[E] (HisA) COG0106 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase 9 genomes BUD0372 9 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG2294 rrnAC2529 HVO_2988 Hbo1534 Hmu3003 Hut2838 hla0593 NP1268A HQ1025A

Pairwise sequence scores
Consensus score	1750	VNG2294	HQ1025A	hla0593	NP1268A	Hut2838	rrnAC2529	Hmu3003	Hbo1534	HVO_2988
1377	VNG2294	1763	1219	1159	1226	1275	1309	1298	1207	1266
1325	HQ1025A	1219	1792	1175	1273	1239	1236	1258	1311	1332
1441	hla0593	1159	1175	1783	1324	1336	1306	1367	1336	1341
1483	NP1268A	1226	1273	1324	1734	1334	1381	1394	1340	1350
1486	Hut2838	1275	1239	1336	1334	2001	1430	1450	1270	1313
1499	rrnAC2529	1309	1236	1306	1381	1430	2208	1479	1362	1384
1610	Hmu3003	1298	1258	1367	1394	1450	1479	1745	1400	1407
1483	Hbo1534	1207	1311	1336	1340	1270	1362	1400	1779	1407
1465	HVO_2988	1266	1332	1341	1350	1313	1384	1407	1407	1746

301 symbols
consensus       -------------------------------------------------------MFPSF
#oth            11111111111111111111111222222222212111222111112221223564113.
VNG2294         ::::::::::::::::::::::::::::::::::::::::::::::::::::::MT:E::
HQ1025A         ::::::::::::::::::::::::::::::::::::::::::::::::::::MSTL:E::
hla0593         :::::::::::::::::::::::::::::::::::::::::::::::::::::MSH::::
NP1268A         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hut2838         :::::::::::::::::::::::MRYGRNECQFGYDSRFSRRTDTLYACASRSRD:::D:
rrnAC2529       MTASSRRASGVRTNVAITIADLSYHSVKAWGYTGSDSRRTSRTDTLSTAATGPPA:Y:E:
Hmu3003         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::E:
Hbo1534         ::::::::::::::::::::::::::::::::::::::::::::::::::::MAEA::T:
HVO_2988        ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::E:

consensus       EVIPAVDMQDGQVVQLVGGERGTEKRYGDPVAAAERWVEAGAETLHLVDLDGAFEGERAN
#oth            2.2....1...2.....1.....122..1..4..42.131..41...1..1.....2.4.
VNG2294         T:L::::::::::::::Q::::::RT:::::D::TD::A::::A::::::::::::A:::
HQ1025A         :::::::::::D:::::Q::::::T::::::V::KQ::::::K:::::::::::::D:M:
hla0593         :::::::V:::E:::::::::::G:::::::E:::::I::::::::::::::::::::V:
NP1268A         ::::::::::::::::::::::::TE::::::::Q:::D:::::::::::::::::::::
Hut2838         :::::::::::::::::::::::G:T:::::N:::::::::::::::I::::::::::::
rrnAC2529       ::V::::::::::::::::::::::T:::::E::Q:::D:::R:::::::::::::::Q:
Hmu3003         A::::::::::::::::::::::G::::E:::::R::I::::T:::::::::::::::::
Hbo1534         ::V::::::::E:::::Q:::::::::::::::::::INE::D:::::::::::::::Q:
HVO_2988        ::V::::::::E:::::Q:::::::T:::::E::R:::D:::::::::::G:::::::K:

consensus       ADAVEAVLDAV--DVDVQLGGGIRTAEDARDLLDRGVDRVILGTAAVENPDIVAEISEAH
#oth            .3.11113221221231.1.....1131.53..23.12........1.2.11.2.13251
VNG2294         :T:::DI:::T::::S::V:::::S::::TA:::::::::::::::I:T::::G::AA:Y
HQ1025A         :T::D:II::::::IP::::::::::N::AS::::::N:::::::::::::L:::LA:SY
hla0593         :::I:::VEN:PDEIGL::::::::::G::E:::L:L:::::::::::T:E:::::D:T:
NP1268A         ::::::::E:T::::S:::::::::VD::DS::SM::::::::::::::::::G::NDR:
Hut2838         :::I::IQAT::::::L:::::::::::::A:::A:::::::::::::D:E:::::::T:
rrnAC2529       :A:ID::::::GA::::::::::::::::VS:::::L:::::::::::T:E::G:::DE:
Hmu3003         :::ID:::::::::A::::::::::::::I::::::::::::::::::::::::::::E:
Hbo1534         :::::::V:::::::P::::::::::A::I:::E:::E:::::::::::::::R:::D::
HVO_2988        :P::D::::::::::PL:::::::::D::::::::::::::::::::::::::::LAADY

consensus       PGSVLVSLDAKDGEVVVSGWTEGTGLDPAEAAARYAELGAGGILFTDVDVEGQLEGVRTD
#oth            12213.....21.....1....1..2..14..3.1122..211...1.....114.1343
VNG2294         SDG::::::::::::::E:::::::M::VA::Q:::D:::A:::::::::::KQ::::::
HQ1025A         ::RII:::::A:::::::::::S::I:::V::::F:DY::C:::::::::::K:A:IQSS
hla0593         ::::V::::::::::::::::::::::::::::::E:::::A::::N:::::::::IDRE
NP1268A         ::::V:::::::::::::::::S::::::::::::EAE::::V:::::::::::S:::A:
Hut2838         :D::::::::SG::::::::::S::::::K::G:::::::A:::::::::::::G::::A
rrnAC2529       :::::::::::::::::::::::::::::D::G:::D:::::::::::::::::D:::::
Hmu3003         :E::::::::::::::::::::::::::::::S::::::::::::::::::::::::::E
Hbo1534         ::::M::::::::::::::::::::::::A:::::E:::::A::::::::::::::IQ:A
HVO_2988        ::G:M::::::::::::::::::::::::::::::E::::AA:::::::::::::::HLE

consensus       PVRRVVDAVDIPVIASGGVATLDDVRALREAGAAAVVVGTALYEGAFTLEEAQAAVE---
#oth            42431111.2...1.....1223.141.341.1.12...1....25...42.33144431
VNG2294         :::DL::S:::::::::::::V::::::EA::::GA:::::::::N:::AD::::::D::
HQ1025A         VTA::I::::::::::::::S:::IQT:HTT::::T::::::::NK:::AD:MEVC:SD:
hla0593         A:ES:::::E::::::::::AI:::V::K:::S::::::::::::E:::R:::T:ADGK:
NP1268A         EIA::::::::::::::::S::S:IE::KD:::::T:::::::::E::::::A:V:-:::
Hut2838         ::E:::E::::::::::::::V::I:::EAT::::::::S:::::K::::D:I:::::::
rrnAC2529       ::::L::S:::::::::::::IN::L:::S:::::::::S:::::Q:::DA:ID:LGESS
Hmu3003         :::::::::E:::::::::::VE::::::D:::::::::S::::::::::::M:::::::
Hbo1534         VTQ::::::T:::V::::::S:S:::::K:::::::::::::::D::::QA::D::SED:
HVO_2988        TTSA:::::::::V::::::S::::::::::::::T:::::::::R::::::ME:--:::

consensus       -
#oth            1
VNG2294         :
HQ1025A         :
hla0593         :
NP1268A         :
Hut2838         :
rrnAC2529       E
Hmu3003         :
Hbo1534         :
HVO_2988        :