[K] (-) COG1813 Predicted transcription factor, homolog of eukaryotic MBF1 9 genomes BUD0510 9 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG1029 rrnAC0535 HVO_1299 Hbo0244 Hmu1491 Hut1051 hla2615 NP2146A HQ3361A

Pairwise sequence scores
Consensus score	1285	hla2615	HQ3361A	HVO_1299	Hbo0244	VNG1029	Hut1051	NP2146A	Hmu1491	rrnAC0535
1020	hla2615	1317	896	947	903	803	835	843	490	874
1041	HQ3361A	896	1305	990	1010	809	779	893	480	859
1077	HVO_1299	947	990	1277	1014	822	782	877	486	868
1056	Hbo0244	903	1010	1014	1278	811	840	883	475	877
923	VNG1029	803	809	822	811	1324	881	848	477	876
967	Hut1051	835	779	782	840	881	1307	980	530	895
1025	NP2146A	843	893	877	883	848	980	1338	519	972
558	Hmu1491	490	480	486	475	477	530	519	717	534
993	rrnAC0535	874	859	868	877	876	895	972	534	1281

189 symbols
consensus       MPQCEMCGAEQASLKTVKVEGAELDLCDDCADFGTEVRTESSS-STSTKYSTSSSSSSSS
#oth            131111114254223221211112321331421111142232211322111131132432
hla2615         :::::::::DE:::T:T:::::::E::SS:T:::::::D::TG::GGS::::::::GT::
HQ3361A         ::::::::SD:S::T:::::::::E::G::KE:::::::::::::::::::::::N:DE:
HVO_1299        ::::::::SD::::::::::::::Q::::::E:::::::::T:::A::::::T:::G:N:
Hbo0244         -----:::K:RP::T:::::::::E:::::SE:::::::::::A:G::::::::::G:::
VNG1029         :A::::::T:VS:P:::::::::I:V:::::E:::::T:Q:::::::::::::::::Q:A
Hut1051         -----:::::T:APN::::::::::V::E::::::::::QE::::A::::::D::G::::
NP2146A         :V::::::::TG:P::::I::::::V:::::::::::Q:QDT:::::::::::::G::::
Hmu1491         -------------------------------------------:----------------
rrnAC0535       :V::::::T:VS:PNR::I::::::V::E:T::::::K::ET::::::::::::::::::

consensus       ---S--SASSGGSSGSSSGGS--RRRDMFDEMDEIAQDYDDRIRQARESRGLSQEELADS
#oth            111233143233213352234223211...2...213.1.3...41..43211..1..42
hla2615         :::GSS:G:::::::::G:ST:::P:::::N:::::T:::::::N::::::::::::::Q
HQ3361A         ::::TN:TG:TT::A:Q::::::P::::::N:::::A:::N:::::::::S::::D::::
HVO_1299        :::-::-SR:S:::S:::SKT:::::::::D:::::T:::::::::::::::::::::Q:
Hbo0244         ::::SS:::::S::S::::::TR:::::::D:::::A:::::::::::NN:M:::D::::
VNG1029         :::-::-G:::::::TN:::R:::::::::::::L:G:::T:::S:::QA:::::::::E
Hut1051         ::S:SG:::G::G::G::::G::S::::::::::LV::F:Q:::S:::AADM:::::::Q
NP2146A         GGS:GS:T::STG::GGG::G::S::::::::::VV::::::::E:::AASMT:::::N:
Hmu1491         :::-::---------------::----:::::::L:::::Q:::E:::E:::T:::::GE
rrnAC0535       :::-::--::SS::S:TG:::SG:::::::::::V:::::::::KG:::Q::::::::KQ

consensus       LNEKASLIRKLERGDILPSDDVQKKLERELDISLV-EGGSD-DDAEWSGGSS-GTTTLGD
#oth            ..1...1...1.21241.2.211421.24.2.3.213.44413151.11.224233....
hla2615         :::::::::::::::T::T::I:R:::S::::T:::::E:A::::D:DS:DA:::M::::
HQ3361A         :::::::::::::S::::::::RE::::R:::::::::TDT::ED::::::::T::::::
HVO_1299        ::::::::::I:::::M:P:S:R::I::K:::::::::E:::::S:::::G::T::::::
Hbo0244         ::::::::::::::::::P:N:R:::::K::::::::::DE:EES::::::::T::::::
VNG1029         ::::::V:::::H::S::::::REE::DY:G:L:TES:AE:AS:TD::S:GDSAGL::::
Hut1051         ::::::::::::H::H:::::::Q::::A:::E:TES::T:::::D:DS::AV:EY::::
NP2146A         ::::::::::::::EV::::S::R::::::::::S:T::GS:::ND::::::T:K:::::
Hmu1491         ::L:::::::::H::T:::::::TT:::::::::S:A:ST::A:E:::::::S:EY::::
rrnAC0535       ::::::::::::Q:NS:::::::::::SA:E:::S:A:::A::ET:::::::D:EY::::

consensus       VVKRK--D-
#oth            112..11.1
hla2615         :::::::::
HQ3361A         :::::::::
HVO_1299        :I:::::::
Hbo0244         :::::::::
VNG1029         K:R::SD:S
Hut1051         ::E:::::S
NP2146A         :::::::::
Hmu1491         :::::::::
rrnAC0535       :::::::::