[F] (PyrF) COG0284 Orotidine-5'-phosphate decarboxylase 9 genomes BUD0612 9 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG1673 rrnAC1515 HVO_2577 Hbo2274 Hmu2063 Hut1618 hla1666 NP1734A HQ3219A

Pairwise sequence scores
Consensus score	2037	VNG1673	NP1734A	HQ3219A	Hut1618	hla1666	HVO_2577	Hbo2274	rrnAC1515	Hmu2063
1552	VNG1673	2032	1449	1325	1449	1438	1449	1454	1415	1467
1647	NP1734A	1449	2068	1383	1593	1568	1504	1492	1537	1552
1620	HQ3219A	1325	1383	2107	1506	1544	1527	1617	1489	1435
1791	Hut1618	1449	1593	1506	2183	1673	1624	1636	1628	1624
1775	hla1666	1438	1568	1544	1673	2099	1602	1662	1641	1651
1745	HVO_2577	1449	1504	1527	1624	1602	2038	1700	1578	1536
1792	Hbo2274	1454	1492	1617	1636	1662	1700	2063	1610	1520
1753	rrnAC1515	1415	1537	1489	1628	1641	1578	1610	2120	1638
1713	Hmu2063	1467	1552	1435	1624	1651	1536	1520	1638	2264

313 symbols
consensus       -------------------------MSFFERLADRIEAADSVVSVGLDPDPDRLPDHLAD
#oth            111111111111111111222223225.113124..4541..1.....2.34.1.24143
VNG1673         ::::::::::::::::::::::::::::V:E:GA::::::::::::::::ME:::EDVQ:
NP1734A         ::::::::::::::::::::::::::::::T:::::DDR::::::::::::::::EF:-:
HQ3219A         ::::::::::::::::::MNSTDTNRP::D:V:T::SRIN::I:::::S::N:I:A::QT
Hut1618         ::::::::::::::::::::::::::T::::::G::D:V:::::::::::::::::::::
hla1666         ::::::::::::::::::::::::::::::T:::::::T::::::::::::N:::EF::N
HVO_2577        ::::::::::::::::::::::::::G::DD:R:::::T:::::::::A:I:::::::L:
Hbo2274         :::::::::::::::::::::::MAQA:::::::::QQT:::::::::S:LS:I::::HE
rrnAC1515       ::::::::::::::::::::::::::H::D::::::AT:::::::::::::A::::SVL:
Hmu2063         MKTGPTIGGPARKETLVSVADARSA:G::D::GQ::AV::::::::::::::::::CV::

consensus       ADLPRWAFNRRIIDATHEHAACYKPNAAFYEDADGWRALRETIAYAHGKDVPVLLDAKRA
#oth            21....1....1.......1121...1.....31...1.2..1......2.........1
VNG1673         :E:::::::::::::::::::VF:::::::::S:::::::::V::::::G::::::::::
NP1734A         :::::::::::V::::::::::::::::::::S::::::E:::::::::G:::::::::G
HQ3219A         :::::::::::::::::::TV:::::T:::::PS::::::::::::::::::::::::::
Hut1618         RE:::::::::::::::::::A::::::::::P::::::A:::::::::::::::::::G
hla1666         :::::::::::::::::::::::::::::::::::::::E::::::::::::::::::::
HVO_2577        K::::::::::::::::::::AF:::::::::E::::S:::::::::::G::::::::::
Hbo2274         K:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
rrnAC1515       ::::::Q:::::::::::::::::::::::::P::::::E:::::::::N:::::::::G
Hmu2063         :E:::::::::V:::::::::::::::::::::::::::E:::::::::::::::::::G

consensus       DIGNTARQYAELLD-----DADAITVNPYMGRDSLQPFLDREDKGVFVLCRTSNPGGADL
#oth            .....1.1..53.33111271....1..11.2.212.1.41324...1.1....2..3.1
VNG1673         :::::::::::I:A:::::HV::::::::L:E:A:::::TQDEA::::::::::E::M:F
NP1734A         ::::::::::T:::DD:GLG:::::A:::::::T:E:Y:S:A:::::I::::::S::::F
HQ3219A         :::::T:::::::N:::::K::::::::::::::::::::::N::::I::::::::::::
Hut1618         :::::::::::V::GD:GL::::::::::::::::E:::A::ET::::::::::::::::
hla1666         :::::T::::AA:::::::R:::::::::L::::::::::::E::::::::::::::S::
HVO_2577        :::::T:K::D:::::::::::::::::::::::I::::S::::::::::::::::::::
Hbo2274         :::::T::::K::::::::EV::::::::::::::::::::G:::::I:::::::::E::
rrnAC1515       ::::::::::QI::EDEGPA::::::::FL:::::E:::Q:A:R:::::G:::::::E::
Hmu2063         ::::::::::TA:E:::::L:::::::::::G:::A:::Q:::G::::::::::S:::::

consensus       QDLELAS-GERLYERVAALADLWN-ENGNVGLVVGATAPDELESIREQVPDLPFLVPGVG
#oth            .4.114411341..21141134..14321........2.1..232.15.111......1.
VNG1673         :H::::AYDR::::H::ER:AE::AQY:D:::::::::::::QA:::R::E:::::::::
NP1734A         :N:TVGN:DK::::Y::QRCQE::::HE:::::::::::E::::V:DL:-::::::::::
HQ3219A         :::::VT:::TV:::I::::EG:::TH::::::::::::E::::L::Y::::::::::I:
Hut1618         :G:::QD:::A::::::::::::::R:D:::::::::::E::::L:::::::::::::::
hla1666         ::::::::::P::::::::::V:::G:D:::::::::::E::AEV::I::EI::::::::
HVO_2577        :S:::DT:::P::::::::C::::::H::::::::::G:::::HL:::::::::::::::
Hbo2274         :::::D:::::V:::::::::::::R:D::::::::::::::::::::::::::::::I:
rrnAC1515       ::::::::::K:::::VH:::::::G:::::::::::N:::::E:::L:::I::::::::
Hmu2063         :::::::::GP::::::T::EA::::R::::::::::N::::AA:::V::::::::::::

consensus       AQGGDAEAAVEHGLAD------GVGLVNSSRGIIFAGE-A-----DDGDAFFRAAGDAAK
#oth            ..1..11...22..2.2122232...1..1..1....132333323323423421141.1
VNG1673         :::::::::::Y::N::::::D:::::::T::V::::::-:::::-H:S:WAA::::::R
NP1734A         ::::::A:::D:::::::::::::::::::::::::::G::::::A:E:EY:::V:A:::
HQ3219A         ::D::P::::TY::V:::::::D:::I::::::::::D:-::::::N:EQ:ADT::V:::
Hut1618         ::::::::::::::::VPGVDPQ:::::::::::::::E:GGPGDA:P::YY::::ES::
hla1666         ::::::::::::::::RPDAAVD:::::::::::::::ESSRP::::EATY:G:::::::
HVO_2577        :::::::::::F:::::::::::::::::::::::::::-::::::::ED:DK:::Q:::
Hbo2274         :::::::::::F:::::::::::::::::::::::::::-::::::N:EE:A:G:::::R
rrnAC1515       ::::::::::::::::::::::::::::::::::::::D:ATRRD:S:::::K:::QS::
Hmu2063         ::::::::::::::::::::::::::::::::::::::D:GRGAGT:E::Y:G::EQ::R

consensus       RLKQRLNQHR---
#oth            2.141..32.132
VNG1673         T:RE:::R:::::
NP1734A         :::::::K:::::
HQ3219A         ::::Q:::F:DTA
Hut1618         :::R:::R::DG:
hla1666         :::K::::Y::::
HVO_2577        :::N::::Y::::
Hbo2274         :::K::::Y:DSQ
rrnAC1515       Q:::::::F::::
Hmu2063         :::E:::E::D::