[H] (SNZ1) COG0214 Pyridoxine biosynthesis enzyme 9 genomes BUD0339 9 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG1793 rrnAC1732 HVO_2336 Hbo2018 Hmu2215 Hut0742 hla1046 NP4528A HQ3323A

Pairwise sequence scores
Consensus score	2255	rrnAC1732	NP4528A	HQ3323A	hla1046	HVO_2336	Hbo2018	VNG1793	Hut0742	Hmu2215
1941	rrnAC1732	2256	2036	1838	1783	1755	1828	1864	1844	1874
1933	NP4528A	2036	2248	1810	1790	1754	1820	1874	1838	1889
1998	HQ3323A	1838	1810	2267	1871	1846	1923	1872	1879	1910
1949	hla1046	1783	1790	1871	2275	1939	1923	1822	1861	1880
1942	HVO_2336	1755	1754	1846	1939	2262	2008	1772	1859	1840
2058	Hbo2018	1828	1820	1923	1923	2008	2266	1855	1956	1951
2022	VNG1793	1864	1874	1872	1822	1772	1855	2272	1931	1993
2064	Hut0742	1844	1838	1879	1861	1859	1956	1931	2253	2015
2108	Hmu2215	1874	1889	1910	1880	1840	1951	1993	2015	2257

302 symbols
consensus       MMEETDLEELRRGTELVKRGFAKMQKGGVIMDVVNREQARIAEDAGAVAVMALEAVPADI
#oth            1424...11.1..11.......2...........32...1...12......2..1.....
rrnAC1732       :T::::::D:::::D::::::::::::::::::::::::::::::::::::H::S:::::
NP4528A         -:SN::::::::::D:::::::::::::::::::T::::::::::::::::H::S:::::
HQ3323A         :S:K:::S::::::::::::::R:::::::::::DA::::::::::::::::::S:::::
hla1046         :P:A::::::K:::D:::::::R:::::::::::T:::::::::T:::::::::::::::
HVO_2336        :P::::::::::::::::::::Q::::::::::::A:::K:::E::::::::::::::::
Hbo2018         :P::::::::::::::::::::Q:::::::::::DA:::::::E::::::::::::::::
VNG1793         :AT::::::::::S::::::::::::::::::::::::::::::V::::::N::::::::
Hut0742         -:T:::::D:::::D:::::::::::::::::::SP::::::::::::::::::::::::
Hmu2215         -:SD::::::K:::::::::::::::::::::::D:::::::::V::::::N::::::::

consensus       RKRGGVARMADPASLTEIIDEVSIPVMGKSRIGHTKEAQILEAIGVDMIDESEVLTPADD
#oth            ......1..1..462431.11....1...1....22..1..114.1..1.......2..1
rrnAC1732       ::::::::::::SK:E:::E:::::::::A:::::A:::::::A:A::V:::::::Q:::
NP4528A         ::::::::::::GG:EDV:::::::::::A:::::A:::::::T:A::::::::::Q:::
HQ3323A         :::::::::P::DIVP:::::::::A::::::::::::E:::SL::::::::::::::::
hla1046         :::::::::P::ENV:::::::::::::::::::R:::E:::SL::::::::::::::::
HVO_2336        ::::::S:::::ETV:::::A::::::::A::::HT::::::S::::::::::::::::N
Hbo2018         ::::::S:::::ETVK::::A::::::::A::::HT::::::S:::::::::::::M:::
VNG1793         ::::::::::::::::G::E::::::::::::::R:::E::Q:V:A::::::::::::::
Hut0742         :::::::::::::DIQ::::::::::::::::::::::::::::::::V:::::::::::
Hmu2215         ::::::S::::::::QA::::::::::::::::::::::::::A:A::V:::::::::::

consensus       RYHIDKREFTAPFVCGARNLGEALRRIDEGAAMIRTKGEAGTGDVNQAVHHQRNIKGSIR
#oth            3..1...2.12.......1.3......2.....................2...2.142.1
rrnAC1732       ::::::::::::::::::::A::::::::::::::::::::::::::::T:::::QR::G
NP4528A         :::::::::::::::::::::::::::::::::::::::::::::::::T:::::QR:::
HQ3323A         :::::::H::::::::::::Q:::::::::::::::::::::::::::::::::::S:::
hla1046         E::T:::D:AS:::::::D:P::::::R:::::::::::::::::::::K:::T::TQ::
HVO_2336        D:::::::::S:::::::::P::::::N:::::::::::::::::::::T:::T::HQ::
Hbo2018         :::::::D:::::::::::::::::::N::::::::::::::::::::::::::::::::
VNG1793         E:::::::::::::::::::::::::::::::::::::::::::::::::::::::SA::
Hut0742         A::::::D::T::::::::::::::::::::::::::::::::::::::::::T:::A::
Hmu2215         :::::::::::::::::::::::::::::::::::::::::::::::::::::S:::A::

consensus       KLEGMSYEEREKWAREHEAPAELVHETAEMGRLPVVNFAAGGIATPADAALMMHHGCDGI
#oth            4.5.2422..14...1.1..12......12.......................211....
rrnAC1732       :::::A::::DE:::::G::RR::::::DR:::::::::::::::::::::::Q::::::
NP4528A         ::S::D::::DE:::::G::R::::::::::::::::::::::::::::::::QL:::::
HQ3323A         E:V:K::::::R:::D::::::::::::::::::::::::::::::::::::::::::::
hla1046         T:T:LNH::::::::::G::RD:::::::A:::::::::::::::::::::::Y::::::
HVO_2336        S:T:LNFD:::::::::::::::::::::::::::::::::::::::::::::Y:E::::
Hbo2018         ::Q::THQ:::::::::::::::::::::::::::::::::::::::::::::::E::::
VNG1793         :::::D::::DM:::D::::R:::::::::::::::::::::::::::::::::::::::
Hut0742         Q:::::H::::A:::::::::::::::::::::::::::::::::::::::::::E::::
Hmu2215         Q:D::::::::::::::::::D::::::::::::::::::::::::::::::::::::::

consensus       FVGSGIFGAEDPEAMGRAIVEAVNNWDDPERLAEIASGIGKGMKGQANADLPEEEKLQGR
#oth            .....1...11.21..311.2....2.1.13.12..232.3..1.22.321312121.2.
rrnAC1732       ::::::::::N:Q:::ESV:A::::Y::::Q:K:::KNP::::::::::::D:::Q::::
NP4528A         ::::::::::N:Q:::E:V:A::::Y::::T:K:::KSP:::::::::ET::::::::D:
HQ3323A         :::::V::::N:R::::::::::::::::DE::Q:::NP::::::E:::::S:G::::T:
hla1046         ::::::::::::::::T::::::::::::DE::D::::::::::::S:E:::D:::::::
HVO_2336        :::::::::::::R::E::::::::::::DT::D::A::::::::E::VGMAD:D:::::
Hbo2018         ::::::::::::::::K::::::::::N:DQ:::::::::::::::S:Q:M:::::::::
VNG1793         ::::::::::N:::::::V:D::::H:::::::::::N::E::Q:DP::::::D:RM:D:
Hut0742         :::::::::A:::::::::::::::Y::::::::::A:T:S::::D::V::::D:Q::::
Hmu2215         ::::::::::::::::T::::::::::::::::::::D::G::::D::::::::::M:::

consensus       GV
#oth            .2
rrnAC1732       ::
NP4528A         :I
HQ3323A         ::
hla1046         ::
HVO_2336        ::
Hbo2018         ::
VNG1793         :N
Hut0742         ::
Hmu2215         ::