[R] (ElaC) COG1234 Metal-dependent hydrolases of the beta-lactamase superfamily III 9 genomes BUD0368 9 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG2239 rrnAC2500 HVO_0144 Hbo1274 Hmu2800 Hut2906 hla0442 NP2254A HQ3403A

Pairwise sequence scores
Consensus score	2366	VNG2239	Hut2906	rrnAC2500	Hmu2800	NP2254A	hla0442	HVO_0144	HQ3403A	Hbo1274
1692	VNG2239	2356	1400	1396	1484	1526	1478	1444	1469	1494
1742	Hut2906	1400	2344	1565	1745	1488	1469	1476	1445	1527
1709	rrnAC2500	1396	1565	2361	1773	1439	1480	1455	1405	1470
1859	Hmu2800	1484	1745	1773	2364	1547	1613	1526	1503	1605
1835	NP2254A	1526	1488	1439	1547	2338	1561	1498	1595	1638
1844	hla0442	1478	1469	1480	1613	1561	2402	1602	1539	1692
1862	HVO_0144	1444	1476	1455	1526	1498	1602	2420	1662	1756
1839	HQ3403A	1469	1445	1405	1503	1595	1539	1662	2440	1802
1954	Hbo1274	1494	1527	1470	1605	1638	1692	1756	1802	2408

323 symbols
consensus       M-MRVTFLGTSGAVPTTERNPSAFFVNRDGDRLLFDCGEGTQRQMMRFGTGFAVSHLFVT
#oth            12111.....1......3.21.13212.2.132...1..1...1..111...42223.11
VNG2239         :TLE::::::::::::::::::SV::R:N::AF:::A::A:::::::YK:::G::DV:I:
Hut2906         -::::::::::::::::::::::VM:R:E:E:::::::::::::::H:::::D:A:I::S
rrnAC2500       :T:::::::::::::::Q::T:SI:::::::Y:::::::::::::::Y:::::ID:::::
Hmu2800         -::::::::::::::::::::::L:::::::K::::::::::::::::::::::D:V:::
NP2254A         :SL::::::::::::::R::T::V:LR:E:::M::::::::::::::::::::::KA:I:
hla0442         :SL:::::::G::::::::A:::L::::E::::::::::::::G::::::::GID::::S
HVO_0144        -:::A:::::G::::::A:A::::L:::::E::::::::::::::::Y::::G:::::::
HQ3403A         -:::A:::::G::::::::G::::::E:::E:::::::::::::::::::::SL::I:::
Hbo1274         :S::::::::G::::::::G::::L:::::E:::::::::::::::::::::T:::::::

consensus       HLHGDHVLGIPGLLQTLDFNDREEPLAIHAPPGTRGHLEDLVHAAGYRPSFPVRITEVSP
#oth            .3....11.1...21.31..1.32212114.4.3355144.1734144121223143352
VNG2239         :G:::::F:L:::VH:W:::::TD::T::V:R:L::DI::::FS::GDVGY::::::AT:
Hut2906         :M::::::::::::::M:::E::::::::::H:::SQ::A:IG:T:D:::Y:L:::QNG:
rrnAC2500       ::::::::::::::::W:::E::RAI:::T:A::::NIKQ:IQ:N:TT:::::::N:::A
Hmu2800         :T::::::::::::::F::::::::::::::A::::TI::::SVT:DT::::::::Q::A
NP2254A         ::::::I::L::::::M:::::::::SVYV:S:KQAE:R::IDT:AGA:::::HVNG::D
hla0442         :::::::::::::V:::G::::A:::T::C::::EDD:H:::::V:HD:A:QI::ES:A:
HVO_0144        ::::::I::::::I::::::::DDS::::G:::SK::::Q::::G::Q:G:H:SVH::R:
HQ3403A         ::::::I::::::I::::::::TDA::::G:::SKP::RH::ET:::::GY:IN:R:IR:
Hbo1274         :::::::::::::I::W::::::::I:::::::SKR::QS::N:G::::::::N:H::K:

consensus       GDVVLDADDYEVRAFETAHR-TASVGYALVEDDRKGRFDREKAE-ELGVPVGPKFGRLHA
#oth            .51132433.111212.5.2234.4.1113.21.2.1.1.32..221.111..2123..3
VNG2239         :A::RSH::::::::::::S::::::::::::::T:::::AR:::::::::::::ST::D
Hut2906         :::::::NE:::Q:I::E::::Q:L::::::::::::::::T::N:::IEP:::YSK:::
rrnAC2500       ::::::RSE::I::I::::::C:::::V:D::::::K:::::::E:F:I:P:::YSK::R
Hmu2800         ::T:::G:G:::::IR:Q:::CQ:::::V:::::::::::::::E:::IEP:::YSK::R
NP2254A         :Q::V::::::I:::::D:D:AR:L::::I:AS::::::::R:::::::::::::QQ:::
hla0442         :E:A::::G::::::::V::::K:Q::V:E::::P:::::P::::::::::::::::::E
HVO_0144        :N:AYR:::::::::D:E::::::::::::::::P::::::::::::::::::A::::::
HQ3403A         :S:AV:TEE:II:S:::S::GVT:I::::I:S::::::N:DR:::S:::::::::::::D
Hbo1274         :N:A:SG:S::::T:::D::NVR:M:F:::::::P:::N::::::A:::::::D:::::E

consensus       GEAVELEDGTVVQPEQVVGDPRPGRRVVYTGDTRPTDSTVEAAEDADLLVHDATFADDRA
#oth            .13.1231.3214112...13....22...1..1.42512512321...1..1..24153
VNG2239         :QP:::D:::::S::::::::::::TL::::::::H:PV:S::::::::I::::::N:AS
Hut2906         :::::-H::RTI:::E:::P:::::T:::::::::VEAVRR:S::::::I::G::G::::
rrnAC2500       :::::-HE:ETI:::A:::PA:::::F::::::L::E:VI::S:::::::::::::E::K
Hmu2800         ::P::-HE:RTI:::A:::PD::::TL:::::::::::V:::S:::::::::::::::W:
NP2254A         ::::::::::::E::::::::::::::::::::::::R::TV::N::::I::::::T:N:
hla0442         ::P::A:::SI:E:D::::P:::::KF:::A::::REG::AV::::::::::::::::ME
HVO_0144        ::D:::::::::RS:::::::::::T:::::::::LN::::V:C:::::::::::T:EE:
HQ3403A         ::S:K:A::SI:H:::::::S:::::::::::::::ET:::::NN:::::::::::A:::
Hbo1274         ::S::::::::IH:::::::::::::L::::::::V:A::DVVDEP:::I::::::E:::

consensus       ERARRTAHSTAREAADVARRAGARRLALTHISSRYAGDASPIEREAREAFDGE-AFVPDD
#oth            3..36.1.1.13..142.63.11231..1.1.2..1133221443.4321112122114.
VNG2239         :::AE:G::::G::::::TE:::KA:::::V:::::::::E:SAG:-SG::::::::AH:
Hut2906         A:::::G:::::::GSL:AE:::K::::::::T::::RSDQLLE::::::GEA::::AA:
rrnAC2500       :::KA::::::::::::::Q:::ST:::::::T:::AS:DELVD:::D::::::VVLAE:
Hmu2800         ::::K:::A:G::::E::QE:::K::::::::T::G:NPT::LSD:::::::::V:::::
NP2254A         D::A:::::::A::::I:S::D::::::V:::::::::P:::::::DD::G:::::::E:
hla0442         D:::D:::::G:::GS::E::::K::::V:::::::A:::::R:::::::::::CLL:::
HVO_0144        :::KQ::::::::::R:::D:DV::F::::::A:::A:P::LLEQ:::VY:::::::AE:
HQ3403A         S::KQ:G::::Q:::QI:T::D::Q:::::V:::::::VT:L:SD:TA::::QR::::::
Hbo1274         :::HG:G:::G::::EI:N:::::::::::::::::::::::::::QA::::::::::Q:

consensus       G--QTIDIPFPDAD---------
#oth            .1144312121.33322222221
VNG2239         :::L:HE::::::::::::::::
Hut2906         ::::S::V:Y::DG:::::::::
rrnAC2500       :MERRVEF:DA:EY:::::::::
Hmu2800         :::RR::V::::E-:::::::::
NP2254A         :::D:V::::::E-:::::::::
hla0442         :::DL:EV::::::E::::::::
HVO_0144        ::::KLEV:YA:S:GGGAETGE:
HQ3403A         :::Y:L::::::::DNHLSDNIP
Hbo1274         ::::K:::Q:::::E::::::::