[H] (MenA) COG1575 1,4-dihydroxy-2-naphthoate octaprenyltransferase 9 genomes BUD0636 9 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG1075 rrnAC0845 HVO_1462 Hbo0085 Hmu1612 Hut1087 hla2155 NP2734A HQ1875A

Pairwise sequence scores
Consensus score	2284	HQ1875A	VNG1075	HVO_1462	hla2155	Hbo0085	NP2734A	Hut1087	rrnAC0845	Hmu1612
1778	HQ1875A	2343	1627	1675	1715	1655	1406	1345	1464	1373
1834	VNG1075	1627	2290	1579	1686	1611	1501	1371	1451	1388
1750	HVO_1462	1675	1579	2285	1651	1654	1379	1311	1406	1318
1962	hla2155	1715	1686	1651	2359	1656	1488	1474	1506	1473
1760	Hbo0085	1655	1611	1654	1656	2224	1366	1346	1377	1393
1708	NP2734A	1406	1501	1379	1488	1366	2411	1471	1586	1562
1623	Hut1087	1345	1371	1311	1474	1346	1471	2213	1628	1566
1716	rrnAC0845	1464	1451	1406	1506	1377	1586	1628	2319	1698
1650	Hmu1612	1373	1388	1318	1473	1393	1562	1566	1698	2213

331 symbols
consensus       ------------T-TADVSRRRAWVMAARPQTLPAAAAPVIVGTGLAVHDGVFAPLPALA
#oth            11112222223344234313331121.1..1....12..13..311.213121.32.221
HQ1875A         ::::::::::MSAQ:QSI::QK:::::::::::::::::IL::::V:I::::::::::::
VNG1075         :::::::::::M:Q::::::Q:::L:::::H:::::::::V:::A::::T::L:VW::V:
HVO_1462        ::::::::::::MS:Q:I:::::::::S::::::::::::V:::AV:::ADL::::::F:
hla2155         MVSLRDDTSLPA:MSTE::::::::I:::::::::::::::::V:::::::A::::::::
Hbo0085         ::::::::::::-:-----------::::::::::::::IF::V::::::::::A:::::
NP2734A         ::::MGAATRVAPM::AA:STK::L::::::::::G::::::::::::YH:::::::::F
Hut1087         ::::::::::::-:-----------:::::H::::GT::::::V:V::::::::LF:T::
rrnAC0845       ::::::::::MS:A:::::K:Q:::::::::::::G:::::::M:::::A::::L:::V:
Hmu1612         ::::::::::::-:-----------::::::::::GS::::::A:::L:::::::::W::

consensus       ALVGALLIQIGTNFANDYYDAVQGADTDDREGFTRVTAGGLIEPAEVKRAMYLTFAAAIL
#oth            .13..1.1.11.......1..13....22.1.....1.1...4174..2.1321123122
HQ1875A         ::L::A:::::::::::::::IK::::A::::::::::::::D:PA:::::::::MI:::
VNG1075         :::::A::::A:::::::::::R::::E::::::::::::::R::R::Q:::V:::::::
HVO_1462        :::::::::V:::::::::::::::::EA:::::::::::::P:S:::::::::::::V:
hla2155         :F:::A:::V:::::::::::I::::::::::::::V:S:::::G::::::W::::::::
Hbo0085         :F:::A:::::::::::::::::::::A::::::::::::::A:KS::::::::::::::
NP2734A         ::F::::L::::::::::::::R::::E::D::::::::::::::A::::::A::GLSMV
Hut1087         ::::::::::::::::::F:::K:::::E:::::::::S:::::D:::::IIV:YGL::G
rrnAC0845       ::::::::::::::::::::::K:::::E:::::::::::::DAE::::::IA:YGL:VV
Hmu1612         ::A::::L::::::::::::::N:::::::::::::::::::PAQQ::Y::AAAYGF:VV

consensus       VGTYLVAVGGVPILVVGLASVAAGIAYTGGPYPLGYHGLGDLFVFVFFGVVAVTGTYYVQ
#oth            3.32..31..2..121..31121.12.1...2.1..2....2...21..12..2..1...
HQ1875A         ::AT::W:::I:::I:::L::GS::::::::::::::::::V:::::::LI:::::::::
VNG1075         D:V:::F::::::::I::::::S::T:::::::::::::::A:::L::::I:::::::::
HVO_1462        L:::::Y:::::::::::L:::S::::::::::::::::::::::::::L:::A::F:::
hla2155         :::S::Y::::::::I::::::::::::::::::::::::::::::::::I:::::::::
Hbo0085         L:::::Y::::::::I::L:::S::::::::F:::::::::::::I::::::::::::::
NP2734A         I:L:::::::::::::::::IV:::T:S:::L:Y::R::::::::::::L:::A::::::
Hut1087         ::L::::I::::::F:::SGI::::L:::::::Y::Y:::::::::Y:::F::V::::::
rrnAC0845       I:V:::::::L::V::::SGI:::VL:::::F:Y::R:::::::::Y::L::::::::::
Hmu1612         ::V:::::::::::::::T:I::::L:::::::Y::R:::::::::Y:::::::::::::

consensus       AAAHA--AGAFPLWIPPGTVPLAAVVASLPAAALSTNILVVNNVRDREEDATTGKRTLAV
#oth            .11452122411332.3222323122.1.12.22..1.11...1..331.231..2....
HQ1875A         :::LI::::T:::G::A:::S:T:I:::::I::::::::::::::::N::::::::::::
VNG1075         ::::L:::::::VA::::::::::::::::V::I::::I::::I::KD::E:::::::::
HVO_1462        ::SVL:::APLSVG::A:::T:V::L::::I::I::::::::::::K:::::::::::::
hla2155         :::L:::G::::::::E:::T:::::::::V:::::::::::::::LK:::E::::::::
Hbo0085         :::VI:::DPLSVG:::N:L:FD:F::::AV:::::::::::::::K:::E:::::::::
NP2734A         ::::-::G:W::::::E::L:A:::::G::::GF::A::::::I::::T::EA::H::::
Hut1087         ::STM:::DL::::V:S:::S::V::::::::T:::A::N:::I::I:T:RKA:::::::
rrnAC0845       :V:S:SGV:T::MTL:::S:TA::IT::::::G:::A::::::I::::T:RAA::K::::
Hmu1612         :V:TSD:::L::T:L:SEIGLAT:::::::::G:::A:::::::::::T::EA:::::::

consensus       RFGYRFSRLEYLAMLGLAYAVPVWFALDG-YGLAVLLPLVTLPLAASVARTVLTETAGDA
#oth            32.1221.4124413331.33.231443451335121.1312.3.34143.143315.23
HQ1875A         :Y::T:A:A:FITL:I:::S::I::LSRTA:T:::G:::::::I:L::MH:IC::::::M
VNG1075         :::::::::::AGL:VV:::A:L::YAT::::AS:F:::::::::V::TK::FER:E:A:
HVO_1462        ::::G:A:A::VT::A:::::::YLWTRAGFDWF::::VFSM:V::RI::::V:::K:EK
hla2155         ::::::::GQ:::L:A:::LT:L::FAE::::::A::::A::::::G:::::::::::::
Hbo0085         ::::T:::G::::::A:::L::::::TRQTF:GV:F:::::::Y:I::::::::K:S:E:
NP2734A         IL:::L::I:WSL:A::G::I::V:W:::::PAT:::::::A:::IAIG:::WNR:D:E:
Hut1087         IL:D:L:::::VF:I:T::V:::V::F:SDF::PA::::L:::::V::TL:::::SG::V
rrnAC0845       YL::GW::V:F:L:V:M::V:::V::::SQ::::A:A::L::::::TISK::::Q:G:::
Hmu1612         M:::::::::F::LV:M::V::IG:::::AF::PA:A::LS::::V::SK:::RR:D:E:

consensus       LNPALERTGKLLAAHSVLFAIGLALP-----
#oth            .1.1.221.122231122.23.224542321
HQ1875A         :::T:::V:::::GYAL::S::::IKTLPVV
VNG1075         :::::S:::Q::::Y:A:::V:V:V-:::::
HVO_1462        ::::::D::::::LYA:::S:::V:A:::::
hla2155         ::::::S:::::::YA:A::V:::V-:::::
Hbo0085         :::::::::::::I::L::G:::SFGGLPL:
NP2734A         :::::Q::::::F::::C::L:F:A:AVI::
Hut1087         :D:::::::QVMV::A::::V:::::QVI::
rrnAC0845       :::T:::V:QT:F:::::::A:::ATQLL::
Hmu1612         :::::::V:QTVF:::::::L::::TA::::