[R] (-) COG0595 Predicted hydrolase of the metallo-beta-lactamase superfamily 9 genomes BUD0362 9 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG1149 rrnAC0080 HVO_2724 Hbo2457 Hmu1254 Hut2754 hla1205 NP3698A HQ2890A

Pairwise sequence scores
Consensus score	3413	hla1205	VNG1149	HQ2890A	HVO_2724	Hbo2457	Hut2754	NP3698A	rrnAC0080	Hmu1254
2992	hla1205	3418	2543	2897	2902	2915	2858	2828	2868	2809
2718	VNG1149	2543	3056	2571	2672	2657	2542	2570	2627	2661
3084	HQ2890A	2897	2571	3413	3158	3168	2880	2854	2934	2780
3249	HVO_2724	2902	2672	3158	3413	3267	3000	2978	3064	2945
3226	Hbo2457	2915	2657	3168	3267	3424	2978	2931	3030	2901
3125	Hut2754	2858	2542	2880	3000	2978	3394	3050	3047	2937
3082	NP3698A	2828	2570	2854	2978	2931	3050	3397	3063	2908
3204	rrnAC0080	2868	2627	2934	3064	3030	3047	3063	3497	3031
3088	Hmu1254	2809	2661	2780	2945	2901	2937	2908	3031	3278

462 symbols
consensus       ------------MEIEIATIGGYEEVGRQMTAVRAGDDVVIFDMGLNLSKVLIHDNVETE
#oth            111111111111112111121111211111111121222121111111121111111111
hla1205         :::::::::::::::::::L::::::::::::::::E:I:::::::::::::::::::::
VNG1149         ::::::::::::------------------------------------------------
HQ2890A         ::::::::::::::::::::::::::::::::::T:::I::::::::::Q::::::::::
HVO_2724        ::::::::::::::::::::::::::::::::::::::::V::::::::Q::::::::::
Hbo2457         ::::::::::::::::::::::::::::::::::::::::V::::::::Q::::::::::
Hut2754         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP3698A         ::::::::::::::V::::::::::::::::::::::N::::::::::::::::::::::
rrnAC0080       MPAAGFPLGATT::V:::::::::A:::::::::::::::::::::::::::::::::::
Hmu1254         ::::::::::::-----------------:::::::::I:::::::::::::::::::::

consensus       RMHSLDLIDMGAIPDDRVMSDLEGDVKAIVPTHGHLDHIGAISKLAHRYDAPIVATPFTI
#oth            4................1..11....1............1111.........1111.1..
hla1205         S:::::::::::::::::::E:::::Q::::::::::::AG:P:::::::::::GS:Y::
VNG1149         -:::::::::::::::::::::::::::::::::::::::::::::::::::::GS::::
HQ2890A         T::::::::::::::::I::::::::Q::::::::::::::L::::::::::::GS::::
HVO_2724        K:::::::::::::::::::::::::Q:::::::::::::::::::::::::V:::::::
Hbo2457         K::::::::::::::::::::::::::::::::::::::::::::::::::::::S::::
Hut2754         ::::::::::::::::::::EI:::::::::::::::::::::::::::::::M::::::
NP3698A         :::::::::::::::::::::I::::Q:::::::::::::::::::::::::::::::::
rrnAC0080       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hmu1254         ::::::::::::::::::::E:::::::::::::::::::::::::::::::V::::Y::

consensus       ELVKQQIEGEEKFGVQNDLVKMEAGETMSIGDSG-VELEFVNVTHSIIDAINPVLHTPEG
#oth            ....11142.3..2.4...1..3..2213..13321.1...1....1.......2.....
hla1205         :::::::AD:G::Q:D::::::K::G::A::::EQ::M::::::::::::::::::::::
VNG1149         ::::GE::S:Q::::E:::::::::G::E:::RC:-:::::H::::::::::::::::::
HQ2890A         :::::::DS:N::N:N:::L::S:::A::::E::N::::::H::::::::::::I:::::
HVO_2724        ::::::::::N::N:N::::::::::::::::::N::::::H::::::::::::V:::::
Hbo2457         ::::::V:::N::N:G::::::::::M:::::::N::::::H::::::::::::::::::
Hut2754         :::::::Q:::::::E::::::D::A:T::::D:::::::::::::::::::::::::::
NP3698A         ::::::::::::::::::::::D::G::P::EKC:-::::::::::::::::::::::::
rrnAC0080       :::::::KS:::::::::::::D::::::::ERN:-::::::::::::::::::::::::
Hmu1254         :::::E:K:::::::::::::::::G::::::KN:-::::::::::V:::::::::::::

consensus       AVVYGLDKRMDHSPVLGDPIDMKRFREIGREGEGVLCYIEDCTNAGRKGRTPSESVARRH
#oth            11.......2..3..21.....2......1221...1.........1..1.....3.121
hla1205         :::::::::L::T::I::::::D:::::::QD:::::::::::::::::::::::Y:KK:
VNG1149         ::::::::::::D:::E:::::E:::::::::::::::::::::::K::::::::T::::
HQ2890A         :I:::::::I::::::E::::::::::::::DN::::::::::::::::::::::H::S:
HVO_2724        ::::::::::::::::E:::::::::::::::N:::A:::::::::::::::::::::::
Hbo2457         :I::::::::::::::E:::::::::::::::N:::A:::::::::::::::::::::K:
Hut2754         :I::::::::::D::V::::::D::::::E--::::::::::::::K:::::::::::K:
NP3698A         ::::::::::::N:::::::::D:::::::--::::::::::::::K::K::::::::SQ
rrnAC0080       S::::::::::::::I::::::::::::::::::::::::::::::K:::::::::::::
Hmu1254         S:::::::::::T:::::::::::::::::::::::::::::::::::::::::::::::

consensus       LKDVMTSVEDYDGGIVATTFSSHIARVKSLVEFAKDIGRQPVLLGRSMEKYSGTAERLDF
#oth            11.123.31..1...........11..111..1.31.1.1.1.......1...1...111
hla1205         VE:TL::M:::S::::::::::::::::T:::Y:RE::::::::::::::::::::::::
VNG1149         ::::L:::A:::::::::::::::S::S:::::::E:::E:I:::::::R:::::::MGR
HQ2890A         :E:TIR:I:::::::::::::::VS::S:::::::::D:::::::::::::::A::::G:
HVO_2724        ::::::::::::::::::::::::S::S::::::::::::::::::::::::::::::G:
Hbo2457         :E::IR:::::::::::::::::VS::S:I::::::::::::::::::::::::::::G:
Hut2754         :::::Y:M::::::::::::::::::::::::::D:::::::::::::::::::::::::
NP3698A         :::::Y:L::::::::::::::::::::::::::E:::::::::::::::::::::::::
rrnAC0080       :::::D::A:::::::::::::::::::::::::D:::::::::::::::::::::::::
Hmu1254         :::::::I::::::::::::::::::::::::::DE::::::::::::::::::::::::

consensus       VDFPDDLGMYGHRKSVDRTFKRIMKEGKENFLPIVTGHQGEPRAMLTRMGRGETPYELED
#oth            .2113.1..1........1...1.31..111..1........1......1..1..11112
hla1205         :::QG:V:::::::::::A:::::::::G::::::::::::::::::::::::::::I:N
VNG1149         :N:::::::F::::::::A:::V:N:::::::::::::::::Q:::::::::::::DI::
HQ2890A         ::L:::V:::::::::::::::::::::::Y::::::::::::::::::::::::F:::N
HVO_2724        ::L:::::::::::::::::::::::::::Y::::::::::::::::::::::::::ID:
Hbo2457         ::::::V::::::::::::::::::::::::::::::::::::::::::::::::::I:N
Hut2754         :E::E:::::::::::::::::::S:::::::::::::::::::::::::::D::::::E
NP3698A         ::::S:::::::::::::::::::D::::DY::V:::::::::::::::A::::::::DE
rrnAC0080       ::::E:::::::::::::::::::N:::::::::::::::::::::::::::::::::D:
Hmu1254         ::::::::::::::::::::::::ND::::::::::::::::::::::::::::::::::

consensus       GDKVIFSARVIPEPTNEGQRYQSERLLKMQGARIYDDIHVSGHLREEGHYQMLDALQPQH
#oth            ...12...11....1.1.....1.3..2.....1..11......12....1.121.2.31
hla1205         ::::V:::SI::::::::::::::Q::R:::::L::::::::::::::::E:::::::::
VNG1149         :::I::::S:::::::K:::::::Q::R::::::::::::::::::::::::::::::::
HQ2890A         ::::::::::::::::::::::::::::::::::::E:::::::::::::::::::::::
HVO_2724        :::::::::::::::::::::::::::R::::::::E:::::::::::::E::Q::::::
Hbo2457         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hut2754         ::::::::::::::::::::::::T:::::::::::EV::::::NR::::E::NT:E:E:
NP3698A         ::::::::::::::::::::::A:K::G::::::::::::::::NS:::::::Q::N:TN
rrnAC0080       ::::L:::::::::::::::::::K::G::::::::::::::::::::::E:I:::::KN
Hmu1254         ::::L:::::::::S:::::::::Q::::::::L:::::::::::::::::::Q:::::N

consensus       VIPAHQNLKGFAPYVDLAESQGYKLGRDLHVTRNGNMIQLVE
#oth            2..1..313.31..13.1312..33.1.1.3.4..1412.21
hla1205         L:::::T:::RS::::::T:::::::::V:::Q::SV:::A:
VNG1149         L:::::DM::M:::AK::K:::::I:::::M:E:::T:::::
HQ2890A         I:::::::E:LS:::::::::::A::::::::::::IV:::G
HVO_2724        :::::::::::::::::::::::A::::::::::::::::::
Hbo2457         :::::::::::S:::::C:::::DM:::::::::::::::::
Hut2754         I:::::SMG::::::E::::E::E::E:::::::::V:T:::
NP3698A         ::::::DM:::S:::E::SNE::E::::::::K:::T:::T:
rrnAC0080       I:::::S:E::::::::::NM:::A:::::I:::::::K:T:
Hmu1254         :::G::SMS::::::S::::::::::::::A:S:::R:T:::