[H] (HemB) COG0113 Delta-aminolevulinic acid dehydratase 9 genomes BUD0409 9 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG2322 rrnAC2610 HVO_0087 Hbo1409 Hmu2939 Hut2063 hla0533 NP0920A HQ3443A

Pairwise sequence scores
Consensus score	2455	VNG2322	HQ3443A	hla0533	HVO_0087	Hut2063	NP0920A	Hbo1409	Hmu2939	rrnAC2610
2073	VNG2322	2455	1925	1938	1912	1945	1949	1966	1988	1950
2017	HQ3443A	1925	2446	1899	1859	1900	1891	1998	1906	1899
2123	hla0533	1938	1899	2446	1967	1999	1946	2013	1993	1950
2132	HVO_0087	1912	1859	1967	2475	2040	1937	2029	2001	1985
2169	Hut2063	1945	1900	1999	2040	2473	1981	2068	2013	2046
2126	NP0920A	1949	1891	1946	1937	1981	2463	1974	2018	2000
2202	Hbo1409	1966	1998	2013	2029	2068	1974	2443	2076	2074
2188	Hmu2939	1988	1906	1993	2001	2013	2018	2076	2463	2075
2169	rrnAC2610	1950	1899	1950	1985	2046	2000	2074	2075	2457

329 symbols
consensus       --MNLTDRPRRLRTDGIRPLVSETELSASDLIAPVFVDATTDERVPIESMPGHERVPVEE
#oth            1115314......2..2.3..1..51313..1..1.1...111.21.111..1....233
VNG2322         :::E:PH::::::R::V:D:::::M:TPA::V::::::::A:::T::P::::Q::::LAD
HQ3443A         MNIE:::::::::R::::S:::::SVT:Q::V::::I::::TT:T::::::::::::I:D
hla0533         :::HP:::::::::::A:S:::::S::::::V::::::::::::::::T:::::::::D:
HVO_0087        :::KF:::::::::::::::::::T:D:T::V:::::::::::::::::I::::::::A:
Hut2063         ::::HPN:::::::::::::::::T:D:::::::::I:::::::::::T::::::::::Q
NP0920A         :::D:::::::::A::V:D:::::::H:::::::I::::::::::E::::::::::::::
Hbo1409         ::::::::::::::::::S:::::N:::T:::::::::::::::L:::::::::::::S:
Hmu2939         :::QP:R:::::::::V:G:::::A::PA:::::I:::::::::::::T::::::::::A
rrnAC2610       ::::::Q:::::::::V::::R::::T:::::::::::::::::::::T::::::::I::

consensus       AVDRVEEVLETGVEAVIVFGIPESKDERGSRAWADDGVVQRAVRRITAETDAYVITDVCL
#oth            .14.13.1131..11121..1.12..42.1..1.41.1..3.2.2114.......1...2
VNG2322         ::::TR:I:D:::::IVL::::A:::DT::::Y::::I::E:T::::S::::::::::::
HQ3443A         ::T::::IR:::::::M:::::AE::::::::::S:::::Q:::::::::::::::::::
hla0533         ::A:::::R:::::::::::::::::AE:T::Y:E:::::::I::::::::::::G::::
HVO_0087        :A:::A::R:A::K::::::::::::PE::::Y:RN::::E:::A:::::::::::::::
Hut2063         ::E::Q:IR::::::I::::V:::::SE::::::::::::K::::::::::::::::::M
NP0920A         ::P:T::::S::::S:::::V:::::SE::::::::::::::::A::D:::::::::::F
Hbo1409         ::A:::::::::::::ML::::::::::::::::E:::::K:T::V:E:::::::::::M
Hmu2939         :::::::::A::::::::::V::A::::::::::T:::::::::S::D::::::::::::
rrnAC2610       ::::::::::::::::ML::::::::::::::::E:::::E:T:::SG::::::::::::

consensus       CEYTDHGHCGVLEDDAATDPTLTVKNDETLELLAKTAVSHAEAGADMVAPSAMTDGMVGA
#oth            ...12.....22.33.341.3..13.13..31.421.1.113...1.1...213..113.
VNG2322         ::::S::::::V:A::D:::::::::::::S:::E::::::::::E:I::::::::::D:
HQ3443A         ::::T::::::V:S:::::::::::::K:::::I::::::V::::E:::::S:::::IT:
hla0533         :::::::::::I:ES:E:::::::::::::::::E::::Q:D::::::::::::::Q:R:
HVO_0087        ::::::::::::::H:ED::::::E:GP::D:::E:::::::::::::::::SM::::::
Hut2063         :::A::::::L:::::RQ::V:::R:::::DA::R::::::A:::::::::::M::::::
NP0920A         ::::::::::I::S:::E::H::MD::A:::::RR::::::::::::::::G:V::::::
Hbo1409         ::::S:::::IV::H:ES::::::::::::A::::::::::::::::::::S::::::::
Hmu2939         ::::S:::::IV::G::D::::::R::P:::::S:::::::R:::::::::S::::::::
rrnAC2610       ::::::::::::::G::EN:R:::R:::::D::G:I:A:::A:::::::::G:I::::::

consensus       IREALDDAGHDDVPIMSYAAKYESAFYGPFRDAADGAPAFGDRRHYQMDPANAREALREV
#oth            ..21..23.243122....1..................1.............31..5..1
VNG2322         ::T::::::FS:::::::::::::::::::::::::::S:::::::::::::R:::S:::
HQ3443A         ::T:::ET::T:I:::::::::::::::::::::::::::::::::::::::SQ::K:::
hla0533         ::::::A:::A::GL::::V::::::::::::::::::::::::::::::::R::::::A
HVO_0087        ::T::::::::EI:::::::::::::::::::::::::::::::::::::::::::::::
Hut2063         :::G::::::TE::::::::::::::::::::::::::::::::::::::::::::M:::
NP0920A         ::N:::A::YEQI:V:::::::::::::::::::::::S:::::::::::::::::R:::
Hbo1409         ::::::ES::ES::::::::::::::::::::::::::::::::::::::::::::I:::
Hmu2939         :::::::D:FS:::::::::::::::::::::::::::::::::::::::::G:::M:::
rrnAC2610       ::T:::AD:F:::A::::::::::::::::::::::::::::::::::::::::::S:::

consensus       ALDVEQGADVLMVKPALPYLDIVRAVRREFDHPVAAYNVSGEYAMLHAAAEKGWLDLEAV
#oth            31.1.2.........1.1...1.4321241.2.1...........1...112..2.1231
VNG2322         :::::::::::::::::::::V:SD::::::R::::::::::::::::::::::::::S:
HQ3443A         R::::A:::::::::::A:::::NT:SSN::R:::::::::::::V::::DR::V::::T
hla0533         RI:A:E:::::::::G:::::::GDL:::::::I:::::::::::::::::::::::::T
HVO_0087        :::::::::::::::G:::::::::I:EGY:::::::::::::::::::::::::::DG:
Hut2063         T::::E::::::::::::::::::D::ER::Q:::::::::::::::::S:Q:::::::T
NP0920A         R::::::::::::::::::::::SEL:::::R::::::::::::::::::DR::::RQS:
Hbo1409         T::::::::::::::::A:::::::::E::::::::::::::::::::::::::M::DET
Hmu2939         :::::::::::::::::::::::S:I:::Y:::::::::::::::::::S:::::::D::
rrnAC2610       D::::::::::::::::::::::KE::ESY::::::::::::::::::::::::::::::

consensus       AHESLLSIKRAGADLILTYFAEDVAERL-
#oth            .4...112........1.....32.54.1
VNG2322         ::::::::::::::::I:::::::::T::
HQ3443A         :V:::IAM::::::::I:::::KL:NQ::
hla0533         :::::::L::::::::I::::::L:::::
HVO_0087        :::::::M::::::::I:::::R::RQ:D
Hut2063         :Y:::::::::::::::::::::::GA::
NP0920A         ::::::::::::::::::::::S::::::
Hbo1409         :F::::AM:::::::::::::::I:DA::
Hmu2939         :R:::::::::::::::::::::I:Q:::
rrnAC2610       :Y:::::::::::::::::::::L:DE::