[OC] (TrxA) COG0526 Thiol-disulfide isomerase and thioredoxins 9 genomes BUD0349 9 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG0711 rrnAC1254 HVO_1250 Hbo0295 Hmu1716 Hut0511 hla1900 NP4154A HQ1809A

Pairwise sequence scores
Consensus score	1465	VNG0711	NP4154A	HQ1809A	Hut0511	HVO_1250	Hbo0295	hla1900	rrnAC1254	Hmu1716
1027	VNG0711	1500	848	724	960	881	839	928	892	872
1041	NP4154A	848	1505	781	901	871	846	924	893	889
916	HQ1809A	724	781	1431	719	932	929	810	771	737
1148	Hut0511	960	901	719	1504	986	936	977	970	1021
1200	HVO_1250	881	871	932	986	1447	1155	982	955	955
1144	Hbo0295	839	846	929	936	1155	1457	973	918	948
1147	hla1900	928	924	810	977	982	973	2513	921	1002
1127	rrnAC1254	892	893	771	970	955	918	921	1543	1242
1151	Hmu1716	872	889	737	1021	955	948	1002	1242	1547

337 symbols
consensus       ------------------------------------------------------------
#oth            111111111111111111111111111111111111111111111111111111111111
VNG0711         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP4154A         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
HQ1809A         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hut0511         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
HVO_1250        ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hbo0295         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
hla1900         MARPAAPCDRETIRLSGGDDRAPGSRRVLTEERDGDGAASSPERRYRRRSFRERRSSRSR
rrnAC1254       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hmu1716         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

consensus       ------------------------------------------------------------
#oth            111111111111111111111111111111111111111111111111111111111111
VNG0711         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP4154A         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
HQ1809A         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hut0511         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
HVO_1250        ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hbo0295         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
hla1900         PSRRYGRRADSSGSGPSRSRCSSSRRGAGWAPSSSRTSRPGSRPGLRIAPGRVDDSHRRE
rrnAC1254       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hmu1716         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

consensus       --------------MVALESDSE-LERGDPAPDFELPGTDGETYSLDDFADYDALLVVFT
#oth            1111111111111112331.2323142.23..5.1..121.2222.22142511112..1
VNG0711         ::::::::::::::::Q:D:EP::::V:A:::G:S:::A::::H::AS:T:V::VV::::
NP4154A         ::::::::::::::-M::::A:DE:DV:::::A:::::V::DQH:::::GG::::::::M
HQ1809A         ::::::::::::::::LV:::::::S::::::Y::::AAA:D:VT:::LLS:::V:I:::
Hut0511         :::::::::::::::T::D:ER:AI:::EV:::::::::::::HA:A::T:HE:V:::::
HVO_1250        ::::::::::::::::L::::::::::::A::::::::::::::::SS::::::V:::::
Hbo0295         ::::::::::::::::LK::::N::SH::V::::S:::::::::T::S::::::::::::
hla1900         TRGTILGSAPEWAC:::M:::::::D:::A::A:::::::::::T::S:-:A:T::L:::
rrnAC1254       ::::::::::::::::S:D:E:DV:G:::E::T:::::A::A::::S::::K::::I:::
Hmu1716         ::::::::::::::::::D:EDDV:Q:::E::V:::::::::S:T::A:::RE:::::::

consensus       CNHCPYAQAKFDELNHLAAEYDDLAVVGINPNDAEEYPDDSFERMQELVADGTIQYDAYL
#oth            ......13..2131.51153.131......1..2221.2..323.212132121411...
VNG0711         :::::::K::V:T::AI::D::RV::::::::::D:::A::MA:::A:::::::::::::
NP4154A         ::::::V::::ETM:R::DD::::::::::::::D:::E::::T:V:YADR:D:DIT:::
HQ1809A         :::::::E::VE:::::TET:PS::::::::::::A::E::LD::R:R:SADEVR:T:::
Hut0511         :::::::V::::P::E::::::::::::::A::SD::::::::K:V:::E::::A:::::
HVO_1250        :::::::K:::E::::::SA:::::::::::::::DR:E:::::::::::::::G:T:::
Hbo0295         :::::::::::::::Y::RT::E:::::::::::::::::::D::::::E::::::T:::
hla1900         ::::::::::::L::D::::::::::::::::::T::::::V:A:R:R::::::A:::::
rrnAC1254       :::::::K::I::::R::T:::::::::::A::P:::::::::::::::ER:E:::::::
Hmu1716         ::::::::::::::::::::::EV::::::A::P:::::::::K:R:::D:::VD:::::

consensus       RDESQAVAAAYGAVCTPDPFLFEN----DGGAFRLAYHGRIDDAMSPDDEPTE---FEMR
#oth            1.12143132...2.......15422212334.313111.2...33.1121342113212
VNG0711         ::AT::T:R::::T:::::::LRTADT::DA:::V:::::L:::LG::ED::RD:GGD::
NP4154A         :::P:ST:E:::::::::::::H::::::::::::V::::F:::LA:::::S:APG::::
HQ1809A         :::::::TDE::::::::::::NRRSSG:ESQ:E:VF:S::::::::NEAVNA:::Y:::
Hut0511         :::::DI:R::::::::::::L::::::::::::::::::::::::::E::ET:::::::
HVO_1250        :::::::::D:::::::::::L::::::T:DG:E::F:S:::::::::::VSD:::Y:::
Hbo0295         :::::D::RE:::::::::::::K::::E:DE:V:RFQS:::::::::::V:D:::Y:::
hla1900         :::TGEA:D:::::::::::::GR::::::D::::Q::::L:::LN:::::::::::YI:
rrnAC1254       F::::N:::::::R::::::::R::::::N:::K::::::L:::PN:::::S::::R::A
Hmu1716         F::::EI::::::R::::::::VD:::::::T::::::::L:::TN::::::::::R::K

consensus       TAVEAVLAGDEIEAEERPSRGCSIKWKDG--------
#oth            43112113133325546..1..1..153232232112
VNG0711         D:ID::::::PV:TAFL:::::::::T::E:::::::
NP4154A         A:I::::N:A:P:PAPG:::::::::LE-::::::::
HQ1809A         R::::::NDEP:PLT:T::Q:::::----::::::::
Hut0511         NV::DL:::R:LTD:F::::::N:::T::SVRPE:::
HVO_1250        :::::L::::D:PV::Y::Q::::::::E::::::::
Hbo0295         :S::::IG::::PLD:I::Q::::::R:-::::::::
hla1900         D::D:::::E:V:VPD::::::::::P:E::::::::
rrnAC1254       :H::TL:D::Q:T:V:K::::::::::P:NEPAYWDV
Hmu1716         AHI:TL:::E::T::AK::::::::::P:NEPDYWDA