[OU] (-) COG1585 Membrane protein implicated in regulation of membrane protease activity 9 genomes BUD0448 9 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG0322 rrnAC1802 HVO_0802 Hbo0733 Hmu0872 Hut0566 hla2735 NP1188A HQ1575A

Pairwise sequence scores
Consensus score	1361	VNG0322	HQ1575A	hla2735	HVO_0802	Hbo0733	Hut0566	NP1188A	rrnAC1802	Hmu0872
664	VNG0322	1236	548	467	535	555	539	562	480	520
925	HQ1575A	548	1707	724	828	823	665	769	663	662
913	hla2735	467	724	1480	854	776	703	770	600	617
994	HVO_0802	535	828	854	1463	942	708	739	713	658
956	Hbo0733	555	823	776	942	1548	755	788	600	667
920	Hut0566	539	665	703	708	755	1537	822	697	712
966	NP1188A	562	769	770	739	788	822	1583	730	791
841	rrnAC1802	480	663	600	713	600	697	730	1444	834
851	Hmu0872	520	662	617	658	667	712	791	834	1381

245 symbols
consensus       ------------MELLLGESLSLLLVLAGAGLSIAEALAPGAHFIVLGVALLAAGLVGLL
#oth            112455433333565233531142.323.221533.13...1112.1.11.131.13.12
VNG0322         ::::::::::::::GVF:Q:::FV::VI::V:C::::::::::L::::::::::::A:MF
HQ1575A         ::MVTQAISVVAQLS:PA:T:::::IT::L::::L::F::::::V::::S:::T::::::
hla2735         ::::MDVL::VQSG::SPDT:P:::LT::LL::M::::::::N:::V:I::IG:::G:::
HVO_0802        ::MAYPPL:PLQTG:VSP:T:P:::::::L:::L:::I::::::V:::::::::::A:::
Hbo0733         ::MLRSPLTAFLQPTIPPDL:PYM:IV::I:V:L:::::::::L::::::::::::I:::
Hut0566         :::::::::::::VTV::AD:::::L:V::L:V:G::F::::::::::I:::V::::::A
NP1188A         :::::::::::::AE:::Y:VPF::::V::V:MVM:GF::::::::V:::::T:::::::
rrnAC1802       MVNPLATVAPLQA:P:::M:::I::F::::::IVG::::::T::F:::::::T::::::F
Hmu0872         ::::::::::::-MS::S::::T::FVG::L:LV:::V::::::F:::::::T::V:::F

consensus       LPP----GAAAPLVLAGLVLVFGAAALYGYREFDIYGGKGSGQTSDSDSLKGKTGRVTER
#oth            35513222343432133212331331122.142131323.432.21.32.3.3412.122
VNG0322         VLS::::::T:-FQ:::::::V:MV:::V::YYE::E:T:::::QS:SD:R::R:Y:VDP
HQ1575A         :--:::::T:S::::S:::VL::S:::L:::::::::TT::E:::::N::T:TY::::::
hla2735         :TSLGVA::GLT::M:V:T:L:::::F:::H:::L:::::QQ::::::A::::::T:::E
HVO_0802        IA:::::-L:S:II:GL::F::::L:::::::L:::::::E:K:::::A:T::M::::::
Hbo0733         :G:::::SL:G:I::GV:::::::L:::::::::L:::::::K::::A::::R:A:::::
Hut0566         ::::SL::IF:VVIM:::::GV:SM:::A::Q::F:::::T:R:::::::::::::::::
NP1188A         VGG:VLP:::L:::::AV:::A:G:::::::Q::F::::::::::::S::Q:Q:::::Q:
rrnAC1802       I:A:SL::IL:::I:TVV::ATT:VT:W:::KL:-FAAP:R:::LS::::T:QF:T::::
Hmu0872         S:V:G::::LGI::::AA:::ATGLT:W:::RL:::D:E::A::L::N::R::F::::::

consensus       VTPTDGEVKLDD-GGFNPYYAARSVDGEIEEGEEVMVVDPGGGNVVTVEAVAG-GEDDID
#oth            ..544.211.3511..112.2..25523131131.2.1.......21..33461561312
VNG0322         :::RE:R:D:EH::::DSS::::TTT:T:PADT::V:::::::::::::P::D:------
HQ1575A         ::::Q:Q::::A::::D:::S:::::D:LTA:T::V:::::::::L:::PLV:::V:E::
hla2735         ::TAG:::::SG::::::::::::IE:T:::::::::::::::::::::SMGY:V:::::
HVO_0802        ::::S::::::E:::::::::::::H::L:A:T::I:::::::::::::G:GP::::E::
Hbo0733         ::::Q::::::EG::::::::::::S:::P::S::::::::::::I:::SFE::TL::::
Hut0566         ::G:G::::::S::::::H:Q::AF:ED:P:::::::::::::::::::SM:TLST:::E
NP1188A         ::ED:::I:::S::::::::Q::AL::::G:::K:::I:::::::::::::SA:F:::::
rrnAC1802       ::RS::::::E:::::::::Q:::SGDP::::A::I:I:::::::LE::::ES::A:E::
Hmu0872         ::Q:::::::Q::A::::::Q:::::::::::A::::::::::::::::::S::-G:A::

consensus       RELARDRARRD----EDRAPDA----------------------------DSESERE---
#oth            331223253461111357446452222233332212233333534111112624133533
VNG0322         ---:AAAGNDA::::::GV:G-::::::::::::::::::::::::::::-------:::
HQ1575A         :A::TEQ:N:ETTNS:NED:TPTPTPNSNMTQTDDTQSDEQRDSESESGLE::::::RER
hla2735         K:::A::::KE::::AQ::A::S::::::::::::::VDDERE:P:::::ET:T::::::
HVO_0802        :::::E::::H:::::ES:ERD::::::::::::::::::::::::::::EE:L:::GTE
Hbo0733         :::::G:SNDG:::::G:SSSDD::::::::::::::EDGETVTD::::::::T:T:QAK
Hut0566         A::D:G:EET::::::TH:D::E::::SPTRETSDGGVGEPTGEF::::::H:T:SA:::
NP1188A         ::::A::K:KT::::SNDE:TPGNESAAASEPESDGGSNEQDHSD::::::T:::S:PA:
rrnAC1802       :A:E:::N:S:::::A:TE:--::::::::::::::::::::::::::::ER::::A:::
Hmu0872         :Q:ET::EQSV::::T:AE:ERE:::::::::::::::::::::F::::::PDA:SDAA:

consensus       -----
#oth            32111
VNG0322         :::::
HQ1575A         EPDLS
hla2735         :::::
HVO_0802        GV:::
Hbo0733         D::::
Hut0566         :::::
NP1188A         :::::
rrnAC1802       :::::
Hmu0872         :::::