[L] (HolB) COG0470 ATPase involved in DNA replication 9 genomes BUD0245 9 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG2280 rrnAC2565 HVO_0203 Hbo1330 Hmu2741 Hut2635 hla0165 NP0900A HQ3671A

Pairwise sequence scores
Consensus score	2398	VNG2280	Hut2635	rrnAC2565	Hmu2741	NP0900A	hla0165	HQ3671A	HVO_0203	Hbo1330
1937	VNG2280	2399	1802	1817	1853	1798	1812	1723	1813	1779
1985	Hut2635	1802	2400	1980	2024	1879	1763	1747	1818	1828
1992	rrnAC2565	1817	1980	2562	2041	1893	1809	1746	1853	1849
1977	Hmu2741	1853	2024	2041	2401	1890	1792	1742	1831	1819
2040	NP0900A	1798	1879	1893	1890	2418	1907	1848	1914	1930
2015	hla0165	1812	1763	1809	1792	1907	2413	1904	1996	1973
2051	HQ3671A	1723	1747	1746	1742	1848	1904	4866	2043	2054
2174	HVO_0203	1813	1818	1853	1831	1914	1996	2043	2438	2206
2140	Hbo1330	1779	1828	1849	1819	1930	1973	2054	2206	2432

673 symbols
consensus       --------------------MSEAAAA----AGGREIWIEKYRPQTLDDVYGHEDIVERL
#oth            11111111111111111111.11225564113212.1.1.....2212114.124112..
VNG2280         :::::::::::::::::::::TD::--::::G:RQ:::V:::::ER:E::V::P::T:::
Hut2635         ::::::::::::::::::::::::ES:R:::::RQ:V::::::::::E:IA:::A:::::
rrnAC2565       MHLRLSTLAGFKTGPRFQSS::::ESESR::::RE:V:::::::::::::M:::N::G::
Hmu2741         :::::::::::::::::::::::VER-::::S:RE:V::::::::::S::V:::T:::::
NP0900A         :::::::::::::::::::::::GD:D::::G:::::::::::::::::IV:::S:T:::
hla0165         ::::::::::::::::::::::::DEQTAAT:T::::::::::::S:::IH:Q:A:::::
HQ3671A         ::::::::::::::::::::::::D:SDAA:PT:::::::::::A::ENI::Q::T:D::
HVO_0203        :::::::::::::::::::::::::ESGDA:PA:::::::::::::F:::::QD::::::
Hbo1330         :::::::::::::::::::::::::D:EEA::T:::::::::::::::::::Q:::::::

consensus       QSYIDRDDLPHLLFAGPAGVGK--------------------------------------
#oth            31.1311.11.1..2....1..11111111111111111111111111111111111111
VNG2280         :::V:::::::::::::::T::::::::::::::::::::::::::::::::::::::::
Hut2635         G::VS:N::S:M::::::::::::::::::::::::::::::::::::::::::::::::
rrnAC2565       K::VS:N::S:M::S::::T::::::::::::::::::::::::::::::::::::::::
Hmu2741         :::V::N::S:M:::::::T::::::::::::::::::::::::::::::::::::::::
NP0900A         KQ::AQN:::::::::::::::::::::::::::::::::::::::::::::::::::::
hla0165         ::::EQ::I:::::G::::T::::::::::::::::::::::::::::::::::::::::
HQ3671A         ::::::::::::::::::::::CVTGSTPILTNKGIRQIGEIVGDVDGFAPAPQNLKVCS
HVO_0203        R:::E:::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hbo1330         R:::EQ::::::::::::::::::::::::::::::::::::::::::::::::::::::

consensus       ------------------------------------------------------------
#oth            111111111111111111111111111111111111111111111111111111111111
VNG2280         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hut2635         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
rrnAC2565       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hmu2741         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP0900A         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
hla0165         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
HQ3671A         LTADGSFQYRHPSHVFGKRASGLQRIKTNDGATLTVTPEHKLLIRTGENTNPTWVPAADI
HVO_0203        ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hbo1330         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

consensus       ------------------------------------------------------------
#oth            111111111111111111111111111111111111111111111111111111111111
VNG2280         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hut2635         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
rrnAC2565       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hmu2741         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP0900A         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
hla0165         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
HQ3671A         TAGMHVLRAKNLPIPAETTGSCAASKNASEVSHIGDEYRYHDSLMADVNTRIATLERLIE
HVO_0203        ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hbo1330         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

consensus       ------------------------------------------------------------
#oth            111111111111111111111111111111111111111111111111111111111111
VNG2280         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hut2635         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
rrnAC2565       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hmu2741         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP0900A         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
hla0165         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
HQ3671A         DYAESRSDGSLKFTLIGAHTPTVSTVSYLLATVGIASRHTSTLIDSEKRVHAIIIDASDT
HVO_0203        ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hbo1330         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

consensus       ------------------------------------------------------------
#oth            111111111111111111111111111111111111111111111111111111111111
VNG2280         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hut2635         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
rrnAC2565       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hmu2741         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP0900A         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
hla0165         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
HQ3671A         VRLEEMIETDWDTVMADQTTTVTSSSTASTTKTTQSYLSSGETQTCGWIPYADGGVTHPS
HVO_0203        ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hbo1330         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

consensus       ---------------------------------------------TTAATAIARELYGDD
#oth            111111111111111111111111111111111111111111111.12111..222..1.
VNG2280         ::::::::::::::::::::::::::::::::::::::::::::::ASSVS::K::::::
Hut2635         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::E:
rrnAC2565       :::::::::::::::::::::::::::::::::::::::::::::::C::::::::::::
Hmu2741         :::::::::::::::::::::::::::::::::::::::::::::::S::::::::::::
NP0900A         :::::::::::::::::::::::::::::::::::::::::::::::::::::K:V::::
hla0165         ::::::::::::::::::::::::::::::::::::::::::::::::::::::QV::::
HQ3671A         TQHSPLHADVVTVSESLDAEKRVYDLTVPGVRNYVGGCIPTVMHN::::::::HAV::::
HVO_0203        :::::::::::::::::::::::::::::::::::::::::::::::S::::::AI::::
Hbo1330         :::::::::::::::::::::::::::::::::::::::::::::::S::::::AI::::

consensus       -WRENFLELNASDERGIDVVRDRIKNFARSSFGGYDYRIIFLDEADALTSDAQSALRRTM
#oth            1.2311.......1.........1.3...2....422.11......1..31..1......
VNG2280         ::QD:::::::::::::::::::::D::::::::HN::V::::::::::D::::::::::
Hut2635         ::E::::::::::::::::::::V:S:::T:::::::::::::::::::A::::::::::
rrnAC2565       ::::H::::::::::::::::::::::::T::::VE::::::::::::::::::::::::
Hmu2741         ::Q:H::::::::::::::::::::S:::T::::V:::::::::::::::::::::::::
NP0900A         :::::::::::::Q:::::::::::S:::A::::::H:::::::::::::::::::::::
hla0165         N::G:::::::::Q:::::::::::G::::::::-:F::V::::::S::DE::A::::::
HQ3671A         ::QN:L::::::::::::::::::::::::::::::H:::::::::S::D::::::::::
HVO_0203        :::G::::::::::::::::::::::::::::::H:::V:::::::S::N::::::::::
Hbo1330         :::G::::::::::::::::::::::::::::::F:::::::::::S:::::::::::::

consensus       EQFSDNTRFILSCNYSSKIIDPIQSRCAVFRFSPLGDDAVAAQIRDIAAAEGIELTEDGL
#oth            ...11.1...1......1..............11.213.1322315..32.4112.11.2
VNG2280         ::::N:::::::::::::::::::::::::::AQ::::::::HL:E::ET::L:H:D::I
Hut2635         ::::N:V::::::::::Q:::::::::::::::::A:E::E::::Q::QE:V:DV::::I
rrnAC2565       ::::N:V::::::::::Q:::::::::::::::::A:::::EE::T:::E:D::::::::
Hmu2741         ::::N:V:::M::::::Q:::::::::::::::::::E::E:E::H::DE::::::D::V
NP0900A         :::::::::::::::::Q:::::::::::::::::::A::DE:::I::DT::::::D::V
hla0165         :::::::::::::::::::::::::::::::::::S:A:::::T:E::::::::V:DE:V
HQ3671A         :::A:::::::::::::::::::::::::::::::SET:IRG:TK::::::N::::::::
HVO_0203        :::::::::::::::::::::::::::::::::::::::I:E:V:::::::D::V:::::
Hbo1330         ::::::::::::::::::::::::::::::::::::::::RE:VK:::ET:E::::::::

consensus       DALVYAAGGDMRRAINGLQAAATTGDTVDEEAVYAITSTARPEDIEEMVTAAIDGDFTAA
#oth            1....1.1....1...2....132.23.1.11.14..1.....2.23..35.22.1.221
VNG2280         :::::::D::::::::A::::SA:::S:N::T:::::A:::::E::T:::E:LG:::A::
Hut2635         E::::V::::::K::::::::SMS::::N::::FE::::::::::R:::DL:L:::::::
rrnAC2565       :::::::D::::K::::::::SVS::::::S::::::::::::E:RT::QS:L::::::S
Hmu2741         ::::::::::::K::::::::SVS::V::::::F:::::::::V:QG::QD:::::::::
NP0900A         :::::::D::::K:::::::::VM:G::::::::T::::::::E:R::::E:M:::::::
hla0165         :::::::D::::::::S::::::::EI::::::::::A:::::E::S:::N:LH::::R:
HQ3671A         ::::::::::::::::S::::::::EV::::T::T:::::::::::T:::::::::::T:
HVO_0203        ::::::::::::::::S::::::::EV:::::::M::::::::::::::R:::::E::::
Hbo1330         ::::::::::::::::S::::::::EI:::::::L::::::::::::::QS::::E:LT:

consensus       RSQLDTLLTDTGIAGGDIIDQLHRSVWEFDLDERAAVRLLERIGEADYRITEGANEQVQL
#oth            .23.22.1123.2....1...1..12.21.231341.2211.2..1....23..1.12..
VNG2280         :AT::D:::NR:L::::::::V::::::::VE:A::::::D:L:::::::A:::::R:::
Hut2635         ::R::::::EE:::::::::::::T::::::SDA::::V:D:V:::::::::::S:RI::
rrnAC2565       :AT::R:::EE::::::::::::::I::::I:DD::::V::::::T:::::R::::R:::
Hmu2741         :::::D:I::E::::::::::::::I::::VPDEQ:::I:D:V::T::::::::::RI::
NP0900A         ::::E:::::V::::::::::::::::::::E::E::Q:M:::::::::::A::S::L::
hla0165         :AT::::::E::M::::V:::::::::::::S::E::A:M::::::::::A:::::::::
HQ3671A         ::::Q:::V:::M:::::::::::TA:NL::::ETT::::::V::::::::V::::::::
HVO_0203        :K::E::IV:::M:::::::::::::::::::::D::::M::::::::::S:::::::::
Hbo1330         ::K:E:::V:::M::::::::::::::D::::::TT:::M::::::::::::::::::::

consensus       EALLASLALAQ--
#oth            .11..11145642
VNG2280         ::::::V::NAE:
Hut2635         :::::::::DGRD
rrnAC2565       ::M:::::QGE::
Hmu2741         ::M::::S:DD::
NP0900A         :::::A::RGNET
hla0165         :S:::::S::E::
HQ3671A         ::::::::DT:::
HVO_0203        :::::::::S:N:
Hbo1330         ::::::::A:TDD