[G] (FbaB) COG1830 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes 9 genomes BUD0363 9 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG0309 rrnAC1881 HVO_0790 Hbo0745 Hmu0826 Hut1878 hla1971 NP3160A HQ1156A

Pairwise sequence scores
Consensus score	1933	VNG0309	NP3160A	Hut1878	hla1971	HQ1156A	HVO_0790	Hbo0745	rrnAC1881	Hmu0826
1462	VNG0309	1960	1167	1226	1366	1287	1338	1234	1281	1185
1452	NP3160A	1167	1937	1207	1326	1286	1328	1327	1397	1260
1475	Hut1878	1226	1207	1774	1382	1310	1377	1305	1309	1293
1686	hla1971	1366	1326	1382	1943	1418	1526	1410	1497	1330
1558	HQ1156A	1287	1286	1310	1418	2017	1510	1520	1342	1255
1647	HVO_0790	1338	1328	1377	1526	1510	1979	1574	1376	1258
1558	Hbo0745	1234	1327	1305	1410	1520	1574	1954	1403	1263
1555	rrnAC1881	1281	1397	1309	1497	1342	1376	1403	1964	1408
1469	Hmu0826	1185	1260	1293	1330	1255	1258	1263	1408	1798

276 symbols
consensus       --------MDAGLSARLNRISTDGRYLIVPMDHGITLGAVDGLVDIESTIDAVTRGGADA
#oth            111111233341351113122132222321....1.1.113..2.1.2.1221.41...1
VNG0309         :::::::MT:::KT:::::::::D:L:TI::::::::::I:::::::A::RE::AN::::
NP3160A         :::::::::TP:IA:::D:VG:::::VV::::::::::::N::K:::::::::::::::S
Hut1878         ::::::::----------------------::::L:M:P:T::E:L:::VEGI:::::::
hla1971         :::::::::T::::::::::::ND::::::::::L:M::::::::::::::G::::::::
HQ1156A         MNTGAGAGARS::I::::::::::::::::::::::::P:K::::L:::V::I:DN::::
HVO_0790        ::::::MNT:V::::::D::::::::::::::::::::P:T::::::::::GI:::::::
Hbo0745         ::::::::::V:IT:::E::::G::::V::::::::::P:K::::L:T:V::I:::::::
rrnAC1881       :::::::::T::KR:::E::G::DT:V:I:::::::M:::K::K:::A::::::S:::::
Hmu0826         ::::::::----------------------::::::::::::::::::::::::T:::::

consensus       VLTQKGIADRVHPNKNDAGYIVHLNGSTTIGPDENDKRLTGTVEDALRAGADAVSFHINV
#oth            ...12.2.4...212121..11.1.1..41...34...6.111.3.2.1...1....1.1
VNG0309         ::::P:::P::::::G:::::::::A:::L:::QT:::R:::::::V:::::::::::::
NP3160A         ::::::::::::G:::G:::::::::::A::::S::::A::S::A:::::::::::::::
Hut1878         ::::::V:::::G:L:G:::::::::::::::::E:::K:::::::V:::::::::::::
hla1971         ::::::::P::::::::::::::V::::::::::S:::V:A:A:::V:::::::::::::
HQ1156A         ::::R:V:S:::::::TK::::::::::V::::TT:::P::S::G:::::::V::::::I
HVO_0790        :::H::T:P:::::::GK:::::V::::D::::::::::::S::::::V:::::::::::
Hbo0745         ::::::V:R::::K::GK::::::::::V::::S:::::::S::E:::V::::::::M::
rrnAC1881       ::::R:::G::::::::::::T::::::::::::Q:::T:::::::I:::::::::::::
Hmu0826         ::::R:::::::E:T:::::V:::::::S:::::S:::P:::::::I:::::::::::::

consensus       GSDHEPDQITQLAELTAEAARYGLPVLAMAYARGPGIDEQDPE----SLGHAVRLAEELG
#oth            ..32.11.222.231255.53213.....3....2112351221221311....11..11
VNG0309         ::::::::::A::DVA:D:D:L:V::::::::::::V::H:AA::::N::::::::::V:
NP3160A         ::KY:RE::EA:GR::DQ::E::::::::T:::::D:EGD:::::::A:::::::G::::
Hut1878         ::EY::::L:::::V:G::E:L:M:::::::::::::::S::D::::::A::::::::V:
hla1971         :::::::::EE::::::D:S:L::::::::::::::V::T::::::::::::::::::::
HQ1156A         ::::::::L:::SN::E::H:::I:::::N:::::::::H:::::::::A::::I:::::
HVO_0790        :::Y::::M::::D:CSR::DFSV:::::S:::::::::::::::::A:A::::::::V:
Hbo0745         ::EF::::M:::G:::EK:H:F:::::::N::::QD::S::A:::::N:A::::::::::
rrnAC1881       ::QY::E::EE:S:::T::SQ::::::::::::::D::SENED:YNE:V:::::::::::
Hmu0826         ::E:::E::S::S:V:SA:RE:::::::::::::HDVRDE:::LFAED:::::::::::D

consensus       ADVVKTAYSGDAESFERVVEATALPVVIAGGSKGTDRETLEMVRGAMDAGAAGVSMGRSI
#oth            ..21..2.1.3311.32.321131..2....1221.2212431.111.11.1.1.1..11
VNG0309         :::I::::::ST:::Q:::D:::K::I::::DPAG:::::QGI:D::::::::::T::TV
NP3160A         ::LI::G:::::::::H:C:S:S:::L:::::PDG:L:S:RD::::::::::::::::T:
Hut1878         :::I::::::::D:::::AA:S:K::::::::::::E:::A::::::::::::I::::::
hla1971         ::::::G::::GD::A::T:S:R::::::::::::::D:V::::::::GD::::::::::
HQ1156A         ::::::::::EP::::Q:CA::Q:::::::::R::::Q:I::::::I:::::::::::::
HVO_0790        :::::::::::::::G::::::R:::::::::R::::::V:::::T::::::::::::::
Hbo0745         ::::::S:T:E::T::::C:::R:::::::::R::::Q:I::::::::G:::::::::::
rrnAC1881       ::I:::G:T:S::T:QH:::S:S:::::::::::::ED:VR::::T:::::S::::::::
Hmu0826         ::L:::::::TP:T::::::S:::::L:::::::::E:::DI::::::::::::::::::

consensus       FQHEDPEAITRAVSAVVHDDASVEEALRAAGLAVEA
#oth            ...24.14111.112.1.2133323.1641116323
VNG0309         :::AT:G:M:A:I::::::::DP:A::AR:::V:D:
NP3160A         ::::S::H:A::::L:::::Y:A:A::E::E:SK--
Hut1878         :::::::::::::A::I:::E:::::MGN:::R::S
hla1971         :::::::G:A:::::::::::::D:::T:G:F-:::
HQ1156A         :::DN:GS::::::::I::G:::DT::DI:::EI:V
HVO_0790        ::::N:::::::::::I::::D:DT::ER:::GI::
Hbo0745         :::D::::::::::::I:R::DT:T::HE:::GL::
rrnAC1881       :::DE::K:A:::::::::::TT:::::E:::::::
Hmu0826         ::::E::K:A:::AS:::E:SEAAD:::::::::::