[S] (-) COG3390 Uncharacterized protein conserved in archaea 9 genomes BUD0219 9 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG1253 rrnAC1135 HVO_1337 Hbo0214 Hmu1442 Hut1237 hla2674 NP3962A HQ2404A

Pairwise sequence scores
Consensus score	4128	HQ2404A	Hut1237	VNG1253	Hbo0214	HVO_1337	hla2674	NP3962A	rrnAC1135	Hmu1442
2066	HQ2404A	5017	1582	1453	1884	1805	1627	1491	1467	1423
2413	Hut1237	1582	4138	1618	1894	1771	1845	1718	1876	1801
2094	VNG1253	1453	1618	3472	1641	1635	1589	1610	1620	1634
2519	Hbo0214	1884	1894	1641	4894	2158	1951	1715	1815	1658
2638	HVO_1337	1805	1771	1635	2158	4702	1957	1915	1836	1798
2607	hla2674	1627	1845	1589	1951	1957	4068	1830	1761	1673
2470	NP3962A	1491	1718	1610	1715	1915	1830	4396	2011	1796
2575	rrnAC1135	1467	1876	1620	1815	1836	1761	2011	4326	2160
2338	Hmu1442	1423	1801	1634	1658	1798	1673	1796	2160	3887

760 symbols
consensus       ------------MDDDGPGRREVAYRLFAAEFDDADFSYSESDEERAPNYVVTPTGARVN
#oth            11111122233454254513..1.1.2.....1.1311.111.21...........1.2.
HQ2404A         ::::::::::::-MSTTQNS::::::::::::E::TL:::AG:D::::::::::::E:I:
Hut1237         MSAENGDGDADDGG::S:::::::::V:::::::S::D:::::AD:::::::::::::::
VNG1253         ::::::MSDADTD::GERN::::::::::::::::::::A::::::::::::::::::::
Hbo0214         ::::::::::::-MSAVEN:::::::I::::::::SL::::G::::::::::::::::::
HVO_1337        :::::::::::MSASPVV:T::I:::V::::::::SL:::::::::::::::::::::L:
hla2674         :::::::::::::S:::::A::::H:V::::::::SL:::::::::::::::::::::::
NP3962A         :::::::::::::SSS:::::::::::::::::::E::::::::::::::::::::::::
rrnAC1135       :::::::::MSESG:S::::::::H:::::::::::::::::::::::::::::::::::
Hmu1442         ::::::::MSTDE:QG:A::::::::::::::::::::::::::::::::::::::::::

consensus       RLFAVGVLTEVESVNDDVLRGRVVDPTGAFVTYAGQYQPEALAFLERADPPAFVALTGKA
#oth            .2.31.1..1117132142.1.11..1.3..2.......22332.13221.311122...
HQ2404A         :::T::A::A::::T::LR:::IA::::V::::::::::T:AS:::Q:T::M::::::::
Hut1237         :::::::::::SPAGE::::A:IA::::T::V:::::::D:QT:::::E:::Y::V::::
VNG1253         :::V:::::A::A:::::V:A::::::::::V:::::::::::A::A:ET:S:::V::::
Hbo0214         ::::::A:::::::::E:::::IA::::V::::::::::::MN::D:ST::M::SI::::
HVO_1337        :T:VA:::::::H:::E:::::IA::::::::::::::::PM:Y:DA:T:::::S:A:::
hla2674         :::VA:::::::R:::ETR:::::::S::::::::::::::QT:::::E:::::::::::
NP3962A         ::::::::::::D::PEMV::::::::::::::::::::DE::::::T:::T:L::S:::
rrnAC1135       :::L::::::L:Q:::::::A:::::::P::I:::::::DE:::::A::::M:::V::::
Hmu1442         :V:L::::::::T:SE:Y::A:::::S:P::V::::::::::::::S::::T:::V::::

consensus       RTYEPDDSDRVFTSVRPESINEVDADTRDRWVVSAAEATLDRIATMAAALDADLRGDDLR
#oth            ..11.1.2.2.21.2...2222..231....3141.22.23.2243251554442.14.2
HQ2404A         :::Q:E:::Q:L::A:::DLTA::T::::::A::::Q:::R::GI:DI:QSLPV:::A:E
Hut1237         ::FQ:::::V:Y::I::::L::::EV:::::T:G::::::E:VG:::T:MEL:V:::E::
VNG1253         ::F::::A:V:Y::::::TVS::::::::::::AT::R::S:VR:A:::H:RVE:::S:E
Hbo0214         :::::::::::::::::::::::::G:::::::A::R:::E:V:::Q:::AM:H::::::
HVO_1337        :::::::A:V:YS::::::V:T::::V::::I::::::::R:::VFDE::SMPY:::::T
hla2674         ::F::E:::::::::::::L:A::::::::::::::::::::L:VF:K:::SE:::EE::
NP3962A         :::::E:G::::::::::::S:::::::::::IT:::R:::::GIV:S:IE:::A::Q::
rrnAC1135       ::FQ::::::::::::::::S::::::::::::Q:::Q:VS::GQ::S:KQ:G:A::E::
Hmu1442         :::Q:::::Q:Y::::::::S::::A:::::::QT::Q:I::V:RA:EGKH:G:T:E:::

consensus       AALEARGVDEGLAAGIPLAIDHYGTTPDYLEALRTLAVDALRVVAGDRDEVESLDVAPDE
#oth            51.444.23343.4.223.221.1.145.1312.4314212211.141231441333.23
HQ2404A         NE::S:::::AR:E:MA:::::::::EF:::S::KSVIQV:E:I::N:ET::A::TN:S:
Hut1237         :::DE:::EP:::::::::L:::::::G::A:M::::TS::E::::E:S:::::SLS::Q
VNG1253         S::A:A::AP:::S:::R:F:::::::A::G:V:D::A::A::::::T:T:GG:A:::S:
Hbo0214         ::::::::::S::M:V::::::::::EH::::V:::::Q::EL::DK:EA:D::T:::::
HVO_1337        R::::::::ST::::V:R::::::::RT::::::EV::Q::EL::::::Q:DP:::::GD
hla2674         V:::TG:APAA::::::K::A::D:STA:V::::R::::::KLI:::::::R:P:I:::A
NP3962A         :::::D::::R::D:VA::L::::::::::D:::E:::::V:::::E::::GR::I::G:
rrnAC1135       L::LD::I::SA::::T::L::::::G:::D::::T:L::A::::D:T::AQG:SLS::D
Hmu1442         :::VDH:::::V:::::I:LER::::G:::A:V:D::T::A:::::Q:::::P:T:R:GQ

consensus       GGDAALGALAELDL-----------------VEAPA------------------GD-DAA
#oth            224272442244351111111111111132454424222222221223334223445655
HQ2404A         T:A:S::::PSIAI:::::::::::::DTTQTST:SPTSTPSPTSTSESIQDSAH:TND:
Hut1237         ::::D:D::::TAS:::::::::::::::::IGE:::::::::::::::::::GETVGT:
VNG1253         A:::T:DFA:D:G-:::::::::::::::::-----::::::::::::::::::--:---
Hbo0214         T:PSE::PVPDVAA:::::::::::::::::AT::E:::::::::::::::::G::VAIT
HVO_1337        ::::V::P:P::::EPAASVDIEVGEADAGE:::D:GEFENESGSEPAATLDSEPEF:DG
hla2674         ::E::I:::P:T:V::::::::::::::::TI::::::::::::::::::::::--:EPV
NP3962A         ::GD:-T:::A::::::::::::::::::::SG::S::::::::::PETAAAAA:IG::D
rrnAC1135       :T:DPIPL::S:::::::::::::::::DTD:ST:E:::::::::::TATEDAE::AT:T
Hmu1442         :S:DQ:AG:-----:::::::::::::::::::R:I::::::::::::::::::--:---

consensus       ADGEAVASESEEEADAEEESAPEDAADAEPAAAQGAADAESTTGASSTEPDSEAAASDET
#oth            454453443424527465532336335533365653252444544442253456553553
HQ2404A         V:NDN::T::DTDTTVTT::S:SQE:TIDTDIV:P:::G:::V-E:AS:::EY:TSDPI:
Hut1237         EQ::SP:T:N::TPSTG:TTSTV:TSASTAD:SPS:D:TA:::AD:DAGAA::ES::AS:
VNG1253         -------------:::SFGG:S:TD:ETQ:DSSA:D:G:PAG:PD:TA------------
Hbo0214         ESD:SE::G::--PVSD:PTESAAT:AD:::TTEAD:T::K:EP:TE:::VT:TEPAPT:
HVO_1337        :ES:::EP:::S:PI::PD:E::S:S:P::V::ETT:A:::QP:::ES::A::PS---T:
hla2674         ::DG::E::::SV:AESD:::S:PEPN::SEP:VTGDETADS:E:D:::T::TETD:T::
NP3962A         DA:AG:EA:P:P:TET:TDTE:AG:S:S:::ETT:TD::L:GD:RDA:GV:EPL:G:::A
rrnAC1135       DS:ATEPTTD::V:::A:KG::A::::::::PGSPG:P:----:DE:::::AG:::::AP
Hmu1442         -----EV:TDD:A:GTVA:ESV:TDRPD:T:DD:R:GT::A:::QQ:SGS:APSIDDESA

consensus       DETEEEPEDTAEEEETAAADDGEDADDTPD--AEPAAETSEPD----G--GDFDT-----
#oth            456555654436544654566563256352115545435425624442333355411111
HQ2404A         PKNDG:NGV:TT:A:N:T:::SLS::V:E:::SA:SD:MT:TVNTTAQDINSTE:HLETE
Hut1237         ADVSG:SD--------::EG::F:S:E::E::::S:T::::ER::::-::SET:::::::
VNG1253         -----------------------SSV::D:::G:::S::AS::::::-::::AGP:::::
Hbo0214         ::::P:TPTESGSA:A::DAETVA:T:SGT::S:A::D:P::E:SSA:GL::::A:::::
HVO_1337        VDS:P:::PA::P:SEP::EPDLTSEPE:EPVTDSLDTE:::::FDD:AL:::ED:::::
hla2674         :SI:TDT::::VSV::EPS:S:S::AGSV::::G:GSAD::S::DES:GL::::A:::::
NP3962A         ATASDG::T:TPAD:PT:DTAERS:T:AL:::ES:T::AAPAAGSEP:AVDTEPP:::::
rrnAC1135       V::P:TAT:A:AD:T:PGESV:::VSS::E::QSEPVDEPPVS::::-::SEPV::::::
Hmu1442         :::T:SVD:V::::PSG:GSPD:T:EAS::::EIDTTTGD::T::::-::DESAS:::::

consensus       ------DTGDAEDDESTADDDSAD-GDLGDFDPG--------------------------
#oth            111111335543433433444354253353226242312111111111111111111111
HQ2404A         IQREVDESEIST:T:N:SAPT::SNS:IMSS:E:IDV:::::::::::::::::::::::
Hut1237         ::::::::QA::T:TP:D:PSEDT:A::E:::G-::::::::::::::::::::::::::
VNG1253         ::::::S::PVT:G::G:A:EDGE:---------::::::::::::::::::::::::::
Hbo0214         ::::::G:SES:TS:T:::TSDSA::G:::::ADDSVPSGSGDTESAPEAIEPDAETSDP
HVO_1337        :::::::AP::GATDAGSL:::GS::T:::::D:FDDPD:::::::::::::::::::::
hla2674         ::::::G:D:T:T:::GT::AE:::L:EPSSE::SDE:::::::::::::::::::::::
NP3962A         ::::::SA:::GL:::D:EA::P::---D:::::::::::::::::::::::::::::::
rrnAC1135       :::::::ADAMGQ::PESSSEPD:G:::::::T-::::::::::::::::::::::::::
Hmu1442         :::::::L:T:A:SSA::EA::V::D:::E:::-::::::::::::::::::::::::::

consensus       -------------------------------------------MYELDEDEREEIEDEFG
#oth            11111111111111111133232333333223222232222321121122..12114.11
HQ2404A         ::::::::::::::::::ESGNSDESTAGSADTDDDITADPTE:::::D:::A::::::V
Hut1237         :::::::::::::::::::::::::::::::::::::::::::EF::::::::Q:K::::
VNG1253         :::::::::::::::::::::::::::::::::::::::::::::::SAE:::AVK::Y:
Hbo0214         TTDTETAADTEPTTDTETATADSPSEAVQADAAADASSAMTGE:::M:DE::A:::A:::
HVO_1337        ::::::::::::::::::PEAGDSTDSTDSASADADDSVDPDG:::::::::A:::S:::
hla2674         :::::::::::::::::::::::::::::::::::::::::::::Q::DE::::::S:::
NP3962A         :::::::::::::::::::::::::::::::::::::::::::EFD:::E:::::KE:::
rrnAC1135       :::::::::::::::::::::::::::::::::::::::::::EF:::::::::::Q:Y:
Hmu1442         :::::::::::::::::::::::::::::::::::::::::::EF::::S::::::S:Y:

consensus       TEFSTGTEVDEP--------GEADIDVPDADEL-------------EAPEGESAAAAEAE
#oth            21.21131133111111111.221113.24334542221212212237535243543453
HQ2404A         ::::::N:::A::::::::::S::::::T:PDEDPSDEETSVDTTTNVT:TA:IDTGSTD
Hut1237         :::TS:A::::::::::::::::G:ET::----::::::::::::::PI:P:T:GDD:GT
VNG1253         VD::::D:IP:A::::::::::H:::A:GP:--::::::::::::::GV:S:A:::STDD
Hbo0214         A:::::N::AD::::::::::::::::::::::EAEGAEASAETNG:T:S:VADSSDTV:
HVO_1337        :::TS:AD::PA:::::::::::::::::::D:T:::::::::::::QL:D:::::::SD
hla2674         :D:::::::::::::::::::::::::::PE:IE:::::::::::::S:TSVG:SESAGA
NP3962A         :::::AD::EPADIEPEAGD:AD:AE-:GQESSSE:::::::::::SE::P:PGLE::S:
rrnAC1135       :D:QS::::::::::::::::::::ET::HE::AD:::::::::::A:Q::AP:D::D::
Hmu1442         :::QS::::::::::::::::A::::T::P---:::::::::::::::VDA:::T::D::

consensus       PAPAE-----A--EPEPATDTEAEPEPDAEPEG-------------------DEDA----
#oth            343452333244443335644553353364533111111111111111111143343343
HQ2404A         GD:H::TPIESDTDTDTD:::DTDTDT:IAVD:ISEASPAGSGDLGDFETTV:F:SESTE
Hut1237         ::TE:TADEA:PAAEKTD:T::G::::A::EP::::::::::::::::::::S:EL::::
VNG1253         GGD:V:::::-::---------:D:-------:::::::::::::::::::::F::::::
Hbo0214         SDTT:::::::AT::KTEM:EPL:::T:ET::S::::::::::::::::::::T:ETASD
HVO_1337        :E::T::::::AA:::::V:S:P::T:::ASD:::::::::::::::::::::::E::::
hla2674         D:::G:::::-::---S:DEAA:::TT:S:::S:::::::::::::::::::E:P:::::
NP3962A         :E:EV::::ETES::::EVE::S::::GV:T:P:::::::::::::::::::EAADTGES
rrnAC1135       :::GSPGAPAGDES:::TA:AATSDA:AET::T:::::::::::::::::::AT::AADE
Hmu1442         :SS:A:::::-::--D:SEGEVGAARSADS:D::::::::::::::::::::G::D::::

consensus       -----------------------ADTGDADDAPAEDVDLEDAVVDAMDDLDDGDGADREA
#oth            44333333333222221122221435675546633.1.1.521333.34....2.13131
HQ2404A         SNSSASETRSNEGETESGTETSAES:NI::SNKTQ:::::Q:A:SM:NE:::::::T:::
Hut1237         ::::::::::::::::::::::::SGA:ESA:EP::I:::::AME::AT:::::::::::
VNG1253         :::::::::::::::::::::::--D:TG::S:PA:::V:EY::EL:::::::::VP:SE
Hbo0214         ESKESGKSEQSDESEQSGKSEVA:::TE:T:E::::::::V::::V:A:::::::::HD:
HVO_1337        :::::::::::::::::::::::::ADPDA:ES:::I:::SV::::::::::::::T:DE
hla2674         :::::::::::::::::::::::---::ETSDADA:I:::A::I:::GA::::A::::::
NP3962A         AAADDLPGDAD::::::::::::GE::VD:GGT:D:::::A::SE::AS:::::::A::E
rrnAC1135       TT:::::::::::::::::::::P:ESASE:::T:::::::::MAV:::::::S:::::E
Hmu1442         :::::::::::::::::::::::----------:A::::::::M:V::::::::::A:T:

consensus       VVSTVVDRHGVDADAVEDAIQDALMGGRCYEPGDGRLKPI
#oth            224322264122132..211121.12.1...14125.12.
HQ2404A         :INE:::M:D:SP::::S:::S:::S:::::S:ENA::A:
Hut1237         :IER:Q:A:::::AD::::::::::N::::::S:::::S:
VNG1253         ::::AA:SL:::::E::A:VTS:::S:::::S::D:::A:
Hbo0214         ::::I:EQY:A::::::::::::::S:K::::SE:T::S:
HVO_1337        ::AA:::E::A:PG:::::::E::L:::::::Q::V::A:
hla2674         ::EA:::D:::A:::::::::::::S:K:::::::T::::
NP3962A         L::::A:EQ::S::::::T::EM:::::::::Q::V::::
rrnAC1135       LR::::S:::A:::::::::::::::::::::E::K:T::
Hmu1442         I:DA::::T:G:PN::::::::::::::::::D::L::::