[E] (GloA) COG0346 Lactoylglutathione lyase and related lyases 9 genomes BUD0528 9 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG1114 rrnAC1409 HVO_0914 Hbo0627 Hmu1918 Hut0935 hla2331 NP4460A HQ1605A

Pairwise sequence scores
Consensus score	2035	VNG1114	NP4460A	hla2331	HQ1605A	HVO_0914	Hbo0627	rrnAC1409	Hut0935	Hmu1918
1484	VNG1114	2094	1273	1291	1374	1391	1383	1253	1264	1279
1580	NP4460A	1273	2019	1428	1410	1451	1459	1410	1451	1474
1688	hla2331	1291	1428	2064	1580	1639	1648	1364	1424	1452
1741	HQ1605A	1374	1410	1580	2070	1671	1786	1391	1461	1409
1810	HVO_0914	1391	1451	1639	1671	2090	1806	1475	1510	1535
1804	Hbo0627	1383	1459	1648	1786	1806	2068	1464	1497	1498
1580	rrnAC1409	1253	1410	1364	1391	1475	1464	2036	1540	1445
1648	Hut0935	1264	1451	1424	1461	1510	1497	1540	2015	1558
1629	Hmu1918	1279	1474	1452	1409	1535	1498	1445	1558	1997

268 symbols
consensus       -MDGTLDHVMIRVEDLDESLDWYTTHLDYEEKGRWEADTFTNVYLGPEDMHDEGALLELT
#oth            124331..1.2..1..11..1..31122.1.12....11....21..2142121.4..1.
VNG1114         MTAF::::::M::G:::A:::::GD:MG:V:HA:::::::::::I::::PA:DA::::::
NP4460A         ::::I:::T::::::::A::E::::::N:::::::::E:::::::::::AG:AA:R::::
hla2331         :::::F::::::::::E::::::Q:::N::::::::::::::::::::E::ED::T::::
HQ1605A         ::A:IF::::::::::EA::E::Q:::::::::::::::::::::::TE::::::M::I:
HVO_0914        ::S:::::::::::::E::::::::::G:::::::::::::::::::::L:E:::V::::
Hbo0627         ::S:V:::::L::::::::::::K::::::::::::::::::::::::E::E:::M::::
rrnAC1409       :-MWS:::T:M::::::A:::::Q:YF:::::::::::S::::F:::::V::::::::::
Hut0935         ::::::::::M:::::E:::::::::F:::::S::::E:::::H:::A:V:::::T::::
Hmu1918         ::GL::::T::::::::::::::::::G:::::::::E:::::F:::::V:ED:::::::

consensus       YNHDDRSYEMGDAWGHIAVRV--DDVEEAYDQLMDEGVEDYRDPESCGGRYAFVKDPDGH
#oth            ...1222.22..11......112331431.42.134..2...1.211112....1.....
VNG1114         ::::TAD:DN:::F::::::::::::SD::EE:LAG::A::::::::::S::::::::::
NP4460A         ::::G:::T::::::::::::::P:::A:::E::QS::::::P:AENP:-::::T:::::
hla2331         :::G:NT::I:::::::::::PE:ALQ:S:::::E:::D:::::::::N:::::::::::
HQ1605A         ::::::::::::G::::::::PNGKL:A::Q::L:D::::::::::::::::::::::::
HVO_0914        :::G:NT::::::::::::::PE:EL:SS:R:::::::::::::::::::::::::::::
Hbo0627         :::::::::::::::::::::PE:EL:SS:Q:::::::::::::::::::::::::::::
rrnAC1409       ::::G:::T:::::::::::C:::::YD:::D:::A::::::::D::::S::::T:::::
Hut0935         ::::G:::T::::::::::::::E:::::::E::::::::::P::ENP:-::::::::::
Hmu1918         ::::G:T::::::::::::::::G::T:::HE::::::::::P::ENP:-::::::::::

consensus       EIEIVER--DHGAKWSLDHTMIRVEDADEALGFWTRKFEY-EHTGRWEADSFANYFMKPE
#oth            .1.1.311113.331.1....2..1.13211.213.312111341.2.312..1..2213
VNG1114         :::L:AG:::A:QR::I::::V::A::TQH::::::V:G::::::::::::::::::::P
NP4460A         :V::::::::Y:T::::::::L::::VNA:::Y:I:T:::::P:::::::::::::VS:Q
hla2331         :::::K::::Y::T::I:::::::::::::::Y:::::::A:AR:::::::::::::A::
HQ1605A         :V:::Q:DP:E:TM::I:::::::::::::::::::::::::::::::S:::::::::::
HVO_0914        :V:::K::::::::::::::::::::::::::::::::G:::::::::S:T:::::::::
Hbo0627         :V:::K:::N::S:::::::::::::::::::::::::::::::::::S:T:::::::::
rrnAC1409       ::::::::::::T::::::::::::::EQ:I:WYV::LN:::LFR:E:F:D::L::L:::
Hut0935         :::::::::::::R::I::::::::::EQ:I:WY::AL:::DLVR:S:HS:::L:::::A
Hmu1918         :::::::::::::RY::::::L::::::A:I:WYA::LGF::PA::::::T::::::ADP

consensus       DAADEAMAVELTYNYDGRSYEMGDAWGHLAVRADD--LEDAWETLMEREAEDYRDPESCD
#oth            2.241..42.1.....1.3.22..1...211231211.433.32.23.2141....1..1
VNG1114         A:S:A:::::::::::D:T:TF::G:::::::::S:::Q:D:A::L:::TA:::::A:::
NP4460A         ::PA:::DI:::::::::::T:::::::V:::CA::::QS:::::Q::::P:::::::::
hla2331         ::PK:::KL:I:::::::E:T:::G::::C::V:::::DE::DQ::V:::L:::::::::
HQ1605A         G:S:A:::::::::::::A:DL:::::::C::::::::::Y:A:::::D:T::::::::E
HVO_0914        G::E:::::::::::::::::::::::::::G::::::H:Y:::::::::::::::::::
Hbo0627         G::E::::::::::::::T:D::::::::C::::::::GEY::::L::D::E::::::::
rrnAC1409       ::P::::S:::::::::::::L:::::::::QT:::::HG::::::G:H:::::::::::
Hut0935         G::E:::S::::::::::::::::::::::::T:EGT:::T:G:::Q:D:::::::::::
Hmu1918         :::Q:::T::::::::::T:::::::::I:A::::::::::::S::V::::E::::::::

consensus       YNYAFTKDPDGHEIEILEAE--------
#oth            431...122..1.1.2255333222111
VNG1114         M::::::T:::::::V:NP:SSPMDRSA
NP4460A         NR:::::A:::::::::PT:::::::::
hla2331         H:::::::Q::::::L:VR:::::::::
HQ1605A         :Q::::T:Q::::::::::T::::::::
HVO_0914        DMF::::::::::::VIP:DFESPE:::
Hbo0627         NR::::::Q:::::::::PTDN::::::
rrnAC1409       DR:::::::::R::::VTN-::::::::
Hut0935         ::::::::::::::::VKR-::::::::
Hmu1918         ::::::::A::::V::VTS-::::::::