[C] (FixC) COG0644 Dehydrogenases (flavoproteins) 9 genomes BUD0495 9 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG1198 rrnAC0359 HVO_2650 Hbo2389 Hmu1304 Hut1465 hla1621 NP3024A HQ2910A

Pairwise sequence scores
Consensus score	3475	VNG1198	NP3024A	HQ2910A	hla1621	Hbo2389	HVO_2650	rrnAC0359	Hut1465	Hmu1304
2328	VNG1198	3565	1928	1981	2042	2036	2055	1957	1981	2012
2394	NP3024A	1928	3525	2119	2083	2053	2075	2084	2172	2260
2639	HQ2910A	1981	2119	3654	2263	2445	2470	2106	2129	2082
2647	hla1621	2042	2083	2263	3591	2321	2470	2110	2091	2169
2713	Hbo2389	2036	2053	2445	2321	3552	2622	2141	2171	2166
2796	HVO_2650	2055	2075	2470	2470	2622	3539	2211	2128	2270
2557	rrnAC0359	1957	2084	2106	2110	2141	2211	3506	2243	2332
2550	Hut1465	1981	2172	2129	2091	2171	2128	2243	3548	2339
2624	Hmu1304	2012	2260	2082	2169	2166	2270	2332	2339	3485

485 symbols
consensus       MERVDVAIVGGGPAGSAAAHAAAEAGADAVVLEKGVPRADR-DGLGPDSTDAAGILDYWV
#oth            .232...11....1.22.13...65..21214.1....2..2331.........2....3
VNG1198         :TD::::V::::::::T::Y:::D:::::::Y::::::S::::R::::::::::F::::L
NP3024A         :QQ:::::::::::::::G::::TN::::::I::::::::::::::::::::::::::::
HQ2910A         :::F:::VI::::::A:::R:::VN::S:::::R:::::::PGQ::::::::::::::::
hla1621         :::::::::::::::::::::::TD::::L:::::::::::::R::::::::::::::::
Hbo2389         :::F:::V::::::::::::::::S::S:::::::::::::P:R::::::::::::::::
HVO_2650        ::::::::I::::::TS::::::S:::S::::::::::::::P:::::::::::::::::
rrnAC0359       ::H:::::::::::::S::E:::NH:::::L:::::::::::E:T:::::::::L::::F
Hut1465         :::T:::V:::::G:A:::R:::M::::VTLF::::::T::N:E::::::::::::::::
Hmu1304         :::::::::::::::TS:GR::::Q::E:::V::::::::::::::::::::::F::::T

consensus       DIMDIDPDEFPDDVVLSELDRAEFIGPTESLTLTETGIDSSYDGFGFTFHRARFDDWLRD
#oth            121133332311412343.24.2.3..42233243.12142115..2121..1...1..4
VNG1198         :VAGL:VADI::::IEHD:AD::::::::RV:VDR::::ND::A::::::::::::::::
NP3024A         ::::LG-EPV::H:KHR::NA::::::EDR:E::D:S::A::PN::::M::::::::::E
HQ2910A         :::::::E::::::I:D:::Q:T::::::::::ES::::::::N:::CM:::::::F::E
hla1621         :::G:H::::D:GI:QR::N::::R::D::A:::S::::::::K::Y:::::::::::::
Hbo2389         :::::H:::M:::::::T:::::::::N:::I:R:::F:T:::H:::CM:::::::F::N
HVO_2650        :::G:H::::::AI::DI:::::::::N:::::RS::::::::E::Y:::::K::::::S
rrnAC0359       :::::PRS:::E::::::::G:K:Y::STEM:::::::S::A::::I::::::::::::E
Hut1465         ::::E::A:I:E::I:::::G:T:H:::::V:IAD::L:G::::::::V::::::::::Q
Hmu1304         ELAGFG::::::S:K:A:::G:::::::::VLIE::::::A:P::::::Q::::::::::

consensus       RAEDAGAEYRVGTSVRDVETD--LS---------------GS---PRHTVRLADGEDIGA
#oth            ..12...3.11232.34111311431111111111111113642232.126.33234241
VNG1198         :::A:::R:EA::T:KT:DSH::ID::::::::::::::::DG::HE::LH:GG::TVTT
NP3024A         :::A:::T::::EA:G:I:S:::::::::::::::::::::R::::T:::T:R::TEFV:
HQ2910A         :::::::T:::::A::::::S::ANQITATDGGVAADVSHATNAG::::IQ:::NTN:::
hla1621         ::::::::::A:V:::G:D::PAV::::::::::::::::PESDD:::V:E::S:DTV::
Hbo2389         :::T:::::::NV::::::S:::RD::::::::::::::::::::::::::::S::::E:
HVO_2650        :::::::::::KA:::::::::::D:::::::::::::::AAVDDA::V::::N:::V::
rrnAC0359       ::T::::D::::V::TS:::::::R:::::::::::::::N::::::::::::N::::A:
Hut1465         :::::::D:::::::TG:::E:::::::::::::::::::::S:::T::LS::GDGTVE:
Hmu1304         :::T:::R:::::::TA::::::::::::::::::::::::G:::VE::LK:S:::S:V:

consensus       DFVVLADGPQRTVTNRVLDQFLPAD--ATDRLSSRRANHIAYQEHRRMPEELFDE--DAI
#oth            2311.......11.4311163.124446334132441.......1.23.32124214441
VNG1198         EYL::::::::QI:M::::PL::::TQ:STV::PPD::::::::Y:QF:DDV::D::ASL
NP3024A         :YLI::::::::::DG:IGSW::DS::K:EG:ET::::::::::Y:EF:A:::ED:::R:
HQ2910A         SV:I:::::::Q:::::::TY:SF:::V:::::T:D::::::::::EL:AAVAE:VSRS:
hla1621         :::::::::::::::K:::EY::::AA:S:::A::T::::::::Y::V:::VYE:VN:::
Hbo2389         :::::::::::Q:::K:::R:::F:::I::::ATTKV::::::::::L::AVARDVEG::
HVO_2650        E::::::::::::::K:::DL::FP::I::::::TE::::::::::EF:P:::::VDG::
rrnAC0359       EY:I::::::::I:GGT:::::::GQTMA:IMP:NKV::::::::::::::::TP::EF:
Hut1465         :AL:::::::::::LD:::::::DGESSGQY::PD::::::::::::::A::::P:::H:
Hmu1304         :AL:::::::::::G:::::::::NESLSE::P:TE:::::::::::::::::P::::R:

consensus       KFWWGVMPGHTAYPWIFPNDDNVARIGLTMPIGLDIDDV-DRDAYALLRADDERIPQGRE
#oth            4....4...1.....1...22411.1.......1112233233414..421.131.4.33
VNG1198         :::::W:::E:::::V:::QG::::V::::::::::A:F::P:DWR::::::DK::S:S:
NP3024A         :::::H:::::::::V::::GT:::V::::::::::::IDN:S::P::QP::::L:::GT
HQ2910A         L::::H::::::::::::::G:I:::::::::::TL:E:S:P:S:P::N::::QL:R:S:
hla1621         V::::::::E:::::::::A:R:C::::::::::::::F:::::::::D::::S::R:S:
Hbo2389         :::::Y:::::::::::::::::::::::::::M:LS:IEA:EK:E:::ES:::::N:K:
HVO_2650        :::::Y:::::::::V:::::::C:V:::::::::::E:D:::::::::E::::::::::
rrnAC0359       E::::I::::::::::::::NS:::::::::::::::AY::SAEWD::N:S:DS:::::Q
Hut1465         E::::::::::::::::::::Y:::::::::::M:::::E:::D::::EP:::S::P::V
Hmu1304         Q:::::::::::::::::::::::::::::::::::::Y::ASEW::::E::DK:::::T

consensus       YIRRLLEQEYGDEYDID-DFPIVEDRGKSNGTETYPISSTRPIDSPTEAGIAVTGGAMGA
#oth            .12.1.1421222.11332..11132..54...1.1....1.11..22111112.....1
VNG1198         ::H:F:TEV::::::::TA::::D:H::AG::::::::::Q::E::V:::::::::::::
NP3024A         ::E::::TV:PE-:ELA:::::L::::::::::::::::::::E:::D:NV:IV::::::
HQ2910A         ::E:::::::::R:::PE:::L::S:::D::::::A::::::::::A::::L:V:::::T
hla1621         :V:::::WQ:::::::EE:::::::A::R:::::::::::::::::::V::::::::::T
Hbo2389         ::::::::::::::::EA::::::G::::K:::::A:::::::::::DV:::::::::::
HVO_2650        :V:::::::::::::::E:::L::::::TK:::::A::::::::::A:::::::::::::
rrnAC0359       ::E::::R:FQA-::L:::::L::E::::K:::::::::::::E::VG:::::A:::::T
Hut1465         :::::::::FP:-::LE:::::::::::QA:::A::::::::VE:::G:NV::V::::::
Hmu1304         :VE::::R:FP:-::L::E::L::::::TD:::::::::::::::::D:NV::V::::::

consensus       TSAFHEGGDHVAVRTGAIAGELAATGDLERYNDAWKDAIGDEILRNVAFADIVRGYGPDD
#oth            ..........1.31..31..11..424146..31.121112.23..121.23.4333.32
VNG1198         ::::::::::::H:::LL::R:::::S::E:::::HA:::::VK::::M:N::GSF::::
NP3024A         ::::::::::::::::KL:::::::EA:GS::A::H::::S:VR::CV:::M::::E:::
HQ2910A         ::::::::::T:M::::::::V::::E::S:::R::::::::::::::M:::::E:E:::
hla1621         :::::::::::::H:::L::::::A::MAP::RR::ES:::::V:::TM::M:AD:::::
Hbo2389         ::::::::::::::::::::::::S:::ST:::R::A:::::VR:::::::V::::::::
HVO_2650        ::::::::::::::::::::::::E:::SD::ER::E:::::::::::M:E::HD:::AQ
rrnAC0359       ::::::::::::::::K:::R:::NDR::::::::H:::::::::::T:::M::DWR:G:
Hut1465         ::::::::::::I:::K::::::::D::GQ::A:::::L:P:MR:::T:::L:::M::T:
Hmu1304         ::::::::::::::::S::::::::DA:D:::::::::LES::::::::::L:E::D:TT

consensus       WDRAFRTARAMLDAD----GILARQALRAGISGAKLAARYKRAKFRYRNGRYVQLRESEY
#oth            .14614333513463133436577554421643523435.23524541413.2225112.
VNG1198         ::DTI:IT:S::::T:DTGSVISKSSA:SAAG:L::YGK:RK:::GL::::::S:HA:D:
NP3024A         ::HL:SLVDGLTSE::::::FTPHE:IY::W::T::F:E::YRA:TF:::G:A:V:::D:
HQ2910A         ::W::K::QSL::DS:AGY::FDINN:T:::GA:R:LT::::T::::::D::::I:::::
hla1621         :N:IIGA:D:::A:::AGD:L::-:PY:S:WESV::L:G::WN:H:VKKD-::GID::::
Hbo2389         :::G:AA::K:MESSSDKLFD:NMGTV:::L:VGRV:TQ::K::YKS:SDK::::S:D::
HVO_2650        ::KT:KA::KL:EK::EGYKAFGAAK:S::F:A::::TQ:Q:T:VK::K:K::::::D::
rrnAC0359       ::::::::NDLM::R::::::K:DA:::G:YN:I:MVLA::WG::SS:::K::::::DD:
Hut1465         :::H:::I:R::ERT:::::SRK:::IA:::::IDVYL::R:KRWS::GD::I::P::Q:
Hmu1304         :::V:A:VN::QTV::::::S:W::::A::TL:L:TV:G::WR:YQ::D:G::::A::::

consensus       AV---
#oth            33211
VNG1198         SL:::
NP3024A         SIR::
HQ2910A         V::::
hla1621         VY:::
Hbo2389         :YADS
HVO_2650        :L:::
rrnAC0359       :::::
Hut1465         T::::
Hmu1304         T::::