[J] (DPH5) COG1798 Diphthamide biosynthesis methyltransferase 9 genomes BUD0378 9 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG1118 rrnAC1406 HVO_0916 Hbo0624 Hmu1913 Hut0931 hla2430 NP1884A HQ1603A

Pairwise sequence scores
Consensus score	1943	Hmu1913	rrnAC1406	Hut0931	VNG1118	HQ1603A	NP1884A	hla2430	HVO_0916	Hbo0624
1400	Hmu1913	1928	1303	1307	1234	1174	1259	1299	1243	1270
1422	rrnAC1406	1303	1942	1311	1303	1150	1255	1265	1269	1269
1543	Hut0931	1307	1311	1956	1364	1230	1356	1353	1401	1355
1521	VNG1118	1234	1303	1364	2116	1327	1350	1411	1387	1381
1431	HQ1603A	1174	1150	1230	1327	1920	1273	1331	1313	1420
1567	NP1884A	1259	1255	1356	1350	1273	1989	1504	1438	1380
1666	hla2430	1299	1265	1353	1411	1331	1504	1977	1476	1508
1651	HVO_0916	1243	1269	1401	1387	1313	1438	1476	2041	1606
1656	Hbo0624	1270	1269	1355	1381	1420	1380	1508	1606	1936

293 symbols
consensus       ----------------------MLTFVGLGLYDERSITVAGREALRDADRVFAEFYTSRL
#oth            1111111111111111111111....1.......1.1221.11.123.1222......4.
Hmu1913         :::::::::::::::::::::::::::::::::::::::E:K:::QT:TDIY::::::K:
rrnAC1406       ::::::::::::::::::::::::::::::::::::V:::::D:I:::::::::::::::
Hut0931         ::::::::::::::::::::::::::::::::::::V:L:::D:I:T:::::::::::Q:
VNG1118         MLTGVVLAATRNPYDAARPTRG::::::::::::A:V:::::D:IAA:::::::::::::
HQ1603A         ::::::::::::::::::::::::::I::::::::::SI:::D::QA::Y:A::::::Y:
NP1884A         ::::::::::::::::::::::::::::::::::::::::::::::S:::::::::::K:
hla2430         ::::::::::::::::::::::::::I::::::::::::E::::::S:::::::::::::
HVO_0916        ::::::::::::::::::::::::::I:::::::::VP:E:::::A::::A:::::::H:
Hbo0624         ::::::::::::::::::::::::::I::::::::::::E:::::A::::A:::::::H:

consensus       VGATVEDLEAYHDIDIEVRDRAGVEQDPEPILDAAEDEHVVFLTAGDTMISTTHVDLRLR
#oth            21121441154111312211.111..3.231.31.332321.2......1....2...1.
Hmu1913         I:T:IQK::Y:::::::LL:::A:::T:DEL:A::::GD:A:V::::::V::::::::::
rrnAC1406       I:TDI:T::DTLETS::R:::::I::::::::E:::S:::::C::::::V::::A:::::
Hut0931         A::SI:EI::F::T:::::::::I::::D::::::LEDE:::::::::::::::::::::
VNG1118         I:TD:AA:::H::TT::R::::::::H::::::::A:GDA::::::::::::::::::M:
HQ1603A         :D:::S:::TA:::::D::::E::::H::D::RK:QS:D:A:::::::::::::T:::::
NP1884A         A:::::E:QNH:::::::::::::::E:G:::::::AGGA::::::::::::::::::::
hla2430         :::D:D:::::::TE::::A:E:::::::A::A::::G:TA:::::::::::::T:::::
HVO_0916        ::::::E:::::::::::::::::::::G:::::::::::::::::::::::::::::::
Hbo0624         :::::::::S:::::VA:::::::::H::D::::::::::::::::::::::::::::::

consensus       AEDRGIDTRVIHGTTAQSAASSLTGLQNYRFGKATTLPFPYAHGGDGVPDSVIDTIEANR
#oth            .43...2.121.12..22..21.1.........11....132..112..3..321121..
Hmu1913         ::E:::H::::::::::T:::::::::::::::::::::ED:::::::::::VE::T:::
rrnAC1406       :A::::E::IV::::::T::G::::::::::::::::::ED:::::::::::VA:::D::
Hut0931         ::Q:::E:Q::::::::A:::::::::::::::::::::ERS:::::::::::E::::::
VNG1118         :A::::::::::AP::A:::AG::::::::::::::::::W:::A::::G::T:::::::
HQ1603A         :I:::::::::::V:::T:::G:::::::::::SV:::::::::AE:::T::T:S:A:::
NP1884A         :DN:::E:QI::::::GA::A::S:::::::::::::::::::::E:::G::L:::AD::
hla2430         ::E::::::::::V::::::::::::::::::::::::::::::::D::G::::::::::
HVO_0916        ::::::E::L:::V:::::::G::::::::::::V::::::V::::P::K::V:SL::::
Hbo0624         :VE::::::::::V:::::::G::::::::::::V:::::::::A::::K::::S:::::

consensus       ERGLHTLVYLDIKVD-----GP-ADRDEYMTADQAAELLADHWE-DALGVVVARAGSPDP
#oth            211...1.1...1131213323343433112114..41113424213111111...1211
Hmu1913         ::::::::::::::::::DPHW:EGEQ:F::::H::G:::::F-::T::::::::::AN:
rrnAC1406       D:D:::::::::::::::DPHWEESD:T::::S:::TM:SEPFP::T:::::::::::::
Hut0931         D:::::::F:::T:E:::::--:S:DGT::RG::::S:::K::RPN::::::::::::::
VNG1118         ::::::::::::::::::::H:RV:G:A::::S:::D:::TN:DA:::::::::::A::A
HQ1603A         ::::::V::::::--:::::--::N::::LR:SD:::M::TDL:::M:AIA:::::::::
NP1884A         K:::::::::::::G:TGPR::DP:HE::::::Y::::::EDL-::TV::AI::::::::
hla2430         ::::::V:::::::G:TGPT::DP:HE::::::V::G::::G::::::A::::::::::A
HVO_0916        DL:::::::::::::WEGRR:VEV:G:Q:::::Y::::F:E::DA:::::A:C:::::::
Hbo0624         :::::::::::::--:::::--::::::::SG:Y:::M:::G::::V::I:::::::E::

consensus       VVAADRLSALADRDFGDPLHLLVIPGDLHHVEADALAALAGAPAEAL-E----
#oth            213.12.21..2531.3...1.12.121.43.311.54211.13353534522
Hmu1913         ::E::S:D::::G:Y:G::::::V:A:::EM:R:::TT::D::LAD-:-::::
rrnAC1406       L::::T:DE::TQT::::::::::::S::PL:::T:ESV:::AL:--:-::::
Hut0931         ::Q:G::::::EM:::G::::::V::S::YI:R:::::IGD:::D::D:NIVD
VNG1118         T:R::::G::::A:::S::::::V::S:::I:R:::RE::::::D:::-::::
HQ1603A         T:R::::::::EK::::::::::L::E:::L:EE::::::D:::DM:NAVDSQ
NP1884A         :L:::::::::::S::::::::IV:::::V::H:::V::::::ES::PDPV::
hla2430         :::::::::::::E::::::::::::::::::::::VG:::::::LVE:::::
HVO_0916        :::::::::::E::::A:::M:::::EV::::::::S::G:::E:LFDDEN::
Hbo0624         L:::::::E::E::::::::M::::::V::::::::RT:G:::D:V:S:NEV: