[F] (Adk) COG0563 Adenylate kinase and related kinases 9 genomes BUD0593 9 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG1724 rrnAC3346 HVO_2496 Hbo2186 Hmu2128 Hut3037 hla1338 NP4910A HQ2767A

Pairwise sequence scores
Consensus score	1644	NP4910A	Hut3037	rrnAC3346	Hmu2128	VNG1724	HQ2767A	Hbo2186	hla1338	HVO_2496
1148	NP4910A	1571	978	1007	993	982	884	963	1039	1069
1226	Hut3037	978	1644	1228	1234	1044	1051	1090	987	1042
1369	rrnAC3346	1007	1228	1672	1427	1068	1095	1126	1087	1122
1323	Hmu2128	993	1234	1427	1668	1044	1148	1120	1066	1122
1220	VNG1724	982	1044	1068	1044	1652	1049	1146	1081	1148
1208	HQ2767A	884	1051	1095	1148	1049	1675	1166	1078	1096
1359	Hbo2186	963	1090	1126	1120	1146	1166	1636	1227	1290
1284	hla1338	1039	987	1087	1066	1081	1078	1227	1709	1290
1365	HVO_2496	1069	1042	1122	1122	1148	1096	1290	1290	1572

233 symbols
consensus       ----------------MMAPRILLLGAPGAGKGTQSKRLAEEYGVEHVTTGDALRANKDM
#oth            1111111212222221336231.11.1.........3211221121.1.......2..41
NP4910A         :::::::::::::::::SQ:K:::::::::::::::SNIVD::::D:I::::::::::::
Hut3037         :::::::::::::::::RN:K:::::P:::::::::SN:VS:F:I::::::::::S::G:
rrnAC3346       :::::::::::::::::SN::::IV:P:::::::::AN:::A:::::I::::::::::::
Hmu2128         :::::::::::::::::A:::::I::P:::::::::SNI::T:::::::::::::G::E:
VNG1724         :::::::::::::::::SH:NV::::::::::::::R::VD:F:::::::::::::::TK
HQ2767A         :::::::MLYGERQISS:EKH:::::P:::::::::::::::F:L::::::::::G::Q:
Hbo2186         ::::::::::::::::-:GKH:::::::::::::::::::S:FDL:::::::::::::::
hla1338         VLAGIFKPLRAAGERSG:SH::::::::::::::::AK::D::D::::::::::::::::
HVO_2496        ::::::::::::::::-::K:::::::::::::::::::::T::::::::::::::::::

consensus       DISDMDTEYDTPREYMEAGELVPDAVVNEIVEEALSDADGFVLDGYPRNLEQAEYLSEIT
#oth            1123224.11..121.13.1....4..12..32.153...1........22.1.2.441.
NP4910A         ET-----:HG::::F:::::::::P::::::QA:IDE:::::::::::::S::::::D::
Hut3037         ::::LGL:::::G:::DR::::::E::TA::::::TS:::::::::::::::::E:ETM:
rrnAC3346       :::::::::::::::::::D::::::::A::D::::Q:::::::::::::::::E:EGM:
Hmu2128         ::::::::::::GA::D::D::::K:::A::D::::Q:::::::::::::::::E:ADM:
VNG1724         ::THL:V:::::GA::D::::::::::::::KT::D::::Y::::::::ES:T:::DS::
HQ2767A         :::E::::::::GA::D:::::::::::K:::::::S:::Y::::::::I::::V::S::
Hbo2186         ::::::F::::::::::S:D::::D::::::KT::QE:::Y::::::::I::::::T:::
hla1338         ET-----::G:::SF:::::::::P::::::KA::A::::::::::::::D:::::::::
HVO_2496        ET-----::G:::SF::K::::::::::::::A::E::::Y:::::::::S:::::T:::

consensus       DLDVVLSLDVSEEELVDRLTGRRVCDDCGANYHVEFNQPEEDGVCDECGGELIQRDDDTE
#oth            21.1223.2.3121..2......11311.331.23.52.2331.1131124.3..1..2.
NP4910A         :V:::AL:::GRD::::::::::MDPET:DI::T:::M:DDEE:RE----R:V:::::::
Hut3037         ::::IA::S:G::::::::::::::S:::E::::::D::DA::::::::::::::E::Q:
rrnAC3346       A:::I::::::R:::::::::::::::::T::::::::::::::::::::D:::::::N:
Hmu2128         ::::I:::S:AR:::::::::::::::::T::::::SP:A::::::D:::D:::::::N:
VNG1724         ::::::Y:::D:D:::G::::::::E::::TF::S:::::TE::::A:::S:Y::E::::
HQ2767A         E:::AIL:S::::::::::::::::PE:::S::I::EP:A:T:::::::AT:T:::::::
Hbo2186         :::A::Y:::::::::E:::::::::::::::::::AP::::::::D::::::::E::::
hla1338         :::A:IF:::D::V:::::::::::::::::F::D:QP:::A::::::::::::::::::
HVO_2496        :::A:IY:N:A:S:::E::::::::::::T:F::K::::::E::::D:::::V:::::::

consensus       ETVRERLDVFDENTEPVIDHYRDEGVLVEVDGEQTPDEVWDDIQDAVDDA---
#oth            .2112.14.142..3..12113242511311..31113.14324312234331
NP4910A         :::N::::::::::Q::::Y:E:::E::RI:::AS:::::::L:A:I:::L::
Hut3037         :A::N:::::A:::::::EY:S:REAF::I::::SL:A::A:LK:::E:ELQS
rrnAC3346       :S::N::::::D::A::::::G:HDGF:AI::::::::::SE::::::AHTA:
Hmu2128         :S::N:::::::::R::::::EGDDAF:A:::::::::::A:::::I:ARVE:
VNG1724         ::A:::IT:YE:::A::VEYF:EQ:::A:::::R::::::T:VAA:::ERTA:
HQ2767A         ::::D::R:YE::::::VE::::RDK::T:N::T::GD:F:S:V:VINS-:::
Hbo2186         :::::::T:YHK:::::VN::::::::::I:::::::G:F::VAEV:E:::::
hla1338         ::A::::E::Y:::::::::F::::D:::::::A:::::FER:R:VL:E-:::
HVO_2496        :::::::S::E:::::::E::::::::::::::::::::FE:::SV:::::::