[H] (MoeA) COG0303 Molybdopterin biosynthesis enzyme 9 genomes BUD0292 9 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG0090 rrnAC1298 HVO_2304 Hbo1990 Hmu1360 Hut0721 hla1140 NP1440A HQ3345A

Pairwise sequence scores
Consensus score	3046	Hut0721	rrnAC1298	NP1440A	HQ3345A	hla1140	HVO_2304	Hbo1990	Hmu1360	VNG0090
1993	Hut0721	3000	1779	1696	1652	1645	1612	1622	1813	1667
2325	rrnAC1298	1779	3050	1951	1985	1987	2037	2049	2036	1996
2276	NP1440A	1696	1951	3004	1984	1969	1948	1987	1902	1893
2305	HQ3345A	1652	1985	1984	3375	1974	1951	2202	1862	1966
2399	hla1140	1645	1987	1969	1974	3121	2122	2125	1824	1916
2345	HVO_2304	1612	2037	1948	1951	2122	3059	2252	1909	1899
2379	Hbo1990	1622	2049	1987	2202	2125	2252	3198	1946	1937
2293	Hmu1360	1813	2036	1902	1862	1824	1909	1946	3061	2030
2295	VNG0090	1667	1996	1893	1966	1916	1899	1937	2030	3062

450 symbols
consensus       ---------------MSDDRREAGFKERTRVADAREQLLDAASPHDRTERVPLGDADGRV
#oth            11111111111112346512332..141.2134.123.13434135.13542254112.2
Hut0721         :::::::::::::::V:S::H:::::RQ:P:TA:::::RSVVTGV::::QIATEA:V:::
rrnAC1298       ::::::::::::::MSNES:KS::::D::P:TT:::T::::V:::E:::::::R:::E::
NP1440A         :::::::::::::::-MA:V::S:::::::::A:::::::-IP:I:::::IS:SA::::A
HQ3345A         MVVMDSTDATDAGDASDP:::SS:::N::KL:E::R:::GDI:::E:IDNLS::Q::S::
hla1140         :::::::::::::::::H::::::::R:::::::LAT:::::E::G:::SA::A::::::
HVO_2304        ::::::::::::::MNH::::T::::Q:::LS::::A::A::T::::IV:R::AE::::A
Hbo1990         :::::::::::::MTNAH::QT::::::::L:::::T::A::T::Q::DTL:::RV:::S
Hmu1360         ::::::::::::::::T::P:GV::R:Q::LGP:::R:::SL::VS:::A::IT:::::A
VNG0090         ::::::::::::::::T::::T::::Q:::::E:::R::S:VD:LA::A::A::::::::

consensus       LAEPVTAPRAVPHYDRAAMDGFAVRAEDTFGASDRSPAVLR---------RDESVGPGEA
#oth            2.343413231.3.4......2..2.31.11.24.1.43.3323321112544323114.
Hut0721         I::Q::PE::::::::::::::::N::E:V:::E:A::R:E::::::::::A:NM:::R:
rrnAC1298       V:GEI::E::::::R:::::::::::::::S::Q::::S:::::::::::V::A:TT:T:
NP1440A         ::A::A:R:NI:::A::::::W::::::::::::::::::::::::::::PGD::::NT:
HQ3345A         ::::I:::::::G:E::::::W::Q:H:::::G::::K::QVADDTAESVP:TP:::N::
hla1140         V:::ID::AP::S::::::::Y:::::::::::::::::::AVGT:::::EAD:IA::::
HVO_2304        :::DAV::AD::G::::::::Y::::S::::::G:::N:::I::::::::V:GP:E::T:
Hbo1990         :::A:::ANP::N::::::::W:::::::::::::::SI::VAVSEAESDA:AA:E::S:
Hmu1360         ::SEH::R:P::::P:::::::::::::::::TR:::VR:E::::::::::S:::::NA:
VNG0090         ::AD:E::::::::E:::::::::::A:::::G::::V::DV::::::::GTG:::::::

consensus       VRVHTGSELPEGADAVVMVEQVERVGDELEVFDAVAEGENVAPIGEDVADGQRLFEPGHR
#oth            21.....21.31.1...21.4225433423112.22412..124.1..33225.123.13
Hut0721         :G:::::::::H:::::R::D:TERN:G:A:ET:::P::::::T:::::ADAT:::::D:
rrnAC1298       A:::::::::::::::::::ET:VT::SVT::::::G::::::V::::EQ::T:Y:D:::
NP1440A         ::::::::::::::::::::AT:Q:::::::::::GA::::G::::::E:::::Y::::Q
HQ3345A         :::::::A::D::N::::I:::TQ::T:I::::::T:R:::::::::::ES:S:YN:::Q
hla1140         A::::::AV:::::::::I::::T:A::V:A::::::::::GEA::::::::::::A::V
HVO_2304        A::::::DV:::::::::::HT::L:::::::::L::::::GER::::RE:TP:::A::E
Hbo1990         ::::::::::P:::::::::HADV::S::::::::T:::::GDA:::::E::E::DI::E
Hmu1360         C::::::::::::::::Q:::::ADDATI:::::::S:Q::::V:D::S:::H::D:::Q
VNG0090         ::::::::::A:::::::I:DA::R::RVD::A:A:G:A:::::::::S:::H:YDA:::

consensus       LRPSDLGLLKSVGVDAVTVYERPTVAVIPTGEELVQSDPGPGEVVETNGLTVSRLVERWG
#oth            .....1...123.5151422311222.2.....1.221.2..111...131.32114...
Hut0721         ::::::::::AT:IEG::A:QP:EI::::::::V:E:::::::I::::::V:I:::::::
rrnAC1298       :::::::::::::N:V:E:::::::S::::::::::N::E::Q:I::::Q::TQY:::::
NP1440A         ::::::::::GA:I:T:E:AA::E:::::::::::::::D:::I::::RF:::::A::::
HQ3345A         :::::::::::::H:R:Q:::::::G:::::::::::N:::::::::::::::H:AN:::
hla1140         :::::::::::::L::AP::::S:I:::::::::::::::::::I:::::::::::::::
HVO_2304        :::::I:::R::::EE::LF:::R:S:V:::::::E::::::::I:::::::::::::::
Hbo1990         :::::::::::::R:E::::D::::G:::::::::::::E::::::::::::::::H:::
Hmu1360         ::::::::::AL::ET:A:FD::RFS:V:::::::::::E:::::::::Q::AQY:R:::
VNG0090         :::::::::::A:::::A:::::::G:L:::::::AA::::::::::::G::AQY:S:::

consensus       GDATYRDVVTDDEAALRAAIERDLD-HDVVVTTGGSSVGERDLLPEVVDDLGEVLVHGVA
#oth            13221.31.1..531.24.13411113.11.........2..12.111331.3.3.....
Hut0721         ::PR:::I::::QQ::AD::::::::A::I::::::::::::::::::E:::D:A:::::
rrnAC1298       :::::::I::::VD::::::SD::::::L:::::::::::::::::::SEI:::::::::
NP1440A         A:V:R:SI::::RE:::::V::::T:R::::::::::::::::I::::S:::::F:::::
HQ3345A         :I::::N:::::P:::::::Q:::T:K::::::::::::S:::V::II:T::S:::::::
hla1140         :E:R:::::::::D::S::::A::::A::::::::::::::::::::I:SI:::::::::
HVO_2304        :E:S:::I:V::ADL::E:V:S:::::::::::::::::::::I:::I::I:::::::::
Hbo1990         :V::::N:::::P::::::VQ:::T:K::::::::::::::::I:::::E::::::::::
Hmu1360         :EP::::::::::::::S::::::::::LI:::::::::::::::A::::::T:S:::::
VNG0090         :VP:R:G::::::::::T::REAV:S:::::::::::::A::HV:::IA:::T:::::::

consensus       LKPGHPVALGVVEDTPVVMLPGYPVAAIVNAVQFLRPLLKHVGHLPARPPPTTEATLTRK
#oth            11.....221222311124......122...2.1.1.3325314445344.23514.31.
Hut0721         H::::::GF:R::A:::L:::::::S:L:::::L:Y:AVAWA:NREPEA::::AGE::::
rrnAC1298       :::::::::::A:G::IL::::::::C::::::::::A:RQA:::RSTD::::K:E::::
NP1440A         ::::::::::R:NGVTI:::::::::::::::::::::I::L:RF:SE:L:SQA::::::
HQ3345A         ::::::::::II:::::II::::::::::::::::::I::YM::::CNS::::T:Q:SQ:
hla1140         :::::::C::::D:::I:S:::::::C::::A::::::Q::::GTT:N:F::RR::::::
HVO_2304        ::::::::V::::G::::::::::::CV:::F:::::V:::::S::E::L::Q:::::::
Hbo1990         ::::::::::::::::::::::::::C::::::::::::::::::DG::Y:SV::R:E::
Hmu1360         ::::::::F:R::E::ILV:::::::T::::::L:::A::KLA:::E:E::V:::R:E::
VNG0090         :Q:::::::C::D:::::A:::::::::::::::::::::A:::A::TAH:::D:V:A::

consensus       IASEPGTRTFARVRLDGEGD-----------ERD----------ATPTRASGSGVLSSVA
#oth            22.11.1.111..445634311111111111366322323333312.1.21.1.1....1
Hut0721         ::::::V:SYV:::HVA::-:::::::::::---::::::::::VE:I:SG:A::::::S
rrnAC1298       :::::::::Y:::E:HD:DA:::::::::::DEQ::::::::TT::::::::::::::::
NP1440A         :R::::V::::::T:SPTD::::::::::::GLE::::::::::::::::::::::::::
HQ3345A         :P::::V:::::::TETTTAADSDIDTDAYIDTNTDTKNVISTI:K::::::::::::::
hla1140         VP:::::::::::SVE:T:E:::::::::::GG:GDGDDSALPA::::::::::I:::::
HVO_2304        LP:S:::::::::K::PS::::::::::::::ST:::::::::::E:::T::::I:::::
Hbo1990         :P::::V::::::::RE:N:::::::::::::G:NGGNDPVERI:E:::T::::::::::
Hmu1360         V:::V:::S:V:::::RD:::::::::::::::T::::::::::::::::::A:::::::
VNG0090         ::::::::S:V::TRH:DE::::::::::::G:P:::::::::TV:::::G:::::::::

consensus       LADGWVVVPESREGYDAGETVAVEDWEWSA
#oth            1.....2...46..232141.3.13..214
Hut0721         A::::::::::Q::IE::A::S:::::::P
rrnAC1298       :::::::::::V::::::D::T:::::::Q
NP1440A         ::::::::::Q:::IP:D:::::Q:::HNV
HQ3345A         ::::::I:::::::L::::::S::Q::::T
hla1140         ::::::::::P:::L::::I:D::L::A:Q
HVO_2304        ::::::::::EI::::E:D:::::G:::::
Hbo1990         ::::::A:::ET:::AK::::T::G:::::
Hmu1360         ::::::::::DS::::::R::::::::::P
VNG0090         ::::::::::DC::::::T:::::Q:::::