[R] (-) COG0384 Predicted epimerase, PhzC/PhzF homolog 9 genomes BUD0295 9 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG0332 rrnAC1794 HVO_0696 Hbo0840 Hmu0865 Hut0398 hla2419 NP1202A HQ1259A

Pairwise sequence scores
Consensus score	2283	rrnAC1794	Hut0398	HQ1259A	VNG0332	Hmu0865	NP1202A	hla2419	HVO_0696	Hbo0840
1312	rrnAC1794	2277	1008	1011	972	1225	1148	990	1029	1077
1526	Hut0398	1008	2245	1235	1266	1234	1226	1240	1223	1271
1590	HQ1259A	1011	1235	2409	1298	1292	1328	1345	1387	1367
1677	VNG0332	972	1266	1298	2266	1288	1309	1397	1335	1412
1631	Hmu0865	1225	1234	1292	1288	2278	1340	1340	1377	1323
1640	NP1202A	1148	1226	1328	1309	1340	2234	1377	1407	1411
1712	hla2419	990	1240	1345	1397	1340	1377	2372	1443	1494
1719	HVO_0696	1029	1223	1387	1335	1377	1407	1443	2258	1508
1731	Hbo0840	1077	1271	1367	1412	1323	1411	1494	1508	2261

338 symbols
consensus       --MDTRRALLVDAFATEPLAGNPAGVVPDADGLTDDQMQAIAAELGASETAFVLPSDD-A
#oth            111323221.....221142.121..1.1223.32313232.1..111..1.2432341.
rrnAC1794       ::::::Q::::::::A::TT:T:T::::E:::::::::::V:S::::T:::::::AE:::
Hut0398         MSTESLDVS::::::::SF::::::::::GED:::::::::::::::::::::RSAE:::
HQ1259A         ::::SC::::::::S:D:::::::::I:::E::A:N:QR:::::::::::V:ITD:EV::
VNG0332         :::TET::::::::TDDSC:::A:::::::G:::::::::::::::::::::LR:::A::
Hmu0865         ::::::Q:::::::TD::M::::::::::::::D:E:FGK::S::::::::::::D:E::
NP1202A         :::E::::::::::T:D::::::::::::::::A:::L::::::::::::::::E:::::
hla2419         :::E:::T:::::::D::::::V::::::VGE:SE:R:GR::::::::::::L:DAGEG:
HVO_0696        ::::S:::::::::T::::S::A::::::::::DAE::R:L::::::::::::CS:AA::
Hbo0840         :::Q:::T:::::::::::S::A::::::G:-::ES:::SV:S::AV::::::QS:GS::

consensus       DRRLRYFTPTTEVDLCGHATIAAHAHLYEDGALDAGTHTLETNVGTLDIEIDDDGTVWMA
#oth            1212.2.1.34.211111.11.2115.33524132133123.23.333113533.3..24
rrnAC1794       :::::C:S::K:LAQAET:AV::::A:::R:EI:DSEW:VA:AR:DVAV:TKQN:M::VE
Hut0398         ::T::::::EN::::::::::::::R:F:Q:D:G::D:SIS::L:::S:::EA:::::::
HQ1259A         E::F:::S:::::::::::::::Y:Y:DAT:EI:P::::V:::::VIE:TV::::::::R
VNG0332         ::::::::::::::::::::::S:::::D::::A::E::::::::V::::VAE:::::::
Hmu0865         :::::::::ER:::::::::V::::L:::HDR::::::::A:AA::FE:::::::::::E
NP1202A         :H:::F::::::::::::::V::::W:A:T:R::D:SY:V::DA:AVAV::-:S::::LS
hla2419         :E:::::::S::::::::::::TYGA:FAE::I:::DR::R::::D:E:T:::::::::R
HVO_0696        :::I:::::QQ::::::::::::::::AAERD:EP:::::::::::::::LG:L:E:::T
Hbo0840         :::::F::::R:I:::::::::T:::::R::VI::::::V:::::V::V:VEA::I:::T

consensus       QNPPTVRSVD------------LDYDRLADALGIDAAALRDVGADLPLAVASTGLPFLVV
#oth            16512144311111111111112423111311.4341113121324.323.22.212121
rrnAC1794       :GRADITE::::::::::::::IP:SDV:::::LN::T:K::::::::VT:GV:ESW:M:
Hut0398         GDD:D:::::::::::::::::IG:::::EI::LTET:FAG::M:::I:R::::M:::::
HQ1259A         :QS:::A:I::::::::::::::A::DV:::::::::::::I:DE::::I:::::::II:
VNG0332         :::::::E:E:::::::::::::S:E:V:E:T:TE:::::GASD:I:::::D::::::I:
Hmu0865         :ATA:::PA:::::::::::::VADEDV:::::::V:T:::::::F::S:::S::::::A
NP1202A         :R:AE:AA:E:::::::::::::::E:::T:::A:P:T:T:::::M:::T::::::Y:::
hla2419         ::::::DVIEPDSGSDGDSGGG::A:::G::::::P:::::::::::V::::::::W:::
HVO_0696        :DA::::PLE::::::::::::V::::::A:::V:D:::::::::::V::::::::::::
Hbo0840         :ES:::E::::::::::::::::::A::GE:::::P::F::::EAV:P::::::::::::

consensus       PVNFLEHLGDADPDAAAIESLCDEHDAAGVYAFTFDTLDAD----STLHARAFAPGIGVD
#oth            .111114124351152.12514343112.3.411..1223211112.4.1.312134124
rrnAC1794       :::YF:::SGLTM:V::VD::::RV::::::P:::::VG::ATRR::F:G:::RV:-SRA
Hut0398         :::YF:Q:::IA:NL::::R:::::::T:L:::::::::RE::::::V:G:L::::V:::
HQ1259A         :::::::V::VN::::::DT:VTSY::::M:I:S::::ESA::::::::::::V:SL:IT
VNG0332         :ITY:SD:::::::FD:V:A:A:DVG:::::M:S::A::RA::::::A:G::WV::V:::
Hmu0865         :::YF:::R::Q::M:::::::ESVG:E:L:::::::::G:::::A:I:::::V:LA::P
NP1202A         ::::::G:SAL::N:D:VA::S::L:V:::::::::::G:E::::T:::::M:::AL:::
hla2419         ::::::R::E:E::M::::AITEA::V:::::::::A:::E::::::::G:::::A:::P
HVO_0696        ::::::::SA::::D:::AD:AA::::::F::Y:::AI:G:::::::::::C::::::IS
Hbo0840         :::::::::N::::FT:V:K:T::Y:V::L:V::::A:E::::::T:::::M::::::IP

consensus       EDPVTGTASGACGAYLRRFGAFDG-LPDEVRFEQGHFLDRPGRVRVRV------------
#oth            .1.1.1..11.23.11253412.426343323.1.1.4....413133111111111111
rrnAC1794       :E:::A::::::A:FV::Y::L:D:TIEQIIA:G:::R::::T:S:DT::::::::::::
Hut0398         :::::::::::VA:::D::AEI:A:--TT::C:::D::::::::Q:::::::::::::::
HQ1259A         ::::::::A:::T:::DT:D:::V:F:ST::C:::::C::::YI:AQLIQPEQQNDKPDE
VNG0332         :::::::::::A::::A:::::::DA:::MV::::::V::::::::::::::::::::::
Hmu0865         ::::::::A::AC:::::HN:L:::ERE:IVV::::::::::::::VT::::::::::::
NP1202A         ::::::::AA:V:::::A:E::::E::A::VV:::::I::::K:::QA::::::::::::
hla2419         :::::::::::V:::::EV:::::DF:::L::::::::::::H:::::::::::::::::
HVO_0696        :::A::::A::::::::QV::::S:M:::L:::::::V::::T:::Q:::::::::::::
Hbo0840         :::::::::::::::::HVD::::E::EKMV:::::::::::::H:::::::::::::::

consensus       -----AGDEVRVGGRAVTTLDGELSVPAADD-DDIIEA
#oth            11111334524...4114221.3241.4761131.1.2
rrnAC1794       :::::D:T::W:::::::A:::TVT:::V:::::::::
Hut0398         :::::-E:G:F:::Q:::::T:DI:I:DIE::G::::V
HQ1259A         SNDSY:QGG:::::H::M::::TVAI:S:N::N::L:P
VNG0332         ::::::::APM::::G:S::::T:A:::ETE:EE:L::
Hmu0865         :::::D:HD:::::::::::::::T::DSE:::::::V
NP1202A         :::::QA:P:T:::E:A:AF:::::::EPG::::::::
hla2419         ::::::::V:::::E::VSM::::R:::D::SGE::::
HVO_0696        :::::-:A:I:::::::QSF:::IV::EFA::::::::
Hbo0840         :::::-:T::::::F:::A:::S::::P:P:::::L::