[S] (-) COG3294 Uncharacterized conserved protein 9 genomes BUD0628 9 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG0804 rrnAC0521 HVO_1164 Hbo0394 Hmu1294 Hut0957 hla2635 NP2902A HQ2504A

Pairwise sequence scores
Consensus score	2019	HQ2504A	HVO_1164	Hbo0394	VNG0804	Hut0957	rrnAC0521	Hmu1294	hla2635	NP2902A
1589	HQ2504A	2046	1457	1553	1431	1383	1418	1471	1370	1341
1687	HVO_1164	1457	2014	1601	1448	1453	1432	1474	1374	1440
1653	Hbo0394	1553	1601	1997	1461	1471	1391	1467	1388	1429
1592	VNG0804	1431	1448	1461	2260	1471	1431	1460	1328	1381
1638	Hut0957	1383	1453	1471	1471	2070	1519	1550	1401	1414
1654	rrnAC0521	1418	1432	1391	1431	1519	2029	1598	1390	1387
1673	Hmu1294	1471	1474	1467	1460	1550	1598	2039	1442	1439
1585	hla2635	1370	1374	1388	1328	1401	1390	1442	3308	1504
1594	NP2902A	1341	1440	1429	1381	1414	1387	1439	1504	2053

447 symbols
consensus       MSDAAD--------------------------DTG--GR---------------------
#oth            14644353222222211111111111111111464432.111111111111111111111
HQ2504A         :AKSGSV::::::::::::::::::::::::::VE::D::::::::::::::::::::::
HVO_1164        :::TE:T:::::::::::::::::::::::::LN::::::::::::::::::::::::::
Hbo0394         :AEVT:::::::::::::::::::::::::::-D::::::::::::::::::::::::::
VNG0804         -MS::PAPGVCTRFPRRLFPGSHPTLPEMTQP:QSNPT::::::::::::::::::::::
Hut0957         :T::T:AGG:::::::::::::::::::::::NE:SA:::::::::::::::::::::::
rrnAC0521       ::VDRP::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hmu1294         ::NDESL:::::::::::::::::::::::::::R:::::::::::::::::::::::::
hla2635         ::A:GHRRSRIAGDR:::::::::::::::::R:CRA::GSSGTGSPLPPSDGSRAFFRE
NP2902A         :DE:::::::::::::::::::::::::::::-SCAT:::::::::::::::::::::::

consensus       ------------------------------------------------------------
#oth            111111111111111111111111111111111111111111111111111111111111
HQ2504A         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
HVO_1164        ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hbo0394         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
VNG0804         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hut0957         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
rrnAC0521       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hmu1294         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
hla2635         EPRRCRRRRAAFGRGSGHTTVCAFGSLIDCASGGNCRSAAPHRFDERLAVARRQRPQSSI
NP2902A         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

consensus       ------------------------------------------------------------
#oth            111111111111111111111111111111111111111111111111111111111111
HQ2504A         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
HVO_1164        ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hbo0394         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
VNG0804         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hut0957         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
rrnAC0521       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hmu1294         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
hla2635         TDIHLYVRRVFFYPMTDPADAGVDADPEDHESDTVRDPETDTVRDPDIDVNPDIDISPDA
NP2902A         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

consensus       ---IYDPEADHAFPDERLNEVLDRILSDEEITAYLEAQNVNPVTRKGYNDHGAKHIEIVR
#oth            1117.2.243.1..1111.31.35234.311211.5...1.1.2.12.....5..13..1
HQ2504A         :::Q:::DD::N::T::::V::PE::::P:::T::Q:::::A::::::::::T:::::::
HVO_1164        :::V::::::::::::K:::::PVL:D:::V:TL:::::::A::::::::::P::::::L
Hbo0394         :::K:::::S:N::::K:::::PTL:D:P:VKT::K:::::A::::::::::E:::::::
VNG0804         :::A:::AQS:::::G:::D::EYV:N::AV::::T::::::::::::::::::::::::
Hut0957         ::::::::GA:::::::::A::EYVRE:A::Q:::S::::::::::Q:::::E:::T:::
rrnAC0521       :::::::::::::::G:::A:::TVTT::::Q:::::::I:::A::R:::::::::G:::
Hmu1294         :::R:::D:::::::::V:D::AA:E::T::Q::::::::::::::R:::::::::S:::
hla2635         DRHE:H:DRE::::::::::M::::E::P::::::::::::::D::::::::S::V::::
NP2902A         :::T:N:::::::::::V:::::::EN::::::::A:::::::D:M::::::R:::::::

consensus       NRALRLYDLLKAGGVEFNGAREQGLDEADEAVIIALAATLHDIGHVVHRDDHPYYSIPLA
#oth            11..2..2...42223.1..321..312..2..1...11...1..1...14.1...1...
HQ2504A         :::::::E:::TSNI:::::T::::SG:::P:::::::::::V:::::::K:::::::::
HVO_1164        ::::::::::::::C:::::A:::::::::P:::::::Q::::::I::::N:A:::::::
Hbo0394         :::::::::::::D:D::::SQ:::A:E:::::V:::::::::::I::::E:A:::::::
VNG0804         :::::::A:::R:::P::::TD:::S::::P::V::::::::::::::::::A:::::::
Hut0957         ::::C::::::E:::T:::::::::::S::P::V::::::::::::::::::::::::::
rrnAC0521       ::::C::::::QA:::::::ADH::::::::::::::T::::::::::::S:::::::::
Hmu1294         ::::C::::::R::I:::::S::::E:::::::V::::::::::::::::::::::::::
hla2635         D::::::::::::::::::::Q::::::::S::::::::::::::::::H::::::::::
NP2902A         :A::S::::::::::::D:::Q::::::::::::::::::::::::::::::::::L:::

consensus       ADLLDRFLPE--FYDIAEAVRIKAEVLHAILCHHTEEDPLTLEAGVVRVADALDMERGRS
#oth            1.2..12.35231.14433.13.1.1.......121.4...3...11.1..1....2...
HQ2504A         ::I::::::QFD::::EQQ::M:::I:::::::::A:::::T:::II:::::::::::::
HVO_1164        S:V::::::::::::L:D::::::::::::::::R:::::::::::I:::::::::::::
Hbo0394         :::::::::Q:::::TS:V::M:::::::::::::::::::T::::I:::::::::::::
VNG0804         ::V:::I::::::::P:D:::V:G:::::::::::::T:::T::::I::::G::::H:::
Hut0957         ::::::I:ADLP:::V:A:::V:::::::::::D:A:K:::V::::::::::::::S:::
rrnAC0521       ::I::DL:D:::::::RQ::Q::G:::::::::::::N::::::::::::::::::::::
Hmu1294         :::::D:::A::Y::TEA:::V:G::::::::::::::::::::::::::::::::S:::
hla2635         :::::D::SS::::GVP:Q::::::::::::::::::Q:::R:::I::I::G::::::::
NP2902A         ::I:::::DGLGY::P::T::L:G:I::::::::S::Q:::R:::I::::::::::::::

consensus       RIPYEKGGRGINTLSSQAIERVSLQPGDDKPVLVEIEMNNAAGVYQVDNLLKAKLHDSGL
#oth            .2..24.....1.2..1..45.5.45.336112.2.2.61........2...2.153.21
HQ2504A         ::::K::::::D:::::::D:::::S:S:C::::K:::I::::::::::::::::R::::
HVO_1164        ::::::::::::::::R::KD:V:K::EESA:::::::L::::::::::::::::DG:::
Hbo0394         :::::::::::::::::::DN:::K::T::::::::::V:::::::::::::::::N:R:
VNG0804         :L:::R:::::::::::::S::A::E:::A::::::::Q:::::::::::::E:::R::I
Hut0957         :::::H:::::::V::::::A:H:RT::GV::::::::T:::::::::::::::::N:::
rrnAC0521       ::::KR:::::D:V::::::T:T:SL:::Y::::::A::::::::::::::::::K::::
Hmu1294         ::::NH:::::::V:::::K::F::D::::::::::::S::::::::::::::::QG:::
hla2635         :V:::E:::::::V::::::::::RE:EET:AQ:V:W:::::::::::S:::::IEG:L:
NP2902A         :::::Q:::::::I::R::TS:A:C::EST:AM:::::TD::::::::E:::H::D::RI

consensus       EDHVRIVAVNTRED-D---QLVERIEL
#oth            1362.1..2.24424211141111...
HQ2504A         QEY:::::::::GG:::::::::Q:::
HVO_1164        :::::::::::KS::::::R:::::::
Hbo0394         ::LI:::::::KAE:S:::::::::::
VNG0804         ::D:::::L:STGEG::::A:::::::
Hut0957         :ERL::::I:::::T::::RI::::::
rrnAC0521       :E::::::L:::::GN::::I::::::
Hmu1294         :PY:::::L:I:::E::::::::::::
hla2635         ::EI:T::I::HR:D:GNGSI:D::::
NP2902A         :SF::::::::DRGE::::-:I:::::