[R] (-) COG2220 Predicted Zn-dependent hydrolases of the beta-lactamase fold 9 genomes BUD0361 9 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG1038 rrnAC0300 HVO_1290 Hbo0253 Hmu1100 Hut0406 hla1904 NP2132A HQ3368A

Pairwise sequence scores
Consensus score	1890	NP2132A	Hmu1100	VNG1038	hla1904	rrnAC0300	Hut0406	HVO_1290	Hbo0253	HQ3368A
1459	NP2132A	1884	1261	1240	1338	1297	1282	1276	1293	1213
1477	Hmu1100	1261	1851	1314	1186	1359	1282	1255	1315	1175
1456	VNG1038	1240	1314	1876	1160	1331	1291	1320	1337	1222
1443	hla1904	1338	1186	1160	1966	1390	1208	1259	1276	1220
1529	rrnAC0300	1297	1359	1331	1390	1908	1337	1292	1298	1271
1477	Hut0406	1282	1282	1291	1208	1337	1839	1341	1361	1233
1526	HVO_1290	1276	1255	1320	1259	1292	1341	1872	1417	1237
1574	Hbo0253	1293	1315	1337	1276	1298	1361	1417	1902	1457
1421	HQ3368A	1213	1175	1222	1220	1271	1233	1237	1457	1867

252 symbols
consensus       --MELTWHGHSTWHVTVDDTDLLIDPFFDNPKTDLDPSDVD-PDYVLLTHGHADHIADVG
#oth            11..1..2....13.5.24.51.1..1.2..3.234.322452.21....1.3..12211
NP2132A         :::::::Y:::::::S:GS:::::::::G::::::E:::L:S::::::::::E::V:HA:
Hmu1100         ::::I:::::::F:::::N:A::V:::::::::::E:GA:::A:::::::::M:::::::
VNG1038         :::::::F:::::R:::GT::::V:::::::H::TA::E:A:V:H::::::::::::H::
hla1904         :::::::::::::::V::::E:::::Y:::::::V::EEL:::::L::::::S:::G::D
rrnAC0300       :::::::Y::::::::::::E::::::::::H::T::EELG:::::::::::::::G::D
Hut0406         :::::::Y:::::S:E:A::R::::::::::::S:S:T::ER::F::::::::::::N::
HVO_1290        :::::::::::::Y:::G::S::::::::::A:S::::::ET:::::::::::::::HA:
Hbo0253         MT:::::::::::::D::G:TF:::::::::F:::S::::ED:::L::::::::::S:A:
HQ3368A         :::::::::::::::N::G:TF::::::S::H:ERK:T:IKK::::::::A:::::G:AD

consensus       AFEDATVVGTPELTGYCEDEFGFEDTI---GMNLGGTVECGDAFVTMHRADHTNGIETGY
#oth            3151222.12..222.43315.45222111.1.1..1.13.2.2..12....1..22.3.
NP2132A         ::S:::L:A::::V::A::N:::::AVGGM::::::S::::::W:::T::::S:::::::
Hmu1100         ::P::::::L::VV:::A:NY:VSE::::::A:::::::L::::::L::::::::M::T:
VNG1038         ::A:THT:::::V:::VA::T:V:::T::::::::::::L:::::::V:::::::L::::
hla1904         RY:G::::A:::::::IQEN::H:NAVGGM:::I:::::::::W:::V::::S:::D:::
rrnAC0300       RY:GCGL:A:::VVE::K:N::EFNAVGGM:::::::::I:::::::::::::::M::S:
Hut0406         ::P:::::A::::AS:I:A:H:-NE:V:::::::::::AA:E::::::::::::::N:::
HVO_1290        E:DG::::::::::::V:A:M:VD:::::::::I:::::L:::::::V::::::::N:::
Hbo0253         ::T::::::V::M:::M:A:V::T:S:::::::::::::::N:::::::::::::LN:::
HQ3368A         V:T:T::::V::M:::M:S:V::TES:::::::I:::::::::Y:::::::::::L::D:

consensus       EH-SAGMPAGFVISDAKPTQESDADSTTFYHAGDTGLMSEMRDVIGPYLEPDAAALPVGD
#oth            15232.2.3.1211143.1142.52412.......2.121.211113111..2..2.4..
NP2132A         :T::::::::::V:ESE:QRA:::AN:A:::::::S::V:::E:::::::::F::::A::
Hmu1100         :STGG::::::::::T::::V:::E:S:::::::::::T:::E:::::::::V::V:I::
VNG1038         :Y::G:T:V:Y:::::A:::TG:G:A:::::::::S:Q:::K:::::::D:::::V::::
hla1904         GT:::::::::::G:K:::::::P:C:::::::::::::::V:::A:::::::::::T::
rrnAC0300       GA::G:::G::I:::T::::V:::E:::::::::::::T::::::::F:::::::V::::
Hut0406         :IG:::::::::::::E::RK::DET:A::::::::::T::::::A:F:::::::I:I::
HVO_1290        :::E::::G:YM::::V:::::::E:::::::::::::TD::EIF:A:F:::::::::::
Hbo0253         :::DI::::::I:::K:::::A:E:A:::::::::A:::::K:::AQ::::::::V:C::
HQ3368A         :Y::I:V:T:YI:::N:::RTA:T:::S:::::::::::::K::::T::::::::::T::

consensus       HFTMGPMQAAIAVDWLDVDHAFPMHYDTFPPIEIDTRDFVREVKATGSDAEVHVLDGDET
#oth            ......51111.11.1211312....1..211.214521331132312512222.2...1
NP2132A         ::::::E:::::A:::GA:Y:A::::::::::::::DE::DALN:::A:::AV::::::S
Hmu1100         :::::::::::::::::::V:L:::::::::::V:PEE:R:::T::::ST::RI:A:::S
VNG1038         ::::::::::V::::::::V:::::::::::::V::A::E:::N::::Q:D:::::::::
hla1904         ::::::AG:G::A::VGA:VV::::::::Q:::::::E::N::::A:AA::PV::E::::
rrnAC0300       ::::::::::V:::::::::::::::::::::::E:Q:::N:::G:::::D:::::::::
Hut0406         ::::::E:::V:::::::ED:::::::::::::Q:AEA:A:::::V::::D:::::::::
HVO_1290        ::::::W:G:V:A:::G:::::::::N:::A::::V:::E:::::A::R::::A:::::S
Hbo0253         ::::::V:::::::::N::::::::::::::V:::ID::E:::N::::T::::::::::S
HQ3368A         ::::::T:::::AE::::::V::::::::G:::::INEL:E::GSGDT::T:::::::::

consensus       FTLE--------
#oth            341432211111
NP2132A         :::G::::::::
Hmu1100         I:VAE:::::::
VNG1038         VD:SDAL:::::
hla1904         YV::NEFGSDGD
rrnAC0300       :E:-::::::::
Hut0406         :E:-::::::::
HVO_1290        ::::::::::::
Hbo0253         ::::::::::::
HQ3368A         :I:-::::::::