[R] (-) COG2520 Predicted methyltransferase 9 genomes BUD0424 9 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG1117 rrnAC1405 HVO_0929 Hbo0621 Hmu1912 Hut0930 hla2572 NP1886A HQ1624A

Pairwise sequence scores
Consensus score	2516	HQ1624A	hla2572	HVO_0929	Hbo0621	NP1886A	VNG1117	Hut0930	rrnAC1405	Hmu1912
1680	HQ1624A	2533	1484	1510	1467	1438	1514	1498	1536	1444
1933	hla2572	1484	2498	1691	1618	1630	1597	1661	1598	1624
1993	HVO_0929	1510	1691	2496	1828	1706	1742	1648	1679	1663
1980	Hbo0621	1467	1618	1828	2597	1705	1667	1685	1649	1693
1930	NP1886A	1438	1630	1706	1705	2627	1568	1718	1677	1674
1916	VNG1117	1514	1597	1742	1667	1568	2466	1710	1778	1620
1960	Hut0930	1498	1661	1648	1685	1718	1710	2480	1839	1837
2033	rrnAC1405	1536	1598	1679	1649	1677	1778	1839	2508	1885
2019	Hmu1912	1444	1624	1663	1693	1674	1620	1837	1885	2566

366 symbols
consensus       --MGVPCVRVPREAGEATRQRLADADLIDDDYEITVDEGTLYIPVTDPA-------AVPD
#oth            111311..2.3324..33.521.1222215412.434224122.121241111111.123
HQ1624A         MSD:I::::::PT:::R::TM::EQG:::TL:::DTT:DY:::::V:ST:::::::::::
hla2572         :::S::::A:E::R:::V:E::::::IL:G:H::A::GD:I::::A::E::::::::::A
HVO_0929        :::N:::::::::S:::A:R:::::G:L:H:H::::A::::::::V:AD:::::::::::
Hbo0621         :::N::::::STDE:::::RA:::R::V:QS:::::H::::::::::AS:::::::::E:
NP1886A         :::S:R:::::::D::TA:G:I::::ALA:::::EL:D:H::L:IVES:DEAALEA:LS:
VNG1117         :::A:::::::VDD::::::::::::::::THA:AAAD:A:H:::::A::::::::::::
Hut0930         :::A:::::::::D:::::A:::ER:::::GH::D:V:DAIL::IV::S::::::::::E
rrnAC1405       ::::::::::::::::E::::::E:N:V::G:D:::VD:Q::V:::::T::::::::::S
Hmu1912         ::::::::P:D:::::ES:::::::::VAEG:D:V:::A:I:::I:::::::::::::::

consensus       -DLD--VVDRDAPVRETQTMPADILGFEPSYERLGDIVIVDEDDPERAREIADAIVASDL
#oth            1334111.343335.24113..15.111.111.1.11212...1511.241.3.123112
HQ1624A         :QF:::I:THVVNT:DVP:S:::K:::D:::::::E:I:I:::NH:K:::V:K:::E::I
hla2572         :::ATAI:E:::AE:DRPQT::A:::Y:::L:::::::::::::D:::::::::VM:::V
HVO_0929        :::T:::::YEP:A:::::T:::L:::::::::::::::L:::::D::::::::::::::
Hbo0621         :EYE::::SF:VES:::::::::::::::T::::::V::L::::A:::SR:::::AE:::
NP1886A         L:A:::I:::RPAA:::::L:::::::::::::::::A:I:::::::::RV:N::AD:E:
VNG1117         :A:S::::SF:::P:R:::T:::::::D:::A::::::::::::SD::HA::::V:E::I
Hut0930         :EYA:::::H:S::::G::::::V:::::::::::EV::I::::ID::::::E::M:A::
rrnAC1405       ::FT::::EA:P::::G::::::A:D:D:::::I::VA::::::D::::M:::::MG:::
Hmu1912         ::::::::EY::::::S::::::R:D:::::::I:EVIV::::::::::V::::::::::

consensus       PVETVLNRASKVKGELRVRDWDVLAGD---------------GTETVHREYGCEFLLDIA
#oth            2321.1..1.112.23.1.2.1111231111111112222214..22.....22.51.22
HQ1624A         ::K:::::D:::S:PH:T:E:E::::E:::::::::::::::E:::C:::::YT:R:::E
hla2572         :C::::::::PIE::::::R::::::N:::::::::::::::::::::::::H:::::V:
HVO_0929        KA:::V::::::::::::::::::V:::::::::::::::::S:::::::::H::R:::D
Hbo0621         RA:::V::::::::A:::::::I:VD:TDEELSADDQRSSAPS:::::::::::::::::
NP1886A         :I:::V::::P:E::::::E::::V:::::::::::::::::T::::::::::A:EV:::
VNG1117         :::A:::::::I:::Q:::E:::I::::::::::::::::::S:::::::::HA:A::V:
Hut0930         :::::V:::::::::Q:::E:::::::::::::::::::::::::A:::::::::V::L:
rrnAC1405       ::RA:::::::I:::Q::::::I:::E::::::::::::::::::VT::::::T:D::L:
Hmu1912         ::R::::::::::::T:::::::::RP::::::::DDEPDRPA::V::::::::::V:LD

consensus       EVYFSPRLATERHRVVEQVGAGEHVFDMFAGVGPFAVPMAKRGAEVVGCDLNEAAIEYLR
#oth            3.............124214221422........111.2.32..42.1312.24.121.2
HQ1624A         S::::::::::::::IT::D:HD::I::::::::::::::A:::D::AAE:::N:V:::S
hla2572         :::::::::::::::I:::DPD:A:I::::::::Y:::::A::::::A:::::R:V::::
HVO_0929        T::::::::::::::::AIQE:::::::::::::::::A:AA:::::A:::::::VAF::
Hbo0621         ::::::::::::::::Q::TE::R:::::::::::VI:::::::::::::::A::V::::
NP1886A         ::::::::::::::I:SD:E:D:S:::::::::::VI:A:::::DC::V:::A:::::::
VNG1117         A::::::::::::::::::T::::::::::::::Y:::::SA::R::AT:V::T::D::Q
Hut0930         A::::::::::::::::::::::QA::::::::::VI::::E::TC::V:V:PD::::::
rrnAC1405       :::::::::::::::TK:::E::QT:::::::::::I:F:::::SC::T:I::T:::::Q
Hmu1912         A::::::::::::::::::::D:RAL:::::::::V::F:Q:::TA::V:V:PT::::::

consensus       ENAERNGVADRVTAIAGDVREVADD-----------YEDWADRIVMNLPHSADEFLETAV
#oth            3..21.2.2114.225....43243111111111111411.1.21.....1.12..11.3
HQ1624A         I:::Q:D:D:NF:IVS::::TLP:S::::::::::::I:::::LI::::::::::::::I
hla2572         ::::::::::::::::::::GI::A::::::::::::A:T:::L::::::::::::::::
HVO_0929        :::A::D::::L:::H:::::::A::::::::::::::G::::LI:::::::SG::D:::
Hbo0621         :::R::::EE::::RQ::::D:::::::::::::::::G::N:::::::::::D::D:::
NP1886A         R:::::S::::I:::H::::::VSEPPDERSEAADS:D::::::::::::::::::D:::
VNG1117         A::A:::::::::GV::::::::GE::::::::::::TG:::::::::::T:::::::::
Hut0930         :::R::D::::I:::E:::::TVPA:::::::::::HA:::::::::::::::::::::L
rrnAC1405       A::::::::::M:G:C:::::::GE::::::::::::::::::V::::::::::::::::
Hmu1912         :::R:::::::::::E::::A::P:::::::::::::::::::L::::::::::::DA:E

consensus       RLAGDECVLHYYDIQHEDDPFGPGERAIRAAAEPAYDVTVETRHTVRSYAPHEYNVCLDV
#oth            31.221142.2.....1122121.33.112.1314.224131122.1....1.3.111..
HQ1624A         :::::::MI:::::::::TLYQ::IE:::S::::N:KL::::::E::::::::::I::::
hla2572         :::::D:AI:::::::::::::::R:::E:::GDE::AV:::ERV:K:::::::::::::
HVO_0929        :::S:D::I:L:::::::::::::LA:V::::::::E:E:VNEYV:::::::::::::::
Hbo0621         ::::E:::::::::::::::::::IE:::E::::Q:::R:D:ERV::::::::::::V::
NP1886A         ::::ND:L::::::::DS:::::::::::E::A:E:::DI:::RE::::::::L::::::
VNG1117         A::::::T::F:::::::GR:DA::A::::::R:::::::A::::::::::::F::V:::
Hut0930         EI::E:A:V::::::::::::::::::::E::GDE::::::::::::::::::L::V:::
rrnAC1405       :::A::::V::::::::::L:::::K:::::::::::::::::::::::::K:H:IV:::
Hmu1912         TI:AND::::::::::::::Y::::::::::F::D::::::::::::::::::H::V:::

consensus       RLTRR-
#oth            2.4211
HQ1624A         ::Q:::
hla2572         ::I:::
HVO_0929        :::K:A
Hbo0621         T::A::
NP1886A         ::::-:
VNG1117         S:S:::
Hut0930         ::S:-:
rrnAC1405       ::::-:
Hmu1912         ::A:-: