[R] (-) COG0618 Exopolyphosphatase-related proteins 9 genomes BUD0364 9 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG0650 rrnAC1272 HVO_0990 Hbo0451 Hmu1704 Hut0500 hla0218 NP2316A HQ1649A

Pairwise sequence scores
Consensus score	3593	VNG0650	HQ1649A	hla0218	HVO_0990	Hbo0451	NP2316A	Hut0500	rrnAC1272	Hmu1704
2135	VNG0650	3551	1509	1571	1780	1666	1573	1704	1680	1749
2087	HQ1649A	1509	3659	1512	1763	1956	1465	1548	1586	1598
2238	hla0218	1571	1512	3557	1853	1934	1635	1593	1672	1703
2529	HVO_0990	1780	1763	1853	3625	2249	1673	1786	1876	1848
2553	Hbo0451	1666	1956	1934	2249	3660	1694	1826	1755	1811
2190	NP2316A	1573	1465	1635	1673	1694	3595	1666	1751	1838
2284	Hut0500	1704	1548	1593	1786	1826	1666	4057	1902	2062
2297	rrnAC1272	1680	1586	1672	1876	1755	1751	1902	4269	2413
2409	Hmu1704	1749	1598	1703	1848	1811	1838	2062	2413	3679

595 symbols
consensus       MVRRLVLGCGPAARALVEQLAERRGELTVLTQDEGRADSLRDDG-IAAREADPTDPSALP
#oth            173..21.3235356322434353141424442352322116441153554222133334
VNG0650         ::S:::::::TVGH:VIGS::D:::::F:FDG::S:V::::NES:V::EVR:V:::A:IT
HQ1649A         :N:::L::::::VHDA:::FID:S:H::IV::H:TVFE:FNGED::DHTQ:N:D:STVY:
hla0218         :A:::L:::SAVGNT:::RTR:A::::IAI:D:T:W:ST:::RN:V:TV:::::::ATY:
HVO_0990        :::::I::::SLGGG::G:::G:G:TV::V:DRQ:::ED::S::::::::G::A:::TY:
Hbo0451         :Q::::::::S::QRA::R:::WP:T::::S:RS:VV::F:::::VS:ERCA:::HE:F:
NP2316A         -MD::::::A:GT:QF::::::QPAS:L::VG::A:::T:::S:::DT:VV:::::A:IR
Hut0500         :RT:::V:S:SI:::VIGS:C::P:R:LATGS::-:E::::EN:AVEVLAV:::VH:Q:A
rrnAC1272       :LS:::::L::T:AD:LDAISDD::::A:V::::H::ET::A::::NVL:::QA:::V:A
Hmu1704         :TS:::::A::LV:S:LDE::AG:::V::::E::H:V:T::T:A::TVQL:::A:R:V:S

consensus       E---DVDMVVVASDD-AARNAAAARAARRAFPDAFLLAYVGADADPD-------VREALD
#oth            53354224131132512431343.6111552.2151223417533641111111534325
VNG0650         LPDRS:::::::GER::D::RL::I::DA:H:::G:VV:L:F::T:K:::::::D:HRI:
HQ1649A         P:::TA::IFI:::E::KQ::IT:ET::TE::NTHITSF:P:T:SQK:::::::I::RIN
hla0218         ::::SAAV:L::::::P:::V:::E::::HY:::MIV:H::TNPTAA:::::::QQ:::E
HVO_0990        D:::E::L:::GGGQSPQ::LD::::::DHY:::P:VV:L:D::::S:::::::::ADIY
Hbo0451         ::::E::V:F::::::::A:LDV:LT::ER::::Y::::::S:::H::::::::T:::::
NP2316A         TVAG:AAS::::PEA:SPEA::I:D:::S:Y::T::::CF:RQPSEP:::::::::SEVA
Hut0500         :VEA::ET::::::N:P:E:LVV:::::::::S::::V:A::TVQD:RIGQRAERLAE:R
rrnAC1272       DLDFHPESII:::E::PKQ::D::T:::DC:::::::::A:HG:TT::::::::Q:DR::
Hmu1704         SLDVTPET:F::VG:::K::::V:Q:V:SV::S:M:V::S:LET::A::::::::DD::E

consensus       SVADRVVDPRAALTDRLNDAVGEGGA-RLRRLRRVLRDIDGPLAVVMHDNPDPDAIASAL
#oth            51112111244334234544326525434441531.342213.2111..1......1112
VNG0650         :::::::::G:E:LSHA:SLTES:ASQ::QA::QT:QG:::R:G:F:::::::::::A:V
HQ1649A         C:SNH:I:A:Q::VS:F::ILTHP::RQ:HQ:FTT:::::DT::I::::A::::::::::
hla0218         A::::::::VE:VVS:VCE:T:VDADEEPV::L::::SLT:::L::A:::::::::::::
HVO_0990        DL::E:I:::RVV:E:IL::::TSHTE::N::M::::NV::R:::::::::::::::A::
Hbo0451         EL:::L::G:RI:::::TELTEGAA:D::H::F:::KSLS::::::::::::::::::::
NP2316A         A:::::::GL:ETR:K:LA::::::L::T:K:QH:::T::::::::A:::::::::G::I
Hut0500         :::::::::GTV:DSY:E:RIET::I:SIHEF::::E:V::T:::::::::::::::::I
rrnAC1272       :::::L:T:ETVV::YVTQS::DE:T::A:Q:HQ::::::DH:::::::::::::::::V
Hmu1704         H::::::::G::I::H:MER:::A:L::T:Q:Q:::::V::T::::::::::::::::GV

consensus       ALARIAERAGCDADACYYGEISHQENRALVNLLEFDLRNLDADA--DLDEYDGFALVDHS
#oth            1.531.242133334..2.2.3..1...2....121.43215461134341222.....1
VNG0650         G:Q::::D::V:SQ:::F::::::::::F::::::::::VETQS::-DA:F:AV::::::
HQ1649A         :::EL:DN:DI:::L::::S:::::::::::::DI::L:FERET:::VE:::SI::::::
hla0218         G::::::SV:IP:::::G:::A::::::M::::DLS::TF:-GI:::::D:G:V::::::
HVO_0990        ::QA::::::V:::V::F:D::::::::::::::L:::V::EVP::AD:::A::::::::
Hbo0451         ::V::::SV:L:::P::F:D:::::::::::::DI::V::ERGE:::T:D:G:I::::::
NP2316A         G:K::::A::VE:T:::::D:N::::::::::::::::S::::C:::PSSFG:I::::::
Hut0500         ::VQ::::L::S:E:::::S:N::Q:::F::::DL::TS:EP:::::::V:G:::::::A
rrnAC1272       ::GAL::::D:EVTI:::::::::::::F::::::::::::::SPDE:EAF:A:::::::
Hmu1704         ::S:L:QAV::ETEL::::::T::::::F::::::::Q:::::::::::A::::::::::

consensus       RPGVNDGLPPDTPVDIVIDHHPPRAPVEARFVDLRSDVGATSTLLADYLRRLGIDPDETV
#oth            11.2..3.132241.1.1.....142141412.1.232...1.1433..32423524352
VNG0650         G:::::Q:A:::D::::::::::TTD:D:G:T:I:P:T:::::I:VE:::GY:::VRTA:
HQ1649A         ::::::::A:::T::::V:::::::T:::S:::I:RN::::::IF::::::INAA:T:S:
hla0218         :A:I::S::EGH:::::V::::::G::AGE:::I:P::::::::IEE::S:V::E::RDL
HVO_0990        ::::::R:::E:TI:V:::::::::::::AY::::RG:::::::::E::E::::V::T::
Hbo0451         :::::::::K::E::::V::::::::::::YL:::REL::::::MTN:::::::E::A::
NP2316A         :::A::::::EADI::::::::::Q:IQ:::::::::::::C::V:G:::E:::PI::NL
Hut0500         :::::::::G::A:::::::::::G::T:A:T:::::::::::::V:::::FDV:IE:::
rrnAC1272       :A::::Q:::E::I::::::::::V:I:::::::::G::::::::V:::Q:FNV:IPTPI
Hmu1704         ::::::Q:::E::I:::V:::::::::::::::::::::::::::::::::FDSLVE:A:

consensus       ATALLFGIRVDTNDFTREVSAADFEAAAWLLPHADLDTLQRIESPSMSAETLETIARAIQ
#oth            .11..1..32..42.3.22263..1.1.5.34411545.211.3.122221231234116
VNG0650         :::::Y::::::D::A::ITPR::T:::::::N::T:V:E:::A::L::D:FD:::AG:R
HQ1649A         :::::::::T:::::A:::::::::::::::T::N:S::DNV:::Q:TSGV:::LSS:::
hla0218         :::::Y:::I::K::::AT:IP::::::S:S::::ES::E:V::::V:P:::RVL::::E
HVO_0990        ::::::::Q:::::::::::T:::::::F:I::V:V:L:E:V:T::LTS::M::L:::VS
Hbo0451         :::::::::I::R:::::::SD::::::::VSY:::S::::V:::::GP:V:D:L:::::
NP2316A         :SG::Y::WT::QS:S:G:AR:::::::A:IET::REA::::::::VT:G::::VQ:::S
Hut0500         :::::::::::::E:S::::V:::::G:F::RE:::GM:E:::D::::SD:F::::D::H
rrnAC1272       ::G:::::Q:::K::R:::A::::::::H:VTN::MA::::::D::V:P:::SV:G:::T
Hmu1704         ::G:::::S:::RE:R::::VD::::::Y::::::::I:::::D:::::D::D::GH::A

consensus       NRDVRGSVLASCVGEIRDRDALAQAADRLLNMEGVATTLVYGYKDGTIYVSARARGADLD
#oth            1.2331321312..3233..2.1.11121.314117414.2.56121114.1.1.2322.
VNG0650         ::QLN:::::::::Q:TA::T:::T:::::A:R:::V:F::::F:::::::::S:RK:::
HQ1649A         ::::::NA:::N::S:T:::S::::::HV::LK::KIAI:::WI:D:V:L:G::::V:I:
hla0218         G::::::TV:::::::G:::::S:::E:::DLD:I:V:F:F::M::V::G::::::::::
HVO_0990        ::::::N::TTN::D::E:::::::::H::G::::EV:V:::LM:::V:::G:::::RV:
Hbo0451         ::::::D:::TN:::::N:::::::S:H::::::IRL:V:::F::::V:::G::::T:V:
NP2316A         ::T::DD::VT:::QVS:::::S::::K::::QDIS::::C::T:E:VFI:::::A::::
Hut0500         :::RH:T::L:G:::L::::T:::::::::A:D::T::::::INA::::I:::S::T:::
rrnAC1272       :::QE::::LTG::::S:::::::::::::DL:::Q::M:::VV::::::::::::::I:
Hmu1704         ::QRE::::L:::::LS:::::::::::::DLQ:INS:::::V::::::A::::::TEI:

consensus       LGETLRDAFGQIGSAGGHADMAGAQIPLGILDDVGDDS-ESLEEVVEDVVAGRFFEALE-
#oth            1.131.3.1242.......11....221143664422353326531323135.2122245
VNG0650         ::AV::S::DDL:::::::::::::L:::LF:A::E:AATT:T:MI:E:::S::::EVHG
HQ1649A         ::::::S:L:TV::::::::L:::::::DA:NLAQEE:TDDHYATIS:A:ST:V:G::DN
hla0218         V::L::::LDPV:::::::T:::::V:::::QE:SES-:::::D:::AF:::::::::DD
HVO_0990        :::AF:E:L:S:::::::::::::::::::::::::::R:::ATI:T:I::::V::T::H
Hbo0451         ::::::::LSP::::::::::::::::::::A:::PE:R:::SR::T::IS::L::T::D
NP2316A         ::::::E::::::::::::::::::::V:::L:DA:E-:RERRS:I:::ITE:::::VG:
Hut0500         ::::::A::::::::::::::::::LD::VMETIS::-:DD::AI::EI:TD::LD:M:V
rrnAC1272       :::A::::::::::::::::::::::DV:MITV--::RE:::::I:RAI:SN::LD:VQ:
Hmu1704         :::V::E:::::::::::::::::::T::V:ESI-E:RD:::H:::RA::DD::LD:VQ:

consensus       AT-----PSPE----TDLAFEYPRDE----------------------------------
#oth            424431154451111454543346665314222212222222222222222222222211
VNG0650         G:SGI::QQG:::::-----------::::::::::::::::::::::::::::::::::
HQ1649A         K:TV:::LE::ESGS:VEP:QF:QKTQ:::::::::::::::::::::::::::::::::
hla0218         :-::::::::P:::::GPLP:FS:E-::::::::::::::::::::::::::::::::::
HVO_0990        ::PT:::::LD::::::V:::::L::::::::::::::::::::::::::::::::::::
Hbo0451         ::RTFGASES:::::R:::::F:P::W:::::::::::::::::::::::::::::::::
NP2316A         --:::::MT:D::::-YVP:V:ADTFGGVE::::::::::::::::::::::::::::::
Hut0500         YPSQL::::ES::::YGEGT:L:D:AAPVSPQLGSGRRNGVAENRPEDTVDRYRVDDTDG
rrnAC1272       --:::::SRSH::::RL:GRV:A:ADYDVAAFTESTALSQDSDDTSATAEGASGEAGDDG
Hmu1704         --:::::AR:N::::HL:SPV:TAPRYGVT::::::::::::::::::::::::::::DG

consensus       -------------------------------------------------------
#oth            3322212222323122221211111111111111111111111111111111111
VNG0650         :::::::::::::::::::::::::::::::::::::::::::::::::::::::
HQ1649A         :::::::::::::::::::::::::::::::::::::::::::::::::::::::
hla0218         :::::::::::::::::::::::::::::::::::::::::::::::::::::::
HVO_0990        :::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hbo0451         :::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP2316A         :::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hut0500         ETETRSTDGSDTVGDDNDGT:::::::::::::::::::::::::::::::::::
rrnAC1272       TADWNSDVMFLENGDEDGGDEPDQAADAAEPTDDEAEQGEDSPETLVEPDDGEPL
Hmu1704         YLD:::::::VEDGEE:::::::::::::::::::::::::::::::::::::::