[EH] (-) COG1685 Archaeal shikimate kinase 9 genomes BUD0333 9 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG1245 rrnAC0753 HVO_1323 Hbo0225 Hmu1516 Hut0680 hla1371 NP3982A HQ2762A

Pairwise sequence scores
Consensus score	2093	VNG1245	HQ2762A	NP3982A	rrnAC0753	Hmu1516	Hut0680	HVO_1323	Hbo0225	hla1371
1469	VNG1245	2097	1208	1280	1276	1230	1349	1273	1072	1320
1432	HQ2762A	1208	2255	1183	1191	1173	1302	1340	1207	1368
1610	NP3982A	1280	1183	2121	1405	1411	1406	1378	1186	1306
1605	rrnAC0753	1276	1191	1405	2308	1711	1449	1335	1165	1314
1540	Hmu1516	1230	1173	1411	1711	2185	1427	1323	1109	1247
1692	Hut0680	1349	1302	1406	1449	1427	2067	1471	1241	1477
1693	HVO_1323	1273	1340	1378	1335	1323	1471	2123	1283	1567
1430	Hbo0225	1072	1207	1186	1165	1109	1241	1283	1890	1309
1615	hla1371	1320	1368	1306	1314	1247	1477	1567	1309	2220

349 symbols
consensus       -------------------MEGRAAAPAAGTVLNALATGTGAAFAIDAETTATVTL----
#oth            111111111111111122214131312211111111123512112214324131432212
VNG1245         ::::::::::::::::::::D:::V::::::::::::::V:::::L:ID:E:S:SV::::
HQ2762A         ::::::::::::::::::::H:::V:LG:::::::::::I:::::L:V::::::DITPEE
NP3982A         ::::::::::::::::MET::::::::::::::::::N:Y:S::::::Y:E:::::::::
rrnAC0753       MTATGVSQLVNRSVWEYTS:::K::::::::::::::::R:::::::EY:::::::::::
Hmu1516         ::::::::::::::::::::Q:K:::::::::::::::HR:S:::::EY:H:::D:FTEA
Hut0680         ::::::::::::::::::::::T:V::::::::::::::::S:::::::LR:E:::::::
HVO_1323        ::::::::::::::::::::H:::T:LG::::::::::A::S::::::::::S:E:::::
Hbo0225         :::::::::::::::::::-------------------------------------::::
hla1371         ::::::::::::::::::::::::::LG::::::::::::::::G::V::R:::::::::

consensus       --D-DEGGVRGEIAGAPDADTRLIERCVELVIERFGDGE--------GGTVRTESDVPMA
#oth            1155345525131124221.12.1.2..2313123.3221111122311312.1.12.1.
VNG1245         ::TPS:S::S:::::H:E:::A:V::::SR::D:Y:::Q::::::::::H:::::E::L:
HQ2762A         ::TL:STR:N:T:::VENG:::::::::::A::TY:P:D:::::MQYIAHIQ::::I:::
NP3982A         :::::T:S:T::::D::::::::::::::A:V::::::Q::::::::::H::::::::::
rrnAC0753       ::STETD::T::VD:::::::::::::::Y::DAH:GPQNVGVPAVS::::::::E::::
Hmu1516         EI:D::EAIV:::::::::::::::T:::Y:LDAH:EP:::::::VA:AV::::::::::
Hut0680         ::EA:-:::S:T:::E:::::A:::H:::::T:::::::::::::::::S::::::I:L:
HVO_1323        :::::S:E:::S::E:::::AH:V::::::A::A:::::::::::::::::E::::L:::
Hbo0225         ::-:--------V:EDA:::::::::::::AV::Y::D::::::::Y:::::::::::::
hla1371         ::NP:AD::::T::ED::G::A:::H::A:AT::W::::::::::::::::::D::::L:

consensus       AGLKSSSAAANATVLATLDALD-----------VDVDREDACRLGVRAARDVGVTVTGAF
#oth            1...........111..22.1122111112244544313311.2..3...11...2....
VNG1245         :::::::::::::::::::::G:::::::::VADE:::V::A::::Q::::A::::::::
HQ2762A         ::::::::::::SI:::A::F::::::::::::ITPEPIS::::::::::::::::::::
NP3982A         S:::::::::::::::::A::::::::::::::::L:::A:::I::D:::::::::::::
rrnAC0753       S:::::::::::::M::::::::::::::::ATERMS:::MA::::M:::::::::::::
Hmu1516         S:::::::::::::M::::::::::::::::GTDRMT:::MA::::M::::::::A::::
Hut0680         ::::::::::::::::::S::::::::::::ADSA:S:V::A:I::Q::::A:::A::::
HVO_1323        ::::::::::::::::::S::GRSVG:::PGPDA:IS:L::::M::::::E::::A::::
Hbo0225         :::::::::::::::::A:::G::::::::::::EP:::E::::::Q::::::::I::::
hla1371         :::::::::::::::::C:::GLAVGDDDADPS:::T:L:::::::::::EA::::::::

consensus       DDASASMLGGVTVTDNDEDELLARDEVDWDVLVWTPPERAYSADADVERCENVAPMAELV
#oth            ...2...1..121.1.53.4.2311321.112.1..1.111..1..251.341111.22.
VNG1245         :::A:::::::AM:::R::D::F::A:E:HAA:::::::::::::::A:::R:SGL::H:
HQ2762A         ::::::::::::::N:N::K:::H:T:E:::V::::::::::::::A:::A:I:::::::
NP3982A         ::::::::::::::::TS::::Q:::P::::::Y::D:::F:::::AD:::RI::::DV:
rrnAC0753       ::::::::::::::::ED:A::::E:I:::::::::::QSF:::::::::RQI::::R::
Hmu1516         :::::::::::::::::A::::::::I::::::Y::::Q:F::::::R:::H:::::R::
Hut0680         ::::::::::::::N:H:::::::ET:E:::::::::::::::E::I:::QQ::::::::
HVO_1323        :::A:::V:::V::::T::G:I:::::::::::::::::::::::::S:::::::::D::
Hbo0225         ::::::::::A:::N::D::::S:EP:E::::::::D:::::::::::S:A:::::::::
hla1371         :::T:::::::::::::A:::RS:ET:::::::::::::::::::::T:::A:::::D::

consensus       ADLALDGDYARAMTVNGLAFSAALDFPTDPAVEAMPHAAGVSLSGTGPSVVAVGD-----
#oth            22..2313.42..1...1..2...11332.22211241411........21..1312122
VNG1245         :A::AA:::GT:::::::::C:::::::A:::T:L::::::::::::::Y::::::::::
HQ2762A         E::::TNQ:TE:::::::::::::G:DPA::::V::Y:S::::::::::::::A:RNSES
NP3982A         YE::R::::E:::C:::F::C:::GY::::L:::L:-::AA::::::::YT:::::::::
rrnAC0753       E::::::::Q::::::::::::::::E:::VLD:LQ:VE::::::::::FT:::E:::::
Hmu1516         E::::::::E::::::::::C:::::DSE:LI:::RQVE::::::::::Y::::P:::::
Hut0680         :::::::A:E::::::::::T:::G:SAE:LL:::::V::::::::::::T:::N:::::
HVO_1323        :::::E:R::E:::::::::::::::::::::::::I:D:::::::::::::::::::::
Hbo0225         :E:::::R::E::::::::::::::::::::::::::::::::::::::::::AERGSAA
hla1371         :::::::R::E:::::::::::::G:DA::::::::::T::::::::::::::A::::::

consensus       ------------RDDLERVRDAWDNREGTTWLTTTQT--DGARTR----
#oth            2111111132321641351655.5513.5213...14113124361111
VNG1245         ::::::::::::E:GI:E:STR:HENP::VRE::::L::A::::T::::
HQ2762A         K:::::::GESDEV::AV:TRR:RS:G::V:K:::RATREESS::PDET
NP3982A         :::::::::::::ET::SLETT:S::::H:::::::Q::T::TRK::::
rrnAC0753       :::::::::::::AA::A:Q::::K:P:A::::::::::E:TH:V::::
Hmu1516         :::::::::::::PA::Q:QVY:EQ:D:N::::::::::E:TH:L::::
Hut0680         ::::::::::::::::::::AI:EQ::::::::::::::::T:::::::
HVO_1323        :::::::::::::T:::::KEL::A:::E:R::::R:::::::IQ::::
Hbo0225         HQTESGDVDDGDESP:K:L::L:AK:D:R::::::RN:::::SI:::::
hla1371         ::::::::PDDPET::DA:A:::S::P::LRR:::RN:::::AVE::::