[C] (FumC) COG0114 Fumarase 9 genomes BUD0643 9 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG1356 rrnAC0028 HVO_2900 Hbo2679 Hmu1082 Hut0317 hla1064 NP3778A HQ2471A

Pairwise sequence scores
Consensus score	3457	HQ2471A	Hut0317	NP3778A	rrnAC0028	Hmu1082	hla1064	VNG1356	HVO_2900	Hbo2679
2878	HQ2471A	3575	2605	2656	2703	2723	2735	2770	2811	2780
2920	Hut0317	2605	3496	2778	2829	2843	2789	2740	2764	2767
3051	NP3778A	2656	2778	3499	2876	2846	2860	2813	2874	2817
3059	rrnAC0028	2703	2829	2876	3472	2983	2804	2830	2856	2857
3053	Hmu1082	2723	2843	2846	2983	3448	2804	2801	2930	2905
3071	hla1064	2735	2789	2860	2804	2804	3466	2923	2950	2980
3082	VNG1356	2770	2740	2813	2830	2801	2923	3468	2905	2977
3131	HVO_2900	2811	2764	2874	2856	2930	2950	2905	3462	3001
3156	Hbo2679	2780	2767	2817	2857	2905	2980	2977	3001	3451

492 symbols
consensus       -------MSDDYRTERDSLGEMQVPADAYWGAQTQRAVENFPISGITFGRRFIRALGVVK
#oth            122222324211.2.3.....11..1...........21...2.23312...1....1..
HQ2471A         ::::::::A::::V:::::::I:::::::::::::::I::::L::::::::::::::I::
Hut0317         MTDSRDYGNE:::I:A::::::E::::::::::::::I::::::DQR:::::::::::::
NP3778A         :MPPMADEDT:::I::::::::E::::::::::::::LG:::V:::::Q::::::::I::
rrnAC0028       ::::::::T:E::::Q::::::::::::::::::::::::::::DV::::::::::::::
Hmu1082         ::::::::::EF::::::::::::::::::::::::::::::::EE::::::V::::I::
hla1064         :::::::::E:::::E::::::::::::::::::::::::::::::PMS:::::::::::
VNG1356         :::::::::E:::::Q:::::::::::::::::::::I::::::::A:::::V:::::::
HVO_2900        ::::::MGD::::I::::::::E::V::::::::::::::::::::::::::V:::::::
Hbo2679         :::::::::E:F::::::::::::::::::::::::::::::::::::S:::::::::::

consensus       KAAAQANRDLGLIDEDKADAIVEAADEVIAGEHDDQFPVDVFQTGSGTSSNMNANEVIAN
#oth            .2..1..2..2222334.22.11........12.......1........1........1.
HQ2471A         ::::::::::D:::A:T:::::A:::::::::F:::::::I:::::::::::::::::::
Hut0317         :G::::::::::L::E::::::A::::::::D::::::::I::::::::T::::::::::
NP3778A         :S::K::L::E:LEA:::E::I::::::::::::::::::::::::::::::::::::::
rrnAC0028       ::::::::::ET:P:::::C::::::::::::::::::::::::::::::::::::::S:
Hmu1082         :::::::E:::TVESET:AY::::::::::::::::::::::::::::::::::::::::
hla1064         ::::::::::::::D:T:::::A::::::::D::::::::::::::::::::::::::::
VNG1356         ::::::::::::V:DER:::::A:::::::::::::::::::::::::::::::::::::
HVO_2900        :::::::::::M:::GV:A:::::::::::::L:::::::::::::::::::::::::::
Hbo2679         :G::::::::::VE:NI:::::::::::::::::::::::::::::::::::::::::::

consensus       RAAEILGGEIGDRVVHPNDHVNYGQSSNDVIPTAMHVAALEAVEKDVLPALETLREELAA
#oth            ..1.15133..3131....1..1.............11211.332.13.1.3..341.43
HQ2471A         ::::::DKS::E:A:::::D::F:::::::::::::I::D:::T::L::::D::ES:::S
Hut0317         ::T::V:::::SKKI:::::::::::::::::::::::V:::I:R::::G::::::::QI
NP3778A         ::T::Y:::::T:EI:::::::::::::::::::::::S:::AR:::::G::::A:::::
rrnAC0028       ::T:LY::D::T:EI:::::::F:::::::::::::::S::::::::I:G:K:::D::E:
Hmu1082         ::T:LS:::::T:AI::::::::::::::::::::::::::::::::::::S:::DA::D
hla1064         :::::A:A::::::::::::::::::::::::::::::::::::::LV::::::HT::E:
VNG1356         ::::L::E::::::::::::::::::::::::::::::S:D:LVN::K:G::::AA::DD
HVO_2900        :::::M:EG:::::::::::::F:::::::::::::::S:::::::L:::::::AAA:GD
Hbo2679         ::::LM:E:::::::::::::::::::::::::::::S::::::::L::::D::::A:E:

consensus       KEDEFDGVVKTGRTHLQDATPVRLGQEFGGYRTQVEKGIDRVEGVRERLSELALGGTAVG
#oth            1141.13.1............13.....2..11.22..16.336244214........1.
HQ2471A         QAEA::D:I::::::::::::IS:::::D::K::IQ:::S:::T:TDH::::::::::::
Hut0317         ::E:::D:::::::::::::::M:::::S:::::I::::A:::ET:::AA::::::::::
NP3778A         ::::::A:::::::::::::::::::::::::::I:::::::::AT:::E::::::::T:
rrnAC0028       ::::::T:::::::::::::::T:::::S::::::::::S::QD:HG:::::::::::::
Hmu1082         ::SA::D::::::::::::::IT:::::S:::A::::::T::KHT:DH::::::::::::
hla1064         ::T::::::::::::::::::I::::::S:::::TA:::E:A:T:QSN:R::::::::::
VNG1356         :A:A:::::::::::::::::::::::::::::::::::::I:A:AP:::::::::::::
HVO_2900        ::A::::::::::::::::::::::::::::::::::::R:::N:::H:G::::::::::
Hbo2679         ::E::A::::::::::::::::T:::::::::::::::LG:LD::::H::::::::::::

consensus       TGLNTHPEFPERAAEYISEETGLEFREADNHFEAQAAHDAMSEAHGALRTVAGSLNKIAN
#oth            .......1..33.12.113..334.11..1...........2.1......1...11.1..
HQ2471A         ::::::::::T::T::::T::TIS:QP::S::::::::::::::::::::::::::::::
Hut0317         :::::::::::L:::::::::L:T:::::::::::::::::::V:::::::::::Q::::
NP3778A         :::::::::::::::::::::::S::::::::::::::::::::::::::::::M:::::
rrnAC0028       :::::::::::K::T::::::D:N::::::::::::::::::::::::::::::::::::
Hmu1082         ::::::::::A:::::::::::ID::::::::::::::::::::::::::::::::::::
hla1064         :::::::D:::L::::::D:::T::::::::::::::::::A::::::::I::::::M::
VNG1356         :::::::::::T::G:::::::VT:::::::::::::::::N::::::::::::::::::
HVO_2900        ::::::::::AK::::MT::::V:::::::::::::::::::::::::::::::::::::
Hbo2679         :::::::D::KK:::::TA:::V:::::::::::::::::::::::::::::::::::::

consensus       DLRLLASGPRNGLGEIEQPENQPGSSIMPGKINPVVAEAVNQVHKQVVGNDAAVSAGAAE
#oth            ...............21..................1..1...111..1.....111...2
HQ2471A         ::::::::::::::::D::::::::::::::::::I::::::A:::::::::::A:::::
Hut0317         :::::::::::::::LD:::::::::::::::::::::S:::AYA::::::::::T:::N
NP3778A         :::::::::::::::V::::::::::::::::::::::S::::::::I:::::::::::R
rrnAC0028       ::::::::::::::::D:::::::::::::::::::::::::::::::::::::::::::
Hmu1082         :::::::::::::::VD:::::::::::::::::::::::::::::::::::::::::::
hla1064         ::::::::::::::::::::::::::::::::::::::S::::::::::::::I:::::R
VNG1356         :::::::::::::::::::::::::::::::::::::::::::::::::::::IA:::::
HVO_2900        :::::::::::::::L::::::::::::::::::::::::::::::::::::::::::::
Hbo2679         :::::::::::::::::::::::::::::::::::::::::::::::::::::I::::::

consensus       GQIDLNLYKPVLAHNFLQSARLIANASEVFGEKFVAKLEANEEHCEERVEQSMALATALN
#oth            .1.........1.3.1.1..621114133.111.12..1.1222.222.21.1..1....
HQ2471A         :::::::::::I::::::::M:LS:T:T::A:R:I:::D:::AV::TQ:D::L::V::::
Hut0317         :::::::::::I:S:V:E:::::::V:GA:AT::::::::DR::::::::::::::::::
NP3778A         :E:::::::::::Y::::::SI::SSA:L:::R::G:::::AD::RTK::::::::::::
rrnAC0028       :::::::::::::S::::::K::::S:A::::::::::::DAD::A::::::::::::::
Hmu1082         :::::::::::::N:::::::::::G::::A:::::::::DR:::A:::Q::::::::::
hla1064         :E:::::::::I:::::E::E:LS::AAT:::R:::::::::::::T:::::::::::::
VNG1356         ::::::::::::::::::::DML::::AA:::::::::::::AA::AQ::R:::::::::
HVO_2900        :::::::::::::::::E::K:L::S::::A:R:::::::::::::T:::::::::::::
Hbo2679         :::::::::::::::::E::Q::S::::T::T:::R:::::::V:::Q::R:::::::::

consensus       PAIGYDKASKVAKKALKEGKTVREVVVEEGYLSEAEADEVLDPEKMTHRGIL-GDD----
#oth            .1.......1...4.11222112211213...2121112..1.23..2.1..1.122111
HQ2471A         :T::::::::::::::::DA:::D::I:Q::::P:K::T::N::T:::::::::ESDDQA
Hut0317         :::::::::E:::E:M:T:Q:I:::A::K:::T::::::::::AT::E:V::::EE::::
NP3778A         :::::::::::::Q:::::::::::A::::::T::::::::::KA::E:V::::::::::
rrnAC0028       ::::::::::::::::ADE::I::::L:::::D:D:V:D::::::::K::::::EE::::
Hmu1082         :::::::::::::Q::A:::::K:::::::::::::::D::::A:::E:V::::::::::
hla1064         :::::::::::::T::::::S:::AA:DA:::T:E:::::::::A::::V::::::D:::
VNG1356         :T:::::::E:::A::::::::T:::::K::::::::AD:::::G:::::::S:::T:::
HVO_2900        ::::::::::::::::A:D:S::Q:A:D::::T:::::::::::::::::::::::::::
Hbo2679         :T:::::::E:::T::::::::::::I:K:::::E:::::::::::::::::::::::::

consensus       ------------
#oth            111111111111
HQ2471A         DDDDTEDTTDEQ
Hut0317         ::::::::::::
NP3778A         ::::::::::::
rrnAC0028       ::::::::::::
Hmu1082         ::::::::::::
hla1064         ::::::::::::
VNG1356         ::::::::::::
HVO_2900        ::::::::::::
Hbo2679         ::::::::::::