[L] (Nth) COG0177 Predicted EndoIII-related endonuclease 9 genomes BUD0541 9 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG0592 rrnAC0739 HVO_0848 Hbo0688 Hmu0759 Hut1276 hla2375 NP4496A HQ1545A

Pairwise sequence scores
Consensus score	1730	VNG0592	Hut1276	HQ1545A	NP4496A	rrnAC0739	Hmu0759	hla2375	HVO_0848	Hbo0688
1289	VNG0592	1742	842	1121	1275	1123	1189	1176	1212	1202
1066	Hut1276	842	1403	957	922	1008	1020	900	914	998
1354	HQ1545A	1121	957	1750	1181	1210	1253	1210	1206	1306
1419	NP4496A	1275	922	1181	1755	1197	1235	1355	1333	1299
1442	rrnAC0739	1123	1008	1210	1197	1715	1442	1305	1324	1391
1465	Hmu0759	1189	1020	1253	1235	1442	1743	1285	1321	1395
1422	hla2375	1176	900	1210	1355	1305	1285	1741	1397	1314
1480	HVO_0848	1212	914	1206	1333	1324	1321	1397	1739	1448
1560	Hbo0688	1202	998	1306	1299	1391	1395	1314	1448	1732

229 symbols
consensus       MGTPLETREAQVEEVLDRLYEEYPDSTISLNFSNRLELLIAVVLSAQCTDERVNEVTADL
#oth            1124244.34.252233.14142.13311.3223.2111211311111111111532241
VNG0592         :::R::::S:::GT:I:::R:QH::PE:::R::S:M:::V::I:::::::::::AE:EH:
Hut1276         ----VYR:AR:RNDA--:TLRDI::AG-R:RRRR:-------------------------
HQ1545A         ::K:RTD:TQ::DT::R::A:R::::::::Q:::::::::::::::::::::::SI::::
NP4496A         ::::::P::S::A:::::::::::EPE:::R::::::::V::::::::::::::T::ET:
rrnAC0739       ::::::S::E:AT::V:::H:::::::::::Y:S::::::::::::::::::::::::::
Hmu0759         :::T:A:::::A:::IG::H::::::A::::YAS:::::V::::::::::::::::::::
hla2375         ::::::P::E:::::::::::::::::::::Y::::::::::I:::::::::::K:C:::
HVO_0848        ::::::S::::A:::::::::::::T::::SY::::::::::M:::::::::::K:::E:
Hbo0688         :::S:D::::::::I::::::A:::T:::::::T::::::::::::::::::::::::E:

consensus       FEKYETAEDYAAADEEELAEDIYGITFHNNKAGYLKSAGEDIVEEHDGEVPDTMSELTDL
#oth            12213434211413522..32131..11.1.11.1321223241311.2.....13..2.
VNG0592         :DT:::VA:::N::::A::AELNS::YY:S::::I:::AQS:L:D:::A::::::D::::
Hut1276         ---------------GQ:::::::::::::::::::GI::IL::::::::::::DA::A:
HQ1545A         :::::::T::::::TD:::::::::::::::::::::I::TLAADY::D:::::D:::A:
NP4496A         ::::::P:E::S::K::::S::DS::YY:::::::T::CA::::K:N:::::::::::::
rrnAC0739       ::::QG:::::::S::Q::::::::::::::G:::QGI::ILT::::::::::::A::::
Hmu0759         ::::QS:R:::E::::Q::::::::::::::::::TA::QIM:::Y::A::::::G::::
hla2375         ::T:::P::::N:PQ:::::A:NS::YY::::K:IR::CA::A:Q:::::::::::::E:
HVO_0848        ::::DD:A::::::Q::::D::SS::YY::::K:IR::CA::I:K::::::::::A::::
Hbo0688         ::::Q:P:::::::V::::D:::::::::::::::Q:I::TL::::::::::::::::::

consensus       AGVGRKTANVVLQHGHDVVEGIVVDTHVQRLSRRLGLTEEERPEAIEQDLMPVVPEDDWQ
#oth            2...............1211........1.11...22.2123.23..3..2221.142.1
VNG0592         S::::::::::::::::LTQ::::::::::::::::I::KK::::::T:::::::::H:K
Hut1276         P::::::::::::::::::::::::::::::T:::::::::::D:::D:::EII:::E::
HQ1545A         S:::::::::::::::::::::::::::::IT::::::D:QT:KQ::T:::ES:::SE::
NP4496A         ::::::::::::::::E:::::::::::::I:::::M:T:K::D:::D::IDI::Q:::K
rrnAC0739       P::::::::::::::::I:::::::::::::::::E::::::::::::::LD::::SE::
Hmu0759         P:::::::::::::::::::::::::::::IT::::::D::::::::E::::I:::SE::
hla2375         ::::::::::::::::::::::::::::::IT:::AI::::S:KK:::::LD::::E:::
HVO_0848        :::::::::::::::::I:::::::::::::::::::::::Y::R::E::::::::R:::
Hbo0688         S:::::::::::::::::::::::::::R:::::::I:::::::K:::::::::::A:::

consensus       QFTHLLISHGRAVCTARNPDCGDCVLEDICPSSKLDHDVDLASGEAW--
#oth            31..12.2...11.2.211..32.2.112...2.5.311...1133.31
VNG0592         NY::W::A:::ET:::::::::A:::A:::::::T:::I:::D:SE:::
Hut1276         A::::M::::::::::::::::::A:::V:::::::S::::::::::E:
HQ1545A         :::::F:::::ET:::Q::::T::I::SV:::::C:::I::::NTP:K:
NP4496A         E::::::::::ET:::::::::::I:::::::::::N:I:::D:NG:SD
rrnAC0739       :::::::D::::::G::SA::EA:::A:::::E:G:SE:::::::::::
Hmu0759         :::::::D::::::D:::::::::::A:::::Q:G:G::::::::P:S:
hla2375         :::::M:D::::T:::I:::::::::A:V:::E:A:G::::::::::::
HVO_0848        :::::F::::::::D::::::DA:::::L:::::R::::::::::::::
Hbo0688         :::::F::::::::D::::::DE:::::L::::::::::::::::::::