[IQR] (FabG) COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) 9 genomes BUD0427 9 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG2158 rrnAC2741 HVO_0296 Hbo3733 Hmu2844 Hut2326 hla0705 NP1294A HQ1840A

Pairwise sequence scores
Consensus score	1929	hla0705	Hbo3733	HQ1840A	VNG2158	HVO_0296	NP1294A	Hut2326	rrnAC2741	Hmu2844
1470	hla0705	1921	1397	1302	1130	1136	1255	1260	1244	1216
1436	Hbo3733	1397	1961	1497	1038	1086	1189	1171	1173	1114
1374	HQ1840A	1302	1497	1940	1008	1064	1093	1191	1158	1131
1243	VNG2158	1130	1038	1008	1907	1257	1046	1141	1048	1058
1398	HVO_0296	1136	1086	1064	1257	1925	1195	1229	1262	1183
1475	NP1294A	1255	1189	1093	1046	1195	1933	1317	1279	1282
1556	Hut2326	1260	1171	1191	1141	1229	1317	1920	1485	1476
1571	rrnAC2741	1244	1173	1158	1048	1262	1279	1485	1936	1568
1535	Hmu2844	1216	1114	1131	1058	1183	1282	1476	1568	1933

265 symbols
consensus       MDLELDGNAALVTASSSGLGLASAEALAREGANVVVCGRDEERLDAAREEL--EAADDGD
#oth            .2.313112112..211...3..14...42.12.1311.232114414332224143413
hla0705         :::QI:::::::::::::::K:::K::::::V:::IN:::::::A::K::I::::VAT:E
Hbo3733         :N::IA::::::::::::::N:::R:::Q::V:::MN::::D::ES:VA:VQAD::::AT
HQ1840A         :::::TD:V:::::::::::K::GR:::S::::::LN::NQD:::::V::VREA:::TAS
VNG2158         :E:G:::DV:V:::::::::K:::A:::::::D::::S:::::VV::A::I::G:DAA:S
HVO_0296        :E:G:::DTVV:::::A:::R:::A:::D:::::::::::P:::A:TES::::-GDL:::
NP1294A         :::DI:::::::::GTA::::::::::::N::::A::::::D::SR:EAK:::::I:G::
Hut2326         :::Q:E::V::A::AT::::::::::::AD:::::::::TA:::ES:::Q:::A::GP::
rrnAC2741       :::::::::::C::AT::::::::::::AD::::A::::TP:HV:E::NR:::::VG:::
Hmu2844         ::::::::V::C::AT::::::::T:::::::H:A::::TASHV:D:::Q:::::TG:::

consensus       VLAVEADITDPDDVAALVEETVEEFGGLDHVVTSAGGPPSGPFLDTTDDDWYDAYDLLVM
#oth            .31342.1.15342222.2421321122..111....12115.3322222.25.111...
hla0705         :V:QP::L::A:E::::::A::D:::TI::L::::::::::A::::D:E::QH:F:::::
Hbo3733         :VGQTG:L:::E:IE::::RP:::::R:::L::::::::::::ME:::::::E:::::::
HQ1840A         :IGHAG:L:::::I:D:::RP:A:::::::LIL:::::::K:::E:::EE::E:F:::::
VNG2158         :RG:P:::::GA::::V::TA::T:::::::::::::V:::Q:TAV:::::T::FE::::
HVO_0296        ::G::T:::NKG::E::::AA::::::V:::::::::V:P:G:A:L:ERE::G:F:M:::
NP1294A         ::::Q:::::REALQGF:GK:I:T:D:::::::::::::::S::::D:E:::::::::::
Hut2326         :R:I::::::::H:E:::A::::T::::::L::::::::::S::::PT:A::::::::::
rrnAC2741       ::::::::::::QIE:::::::DS::::::::::::::AP:::ME::ERE::S:::::::
Hmu2844         ::::::::::Q:H:::F:::::G:L:::::::::::::S::D::S:::::::Q:::::::

consensus       SVVRTVRAAYPHLRESDGGTIVNITSRSVKEAIDDLVLSNAVRRGVIGLMKTLSRELAPE
#oth            .1.12313.521.52223.1111...2..3.2112.1...1..12.1..3.1313.21.2
hla0705         ::::LA:E:::::K:G::::::::::::::::::S:::::S::M:::::E::::K:F:::
Hbo3733         ::::S::::AD:::AG::::::::::::::::::G:::::S::M:::::E::::K:::::
HQ1840A         :A:::::::E:::T::EH::::::::A:::::::G::::::::MS::::E::I:K::::D
VNG2158         :::::LD::HE::VAG::::VTC:::T::S:P:EG:::::::::::V::A::VA::W::D
HVO_0296        :A:W:::::R:::EA::V:::TC:::T::::V::::I::::::::::::V:S:::::::G
NP1294A         :::::::S:L:T:A:DG:::V::::::::Q:VM:::::::S:::S::::::S::H::G::
Hut2326         :A:::T:::::::K:::V:S:::::::::R:V::::::::::::A:::::::QA::F::D
rrnAC2741       :::W:T::::::::D::A:::::::::::R::::::::::::::A:::::::QAN:F:::
Hmu2844         :A:W:T:F::::::D:EA::V::::::::R:V::::::::S:::A:::::::QA::F:::

consensus       VRVNAVLPGAHETPRIEELVEAAVERGEYDSYEEGLDDWADGIPLGRIGDPRELGDVVAF
#oth            1.1.1.1..3...2..21.1221.2.11212..4.233.2342.331212.31..31..2
hla0705         I:A::::::P:::S::RD:::::::::D::::::::::::QN-::::::::M:::NT:::
Hbo3733         ::A::::::S:::::::::I:QG::::::ED::D:::::GQ:::V:H::::MD::RT::Y
HQ1840A         I:A::::::T:::::::::::QG:::D::E:::S::EE::::::I::V:::M:::RT:::
VNG2158         ::A:V:Q::P:::A::::::S:::A:::A::::A::AG:SEEV::D:L:E:S::::::::
HVO_0296        :::::::::::::S:::::::::::::DH:T::::::S:S:::::::V::::::::::::
NP1294A         :::::::::::::S:::::::D:::::D::D::A:::::SE:V::E:V:::::::ET::W
Hut2326         :::::::::::::A:::::IDD::::::::::::::A:::ADV:M::::E::::::::::
rrnAC2741       :::::::::::::::::::::::::::::::::::IKS:::A-::Q:V:R:E::::::::
Hmu2844         ::::::::::::::::Q::I:D::S::::::::Q:RAE:S:A-:::::A:::::::::::

consensus       LSSPRSSYVTGAALPIDGGSMRS--
#oth            .1.3313123.232.1...234231
hla0705         ::::K:G:IN:T::::::::TGANL
Hbo3733         ::::Q:E:IN:V:V::::::GA:NL
HQ1840A         ::::V:T:LD:V:I::::::GA:NL
VNG2158         :A:D:A:F::::SV:V:::RLWG::
HVO_0296        :A:D:A:F::::CV:V:::RL::A:
NP1294A         :::E:A:::S::T::V::::T::V:
Hut2326         :::::A:FL::::I:::::::::::
rrnAC2741       :::::::::::T:::V:::A:Q:::
Hmu2844         :::A:::::::T:::::::::::::