[H] (IspA) COG0142 Geranylgeranyl pyrophosphate synthase 9 genomes BUD0354 9 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG2153 rrnAC3146 HVO_0303 Hbo1178 Hmu2605 Hut2126 hla0293 NP0604A HQ3255A

Pairwise sequence scores
Consensus score	2041	VNG2153	NP0604A	HQ3255A	hla0293	HVO_0303	Hbo1178	Hut2126	rrnAC3146	Hmu2605
1468	VNG2153	2190	1361	1246	1384	1363	1377	1312	1353	1392
1711	NP0604A	1361	2117	1407	1542	1448	1509	1455	1525	1562
1631	HQ3255A	1246	1407	1975	1460	1491	1612	1348	1432	1478
1696	hla0293	1384	1542	1460	2058	1559	1628	1397	1502	1536
1705	HVO_0303	1363	1448	1491	1559	2041	1638	1455	1489	1555
1749	Hbo1178	1377	1509	1612	1628	1638	2057	1438	1535	1584
1608	Hut2126	1312	1455	1348	1397	1455	1438	2041	1540	1601
1692	rrnAC3146	1353	1525	1432	1502	1489	1535	1540	2035	1797
1785	Hmu2605	1392	1562	1478	1536	1555	1584	1601	1797	2053

301 symbols
consensus       -MEYLERRRALVEDRLEAVLDAVEPDELSDELEHVALAGGKRVRPAVTILACEAAGGE--
#oth            11112221243224.113123321.521322141.2.1.......2122.21..411321
VNG2153         ::::V:A:::AI:Q:ITEAVGG:::T::G:Q::::V:::::::::TL:V:V::::::AVW
NP0604A         :::::::::::::S::::::::T:::AMT:R::::S:S:::::::M:AL::F::::::L:
HQ3255A         :---------M::::::S:V::ID:AV::::VA::::S::::::::::::::::C::A::
hla0293         ::::::::V::A:::::::I:E:::::::E:VG::V::::::::::::::::::FD:D::
HVO_0303        ::::::::VTM:N::::E:VS::::S::A:Q:D:::::::::::::::::::::V::T::
Hbo1178         ::::::::VSM:D::::::I:::D:P::::::A:::::::::::::::::S:::C::D::
Hut2126         :::::::::D:I:T:::D::AS:D:A:::S:::N:V:::::::::T:SL:V:::V:A:::
rrnAC3146       :::::::::DR::E:::::::S:::E::A::VR::::S:::::::T::V:V:::L:::::
Hmu2605         M::::Q:::DR::E:::::::G::::::A::VR::::::::::::T::V:V:::L:::::

consensus       ------------------PEDAVDFAVGIELVHNASLVVDDIIDRSDLRRGTPSAWAAFG
#oth            111111111212222122332.211.111.1.......1.....1.13..1231..211.
VNG2153         TGAAEAAAVRENAALSAGG:::L:Y:::V:::::::::::::::::E::::SA::::EY:
NP0604A         ::::::::VGEDGRGSEPSRN:I:::::::::::::::::::::E:E::::VD:::::::
HQ3255A         :::::::::::::::::::::::::::AV::::::::::::::::::V::::E:::S:::
hla0293         :::::::::::::::::::DA:::::A:::F:::::::I:::::::EV:::::::::EY:
HVO_0303        ::::::::::::::::::::::::::::V::::::::::::::::::I:::::::::EY:
Hbo1178         ::::::::::::::::::ADA::::::A::::::::::I::::::::I:::::::::EY:
Hut2126         ::::::::::::::::::::::::::::V:::::::::::::::E::R::DS::::S:::
rrnAC3146       :::::::::::::::::::A::::::::::::::::::I:::::E:E::::S:A::E:::
Hmu2605         :::::::::::::::::::A:::E::::::::::::::I:::::E::V::::::::::::

consensus       YGPAIIASDGLLGEAFALFSADERAMRIVAESMVELGEGEATELVARPTNEAEYMELARR
#oth            1..2121....1....2.114121.123.2111........2..124.32.41.21..1.
VNG2153         :::G:V::::::::::::::R:P:::EC:TD:L::::::::I::::::ET:R::::::::
NP0604A         :::::TT:::::::::S:::::P::::T:::A:::::::::::::E::DS::A:::::::
HQ3255A         H:::L:::::::::::::LA:::H:TE::::::::::::::::::::::::::::Q::::
hla0293         ::::::::::::::::::::::P::::T:::AL:::::::::::A::::T::::::::::
HVO_0303        ::::::::::::::::::L:SSD::T::::::::::::::::::::V:S::::::Q::H:
Hbo1178         :::S::::::::::::::L:V:DH::Q:::::::::::::::::::::::::::::::::
Hut2126         H:::L::::::I::::::::T::::::A:S:A::::::::::::A:M:DS:DA:RQ::::
rrnAC3146       H:::::::::::::::N:::T:::::QT:S:::::::::::M::::E:S::K::::::::
Hmu2605         H:::::::::::::::::::S:::::QA:T:::::::::::::::SQ::::T::I:::::

consensus       KTGALFRAAAELGAIAADADAYTVEAFGQYAERVGVAFQIRDDVLDATADADDLGKPTGQ
#oth            ........1..1..1.122.4321131.2..11..1...1........1.125....1.3
VNG2153         ::::::::::::::::::::GRA::R::E:::::::::::::::::::::S:A::::A:V
NP0604A         ::::::::::::::::::::T:A:D::::::::::I::::::::::::::::::::::::
HQ3255A         ::::::::S::V::V:GG::PF:IDL::E::::::::::::::::::::::T::::::::
hla0293         ::::::::::::::::GG::SHA:DS::E::::::::::M::::::::::::::::::::
HVO_0303        ::::::::::::::V::SG::HV:::::D::A:::::::::::::::::::EE:::::::
Hbo1178         ::::::::::::::V:::::PF::::::E:::::::::::::::::::::::E:::::::
Hut2126         :::::::::::::::::::::R::::::::::Q::I::::::::::::G::EQ::::A:H
rrnAC3146       ::::::::::::::::::S:P:::::V::::::::::::M:::::::::::ET::::A:T
Hmu2605         :::::::::::::::::::::::::::::::::::::::M:::::::::::EK::::A::

consensus       DAEMDRPSLVQVTDLSPEEANERAREESDAALDALATADLDDSEALEYLRDLAEFVVVRE
#oth            .1212...3211.3212412221.251125..42.334554232252..21..1..12.1
VNG2153         :EAL::::I:::::R::DAL:RL:G:Q:ER::G:::ELE:P:G::KD::QY::::::E:D
NP0604A         ::::E:::V::I::M::D:::::::T::::::SS:SA::TV::::VG::E::::::::::
HQ3255A         ::A::::::I:::A::DT::::::HN::QQ::::::A:NI::T:S:G::::::::::I::
hla0293         ::::::::VL:::S:::::ID:::::Q:EL::A::DD::PPET::I::::::::::::::
HVO_0303        ::::G::::::::::T:::::R:::KQA:E::S::DDSGV::::P:::::::::::I:::
Hbo1178         :EQ:::::V::::::T:V:::Q::::Q::K:::::D::K:SETDS:G:::::::::::::
Hut2126         ::::::::I::::::::A::T::::S:A:::::Q:E:VPVENEQ:V:::::::N:::E::
rrnAC3146       ::::E:::::E::E:TT::::::::A::::::ES:S:I:APE:QSM::::::::::::::
Hmu2605         ::::::::F:E::::T:A:::::::A::::::E::::V:T:::Q:T:::Q::::::::::

consensus       R
#oth            2
VNG2153         A
NP0604A         :
HQ3255A         :
hla0293         :
HVO_0303        S
Hbo1178         :
Hut2126         :
rrnAC3146       :
Hmu2605         :