[G] (TpiA) COG0149 Triosephosphate isomerase 9 genomes BUD0334 9 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG1027 rrnAC0537 HVO_1300 Hbo0242 Hmu1493 Hut1049 hla2618 NP2182A HQ3360A

Pairwise sequence scores
Consensus score	1573	VNG1027	NP2182A	rrnAC0537	Hmu1493	HQ3360A	Hut1049	hla2618	HVO_1300	Hbo0242
1264	VNG1027	1570	1161	1171	1233	1073	1139	1215	1140	1122
1227	NP2182A	1161	1560	1253	1244	1079	1158	1131	1138	1141
1330	rrnAC0537	1171	1253	1566	1374	1132	1191	1174	1198	1163
1327	Hmu1493	1233	1244	1374	1635	1110	1182	1212	1199	1186
1266	HQ3360A	1073	1079	1132	1110	1565	1190	1194	1230	1238
1380	Hut1049	1139	1158	1191	1182	1190	1578	1213	1309	1301
1355	hla2618	1215	1131	1174	1212	1194	1213	1655	1329	1268
1388	HVO_1300	1140	1138	1198	1199	1230	1309	1329	1564	1383
1376	Hbo0242	1122	1141	1163	1186	1238	1301	1268	1383	1577

228 symbols
consensus       ------------MFVLVNLKAYPCDPVEVATAAADVADESGVRIAVAPQAADIARVADTG
#oth            1112212222221.111...1.....211.3..31.123111111.11.2.2241.11..
VNG1027         :::::::::::::::::::::::::::AI:E::::::ETTPAT::::::P:::G::::::
NP2182A         :::::::::::::::V:::::::::::A::E::::::::T:::::::::::::S:::E::
rrnAC0537       ::::::::::::::::::::::::::::::::::::S:D::::V:::::::Q:SA::E::
Hmu1493         :::MIPASGGLC::::::::::::::I:::::::::S::T:::V:::::::HLDA::E::
HQ3360A         ::::::::::::::I:I:::::::::L:I:N::R:::ND:::::::S:::::::::S:::
Hut1049         ::::::::::::::::::::T:::::::::K::K::S:::::::G::A:D::::::::::
hla2618         MKLFAPRTPSVG::I:::::::::::I::::::R:::EA::A::::S:::::::::::::
HVO_1300        ::::::::::::V:I:::::::::::I::::::R:::EA:::::::S::::::S::::::
Hbo0242         ::::::::::::V:I:::::::::::L::::::HE::E::::::::::::::VR::::::

consensus       VETWAQHVSPNEHGSHTGSTLAEAVADAGAVGTLINHSENRLKLADIDGSVDAAERAGLE
#oth            11.1....12341..2..11...21121..3...1....3.12.....1216..3.22.1
VNG1027         AT:Y::::::T::::::::V:::S:::N::::::L::::H:RR::::::::A:::::::D
NP2182A         ::::::::DAVD::::::::::::A:E:::E:::L::::K::R::::::GLR::::V:::
rrnAC0537       :::::::::AV:::::::::::::A:::::::::L::::::::::::::AL:::D::D::
Hmu1493         ::::::::::V:::::::::::::AV::::T:::L:::::::::::::::L:::D::D::
HQ3360A         :::::::::A:NY::Y::::::::::N:::T::::::::R::T:::::TA:N::S:VD:D
Hut1049         ::::::::DSI:Y::N::H::::T:::::::::::::::::::::::::::E::::::::
hla2618         :::::::::::A:::::::::::::::N::E::::::::::::::::::::H::::TE::
HVO_1300        ::::::::D::G::::::::::::::E::::::::::::K:::::::::::Q::::::::
Hbo0242         ::::::::D::GY:::::::::::::E:::D::::::::K:::::::::::Q::A:::::

consensus       TCVCANNPAQIGAAAALGPDAVAVEPPELIGGDTSVSTADPDIVTDAVEAAAAVDEDVDV
#oth            12......2.11.12..3..2......1...1131.121..21.321.311331233.1.
VNG1027         :V::::::::VA:::::::::::::::A:::TG:P::Q::::::S:::A::E:::PS:::
NP2182A         SI::::::R::A:::::E:::::::::A:::TG:P::Q:::EV:::S::::D::-G::::
rrnAC0537       :I:::::::::::::::D::G::::::::::TG:P::K:::::::G::D:::R:NG::::
Hmu1493         :I::::::E::A:::::::::::::::A:::TG:P::K:::E::::::S:::S:::S:::
HQ3360A         :::::::::::::VT::S::S::::::A:::::A::A:::::::SN:::STNSI:KT:::
Hut1049         :::::::::::::VT:::::S::::::::::::V::A:G::::::::::::E::::::E:
hla2618         :I::::::::V::::::::::::::::::::::V:::::::G::E:::A::E:::PA:::
HVO_1300        :::::::::::::VS:::::S::::::::::::V::A::::G::::::D:::N:::::E:
Hbo0242         :::::::::::::V::::::S::::::::::::D::A:::::::R:::::::N:::S:E:

consensus       YCGAGISTGDDVVAAGDLGASGVLLASGVAKADDPRAALEDLVEPL--
#oth            2....112.1.132.41...3.1..........2.111.2...31131
VNG1027         ::::::T::E:::S:::::::::::::::::::::::::A:::A::::
NP2182A         L::::::::::LE::AE:::E::::::::::::A:K:::R:::::IAE
rrnAC0537       L::::::::E:L:S:S::::::::::::::::::::::::::::::L:
Hmu1493         L::::::::E:::S::E::::::::::::::::::::::::::A::E:
HQ3360A         :::::::A::::I::R::::::I::::::::::N::K::::::V:I::
Hut1049         ::::::::::::ES::E:::T:::::::::::::::::::::::::A:
hla2618         F::::V::::::::::::::A::::::::::::::K:V:::::SGI::
HVO_1300        :::::::::::::T:EE:::::I::::::::::::::::::::SG:::
Hbo0242         F::::::S::::D:::::::T:I:::::::::::::::::::::::::