E:AT
Hmu1190         ::T:GPPSEG::::::::D::::::::::VA:::K:A:TR::::::I:::::::::G:AD
NP3678A         ----::::::-:::::::--::M::::::LV:::V::::ER:::::I:::::::L:G:::
HVO_2746        ::S:GSEQVRE:::::::VA:::::::::::::::::N::H::::::::::V::::::::
Hbo2479         ::EPEPDRTET:::::::AAHPP::::R::::::L:::::::::::::::::::::S:::

consensus       D-DADTSHVLEIGAGTGALTDRLLAVAD------------RVTVVERDPDLAAFLREEFA
#oth            2144.23.2..1.1.3.1......422211111111111131111.1.542.41.13..1
hla1155         ::::::::L::::G:A:::::::::AITSSADTDTAPAPGHLS:I:::GTF:D:::::::
HQ2878A         ::ST::T:I:::::::::::::::::G:::::::::::::T:::I:::AT::::::::::
VNG1165         -:GF:RG:::::::::::::::::S::::::::::::::::::A::::ESY:S:::::::
Hut1311         EAGI:LG::::::::N::::::::::::::::::::::::W::A::::::::::::T:::
rrnAC0257       :A:I:L:::::::::P:::::::::T:E:::::::::::::::A::::::F::H:::::T
Hmu1190         -:QM:R:::::V:::P:::::::::::::::::::::::::::AI:::::F::H::::::
NP3678A         ::S:::D::::::G::::::::::D:::::::::::::::::::I::::G::T::TD:::
HVO_2746        E:E::R:::::::G:P:V::::::G:::::::::::::::::::::Q:RTF::H::R:::
Hbo2479         E::T:::::::V:G::::::::::R:::::::::::::::::::::::TR::E:::::::

consensus       DAIEAGRLTVIEGDALEVDLPDFTACVSNLPYGASSEIAFRLLPAGKPLVLMFQQEFAER
#oth            3212213.2121....212..2112211.....21..13.1...233.122.2.4..11.
hla1155         T::DD:L:D:::::::D::::::::::A:::::V::::::::::E:::::::::A:::::
HQ2878A         VM:DD:::NI::::::::T::A::T:I::::::I::::L:E::::DC::IV:V:R::G::
VNG1165         :::A::D:D:VA::::A::::A::CA:::::::VA::VT:::::::::M:::Y:L:::::
Hut1311         ::::::::::::::::::::::Y::SI:::::::::::L::::::::::IA:V:A:::D:
rrnAC0257       EEVA:D:::IV::::::::::::::SI:::::::::::::::::EQR::L::::::::::
Hmu1190         :::D:D:::IV:::::D::::E:S:S::::::::::::::::::R:::::::::::::::
NP3678A         :E::::S:::::::::::P::::::S:::::::V::::::::::EKR:::::::::::::
HVO_2746        :EV:SD::::V:::::D::::E:::::::::::I::::S:::::R:::::::::K::G::
Hbo2479         :::::D:::IL::::::I:::E:::::::::::I::::T:::::R:V:::::::K::G::

consensus       MAADPGTDEYGRLSVSAQHYADVEVVETVPPEAFDPQPAVESAVVRATPREPDYEVPDEA
#oth            .1.221212......211..13.121.3..32..2.4.1.3.121.54..3.3.3.4113
hla1155         :V:SA:ES:::::::::::::A::I::R::K:::::::::::::::CL::D:::::G:::
HQ2878A         ::::::::A::::::::::::T:::::::::T::A:E:::D::LI::E::D:::T:T::T
VNG1165         :::::::S:::::::AT::::::SI:::::AA::::::R:::::::V:::D:::V:A:::
Hut1311         ::::::S:D::::::T:G:::::::::P::::::S:P:::D::L:::L::::N:T:::DD
rrnAC0257       :::::A::D::::::T:G::::::::::::::::::::R:T::L::TM::T:::T::SDD
Hmu1190         ::::::S:D::::::T:G::::::I::::::T::::::R:D::I::LR::::::S:::DD
NP3678A         :::E:::::::::::T:G:::::::::P::K:::S:P:::::::::T:::::P:::::DE
HVO_2746        :::EA::S::::::::T:::GE::LC:H::R:::::K:::Q:V:::I:::::E:::D:::
Hbo2479         :::ET:::::::::::::::G:::::::::K:::::A:::::V:::V:::A:::::D:::

consensus       FFLDFVKAVFTQRRKTMRNAIRNTAHISGLDDPDAVVEAADEDLLRKRAGNLSPAAFAAL
#oth            1.1311111.......3..11...2..1213111...3.11141123.1.424.34..3.
hla1155         :::R::::L:::::::V:::::::G::::::::E:::D::::::::Q:P:D:E:SS::::
HQ2878A         :::R::::::::::::V:::::::::::M::T:::::N::::A::SQ:::D:T:SE::E:
VNG1165         :::S::::L:::::::T::::::::::::::::::::A:V:D:V:GT:P:S::::T::::
Hut1311         :::G::::::::::::V::G:::::::::::::::::D::::E:::::::D:::TD::E:
rrnAC0257       ::M::L::::::::::::::V:::::::::G:::::::::::G:MSA:::K:T::D::T:
Hmu1190         ::M::L:G::::::::::::V::::::TD:G::::::D::::S:MG::::E::::T::::
NP3678A         L:MRL:R:::::::::::::V:::T::::IE:AE::::::G:::MS:::::VP:E:::R:
HVO_2746        ::::::::L:::::::I::G::::::::::S::E:::::::::V:::::::MA::E::E:
Hbo2479         ::::::::L:::::::I::G::::::::::E::E:::::::::V:::::::M::E:::::

consensus       ATLAAEVG---RP---
#oth            152.523211152544
hla1155         :E::R:H::::S:TEV
HQ2878A         ::I:::K::::K-:::
VNG1165         :NV:WG:ETAPG:DPQ
Hut1311         :S::H::::::LDSDD
rrnAC0257       ::::Y::::::Q:EA:
Hmu1190         ::::Y:T::::::GEY
NP3678A         :AI::::D:::G-:::
HVO_2746        :Q:::S::::::-:::
Hbo2479         TA::D:H:::::-:::