[S] (-) COG1931 Uncharacterized protein conserved in archaea 9 genomes BUD0283 9 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG2454 rrnAC3144 HVO_0127 Hbo1369 Hmu2608 Hut2805 hla1387 NP0868A HQ3046A

Pairwise sequence scores
Consensus score	1059	VNG2454	NP0868A	Hut2805	rrnAC3144	Hmu2608	HQ3046A	hla1387	HVO_0127	Hbo1369
554	VNG2454	1051	441	492	498	482	460	513	480	487
700	NP0868A	441	999	661	660	620	632	579	624	569
780	Hut2805	492	661	1074	680	728	629	646	615	593
748	rrnAC3144	498	660	680	1065	743	572	662	606	546
721	Hmu2608	482	620	728	743	1048	541	598	582	534
729	HQ3046A	460	632	629	572	541	1054	582	653	699
805	hla1387	513	579	646	662	598	582	1141	708	626
829	HVO_0127	480	624	615	606	582	653	708	1053	827
792	Hbo1369	487	569	593	546	534	699	626	827	1050

152 symbols
consensus       --MIYSVDVRITAPVRDTEVTDRVADAVRNLFPNAEPEHEPGQLVAETHSLEEFSELLHE
#oth            1242112322122..32..21...2..1412..412445341323114132361224.12
VNG2454         MTDTTD:T::V::::YP::PD::::::ILR:::D:TVTV:DDRA::::DTTAS:R:Q:FD
NP0868A         :::::::::Q:::::NE::::::::::IE::::E::I:SH::E:MGTG::M:T:::R:::
Hut2805         MSEV:::::E:::::Y:::::::::::IT:V::::DV:QR::E:H::::D:AH::::::R
rrnAC3144       MSAV::::I::E:::N:::::::::::::::::E:D:T:QQ:A::::V:TMDG::::::R
Hmu2608         MSAV::::::V::::H::::::::::::T:I::T:D:SY:GD:I:::C:DMSHV:::::R
HQ3046A         :::::::EIQ::T::H:::I::::E:::Q:::::VTF:QH::EIIG::::::::AV::::
hla1387         ::V:::I::::E:::::::::::::::I::V::D:::I::D:R::::G:T:DA::DV:::
HVO_0127        :::::::::::EV:::::::::::G:::E:I::GV:LD:::::::G:A:E::R:::R:::
Hbo1369         ::::::AHA::VV:::::::::::E:::::I:::V:F:R:A::I:G::::::::::K:::

consensus       QEILDTARRVFFDRLDDDGFSFALKKQAAFEGVVNFAVGNPDELGDIHVEVTVREPDVEE
#oth            22...1..33.44554233.4.521.....31311.1..412...122.6.3152.3124
VNG2454         :R::::::EQ:QASQT:A::::D:::::::N:T:::::::::::::L::::::A::A:QQ
NP0868A         :A:::S::GA::SD:EG:T:::R:::::::Q::I:::::SES:::::::R:K:N:::A:T
Hut2805         R:::::::G::::T:QG:R:::T:::::::::::T:S::E:::::E:::S:R:E:::::S
rrnAC3144       R:::::::S::::N:EG:T:A:DV::::::::RI:::::D:S:::::::N:::T::TA::
Hmu2608         E:::::::G::::T::::T:T:E:N:::::::RI::S::G:A:::::::Q:R:T::SA:A
HQ3046A         :::::::::E::KHAN:ES:R:SI::::::K:II:::::::::::::E:T:I:H:::::S
hla1387         :::::::::::LQNST:E::D:S::::::::::::::::E:::::EVN:::RI::::::A
HVO_0127        :A:::::::E:AK:R:::::::::::::::K:::::S::::::::::E:H::::D:S:D:
Hbo1369         :A:::::::E:SK:D:ES::::::::::::KD::::S::::::::::E:H:::EN:S:::

consensus       FIDHIAPPTEDGRPVDP----DDR--------
#oth            2..331.1.22.3.334211144431111111
VNG2454         ::::L::::DG:E:LEDP:::---::::::::
NP0868A         Y::SV:::::::A::E-::::---::::::::
Hut2805         :::::::::Q::::I:::::::RSA:::::::
rrnAC3144       Y::YV:::::::Q::YD::::E:T::::::::
Hmu2608         :::A::::::::A:I:T::::E--::::::::
HQ3046A         Y:::TV::::::Q:QPV:::::AE::::::::
hla1387         :::YV::E:DE::::::VREYG::VDPEDIDY
HVO_0127        V::Y::::::E::::::::::N::::::::::
Hbo1369         ::::::::::E::::P::::::E:E:::::::