[F] (-) COG3363 Archaeal IMP cyclohydrolase 9 genomes BUD0615 9 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG2371 rrnAC2659 HVO_0011 Hbo1495 Hmu2957 Hut1733 hla0588 NP0732A HQ1006A

Pairwise sequence scores
Consensus score	1455	HQ1006A	VNG2371	hla0588	NP0732A	Hbo1495	HVO_0011	Hut1733	rrnAC2659	Hmu2957
961	HQ1006A	1457	870	772	870	962	888	814	848	868
1012	VNG2371	870	1463	874	889	927	982	910	890	901
1042	hla0588	772	874	1532	1004	928	989	989	969	984
1074	NP0732A	870	889	1004	1460	1046	1076	986	981	992
1150	Hbo1495	962	927	928	1046	1483	1062	937	988	1001
1217	HVO_0011	888	982	989	1076	1062	1451	1010	1020	1060
1165	Hut1733	814	910	989	986	937	1010	1931	1175	1147
1184	rrnAC2659	848	890	969	981	988	1020	1175	1525	1224
1206	Hmu2957	868	901	984	992	1001	1060	1147	1224	1514

278 symbols
consensus       ------------------------------------------------------------
#oth            111111111111111111111111111111111111111111111111111111111111
HQ1006A         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
VNG2371         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
hla0588         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP0732A         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hbo1495         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
HVO_0011        ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hut1733         VTSATTSSRRSAAASVPPISLSRPVVIATGEELRADNATESDAVDRGTDTYFPVCVSGGN
rrnAC2659       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hmu2957         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

consensus       MYVGRFVVVGPDVGAYRVSSRSFPNRRAVDRDGTLTVGPTPDAPETDNPYISYNCVR-E-
#oth            ..2...111215411.......1...2333.1342..3..31.21.2...11..23.241
HQ1006A         ::L:::III:ETTAV:::::::Y:::QIIS::NM:::V::SE:AQ:N:::V::::M::Q:
VNG2371         ::I::::::::S:A::::::::::::KLIE:PAG:::V::A::E::T:::V:::::::T:
hla0588         :::::::::A:GI::::::::::::::VT::::R::::::::::::::::V::::A:AVR
NP0732A         ::::::I::A::RA:::::::::::::I::::::::::::E::::::::::::::L:TV:
Hbo1495         ::::::I:I:::F:::::::::::::QV:E:::::::A::::::::::::::::::::::
HVO_0011        :::::::::S:GI::::::::::::::V::::DA:::::::::::::::::A::::::::
Hut1733         :::::::::A:E::::::::::::::K:::::::I::A::A:::::::::::::A:::L:
rrnAC2659       :::::::::S:E::::::::::::::Q::Q::::V::E::::::::::::::::G:::V:
Hmu2957         :::::::::::Q::::::::::::::::L:::::I:::::E:::::::::::::A:::::

consensus       ---GGRGAVVGNGSHVDPIAEKLDLGYPARDALAEPLLALDYEKDDYDTPRIAGVVGVD-
#oth            11132452.1...11...11..231.1.1...2113.111.1.....1...1..111525
HQ1006A         :::::EKI:I::::::::::::I:R::::::::::A:::::::::::N::::::I::SS:
VNG2371         :::A:GH::::::::::::T::VER:::P::::T:A:::M:::::::::::::::LAP:G
hla0588         TPTDEPL::::::::::::::::E::::::::::T::::::F:::::::::::::::AET
NP0732A         ::::DDY::::::TQ::::::::S::::P::::::S:::::::::::::::::::::DE:
Hbo1495         :::::DSV:::::::::::::::::::::::::::S:::M:::::::::::::::::EE:
HVO_0011        :::::DYV::::::Q:::V:::::::::P::::::I:::::::::::::::::::::D:E
Hut1733         :::TD::::I:::::::::::::A::T::::::::::K:::F::::::::::::I:::SE
rrnAC2659       :::TE::::::::::::::::::E::::::::I:::::S::F:::::::::V::I::::A
Hmu2957         :::TD::V:::::::::::::::S::::::::V::S:::::F::::::::::::I::::P

consensus       -----------AYIGIVRRDALLVEAVTE-PTLVATYEEDDPEAFDLDAA-----DAAEA
#oth            31111213231231.21.3.11211313.1.11.1...423.435514251111222233
HQ1006A         :::::::::::S:V::I:Q::VIIRSIS::::::S:::N:A:TTAQ:SLK::::G:IE:I
VNG2371         T::::::::::::V::::A::V::R::E::::::::::K:A:::IGF::::::::T::D:
hla0588         ::::::::::::T::V::::G:V::::D::::I:::::T:S::PYA:A::DAETP:::A:
NP0732A         :::::::::::S:::T::::::I::::E::::::::::KSE::PTS:G:D::::::PS:L
Hbo1495         :::::::::::S::::::::::::RP:::N:M::::::::::AVVVF:GD::::GSP::L
HVO_0011        ::::::::::::::::::K:::V:::::::::::::::::::R::::::E:::::T::D:
Hut1733         DDPT::AGEAG:A:::::::::V::::E::::::::::R:::VP:::G:N::::::::G:
rrnAC2659       ADPTTNADGPG:V::T:::::::::E:::::::::::::NS:T::::A:T:::::::SDV
Hmu2957         DDPTTRAEGHGGV::T:::::::::E::::::::::::T:S::::::E:T:::::::E:I

consensus       AREAYDHEFEHAVCAAGVT--GDG--GDVETAIYNGE-
#oth            .42213422..1..1.113224321114433332.241
HQ1006A         :QK::EL:Y::P::::A::HQ:Q:ES::IVAQ::::K:
VNG2371         :::::SAA::::::::::SRR:V:::DGYD::VV:DP:
hla0588         :T:VLGAD:::P:::::A:::V:A::DGATL:FD:DAE
NP0732A         :A:L::RDL::P::::::V::A::::DSF:VGY:::::
Hbo1495         :ER::EMDY::::::::::::Y:D:::::DVGF::D::
HVO_0011        :::L::::::::::::AA:::-V:::DA:::SF:::::
Hut1733         :::L::::::::::::::S:::SA::::Y::::V:E-:
rrnAC2659       :::V::::Y:::::S:::A:::SA:::EFDV:V:::::
Hmu2957         :::V:G:::::::::::::::-VD:::G::::::::-: