[TD] (RIO1) COG1718 Serine/threonine protein kinase involved in cell cycle control 9 genomes BUD0623 9 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG2233 rrnAC2476 HVO_0135 Hbo1361 Hmu3160 Hut2308 hla0633 NP1312A HQ3398A

Pairwise sequence scores
Consensus score	2221	VNG2233	hla0633	NP1312A	rrnAC2476	Hmu3160	Hut2308	HQ3398A	HVO_0135	Hbo1361
1190	VNG2233	1743	1145	1093	954	1049	1005	1086	1107	1063
1884	hla0633	1145	2538	1700	936	1549	1537	1638	1670	1741
1776	NP1312A	1093	1700	2197	986	1666	1591	1521	1517	1575
1085	rrnAC2476	954	936	986	1481	1040	1013	901	889	951
1728	Hmu3160	1049	1549	1666	1040	2306	1739	1442	1543	1552
1724	Hut2308	1005	1537	1591	1013	1739	2552	1437	1554	1537
1732	HQ3398A	1086	1638	1521	901	1442	1437	2635	1574	1706
1816	HVO_0135	1107	1670	1517	889	1543	1554	1574	2225	1776
1889	Hbo1361	1063	1741	1575	951	1552	1537	1706	1776	2299

420 symbols
consensus       ----------------------------------------------MDEEFGLVEPEEAD
#oth            111111111111111111111111111111111111111111112244523233444433
VNG2233         ::::::::::::::::::::::::::::::::::::::::::::::--------------
hla0633         :::::::::::::::::::::::::::::::::::::::::::::::S:::V:L:::--:
NP1312A         :::::::::::::::::::::::::::::::::::::::::::::::T:DD::LSADDGE
rrnAC2476       ::::::::::::::::::::::::::::::::::::::::::::::--------------
Hmu3160         ::::::::::::::::::::::::::::::::::::::::::::MSD:GD::::DT::::
Hut2308         ::::::::::::::::::::::::::::::::::::::::::::::-MT::::IDD:G:E
HQ3398A         MTDHDHDNNHENSGHRSDIDNAEDEAEAEADIESTDAEMSKINAETT:SDS:F:A:DVV:
HVO_0135        :::::::::::::::::::::::::::::::::::::::::::::::TD:::M:::Q:GE
Hbo1361         ::::::::::::::::::::::::::::::::::::::::::::MTES::::::::A::G

consensus       QPGDEWEEIDVSDTEADRIARRRDREFDEFRKRIKDTEQFKVEASVFDDATFAAIYKLVQ
#oth            531212232113121112111431131321131222221112331111111321211111
VNG2233         ------------------------------------------------------------
hla0633         :::::::KL:::::::::::::Q::::::::::::::::::LQE:::::::L::::::::
NP1312A         ::::::::L::::::::::::AQ::::L:::::::N:::::::::::::::LG:L:::::
rrnAC2476       ------------------------------------------------------------
Hmu3160         GV:::::S:::::::::E:::T:::::S:::::::N::::::T::::::::YG:L:::::
Hut2308         L::::F:::::A:::::::::::::::S:::::::N::::::::::::::::::L:::::
HQ3398A         T::N::A::::::::::::::::::::ST::E:LT:AD:::::Q::::::::::::::::
HVO_0135        AF:::::::::::D::::::::K::D:::::M:L::AD:::::Q::::::::::::::::
Hbo1361         T::::::S:::T:::::::::K:::K:::::::L::AD:::::Q::::::::::::::::

consensus       DGHIDAFGGPISTGKEANVYEALGGDDA--------------------------------
#oth            132231212121111112222124446532333222111111111111111111111122
VNG2233         ------M::::::::::::::::DAEGG::::::::::::::::::::::::::::::::
hla0633         ::YV::::::V::::::S:F:::::QAGERPEPGSA::::::::::::::::::::::AA
NP1312A         :SYV::::::::::::::I:T::AP:G-::::::::::::::::::::::::::::::::
rrnAC2476       ----------------------------::::::::::::::::::::::::::::::::
Hmu3160         ::::::::::::::::::::T::A::SEARSASGQS::::::::::::::::::::::::
Hut2308         ::Y:E:::A:::::::::::T::S:AQSRSAPDESSRPDRRSAESKAAEPRDYGDEPEPR
HQ3398A         :D::A:::::::::::::::::R:T:T:::::::::::::::::::::::::::::::::
HVO_0135        :::::::::::::::::::F::::::::::::::::::::::::::::::::::::::::
Hbo1361         ::::::::::::::::::::::::PE:T::::::::::::::::::::::::::::::::

consensus       -----------DVAVKVYRINASNFRQMRDYLEGDPRFEGIGSDKKKVVLAWTRKEFANL
#oth            221231333332113121111212133..3..1.....11124..131.31.12..21..
VNG2233         ::::::::::::::L::::::::::Q:::A::::::::::LRG:::A:::S::::::S::
hla0633         GGGPEGVHPERE:::::::::S:::::::::::::::::::A::::A:::::::::::::
NP1312A         :::::::::::E:::::::::::D:K:::A:::::::::::::::::::V:::K::Y:::
rrnAC2476       :::::::::::----------------::S::D::::::::::::::::T::V:::SS::
Hmu3160         ::GGDGEPRDEE:::::::::::D::D::G::D::::::::::::::::T::V:::::::
Hut2308         DDGGRGTKGGHE:::::::::::D:KD::G::D::::::::::::::::T::V:::::::
HQ3398A         ::::::::::::::::I::::::::Q:::S::::::::D:L:Q:::AI:::::Q::::::
HVO_0135        ::::::::::::::::I::::::D::H::::::::::::N::H::GQ::R::V:::::::
Hbo1361         ::::::::::::::T:I:::::::::H:::::::::::::::N:::R::::::Q::::::

consensus       ERARRAGVRVPEPIAVERNVLVMELVGTE-EDRARRLSEVHIENPETAYEVVREYMRRLY
#oth            3..33....1.3.1..1.......121531231121.21.31...1111..12..21..2
VNG2233         R::KA::::::A:L::Q::::::::I:R::G:A:PT::D:D::::QM::::::::V::::
hla0633         ::::K:::::::::::Q::::::::::HA:::::::::::DV:::::::::::::::::F
NP1312A         ::::K:::::::::::::::::::YL:DD:DR::K::N:::::::::T::::::::::::
rrnAC2476       K::::::::T::::::::::::::YL:::::G:SK:::::::::::::::::K::T::::
Hmu3160         Q::QK::::::N::::Q:::::::YIA:::DG::K::N::::::::::F:::::::::::
Hut2308         K::QQ::::::N::::::::::::YIA:DA:G::K::N::::::::::F::L:::::::H
HQ3398A         R::M:::::::::::::::::::::::LV::E:::::A::D::::Q::::::Q:::Q:::
HVO_0135        :::Q:::::::K::::Q::::::::::VV:D:::::::::RV:::Q:::::::::::::H
Hbo1361         ::::Q::::::::::::::::::::::LV::::::::A::SV:::Q::::::::::::::

consensus       DAGLVHGDLSEYNIVIHEGELVVIDLGQAVTVHHPNAEEFLRRDCRNVANFFARQGVDVD
#oth            3...1......1.31212.1.221.2.....1.11.1431.2...3...3..31..3122
VNG2233         :::::::::::::V:VY::::::::V:::::I::::SAT::E::::::::::::::A:A:
hla0633         R:::I::::::::MI:::::::I::M:::::::::::G:::D:::E:::T::T:::I:::
NP1312A         :::::::::::F:::V:::::CLL::::::::::::SR:::E:::E:::G::::::::::
rrnAC2476       :::::::::::::::F:::Q:YI::::::::I:::::DD::E::::::::::::::::AT
Hmu3160         :::::::::::::::F:::Q::::::::::::::G::RDY:E:::E:::::::::::::T
Hut2308         A::::::::::::V:F:::::::::::::::::S::::D::::::Q:::::::G:::E:T
HQ3398A         S:::I::::::::MI::N::::::::::::::::::::M::::::K:::T::S:::I:T:
HVO_0135        R::::::::::::LI::D::::::::::::::::::::::::::::::::::R:::A:A:
Hbo1361         S::::::::::::MI::D::::I::::::::::::::D:::::::::::K::S:::T:TS

consensus       ADDLLEYV---------------TDDDPDPSGDPA---D---------------------
#oth            233.233.21211122211111123325445.5537454454432221111111111111
VNG2233         P::::S::HEHATPRAEADTA::AG:RDGTE:SLDRGS:ADDA:::::::::::::::::
hla0633         P:::Y:::::::::::::::::::EPE:::::E:ESGGESKSGGESKSGGESKSGGESDK
NP1312A         :::::AH:::::::::::::::::EPE:::::NAE:::-:::::::::::::::::::::
rrnAC2476       PEE::A::REYATPKDKADTAPGS:::AV:Q:T::DRR:DE:::::::::::::::::::
Hmu3160         :E:::AT:::::::::::::::::RA:EAAD:---:::-:::::::::::::::::::::
Hut2308         ::A:YD::::::::::::::::::::EQQDY:SS:ASK:T::::::::::::::::::::
HQ3398A         PAA:I:T:::::::::::::::::EP::::::TL:QSEHSVQSTDEES::::::::::::
HVO_0135        G:S:Y:F:::::::::::::::::G:E-GED::GDE::-:::::::::::::::::::::
Hbo1361         :T::Y:F::::::::::::::::::V:A::T:::DVDERDAGTDE:::::::::::::::