[C] (NtpD) COG1394 Archaeal/vacuolar-type H+-ATPase subunit D 9 genomes BUD0600 9 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG2135 rrnAC3162 HVO_0319 Hbo1163 Hmu2586 Hut2143 hla0254 NP0264A HQ3242A

Pairwise sequence scores
Consensus score	1656	VNG2135	Hut2143	NP0264A	rrnAC3162	Hmu2586	HQ3242A	hla0254	HVO_0319	Hbo1163
1345	VNG2135	1618	1253	1295	1279	1291	1315	1300	1305	1332
1393	Hut2143	1253	1620	1342	1367	1331	1297	1344	1354	1345
1466	NP0264A	1295	1342	1668	1392	1373	1376	1393	1412	1395
1493	rrnAC3162	1279	1367	1392	1666	1505	1360	1401	1419	1427
1473	Hmu2586	1291	1331	1373	1505	1676	1383	1373	1393	1426
1465	HQ3242A	1315	1297	1376	1360	1383	1687	1411	1415	1479
1513	hla0254	1300	1344	1393	1401	1373	1411	1644	1448	1483
1512	HVO_0319	1305	1354	1412	1419	1393	1415	1448	1687	1485
1575	Hbo1163	1332	1345	1395	1427	1426	1479	1483	1485	1655

236 symbols
consensus       MAKDVKPTRKNLMAIEDRIELSERGHDTLEQKRDGLIMEFMDILDQAQDVRSDLNENYER
#oth            .12.1.....1..3.1...2..........1...............1.1..231343.21
VNG2135         ::Q:I::::::::E:::::D::::::::::::::::::::::::::S:::::G:EGD::T
Hut2143         ::Q::::::::::Q::::::::::::::::::::::::::::::::::N::A::E:T:D:
NP0264A         :S::::::::::::::::::::::::::::K:::::::::::::::::::::::D:::::
rrnAC3162       :::::::::::::Q::::::::::::::::K::::::::::::::::::::E::DGS:::
Hmu2586         ::::::::::E::R:::::D::::::::::K:::::::::::::::::::::::DDS:G:
HQ3242A         ::E::::::::::::D:::Q:::::::::::::::::::::::::::::::::::A:::T
hla0254         :::::::::::::::::::D:::::::::::::::::::::::::::::::::VS::::T
HVO_0319        ::E::::::::::::::::::::::::::::::::::::::::::::::::AN::QD:::
Hbo1163         ::E:::::::::::::::::::::::::::::::::::::::::::::::::E::::::T

consensus       AQRKINMARAMEGDVAVRGAAAALKEHPEITTQSKNIMGVVVPQIESSKVKKSLDQRGYG
#oth            ..5311.....1.....1...1..1.1..1.12.1............11.1..1.2....
VNG2135         ::Q::::::::::::::S::::::E:Y::::VE:M::::::::::::T:::::F:K::::
Hut2143         ::AR:D:::::::::::::::::::::::::::::::::::::::::T::R::::E::::
NP0264A         :::N:::::::::::::::::::::::::::::::::::::::::::T::::::::::::
rrnAC3162       :::A:::::::::::::::::::::::::L::::::::::::::::::::R::::E::::
Hmu2586         ::HA:::::::D:::::::::::::::::L::::::::::::::::::::R::::E::::
HQ3242A         ::Q:L:::::::::::::::::::::::::::R:::::::::::::::R:::::::::::
hla0254         :::::D:::::::::::::::::::::::::::::::::::::::::::::::::E::::
HVO_0319        ::N::::::::::::::::::S::::Y:::::::::::::::::::::R:::::::::::
Hbo1163         ::S:::::::::::::::::::::::::::::::::::::::::::::R:::::::::::

consensus       LLGTSARIDEAADAYEELLESIILAAEVETAMKKMLEEIETTKRRVNALEFKLLPDLYEN
#oth            22.1......1.1.....1.411..........11.3...1..........1...2.223
VNG2135         I:::::::::::::::::::::V:::::::::::::T::::::::::::::::::E:H:G
Hut2143         V:::::::::V:E:::::::Q::::::::::::EL:D::::::::::::::T:::::RSS
NP0264A         :V::::::::::::::::::T:::::::::::::::D:::K::::::::::::::E:H:A
rrnAC3162       VM::::::::::E:::::::N:::::::::::::::::::::::::::::::::::::D:
Hmu2586         VM::::::::::::::::I:N:::::::::::::::::::::::::::::::::::::D:
HQ3242A         :::S::::::::::::::I:T:::::::::::::::K:::::::::::::::::::::::
hla0254         :::S::::::::::::::::KV::::::::::::::T::::::::::::::T:::R::::
HVO_0319        :::S:::::::::::::::::::::::::::::::::::::::::::::::::::E::::
Hbo1163         :::S::::::::::::::::::::::::::::::::::::::::::::::::::::::::

consensus       QEYIEQKLEEQEREEIFRMKKIKAKKEEEEKAEAEAEAAEAEAAA------VPADD
#oth            11..1.....1....1..1..1.21..11132332225234445311112434122
VNG2135         K:::D:::::K::::M:::::V:D:::AQ:E:AD::A:::STG:-::::::-----
Hut2143         :D::::::::::::::::::::::N::A:::::R:::EDAES:S:::::::-----
NP0264A         ::::::::::::::::::::::::::::::EENPV:DTES:AE:::::::VTE:GQ
rrnAC3162       ::::::::::::::::::::::::::::::D:L:AE:E::E:PE::::::::T:::
Hmu2586         K::::::::::::::::::::::N::::::A:AR:E:N::::E:::::::A:A:::
HQ3242A         K:::::::::::::::::L::::N:::A::ED:D:D:SEMTDETV::::VQT::::
hla0254         ::::::::::::::::::L:::::::::::::::A::::AV:DPE::::::-:::-
HVO_0319        ::::::::::::::::::L::::::::::::E:RA::K:A:::D:DADAEAAT::-
Hbo1163         K:::::::::::::::::L::::::::::A:::::E:::::S::E:::::T:::::