[H] (-) COG3252 Methenyltetrahydromethanopterin cyclohydrolase 9 genomes BUD0588 9 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG1686 rrnAC1616 HVO_2573 Hbo2282 Hmu2049 Hut1844 hla1573 NP2634A HQ2798A

Pairwise sequence scores
Consensus score	2303	VNG1686	Hut1844	NP2634A	rrnAC1616	Hmu2049	hla1573	HQ2798A	HVO_2573	Hbo2282
1570	VNG1686	2299	1400	1326	1307	1256	1333	1302	1401	1344
1709	Hut1844	1400	2271	1470	1500	1467	1365	1355	1376	1459
1750	NP2634A	1326	1470	2289	1522	1512	1385	1367	1370	1441
1775	rrnAC1616	1307	1500	1522	2274	1792	1373	1340	1445	1528
1709	Hmu2049	1256	1467	1512	1792	2228	1394	1302	1402	1455
1739	hla1573	1333	1365	1385	1373	1394	2311	1522	1646	1653
1728	HQ2798A	1302	1355	1367	1340	1302	1522	2315	1589	1747
1780	HVO_2573	1401	1376	1370	1445	1402	1646	1589	2327	1778
1869	Hbo2282	1344	1459	1441	1528	1455	1653	1747	1778	2347

315 symbols
consensus       MDSINRMAIELVDEAIDFADELRIAVYELDNGATVLDFGVEAAGGVEAGLLLAEIQTAGL
#oth            122211213..1...21.12..414542.13213.3...1224.12...1112.11.1..
VNG1686         :E:L::::L::A:::LE:TE::D:GAF:::T:T::I:::::HD::L::::::::L:::::
Hut1844         ::QL::LGT:::::::::::::G::E:R:::ET::::::::H::::::::M:T:::::::
NP2634A         :E:L::::V::::::V::::::A:EIE::::::M:C::::::T::I::::::T::::G::
rrnAC1616       :::L::::T:::::::::::::T:D:HA:EGD:A:::::::VP:A::::M::::::::::
Hmu2049         ------::T:::::::::::::T:::HA:EGD:A::::::DVP:A::::::AT:::::::
hla1573         :E::::T::::::::L:::G::DVVG:::::::::V:::ID:::::::::::::::::::
HQ2798A         ::::::::V::::::::::E::::VPQ:::S::R::::::N:E:::::::::::::::::
HVO_2573        :::::::::::::::L:::G::G:EG::::S::::I::::D:D::::::M::::::::::
Hbo2282         :::::::::::::::::::::::VD:::::T:::::::::N:E::I::::::S::E::::

consensus       ATVQTRMGEVAGAPLPHVEVSTDHPALALLCSQKAGWELAFDD--FEGLGSGPARALVAE
#oth            .22213243111233311.132.2.1212.22..1...1322212121..1.......13
VNG1686         ::::::VDT:GD:TF:::::AC:Q::V:M:GA::::::::V::::Y:A:::::::::::T
Hut1844         :S:T::LES:GD:A::::::T:::::::::AG::::::::TE:::::::::::::::::R
NP2634A         :::::TV::::D:::T:::::S:::GI:F:AA::::::ISV:G:::::::::::::::::
rrnAC1616       ::::ST:AT:G::::N:::L::::::::::::::G:::::V:::::QA::::::::::::
Hmu2049         :::::KLSS::::::T:::L:::::::G::::::G::::SVGG:::::::::::::::::
hla1573         :NLR::::::::::RQY::L::::::I:::::::::::::::S:G:::::::::::::GQ
HQ2798A         :::::::D:I::VQT:::::Q:::::V::::::::::::E:::PT:::::A:::::::::
HVO_2573        ::::::::::::T:R::::L:::R:::::::::::::::T::::::D:::::::::::G:
Hbo2282         ::I:SQ::D:::::R:YI::Q::::::::::::::::::::ES:G:::::::::::::::

consensus       EEEFQRLGYRDAFDFAVLAVESDELPTEAVAEHVAERAGVPESGVFLPTYATASVTGSVA
#oth            .3223322.41321111.32.226..3331132..331213422.1..312.1.32...3
VNG1686         :G:::AID:V:::E::::TL::TG:::T:A:SE::A::::T:ES::::::R::::A:::S
Hut1844         :DI:E::E:VE::::::::::::A:::::A:AQ::DL::::::S::::AFS:::I:::::
NP2634A         :::H::::::::A::::::I:::R::::::::Q::::::::T:S:::::FS:::I:::::
rrnAC1616       ::A:::I:::EDA::::::::T::::D:D::SQ::::T::::T:::::SF:::::::::V
Hmu2049         ::IYS:V::H::A:::::TI:A::::EQD::G:::::T::::TA::::V::::::::::V
hla1573         :A::E:V::Y:SSE::T:T:::TT::::E::::::DL:E:EAE:::::A:::G:TA::::
HQ2798A         :D:::A:E:F:E::L:::S:::IS::S:T:I::::NKTD:NL:::M::::::G::V:::T
HVO_2573        ::::HH:::Y:E::LT::::::ID:::DE:::::::TT:LEP:A::::::::G:LV:::T
Hbo2282         :D::HQVE:F:E::LT::G:::I:::DDE:::::::T:::EP::::::::::G:TV:::T

consensus       AAARAAELAVFRLFELGYDPTDVLSASGSAPVAPVAYDEETAMGRTNDALAYGGRVHLTV
#oth            31..13.1.2.2.4.1.111432112314..3..2241154.11..1..1.1.13..11.
VNG1686         ::::TV:::::::Y::::::::::::::C:::::::G::Q::I::::::::H::::::::
Hut1844         :G:::S:S:::Q::::::::E::H:V::V:::::::ES::A:IA::::::::::::::::
NP2634A         L::::G:::A:::S::::::L:M:::TA::::::I:G:D::::A::::::::::::::::
rrnAC1616       :::::::::::::A:::F::VS::::::R:::::::D::A:::A::T::::::SE:::::
Hmu2049         :::::::::A:::S::::::VSI:::T:::::::::DS::A::A::T:::::::Q:::::
hla1573         T::::::::::::L::::E:::::H:::A::M::ATR::DL:::::::::::::E:::Q:
HQ2798A         :::::::::L:::::::::VRN:H::F::::I::IS:::SI:::::::::::::T:::::
HVO_2573        G::::::::::N:::A:::::N:::IN::::L:::S:::SV::::::::V:::::::V::
Hbo2282         ::::::::::::::::::::RKI:::F:A::::::S:::GV:::::::::::::E:::::

consensus       AEDFDRFDEVPSTAAEEYGTPFEEIFEDADWDFYDVPVEVFAPAQVTVDVVGGPTHVVGE
#oth            43312413333.2.443124.123313331..15221451.1..21.2..32.32324.2
VNG1686         :::::A::A:V:S::AR:DD::A:VVGTD:::AG::DNG::G:::L::::::::::AF:T
Hut1844         ESG::::E:I::::G:::SQ::A::::::::::EEL:AD::G::::::::I::E:A:Y::
NP2634A         DS::E:LS:AT:::SD:F::::AD:::SHE:::Q:L:::::::::::F::A::GLD::::
rrnAC1616       D:S:::::::::V::R:::E:L:GV:::V::::AEL:::L:G::A::I:::::D::::::
Hmu2049         E:E:::::::V:V::::::::LV:A:D::::::SE:::::::::::::::L::E:::F:D
hla1573         :R:D::::QIV:::R:::::::V:V:::::::::E:DER:::::K::::::D::VYT:::
HQ2798A         TA:DPVLK:L::::RDK:::::::::AE:::::::::ES:::::::::::ID:::::L::
HVO_2573        S::::E::RAI:::ESD::V:::QL::::::::GA:DPD::G:::::::::D:::YTL::
Hbo2282         T::::D::::::::G::::::::Q:::E:::::::I:AT:::::K::I:::N:::Y:H::

consensus       TDEDLLAESFGL---
#oth            24.221111.12421
VNG1686         VR::V::DG:::S::
Hut1844         :::A::V::::::::
NP2634A         LN:E:::::::IESA
rrnAC1616       :S::V::::::::::
Hmu2049         :H::V::::::::::
hla1573         :::E:::::::YR::
HQ2798A         :N:E:V::::EY:::
HVO_2573        ::::V::D:::::::
Hbo2282         :::EI::::::IQP: