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[NOU] (PulO) COG1989 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases
9 genomes BUD0419 9 proteins
a Hsa
Halobacterium
sp. NRC-1		 b Hma
Haloarcula
marismortui		 f Hvo
Haloferax
volcanii		 g Hbo
Halogeometricum
borinquense		 h Hmu
Halomicrobium
mukohataei		 i Hut
Halorhabdus
utahensis		 j Hla
Halorubrum
lacusprofundi		 q Nph
Natronomonas
pharaonis		 x Hwa
Haloquadratum
walsbyi

VNG2285

rrnAC2525

HVO_2993

Hbo1527

Hmu3007

Hut2484

hla1126

NP1276A

HQ1021A

Pairwise sequence scores
Consensus score2446 HQ1021A hla1126 Hut2484 HVO_2993 Hbo1527 NP1276A VNG2285 Hmu3007 rrnAC2525
1400HQ1021A 2633 1130 1100 1234 1320 1050 764 1006 691
1603hla1126 1130 3840 1250 1363 1423 1183 931 1116 898
1710Hut2484 1100 1250 2788 1244 1325 1449 1006 1396 1006
1729HVO_2993 1234 1363 1244 2669 1587 1293 1010 1199 990
1779Hbo1527 1320 1423 1325 1587 2432 1285 1005 1272 950
1656NP1276A 1050 1183 1449 1293 1285 2741 873 1272 1073
1216VNG2285 764 931 1006 1010 1005 873 1664 918 1033
1646Hmu3007 1006 1116 1396 1199 1272 1272 918 2567 1186
1285rrnAC2525 691 898 1006 990 950 1073 1033 1186 1875 

545 symbols
consensus       ------------------------------------------------------------
#oth            111111111111111111111111111111111111111111111111111111111111
HQ1021A         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
hla1126         MIATSVGVERSPSDTISVVAQAGAWTASVAIIAQLVATSETVALAASRNPAGENAGAVAV
Hut2484         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
HVO_2993        ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hbo1527         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP1276A         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
VNG2285         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hmu3007         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
rrnAC2525       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

consensus       ------------------------------------------------------------
#oth            111111111111111111111111111111111111111111111111111111111111
HQ1021A         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
hla1126         RLAPGAISHHAVSPATPPMRWLPTIRAARPRSLRRSNASRNADGPRLGKTNGWPVAHAIA
Hut2484         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
HVO_2993        ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hbo1527         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP1276A         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
VNG2285         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hmu3007         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
rrnAC2525       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

consensus       -------------------------------------------------------MNATL
#oth            111111111111111111111111112222222222222332333333333334335234
HQ1021A         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::I:SI
hla1126         PRTVKRSPAYRLVPRRRRIARRSWVSPQSTGGSVRAIDRDTRTRTPNYARAGRGD:F:::
Hut2484         :::::::::::::::::::::::::::::::::::::::::::::::::::::::V::::
HVO_2993        :::::::::::::::::::::::::::::::::::::::::::::::::::::MFGIG::
Hbo1527         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP1276A         ::::::::::::::::::::::::::MSILHARRPRHRGFIRDSDAVCRVSSLLFGT::G
VNG2285         :::::::::::::::::::::::::::::::::::::::::::::::::::::::-----
Hmu3007         :::::::::::::::::::::::::::::::::::::::VLSSTFDSLVTVPGIGVA:PA
rrnAC2525       :::::::::::::::::::::::::::::::::::::::::::::::::::::::-----

consensus       PDLLRLAVVPVFAWAAWRDVRTRRVPNRLWLPLAALGIVLLAWDTLAHF-----------
#oth            213111534132313142123111313451311433234214123655511122333355
HQ1021A         S:::::CIM:ILV:::::::K:::L:SY::P::VM::V:::V:::SVY:::::SGLSPIY
hla1126         ::A:::F:::::::::LQ::::::L:::::P::Y:F:AL::I:ELA:IW::::::::PLA
Hut2484         ::::::L:::::G:V:::::::::::::T::::LV::V:::V::GWLVWTDGLVVDPRVF
HVO_2993        ::::::::L::L::T:V::::::::::IV:Y:::::::A::::EL:G::::::::::PPE
Hbo1527         ::I:::VI:::LG::::Q:IE:::::SVI:Y::V:::V::::::::P:L:::::::::AF
NP1276A         :::::::A::A:::::Y::IE:::I:::T::::L:V::IA:L:::V:VT::GFVTPTEVP
VNG2285         -------------------------------------------------:::::::::::
Hmu3007         S:::::VAI:::G:::Y:::K:::::T:A:::::::A:A:::::GYGAY:::::::::::
rrnAC2525       -------------------------------------------------:::::::::::

consensus       TPEDRLFLVRVAISLGFVAPLSYAFWRLGGFGGADAKALIVLAILFPTYPIYYLA--GLA
#oth            4455432432344133333114242143131111121232321213.32.6.52311454
HQ1021A         ::IAIA::F::SV:CLIII::::GL:AI:::::::::V:MT::::I::V:::QFL:::MT
hla1126         GF:EVR:A::A::::L:::::G::::Y::A::::::::::AI::::::F:E:AV:::::I
Hut2484         ::TPA::VFQ::F:::LLV::A::::WM::::::::::::::::::::::T:LV:::DM:
HVO_2993        :VF:::Y:I::GV:VCL:V::::L:::::::::::::::M:F:V:L::F:S:T:::::TE
Hbo1527         A:::I:YF:::G:::L:::::::I::::::::::::::::TIS::V::F:Q:L:P::::S
NP1276A         :F:R:R:V:QTLL:V::::::G:I:::I::::::::::I:T::VA::V::T::VF::QS:
VNG2285         ---------------------------------------M:::V::::::A:EF::::Y:
Hmu3007         VGG::::F:QA::::::IV::VT:::YM:S:::::T::FY:::L:::A::::::P::TTT
rrnAC2525       ---------------------------------------MLI:V:::I::V:::PMPSV:

consensus       LPLVRTPLGVFSLTILTNTVLLGLAYPLALAARNLARGEIELP-MFIGRPVAVDDLTTEH
#oth            3.455342...12.1.1.1.23223..241223.25314535332231111235325231
HQ1021A         F:V:TA::::::::::::::V:TA:::IN:ILH:ITDRVW:F:AALFA:::SI:::N:::
hla1126         ::::D:Q:::::::V:::::::A:::::G::VS::L:::RSAT:::FA::::T:S:PDR:
Hut2484         ::AI:Q:V:::A::::S:A::V:::::::::V::AFG:H:GKA::V::::I:AE:AVE:Y
HVO_2993        F::AT:R:::::M:V:::::IV::::::F:::::::D::F:F:IS:V::R:S:TS:S:A:
Hbo1527         ::T:::T:::::M:::::::V:AVG::::::::::VD:NA:::L::L::RIP:GS:A:A:
NP1276A         Y::YEA::::::F:::S:A:VV::::::V::V:::P::::TPA::::::::S:SAV:::Y
VNG2285         ::G:S:T:::::::V::::::FA:::::V:G:::ALT:NVSVV:::V::R::A:::A:V:
Hmu3007         V:TFQPAI::::::::S:::VA:AL::VGV::S:::::RVG::::V::K:::TPE::E:Y
rrnAC2525       :::QQ:AI::::::V:S::::A:VV::::V::G:::::RFS:A::::::::::P:V:E:Y

consensus       GRLLETPD-GFTRNGLDLDALRMYLRWRGCTLADLRADPDTHRDPDSLPETPHDPTDGAV
#oth            .3.2.2331141.3.1.1.......2..1521231125.464.4131234314411..33
HQ1021A         :Q:A::S::RI::::I:::::::::::::T::SAI:ES:T:::N:A:IIQ:-YA::::::
hla1126         :::F:DDA::T::::::::::::::::::A::::::EN::RF:::::VG::-::::::GT
Hut2484         :::::::::::::R:::::::::::T:::RS:SE:::::::Y:::A:::DE::S:G::SI
HVO_2993        :::F:S:E::V::::::::::::::::::L:F:::L:G:E:L:::::IG::-F:::::::
Hbo1527         :::F::TT::Y::::::I:::::::::::T::SE::EH::KL:::T:IT::-:E::::::
NP1276A         :::::::::::::G:::I:::::::Q:::SD:ES:::A::D::R--TV:TD:NR:G:::I
VNG2285         :S:::SSAG::::S::::::::::::::D:::::::S::G-L:H::T::D::G:::::::
Hmu3007         :L:::::::::::R::::::::::::::D::::E:::::AA::::::::AV:GEVG::NI
rrnAC2525       :::::S:::::D:G:::::::::::Q::::S:::I::::AQR:L:T:::AV:N::G::SL

consensus       ------ATDGGTVAAPDG----------------------------DDPWGAEAFLDDID
#oth            31134533112545762444643554333343342342222211223.1.1.23.12323
HQ1021A         ::::SITP:RSS:ERTSAKSHTDMRSSNLTDFDSVDA:::::::::T:V:::DR::EAVN
hla1126         H::VGPR::::::TGV::EGGADRPG::::::::::::::::::::::::A::R::EE::
Hut2484         ::::::PP::EGPLF:::EEMIQSEGEGTAHQTDDESTPRSDGGEYE::::::::FA::E
HVO_2993        :::HRA:::::AS:DF::DGETADAAGGDAP::GDDGREADSGGSF::::::AQ:::S:E
Hbo1527         G::DGM:V:::::ET---::::::::::::::::::::::::::::E:::::A:::::::
NP1276A         DEWDTSPET::S:::A--:::::::::::::::::::::::::::::::::::M:::A--
VNG2285         ::::::::::S-------::::::::::::::::::::::::::::G:::::A:::A:::
Hmu3007         ::::::R:::::TP::SPADY:::::::::::::::::::::::::::::::::::::::
rrnAC2525       :::::::::::DS:SG:VAEPSANDIGADGMDHPDQI::::::::::::::::R::::::

consensus       HSAYGTTPEQLRDGLDVLAD--RDEVWISPGIPFLVPMFAGLVVALTYGDVLFGVLGALG
#oth            34...12134.121.4123522625.111..2..21.324.1.21312..3124215221
HQ1021A         :R:::SS:T::::T:TL:SAPD:QT::V:::::::::ICL:T:I:F::::I:::LVIS:Y
hla1126         :G::::DA:T::G::A:V:R::K:R:LV:::M::V:::AI::::S::F::A::A::::V:
Hut2484         ::::::::AE::E::E::::::S:T:::T::::::::::G::::S:VA::M:LW::E:::
HVO_2993        G:::::S::K::G:::LVTT:::ES::::::::::::::V:::::FV:::::::::::::
Hbo1527         ST:::::::K:::::Q:V:S::Q:::::::::::I::::V:T:I:F::::IV::IV::::
NP1276A         :D::::::::::E::A::::AETEQ:::::::::I::::V:::::V:::::::A::D:F:
VNG2285         ::::::::A:::::::LIT:::H:D::VT::V:::L:L:::::::::F:::::Y::D:::
Hmu3007         -G:::::::G:C:::::I:A::E::::::::::::::T:::::LSI::::::VSL:RT::
rrnAC2525       ::::::S:Q:::::::::VE::Q:::::::::::::::::::::S::::::::SL:Q:V:

consensus       LA---
#oth            33121
HQ1021A         M-:::
hla1126         :V:::
Hut2484         IGALG
HVO_2993        IV:::
Hbo1527         :V:::
NP1276A         :::::
VNG2285         F:AA:
Hmu3007         :G:::
rrnAC2525       :::::