[E] (AmpS) COG2309 Leucyl aminopeptidase (aminopeptidase T) 9 genomes BUD0224 9 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG0096 rrnAC2261 HVO_0477 Hbo1015 Hmu0131 Hut0212 hla1593 NP0014A HQ1359A

Pairwise sequence scores
Consensus score	2382	HQ1359A	Hut0212	rrnAC2261	Hmu0131	HVO_0477	VNG0096	Hbo1015	hla1593	NP0014A
1695	HQ1359A	2389	1482	1414	1486	1585	1583	1586	1593	1533
1838	Hut0212	1482	2370	1694	1639	1686	1614	1670	1643	1629
1842	rrnAC2261	1414	1694	2574	1876	1614	1634	1704	1554	1584
1837	Hmu0131	1486	1639	1876	2363	1587	1683	1680	1693	1584
1971	HVO_0477	1585	1686	1614	1587	2395	1749	1853	1718	1638
1966	VNG0096	1583	1614	1634	1683	1749	2353	1821	1740	1656
2037	Hbo1015	1586	1670	1704	1680	1853	1821	2494	1752	1623
1988	hla1593	1593	1643	1554	1693	1718	1740	1752	2448	1781
1863	NP0014A	1533	1629	1584	1584	1638	1656	1623	1781	2400

342 symbols
consensus       ------------------------MSDSSLRAAAETAVEQCLNLQPDESCVVVTDDKRAP
#oth            11111111111233333444444545535114112...41.252323.12211..23.53
HQ1359A         ::::::::::::::::::::::MPQ:K:K:A:::T::::K:AS:::T::::II::HN:R:
Hut0212         :::::::::::::::::::::::::::TG::GP:::::L:::A:ESG:::LI::::E:R:
rrnAC2261       MVRVSPAYAGSLSRVIQPEYAISC:DN:::::P:::::K::::::S::::A:I:::Q:KA
Hmu0131         ::::::::::::::::::::::::-MN::::KP:R::::::::::ST:::A::::E::TA
HVO_0477        ::::::::::::::::::::::MTEA:AD::::S::::R:::D::::::L::::::::ER
VNG0096         ::::::::::::::::::::::::---M:::D::::::::::G:H:E:::::::::::EE
Hbo1015         :::::::::::MGTPNRTGVPHGD:T:AE:::::::::V::M::A:::::::::::::LA
hla1593         ::::::::::::MGRTNARRRGSTGMS:D:AK::::::::::RVA:G::V::::::::::
NP0014A         :::::::::::::::::MADELEIE:P:AVAS::::::::::AIEAG:R:::::::::::

consensus       IGEALYEVASEITDDATILRYPPGDQHGEEPPAPVAAAMADADVFLAPTTKSLSHTRARG
#oth            .11.113115321.233321...14...3...12..3..362.112......11..2..2
HQ1359A         :A:::FD::QT:S:TVSLIQ::::S::::::::F::T::KN::::F::::::I:::::::
Hut0212         ::::::A::::T::::M:IQ::::::::::::E:::T:::S:::V::::::::T:::::T
rrnAC2261       ::::::R::A:::::SVFV:::::E:::S:::::::G::ET:::V:::::::::::E::T
Hmu0131         ::::::R:::::S::TVF::::::E:::::::E:::::::G:::V:::::::::::Q::S
HVO_0477        :::::::::G:V::::::V:::::N::::::::::::::QAC:A::::::::::::::::
VNG0096         ::R:I::A:RDVS:AT:M:Q:::::::::::::::::::::::::V::::::::::::::
Hbo1015         ::::::D::::V:::T:L::::::::::A::::A::V:::E:::::::::::::::::::
hla1593         :::::::AV:A::::::::::::A::::T:::::::::::ES:A::::::::::::::::
NP0014A         :::::::A:LAV::::::V:::::P:::A::::::::::::::A:::::::::::::::S

consensus       DACDAGARGATLPGITEDVFTTGLDADYDAIAAHCEDVLAQVADADEIRVTSPQGTDITF
#oth            2.31..1.1......123..21...1..53.5422443121.42.412.1.114...111
HQ1359A         E:::::::::::::::Q:::::::::::QT:SD:SRNIYD:::::N:::I:::A:::LRV
Hut0212         ::T:::::V::::::::E:::::::V::TE:H:AS:RL:DA:E::A:L:::::::::::V
rrnAC2261       ::NE::::V::::::S:G::LM::::::HL:EQ:::::::::D::E::::::::::::::
Hmu0131         E:NE::::V::::::::G::LM::::::E:::G::R::::::E:::::::::::::::::
HVO_0477        :::::::::::::::::E::V::::::::::YD:SAAM:DA:GG:::L:::TEK::::::
VNG0096         A:N:::::::::::::A:::::::::::ET:E:::::::::::::T:V:::T:L::::::
Hbo1015         ::::::::::::::::::::L::::::::T:SQ::L:::K::TE:E:::::T:S::::::
hla1593         A:::::::::::::::::::::::::::A::D:A:D:::::::::::V:::::A::::::
NP0014A         E:SE::V::::::::::S::::::::::::::ETTAT:Y:A::::ERV::::::::::::

consensus       EIGDREWLADTGIVHEAGEFSNLPAGEVFLSPETADGTYVVDGTMMPHGLLDEDQELRFE
#oth            34.2.2.45...31312.42.......2.41.33.2..2..1..12.1131142442211
HQ1359A         TP:E:::YQ:::SIDT::S::::::::::TA:V::T:::::::::R:::RV:P:DL:E::
Hut0212         TP:::::QL:::::::P:QL:::::::I::::::::::I::T:::A::::::KA:SI:L:
rrnAC2261       G::S:::HM::::::::::M::::::::::A:::::::F::::::R:::K::-GKQ:T::
Hmu0131         GL:::::QL:::::::P::M:::::::::C::T:::::F::::::::::Q:E-GEL:E:T
HVO_0477        VR::::::::::AIA:::S::::::::I::::AS:T:::::::::::::::::GR:::::
VNG0096         :A:::A:RD:::::R:G::::::::::::V::TD:N:::::::::::::K::-:E:::::
Hbo1015         :P:S:D::::::::::::G::::::::::V:::N:N::::::::::::A::E:G::::::
hla1593         G:::::::::::M:::P:D::::::::::I:::::T:::::::::::Y:::::::T:T::
NP0014A         ::::::::E:::::::P:S::::::::T:V::TS::::::::::IR:::R::A::TVT::

consensus       VEDGYVTEISDDAIREQVEAAAEEVGDDAYNLAELGIGTNVGVTELVGSVLLDEKAAGTV
#oth            .1..4.1312.231.512.211221.21......1.....11.54.1.........1...
HQ1359A         ::::T:SR:::::::N:I:T:::TA::A:::::::::::::::ST:G:::::::::::::
Hut0212         :::::::S:D::T::::::T::::::R::::::::::::::::VQ:::::::::::G:::
rrnAC2261       :::::::D:D:PD::A:::D::D:::R::::::::::::::A::::::::::::::G:::
Hmu0131         ::::L::::G:::V:Q:I:::::T:::A:::::::::::::A:RD:::::::::::G:::
HVO_0477        ::::::::::::D:::::::::::::::::::::I:::::::::D:::::::::::::::
VNG0096         :A::V:::::::RV::::::GS::::E::::::::::::::A::::::::::::::::::
Hbo1015         ::::::::::::DV:K:I::G:::::R::::::::::::::::D::::::::::::::::
hla1593         ::::L::SV::::V::EL:T:::S:::A:::::::::::::::D::::::::::::G:::
NP0014A         ::::F::DVD:A:::DEL:T::A:::E:::::::::::::L::EA:::::::::::::::

consensus       HIAIGDDAGIGGDTDAPIHLDGILREPTVYADGEEVELPSA-
#oth            .2.1..1211..112..2.1...122.1.21..2322..331
HQ1359A         :V::::NL::::E::::L:::::IQD::::::::K:S:::-:
Hut0212         :F:V:::::::::::::::::::::N:::::::::ID::TP:
rrnAC2261       :::::::HAM:::VH:::::::::T::::::::::::::RVE
Hmu0131         :::::::HA:::::T::::::::::::::F:::VA::::Q:E
HVO_0477        :::V:::::::::::::L:::::I:::A::::::::D::QP:
VNG0096         :::::::::::::::::L:::::I:::::::::::::::QP:
Hbo1015         :::::::::::::::::L:::::I:::::::::AV:D:::VE
hla1593         ::::::N:::::E::::V:::::::N::::V:::AI::::::
NP0014A         :::V::::::::E::::::M:::::::::LV::::LS::::E