[L] (PRI1) COG1467 Eukaryotic-type DNA primase, catalytic (small) subunit 9 genomes BUD0294 9 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG1470 rrnAC0292 HVO_2697 Hbo2417 Hmu1379 Hut0409 hla1441 NP3990A HQ2719A

Pairwise sequence scores
Consensus score	2938	hla1441	HQ2719A	HVO_2697	Hbo2417	VNG1470	NP3990A	Hut0409	rrnAC0292	Hmu1379
2135	hla1441	2982	1812	1909	1925	1620	1635	1856	1748	1694
1998	HQ2719A	1812	2945	1907	2069	1462	1487	1650	1626	1515
2210	HVO_2697	1909	1907	2960	2147	1531	1636	1863	1740	1650
2224	Hbo2417	1925	2069	2147	2942	1547	1616	1857	1732	1683
2015	VNG1470	1620	1462	1531	1547	3273	1711	1721	1869	1893
2031	NP3990A	1635	1487	1636	1616	1711	2993	1777	1939	1896
2222	Hut0409	1856	1650	1863	1857	1721	1777	2958	1946	2008
2298	rrnAC0292	1748	1626	1740	1732	1869	1939	1946	3006	2497
2200	Hmu1379	1694	1515	1650	1683	1893	1896	2008	2497	3016

430 symbols
consensus       ---------------------------------MEERTRAYLRGRFGDYYRRAEVALPPA
#oth            111111111111111111111111111111111.231.12..2.....2.1323552..3
hla1441         ::::::::::::::::::::::::::::::::::DD:::E::K::::::::::SP::::D
HQ2719A         :::::::::::::::::::::::::::::::::::D:::T::K:::::::A::RMDT:::
HVO_2697        ::::::::::::::::::::::::::::::::::DG:::E::E::::::::STD:P::::
Hbo2417         :::::::::::::::::::::::::::::::::::AH::E::E::::::::G:D:::::T
VNG1470         MHRAPGRFVRPRRAVDPGETTLIYPRSAYCRPD:::::::::::::::V:::::ID:::R
NP3990A         ::::::::::::::::::::::::::::::::::NG:::E::K:::::H::::SLSP:::
Hut0409         ::::::::::::::::::::::::::::::::::::::::::::::::::::T:PLP::D
rrnAC0292       ::::::::::::::::::::::::::::::::::::::::::::::::H::Q:S:TP:::
Hmu1379         ::::::::::::::::::::::::::::::::::::::Q:::::::::H:::S:FTP::D

consensus       ANEREWGYIPWTAGPGTTMVRHQSLLDL---GDLGDFLAREAPRHVYFSAGRYDDPGAST
#oth            143....3.1.2312211.2..3.2113111.4344115253.2.1...111142.1.31
hla1441         ::L::::H::::P:S::::L:::::Y:::::::VDT:F:DN::::A::::A:::::::::
HQ2719A         ::R::::H:::S::-S::::::::::E:::::T:D:::H:T::K::::::A:FN::::T:
HVO_2697        PG:::::V:::S::-::R:H::::::::::::::S:Y:::S::::::::SA:FA::::GS
Hbo2417         PER::::::::S::-::::::::::::I::::N:::::T:T::Q::::::A:FN::::G:
VNG1470         :DD::::::::::::D::::::K:T:::::::SMTS::E:KC:::::::::T::A:::A:
NP3990A         :::::::::T:GD:-:::::::H:Y::VTGG::::G:::G:R:::::::::::::::::S
Hut0409         :H::::::::::DS::E::::::::::M::::::ES:::::R:::::::::::T::::GS
rrnAC0292       :::::::F::::E:::E:::::R:::::::::EIE:::G:RK::::::::::::E:S:::
Hmu1379         :::::::F::::D:::E:::::R:::::::::E::E::Q:KR:K:::::::::R::S::S

consensus       MDQKGWRSSDLVFDLDADHLPGVDPGETSYAEMLAACKDALLRLLDFLEDDFGFEDLTVV
#oth            .23.3.121.11..1......31414322.13..421.32.43..12123..3.222221
hla1441         :S::::::A::::::::::::::::DA:::P::::E::Q:::::::::::::S:D:::::
HQ2719A         ::::D:Q:A::I:::::::::::N:DT::::D::T:::TE:QT::E:ID:::N:DETQ::
HVO_2697        ::D::::EA:::::I::::::::::ET:G::D::D:G:::::D:::L:::::D::EMQA:
Hbo2417         ::E:::Q:A::::::::::::::::ET::::D:::::::D::S:::I::N::D:T:TQ::
VNG1470         ::E:H:QG:::::::::::::R:TL::D::::::SK:::::::::::::R:::::E:::T
NP3990A         :G:::::G::::::::::::::I::S:::::A::E:::G::S::::L:VE:::::P:A::
Hut0409         :SA:D::G::V::::::::::S:::TQAT::::::::::::F:::::::N::::::::I:
rrnAC0292       :SD::::::::::::::::::S:VL::D:::::::K:::::R::::::::::::D:::I:
Hmu1379         :SA:E::::::::::::::::A:EL::D:::Q:::K:::::::::::::N::::::::::

consensus       FSGGRGYHVHVRDEGVRELDSEARREIVDYVRGIDLDFEGLVETESVAGTT-------KR
#oth            ............125133.2131...1.1.11121.34151152344323212221223.
hla1441         ::::::::::::::S:::::::::::V:::::A::::T:::IR:V:ER::::::::::::
HQ2719A         ::::::::::::::Q::S:::A::::::::I:A:::NI:T:I::Q:NH::::::::::Q:
HVO_2697        ::::::::::::::S::S::::::::::::I:A:::::DA:I::RQHGT:::::::::Q:
Hbo2417         ::::::::::::::N::::::D::::::::::A::::V:::IG:::NR::::::::::R:
VNG1470         :::::::::::::A::Y::G::E::::::::::N::AL:T:::A:P:G:RG:LENPTE::
NP3990A         ::::::::::::RDD:L:::RT::::::E::L:EG:::DDI:S:QA:::SAGRSSPAQ::
Hut0409         :::::::::::::D:IQQ:ER:::::::::::::G::LD:::T::MRGNV::::::::A:
rrnAC0292       ::::::::::::::RI:H:ERD::::V:::::::G:E:DE::DE::::::AGRSSPAQ::
Hmu1379         :::::::::::::A:IQQ:ERD::::::::::::G:E::Q::DE:A::::AGRSSPAQ::

consensus       TLRTEGGWGARVHRRLLALVDDLLEMEEEAALERLQELDGIGEGRAKTILGAARNNPEAI
#oth            3.343...24.3242254331414233233.442.4222.1.212.312232355.4222
hla1441         V::::::::::::EA:IEYA:::R::DA:D:R:::M::::::::::E:::::FDR::T:V
HQ2719A         I:KHR::::Q:I:K::VE:IET:QASDDTE::::::SFE:::T:::E::::QIQ::::::
HVO_2697        V::::::::R:T:::::DF::A::::::D:::S::K::::::D:::::V:::F::::D:V
Hbo2417         V::RH::::::::D:::E:AEN:R::::::::::::::Q::::::::::::QIH::F:::
VNG1470         M:PAD::::R::TT::E:FA:::I:RG:DD:VAT:T:F::V::RS:RA:YNVVAD:TT:V
NP3990A         ::P-D:::AG::RT::TT:F:EV:T:::A:::D::R:F::::::K::AA:T:::::R:EL
Hut0409         :::::::::K:::EA:::F::EVEALP::Q:MT:::D:E::::::::::R::IEE:R:::
rrnAC0292       ::S:::::S::A::HM::V:::::A:::AD:::Q:::Y::::::K:TAA:N:::S:Y:QL
Hmu1379         ::S:::::SR:A::HVMSV::::::RD::::I:::M:YE:::::K:TAA:S:::Q:YDQL

consensus       RAGNVEAGGPGFRQLARALAEEVVAAETAPIDEPVTTDTNRLIRLPGSLHGGSGLEVQRL
#oth            54..3111111335215425632324231.........12......21....1..4.441
hla1441         :E:::::::::V:R:VS:::AR:T:TD::::::::::::R::::::RT:::::::V:TPI
HQ2719A         H:::L::::A:I:I::D:::QTAFE::::::::::::::::::::::::::::::L:TP:
HVO_2697        :E:::::::::V:T:VE:::H:T:EDQ:S::::::::::K::::::K::::::::V:EP:
Hbo2417         :E:::::::::T:I:VN:::::A:T::::::::::::::K:::::::::::::::R:KT:
VNG1470         KR:::DVH-:A:LTV::RYID:T::::Q::::::::::::::::::::::::::::::::
NP3990A         TK:::DVH-:AVYSI::E:F:T::E::S::::::::::I:::::::::::::T:::::H:
Hut0409         ED::M::::::I:K:VE:ITGD:IEGQN:::::::::::::::::::::::::::A:RK:
rrnAC0292       E:::IDVH-:A:Y:::KI:LH:::::DN:::::::::::::::::::::::::::::::I
Hmu1379         A:::IDVH-:A:F:I:KP:MT::::MDN:::::::::::::::::::::::::::::R:I

consensus       DRDEIDAFDPLVDAVPETFRGHDITIEVTDPGTVELDGDSFTLEEGVQTVPEYLGVFLMA
#oth            2.22224.1..3111111.1.32.5133344341113.1222253.45113.42.1.2.2
hla1441         :::DL::::::R::::DR:V:RE:R::TDVDR::::N:ERVRV:P:RN::::FA::::::
HQ2719A         ::E::PS:H::EH:IADR:::R::Q:RI::S:VTTF::ET:DIT::NK::E:C::I::::
HVO_2697        ::::::G::::S::::DR:::R::SVN:::::E::F:::::::DS:::S:D:S::::::T
Hbo2417         E:::VAD::::E::I:DR:::EK:K:R::E::P::F:::::::SA:D:S:K:C:::::::
VNG1470         ::AAL:D::::::::::::V:::::V:LPTEH::::R:E:L:VGP::S:::::A:::M::
NP3990A         :::A:::::::S:::::::V:NE:A:YTQE:T::::R:E::R:S:::SS::::V:::A::
Hut0409         S:::LAE::::::::::::V::E::V:::A::::::G::::::P:::TS::::::::::S
rrnAC0292       :::DL::::::::P:::::::::::V::::G:L:::::::::::A:N:::::HV::::::
Hmu1379         E::D::E:::::::::::::::::::::::G:P:::G:::::::P:IG:Y::HV:::A::

consensus       RGRAEKATE-
#oth            ..3.2.3411
hla1441         ::E:R::P:R
HQ2719A         ::::::V:::
HVO_2697        ::::::V:::
Hbo2417         ::::::E:K:
VNG1470         ::T:::::::
NP3990A         ::Y:S::G::
Hut0409         ::::::GQ::
rrnAC0292       ::::::GK::
Hmu1379         ::::::GP::