[S] (-) COG1849 Uncharacterized protein conserved in archaea 9 genomes BUD0383 9 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG1260 rrnAC1128 HVO_1124 Hbo0435 Hmu1449 Hut1245 hla2754 NP4324A HQ1653A

Pairwise sequence scores
Consensus score	722	HQ1653A	VNG1260	NP4324A	Hut1245	rrnAC1128	Hmu1449	HVO_1124	Hbo0435	hla2754
493	HQ1653A	710	452	450	469	445	454	446	482	479
595	VNG1260	452	718	519	548	521	561	457	461	519
603	NP4324A	450	519	722	579	557	562	428	480	502
618	Hut1245	469	548	579	722	594	547	462	500	496
596	rrnAC1128	445	521	557	594	722	621	484	446	448
633	Hmu1449	454	561	562	547	621	731	474	484	473
520	HVO_1124	446	457	428	462	484	474	735	483	501
526	Hbo0435	482	461	480	500	446	484	483	733	520
545	hla2754	479	519	502	496	448	473	501	520	930

122 symbols
consensus       ---------------------------MAADLAEKTDRYERLLADALAAAEIAPPEGTPL
#oth            111111111111111111111111111.3.1141..11.111.21.122.4321143111
HQ1653A         ::::::::::::::::::::::::::::T:E:IA:::Q:::M:::::EV::::V:KT:::
VNG1260         ::::::::::::::::::::::::::::::::::::::::G:::::::::DPV::A:S::
NP4324A         ::::::::::::::::::::::::::::S:::E:::::::::::E:::::::::Q:::::
Hut1245         ::::::::::::::::::::::::::::P::::::::::::::TE::E::TVR:::::::
rrnAC1128       :::::::::::::::::::::::::::::::IE:::::::G:::E::D::SV:::::::M
Hmu1449         ::::::::::::::::::::::::::::::E:W:::::::G:::::V::::::::::::M
HVO_1124        ::::::::::::::::::::::::::::::::Q:::N:::GM:::::DE:VQ:V:DE:H:
Hbo0435         ::::::::::::::::::::::::::::P:E::::::::G:M:E::::::T::V:PE:::
hla2754         MPVGFGSGGIGVALRRRLFERLPGTGR:T:::E::::::::M::::::V::PR::AD:::

consensus       GEAAAECEEMAESYLEDGRHFRADDDPVNALASFSYGHGWLDAGARIGLFDVPTDGHLFT
#oth            24..3154...51..1..1..1331.2.....11...11.1...1.2.1.31.3222...
HQ1653A         :R::H:TR:::R::::::::::TV::L:::::A::::Y::::::V:::::NI:AESD:::
VNG1260         ::::::YF:::::::::::::::H::::::::A:::::A::::::::::::::AA:E:::
NP4324A         Y:::V:FR:::Q::::::::::DN::::::::::::::::M:::::V:I:E:::::::::
Hut1245         ::::::F::::Q::::::::::D:::L:::::A:::::A:::::::V:::::::::::::
rrnAC1128       HN::L::::::SA:::::::::D:::L:::::::::::A:::::::::::::::E:::::
Hmu1449         HD::V::A:::A::::::::::::::::::::::::::A:::::::::::::::E:::::
HVO_1124        :A:::D:L:::::::D:::::K::::W::::::::::Y::::::V:M::::I:D:S::::
Hbo0435         :D::VDI::::I::::::H:::EN:::::::::::::Y::::::V:M::::::E:TD:::
hla2754         :::::DVL::::::::::::::E:G::::::::Y:::Y::::::V:M:::A::D:TE:::

consensus       V-
#oth            32
HQ1653A         TS
VNG1260         ::
NP4324A         Q:
Hut1245         ::
rrnAC1128       ::
Hmu1449         ::
HVO_1124        M:
Hbo0435         ME
hla2754         T: