[R] (-) COG0613 Predicted metal-dependent phosphoesterases (PHP family) 9 genomes BUD0542 9 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG0865 rrnAC1361 HVO_1049 Hbo0544 Hmu1880 Hut1422 hla2685 NP2980A HQ1692A

Pairwise sequence scores
Consensus score	1660	VNG0865	Hut1422	rrnAC1361	Hmu1880	HQ1692A	hla2685	HVO_1049	Hbo0544	NP2980A
1204	VNG0865	1525	1009	865	1100	1014	998	1082	1014	1055
1258	Hut1422	1009	1676	873	1246	1049	1096	1108	1071	1049
1004	rrnAC1361	865	873	1232	969	765	861	911	873	817
1392	Hmu1880	1100	1246	969	1675	1163	1163	1221	1208	1203
1303	HQ1692A	1014	1049	765	1163	1644	1188	1207	1246	1216
1317	hla2685	998	1096	861	1163	1188	1733	1276	1262	1285
1429	HVO_1049	1082	1108	911	1221	1207	1276	1668	1320	1296
1383	Hbo0544	1014	1071	873	1208	1246	1262	1320	1669	1321
1385	NP2980A	1055	1049	817	1203	1216	1285	1296	1321	1670

237 symbols
consensus       ---------VLSVELHAHSSLSYDGRDPVELLLEQAAAVGLDALAVTDHDEIDASLRAAE
#oth            111111111212111131121111221222411221423111111111111121124124
VNG0865         :::::::::---------------------M:::::Q:::::::::::::::::::::::
Hut1422         :::::::::::::::::::::::::::G::K::AR::DA:::::::::::::A:::::V:
rrnAC1361       :::::::::---------------------------------------------------
Hmu1880         :::::::::::T::::::::::::::::::::::::E:::::::::::::::::::E::R
HQ1692A         :::::::::M:::::::::::::::H::::::::::::I:::::::::::::::::::::
hla2685         LKTTPEVKR:::::::T::A:::::::::D:::::::::::::::::::::::::IE:::
HVO_1049        ::::::::::::::::S:::::::::::I:Y:::::V:::::::::::::::::::E:::
Hbo0544         ::::::::::::::::::::::::A:::I:::::::E:::::::::::::::::::Q::D
NP2980A         :::::::::M::::::::::::::::::::::::::E:::::::::::::::::::A::S

consensus       LAADYGLVGIPGMEVTSAAGHVLALGIEELVPAGLSYDETLDRIRDQGGIAVVPHPFQES
#oth            3142121311221.11111..1.12.15141231.1131.121.122..2111.....31
VNG0865         :::::D::::::::::::D:::::I:V:RA:::::PFA:::AE:::R::::I::::::S:
Hut1422         ::PE:::L::::::::::::::::::VD:KITD::PFGT:::::H::::VV:::::::::
rrnAC1361       ------------::::C::::::::::Q:AI:PH:PF::::::::E:::L::::::::::
Hmu1880         ::PE:::I::::A:IS:Q:::::G::::::::::::FS::::::HE:::V::::::::::
HQ1692A         ::SE:D:I:::A:::S:::::::GF::T:Q::::::::::VT:::S::::::::::::SA
hla2685         K:P:::::::V::::::::::I::F::S:R:ES::P::::::::::::::::I:::::K:
HVO_1049        ::::::::::::::::C:::::::::V:::I:::::::::::::::A:::::I:::::K:
Hbo0544         I:E::::::::::::::::::I:::::N::I::::::::::::::E::::::I:::::S:
NP2980A         K::::::::::::::S:::::I::::V:::::::::::::::::::::::::::::::T:

consensus       RHGVAPHISRAQLAAADAIEVYNSRLLTGRANRQAERFARRRDLPMTAGSDAHISEMVGQ
#oth            .1..232.2441.13...1.1.....1..21.12.43..6434312........1....1
VNG0865         :S::::::::RE::S::::::::::::::L:::K::T::EHN:C::::::::::A:::::
Hut1422         :S::MAK::::E::R::::::::::::::::::::RT:::EHGI:Q:::::::::::::R
rrnAC1361       ::::LE:::KDE::T:::::::::::::::S:::::::::::G:::::::::::A:::::
Hmu1880         :S::LDK::KDE:T::::::::::::::::S::::HQ::S::G:::::::::::::::::
HQ1692A         :::::AE:AT:::T:::::::::::::::::::K:KK::QTH:IA:::::::::::::::
hla2685         :::::A::TDE:::S:::L:::::::F:::S:::::K::I:NRI::::::::::::::::
HVO_1049        :::::::::S::::S:::::I::::::::I::QR:::::K::N:::::::::::A:::::
Hbo0544         ::::::::T:T:::::::::::::::F:::S::K:D:::TA:E::K::::::::::::::
NP2980A         ::::::::TD::::::::::::::::F::::::::::::E:Y:V::::::::::A:::::

consensus       AVTEVDTDERSVEAILDAIRAGRTSVVGKRTPWRISFRQAAGGAKRRIKRRLAELL-
#oth            ...41312421231..31132.3.213.41...21.22.12..11.14544355252
VNG0865         :::RI:A:GHT:::::::::::E:T:N::::::H::::::::::::::TN::::FF:
Hut1422         :::L:E::::::P:::E:::E:::HIE:R::::H::::::::::::KFRE:::S::E
rrnAC1361       :::N:G::::T:::::::::E:K:T:E::::::::::::::::::::V:NGI::::Q
Hmu1880         :::H::::::::::::::::::::T:E::::::H:::::::::::::V:N:FSQ:IE
HQ1692A         :::::A:ETQ::DG::N::V::E:::I:TK::::V::K:FS::V::::M:T:S::V:
hla2685         :::::GA:D::A::::NG:AD:::::::::::::V:L::FS::::::AL:A:NA:R:
HVO_1049        :::::G::T::AD:::S:VAD:::::::NK::::::::::::::T::L:HA:TD:F:
Hbo0544         :::::A::D::ESG:::::TD:Q:::::SK:::::::K:FG::VT::VR:GVF::::
NP2980A         ::::::AYH::A:G:::::AE::::::::::::A::IQ:FG::VT:::AGL:PW--: